Proteomic analyses lead to a better understanding of celiac disease: Focus on epitope recognition and autoantibodies

Digestive Diseases and Sciences

Volumn 55, Issue 11, 2010, Pages 3041-3046

  De Re, Valli ^a   Simula, Maria Paola ^a   Canzonieri, Vincenzo ^a   Cannizzaro, Renato ^a  

^a CENTRO DI RIFERIMENTO ONCOLOGICO   (Italy)

Author keywords

Celiac disease; Epitope; Mass spectrometry, MALDI TOF; Metabolomic strategy; Proteomics; Two dimensional gel electrophoresis: DIGE

Indexed keywords

ACTIN; ALPHA ENOLASE; AUTOANTIBODY; CELL ADHESION MOLECULE; CYTOCHROME P450; CYTOKINE; ENDOMYSIUM ANTIBODY; EPITOPE; GLIADIN; GLUTEN; HEAT SHOCK PROTEIN 60; HEAT SHOCK PROTEIN 70; HEAT SHOCK PROTEIN 72; HEAT SHOCK PROTEIN 90; HLA DQ ANTIGEN; HLA DQ2 ANTIGEN; IMMUNOGLOBULIN A; INTERLEUKIN 15; NATURAL KILLER CELL RECEPTOR NKG2D; PEPTIDE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR; PROLYL ENDOPEPTIDASE; PROTEIN GLUTAMINE GAMMA GLUTAMYLTRANSFERASE 2; PROTEINASE; PROTEOME; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATE SYNTHASE; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 3; TOLL LIKE RECEPTOR 4; UNINDEXED DRUG;

ANTIGEN RECOGNITION; CD4+ T LYMPHOCYTE; CELIAC DISEASE; DRUG ANALYSIS; DRUG IDENTIFICATION; ENZYME SUBSTRATE; GLUTEN FREE DIET; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; INTESTINE; LACTOBACILLUS; MASS SPECTROMETRY; METABOLOMICS; METHODOLOGY; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN MICROARRAY; PROTEIN PROCESSING; PROTEOMICS; RECEPTOR DOWN REGULATION; REVIEW; T LYMPHOCYTE ACTIVATION; TECHNOLOGY; TISSUE MICROARRAY; TWO DIMENSIONAL GEL ELECTROPHORESIS;

AUTOANTIBODIES; CELIAC DISEASE; CYTOCHROME P-450 ENZYME SYSTEM; ELECTROPHORESIS, GEL, TWO-DIMENSIONAL; EPITOPE MAPPING; GTP-BINDING PROTEINS; HUMANS; MASS SPECTROMETRY; PROTEIN ARRAY ANALYSIS; PROTEOMICS; TISSUE ARRAY ANALYSIS; TRANSGLUTAMINASES;

EID: 78149357599     PISSN: 01632116     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10620-010-1323-1     Document Type: Review

References (43)

