-
1
-
-
0036687120
-
Functional expression of the lymphoid chemokines CCL19 (ECL) and CCL 21 (SLC) at the blood-brain barrier suggests their involvement in G-protein-dependent lymphocyte recruitment into the central nervous system during experimental autoimmune encephalomyelitis
-
DOI 10.1002/1521-4141(200208)32:8<2133::AID-IMMU2133>3.0.CO;2-W
-
Alt, C., M. Laschinger, and B. Engelhardt. 2002. Functional expression of the lymphoid chemokines CCL19 (ELC) and CCL 21 (SLC) at the blood-brain barrier suggests their involvement in G-protein-dependent lymphocyte recruitment into the central nervous system during experimental autoimmune encephalomyelitis. Eur. J. Immunol. 32:2133-2144. doi:10.1002/1521-4141(200208)32:8〈2133::AID- IMMU2133〉3.0.CO;2-W (Pubitemid 34965876)
-
(2002)
European Journal of Immunology
, vol.32
, Issue.8
, pp. 2133-2144
-
-
Alt, C.1
Laschinger, M.2
Engelhardt, B.3
-
2
-
-
33644798295
-
The crystal structure of murine coronin-1: A regulator of actin cytoskeletal dynamics in lymphocytes
-
doi:10.1016/j.str.2005.09.013
-
Appleton, B.A., P. Wu, and C. Wiesmann. 2006. The crystal structure of murine coronin-1: a regulator of actin cytoskeletal dynamics in lymphocytes. Structure. 14:87-96. doi:10.1016/j.str.2005.09.013
-
(2006)
Structure
, vol.14
, pp. 87-96
-
-
Appleton, B.A.1
Wu, P.2
Wiesmann, C.3
-
3
-
-
70349794451
-
Immune proteins in brain development and synaptic plasticity
-
doi:10.1016/j.neuron.2009.09.001
-
Boulanger, L.M. 2009. Immune proteins in brain development and synaptic plasticity. Neuron. 64:93-109. doi:10.1016/j.neuron.2009.09.001
-
(2009)
Neuron
, vol.64
, pp. 93-109
-
-
Boulanger, L.M.1
-
4
-
-
42649127027
-
The actin cytoskeleton in T cell activation
-
doi:10.1146/annurev.immunol.26.021607.090347
-
Burkhardt, J.K., E. Carrizosa, and M.H. Shaffer. 2008. The actin cytoskeleton in T cell activation. Annu. Rev. Immunol. 26:233-259. doi:10.1146/annurev.immunol.26.021607.090347
-
(2008)
Annu. Rev. Immunol.
, vol.26
, pp. 233-259
-
-
Burkhardt, J.K.1
Carrizosa, E.2
Shaffer, M.H.3
-
5
-
-
0031018336
-
Mice lacking p35, a neuronal specific activator of Cdk5, display cortical lamination defects, seizures, and adult lethality
-
doi:10.1016/S0896-6273(01)80044-1
-
Chae, T., Y.T. Kwon, R. Bronson, P. Dikkes, E. Li, and L.H. Tsai. 1997. Mice lacking p35, a neuronal specific activator of Cdk5, display cortical lamination defects, seizures, and adult lethality. Neuron. 18:29-42. doi:10.1016/S0896-6273(01)80044-1
-
(1997)
Neuron
, vol.18
, pp. 29-42
-
-
Chae, T.1
Kwon, Y.T.2
Bronson, R.3
Dikkes, P.4
Li, E.5
Tsai, L.H.6
-
6
-
-
0035877992
-
Expression of the neuronal cyclin-dependent kinase 5 activator p35Nck5a in human monocytic cells is associated with differentiation
-
doi:10.1182/blood.V97.12.3763
-
Chen, F., and G.P. Studzinski. 2001. Expression of the neuronal cyclin-dependent kinase 5 activator p35Nck5a in human monocytic cells is associated with differentiation. Blood. 97:3763-3767. doi:10.1182/blood.V97.12. 3763
-
(2001)
Blood
, vol.97
, pp. 3763-3767
-
-
Chen, F.1
Studzinski, G.P.2
-
7
-
-
58149142509
-
The coronin family of proteins
-
doi:10.1007/978-0-387-09595-0-1
-
Clemen, C.S., V. Rybakin, and L. Eichinger. 2008. The coronin family of proteins. Subcell. Biochem. 48:1-5. doi:10.1007/978-0-387-09595-0-1
-
(2008)
Subcell. Biochem.
, vol.48
, pp. 1-5
-
-
Clemen, C.S.1
Rybakin, V.2
Eichinger, L.3
-
8
-
-
0036527429
-
Protein kinases - The major drug targets of the twenty-first century?
-
Cohen, P. 2002. Protein kinases-the major drug targets of the twenty-first century? Nat. Rev. Drug Discov. 1:309-315. doi:10.1038/nrd773 (Pubitemid 37361447)
-
(2002)
Nature Reviews Drug Discovery
, vol.1
, Issue.4
, pp. 309-315
-
-
Cohen, P.1
-
9
-
-
0037180757
-
Inflammation and cancer
-
doi:10.1038/nature01322
-
Coussens, L.M., and Z. Werb. 2002. Inflammation and cancer. Nature. 420:860-867. doi:10.1038/nature01322
-
(2002)
Nature
, vol.420
, pp. 860-867
-
-
Coussens, L.M.1
Werb, Z.2
-
10
-
-
4444262625
-
Cdk5 deregulation in the pathogenesis of Alzheimer's disease
-
doi:10.1016/j.molmed.2004.07.001
-
Cruz, J.C., and L.H. Tsai. 2004. Cdk5 deregulation in the pathogenesis of Alzheimer's disease. Trends Mol. Med. 10:452-458. doi:10.1016/j.molmed.2004.07. 001
-
(2004)
Trends Mol. Med.
, vol.10
, pp. 452-458
-
-
Cruz, J.C.1
Tsai, L.H.2
-
11
-
-
0037434789
-
Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain
-
doi:10.1038/nature01355
-
Cua, D.J., J. Sherlock, Y. Chen, C.A. Murphy, B. Joyce, B. Seymour, L. Lucian, W. To, S. Kwan, T. Churakova, et al. 2003. Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain. Nature. 421:744-748. doi:10.1038/nature01355
-
(2003)
Nature
, vol.421
, pp. 744-748
-
-
Cua, D.J.1
Sherlock, J.2
Chen, Y.3
Murphy, C.A.4
Joyce, B.5
Seymour, B.6
Lucian, L.7
To, W.8
Kwan, S.9
Churakova, T.10
-
12
-
-
0026041203
-
Coronin, an actin binding protein of Dictyostelium discoideum localized to cell surface projections, has sequence similarities to G protein beta subunits
-
de Hostos, E.L., B. Bradtke, F. Lottspeich, R. Guggenheim, and G. Gerisch. 1991. Coronin, an actin binding protein of Dictyostelium discoideum localized to cell surface projections, has sequence similarities to G protein beta subunits. EMBO J. 10:4097-4104.
-
(1991)
EMBO J
, vol.10
, pp. 4097-4104
-
-
De Hostos, E.L.1
Bradtke, B.2
Lottspeich, F.3
Guggenheim, R.4
Gerisch, G.5
-
13
-
-
0035489777
-
A decade of CDK5
-
doi:10.1038/