1. F Hausch L Shan NA Santiago GM Gray C Khosla 2002 Intestinal digestive resistance of immunodominant gliadin peptides Am J Physiol Gastrointest Liver Physiol 283 G996 G1003 1:CAS:528:DC%2BD38XotV2qsb8%3D 12223360
2. P Ferranti G Mamone G Picariello F Addeo 2007 Mass spectrometry analysis of gliadins in celiac disease J Mass Spectrom 42 1531 1548 1:CAS:528: DC%2BD1cXitFWqtLg%3D 10.1002/jms.1361 18085572
3. O Molberg S McAdam KE Lundin C Kristiansen, et al. 2001 T cells from celiac disease lesions recognize gliadin epitopes deamidated in situ by endogenous tissue transglutaminase Eur J Immunol 31 1317 1323 1:CAS:528:DC%2BD3MXktVWjtbk%3D 10.1002/1521-4141(200105)31:5<1317::AID- IMMU1317>3.0.CO;2-I 11465088 (Pubitemid 32454680)
4. CY Kim H Quarsten E Bergseng C Khosla LM Sollid 2004 Structural basis for HLA-DQ2-mediated presentation of gluten epitopes in celiac disease Proc Natl Acad Sci 101 4175 4179 1:CAS:528:DC%2BD2cXivFart78%3D 10.1073/pnas.0306885101 15020763 (Pubitemid 38405902)
5. VM Salvati G Mazzarella C Gianfrani MK Levings R Stefanile B De Giulio 2005 Recombinant human IL-10 suppresses gliadin dependent T cell activation in ex vivo cultured celiac intestinal mucosa Gut 54 46 53 1:CAS:528: DC%2BD2MXntFOqsw%3D%3D 10.1136/gut.2003.023150 15591503 (Pubitemid 40007217)
6. LM Sollid C Khosla 2005 Future therapeutic options for celiac disease Nat Clin Pract Gastroenterol Hepatol 2 140 147 1:CAS:528:DC%2BD2MXjtFyjt7c%3D 10.1038/ncpgasthep0111 16265155 (Pubitemid 40812513)
7. J Gass MT Bethune M Siegel A Spencer C Khosla 2007 Combination enzyme therapy for gastric digestion of dietary gluten in patients with celiac sprue Gastroenterology 133 472 480 1:CAS:528:DC%2BD2sXhtVWqsr7E 10.1053/j.gastro.2007. 05.028 17681168 (Pubitemid 47187353)
8. C Mitea R Havenaar JW Drijfhout L Edens L Dekking F Koning 2008 Efficient degradation of gluten by a prolyl endoprotease in a gastrointestinal model implications for coeliac disease Gut 57 25 32 1:CAS:528:DC%2BD1cXitVKqsbc%3D 10.1136/gut.2006.111609 17494108
9. CG Rizzello M De Angelis R Di Cagno A Camarca, et al. 2007 Highly efficient gluten degradation by lactobacilli and fungal proteases during food processing new perspectives for celiac disease Appl Environ Microbiol 73 4499 4507 1:CAS:528:DC%2BD2sXot1egsrk%3D 10.1128/AEM.00260-07 17513580 (Pubitemid 47122594)
10. T Marti O Molberg Q Li GM Gray C Khosla LM Sollid 2005 Prolyl endopeptidase-mediated destruction of T cell epitopes in whole gluten chemical and immunological characterization J Pharmacol Exp Ther 312 19 26 1:CAS:528:DC%2BD2MXhtVWmtro%3D 10.1124/jpet.104.073312 15358813 (Pubitemid 40096448)
11. I Caputo A D'Amato R Troncone S Auricchio C Esposito 2004 Transglutaminase 2 in celiac disease Amino Acids 26 381 386 1:CAS:528: DC%2BD2cXmtVWktb4%3D 10.1007/s00726-004-0083-7 15290344
12. SM Stenman K Lindfors IR Korponay-Szabo O Lohi, et al. 2008 Secretion of celiac disease autoantibodies after in vitro gliadin challenge is dependent on small-bowel mucosal transglutaminase 2-specific IgA deposits BMC Immunol 9 6 10.1186/1471-2172-9-6 18312620 (Pubitemid 351467856)
13. R Shaoul A Lerner 2007 Associated autoantibodies in celiac disease Autoimmun Rev 6 559 565 1:CAS:528:DC%2BD2sXht1ylsb%2FP 10.1016/j.autrev.2007.02. 006 17854749 (Pubitemid 47374617)
14. PJ Utz P Anderson 1998 Posttranslational protein modifications apoptosis and the bypass of tolerance to autoantigens Arthritis Rheum 41 1152 1160 1:CAS:528:DyaK1cXkslWjtL8%3D 10.1002/1529-0131(199807)41:7<1152::AID- ART3>3.0.CO;2-L 9663470 (Pubitemid 28313415)
15. MC Arrieta L Bistritz JB Meddings 2006 Alterations in intestinal permeability Gut 55 1512 1520 1:CAS:528:DC%2BD28XhtFeht7rE 10.1136/gut.2005. 085373 16966705 (Pubitemid 44476799)
16. B Szebeni G Veres A Dezsofi K Rusai, et al. 2007 Increased mucosal expression of Toll-like receptor (TLR)2 and TLR4 in coeliac disease J Pediatr Gastroenterol Nutr 45 187 193 1:CAS:528:DC%2BD2sXotlKjtro%3D 10.1097/MPG.0b013e318064514a 17667714 (Pubitemid 47220526)
17. S Hue JJ Mention RC Monteiro S Zhang, et al. 2004 A direct role for NKG2D/MICA interaction in villous atrophy during celiac disease Immunity 21 367 377 10.1016/j.immuni.2004.06.018 15357948 (Pubitemid 39208338)
18. B Meresse Z Chen C Ciszewski M Tretiakova, et al. 2004 Coordinated induction by IL15 of a TCR-independent NKG2D signaling pathway converts CTL into lymphokine-activated killer cells in celiac disease Immunity 21 357 366 1:CAS:528:DC%2BD2cXotFakt7c%3D 10.1016/j.immuni.2004.06.020 15357947 (Pubitemid 39208337)
19. M Schumanm JF Richter I Wedell V Moos, et al. 2008 Mechanisms of epithelial translocation of the alpha(2)-gliadin-33mer in coeliac sprue Gut 57 747 754 10.1136/gut.2007.136366 (Pubitemid 351716965)
20. S Orrù I Caputo A D'Amato M Ruoppolo C Esposito 2003 Proteomics identification of acyl-acceptor and acyl-donor substrates for transglutaminase in a human intestinal epithelial cell line. Implications for celiac disease J Biol Chem 278 31766 31773 10.1074/jbc.M305080200 12799366 (Pubitemid 37048357)
21. L Piredda A Amendola V Colizzi PJ Davies, et al. 1997 Lack of 'tissue' transglutaminase protein cross-linking leads to leakage of macromolecules from dying cells relationship to development of autoimmunity in MRLIpr/Ipr mice Cell Death Differ 4 463 472 1:CAS:528:DyaK2sXotVehtrk%3D 10.1038/sj.cdd.4400267 16465267
22. B Nicholas P Smethurst E Verderio R Jones M Griffin 2003 Cross-linking of cellular proteins by tissue transglutaminase during necrotic cell death a mechanism for maintaining tissue integrity Biochem J 371 413 422 1:CAS:528:DC%2BD3sXisleqsrw%3D 10.1042/BJ20021949 12533191 (Pubitemid 36547624)
23. A Carroccio I Brusca G Iacono L Di Prima, et al. 2005 Correlation with intestinal mucosa damage and comparison of ELISA with the immunofluorescence assay Clin Chem 51 917 920 1:CAS:528:DC%2BD2MXjvVKjs7g%3D 10.1373/clinchem.2004. 041665 15855673 (Pubitemid 40577937)
24. G Multhoff 2006 Heat shock proteins in immunity Handb Exp Pharmacol 172 279 304 1:CAS:528:DC%2BD2MXhtlWqsbvP 10.1007/3-540-29717-0-12 16610364
25. L Caggiari R Cannizzaro M De Zorzi V Canzonieri A Da Ponte V De Re 2008 A new HLA-A 680106 allele identified in individuals with celiac disease from the Friuli area of northeast Italy Tissue Antigens 72 491 492 1:CAS:528: DC%2BD1cXhsVCmsbfI 10.1111/j.1399-0039.2008.01123.x 18764807
26. P Collin K Kaukinen H Vogelsang I Korponay-Szabo, et al. 2005 Antiendomysial and antihuman recombinant tissue transglutaminase antibodies in the diagnosis of coeliac disease a biopsy-proven European multicentre study Eur J Gastroenterol Hepatol 17 85 91 1:CAS:528:DC%2BD2MXjs1WhtQ%3D%3D 10.1097/00042737-200501000-00017 15647647 (Pubitemid 40136613)
27. T Salmi P Collin I Korponay-Szabó K Laurila, et al. 2006 Endomysial antibody-negative coeliac disease clinical characteristics and intestinal autoantibody deposits Gut 55 1746 1753 1:CAS:528: DC%2BD2sXkvFKqtw%3D%3D 10.1136/gut.2005.071514 16571636 (Pubitemid 44893572)
28. J Stulík L Hernychová S Porkertová O Pozler L Tucková D Sánchez J Bures 2003 Identification of new celiac disease autoantigens using proteomic analysis Proteomics 3 951 956 10.1002/pmic.200300370 12833519 (Pubitemid 36801682)
29. I Bertini A Calabrò V De Carli C Luchinat, et al. 2009 The metabonomic signature of celiac disease J Proteome Res 8 170 177 1:CAS:528:DC%2BD1cXhsV2hurzI 10.1021/pr800548z 19072164
30. MP Simula R Cannizzaro V Canzonieri A Pavan, et al. 2010 PPAR signalling pathway and cancer-related proteins are involved in celiac disease-associated tissue damage Mol Med 16 5-6 199 209 1:CAS:528:DC%2BC3cXmtlSqtrw%3D 20454521
31. De Re V, Simula MP, Notarpietro A, Canzonieri V, Cannizzaro R, Toffoli G. Do gliadin and tissue transglutaminase mediate PPAR downregulation in intestinal cells of patients with celiac disease? GUT (in press).
32. AL Barabási ZN Oltvai 2004 Network biology understanding the cell's functional organization Nat Rev Genet 5 101 113 10.1038/nrg1272 14735121 (Pubitemid 38160277)
33. A Luciani VR Villella A Vasaturo, et al. 2010 Lysosomal accumulation of gliadin p31-43 peptide induces oxidative stress and tissue transglutaminase- mediated PPARγ downregulation in intestinal epithelial cells and coeliac mucosa Gut 59 311 319 10.1136/gut.2009.183608 19951908
34. M Bünger HM van den Bosch J van der Meijde S Kersten GJ Hooiveld M Müller 2007 Genome-wide analysis of PPARalpha activation in murine small intestine Physiol Genomics 30 192 204 10.1152/physiolgenomics.00198.2006 17426115 (Pubitemid 47173282)
35. HE Tong-Chuan TA Chan B Vogelstein KW Kinzler 1999 PPAR delta is an APC-regulated target of nonsteroidal anti-inflammatory drugs Cell 99 335 345 10.1016/S0092-8674(00)81664-5 (Pubitemid 29519912)
36. Min/+ mice Nat Med 4 1053 1057 10.1038/2036 (Pubitemid 28417338)
37. E Saez P Tontonoz MC Nelson JG Alvarez, et al. 1998 Activation of the nuclear receptor PPAR gamma enhance colon polyp formation Nat Med 4 1058 1061 1:CAS:528:DyaK1cXlvFGgtbs%3D 10.1038/2042 9734400 (Pubitemid 28417339)
38. CR Curley AJ Monsuur MC Wapenaar JD Rioux C Wijmenga 2006 A functional candidate screen for coeliac disease genes Eur J Hum Genet 14 1215 1222 1:CAS:528:DC%2BD28XhtFaks77N 10.1038/sj.ejhg.5201687 16835590 (Pubitemid 44642588)
39. V De Re MP Simula R Cannizzaro A Pavan MA De Zorzi G Toffoli V Canzonieri 2009 Galectin-10, eosinophils, and celiac disease Ann NY Acad Sci 1173 357 364 10.1111/j.1749-6632.2009.04627.x 19758173
40. V De Re MP Simula L Caggiari N Orsez, et al. 2007 Protein expression profile of celiac disease patient with aberrant T cell by two-dimensional difference gel electrophoresis Ann NY Acad Sci 1109 429 440 10.1196/annals.1398. 049 17785332 (Pubitemid 47511386)
41. JE Crabtree RV Heatley ML Losowsky 1989 Immunoglobulin secretion by isolated intestinal lymphocytes spontaneous production and T cell regulation in normal small intestine and in patients with coeliac disease Gut 30 347 354 1:STN:280:DyaL1M3ht1Wktg%3D%3D 10.1136/gut.30.3.347 2565279
42. BB Scott DG Scott MS Losowsky 1977 Jejunal mucosal immunoglobulins and complement in untreated coeliac disease J Pathol 121 219 223 1:STN:280:DyaE2s3gvFaktA%3D%3D 10.1002/path.1711210405 327040
43. TS Halstensen M Hvatum H Scott O Fausa P Brandtzaeg 1992 Association of subepithelial deposition of activated complement and immunoglobulin G and M response to gluten in celiac disease Gastroenterology 102 751 759 1:STN:280:DyaK387msFSjsw%3D%3D 1537512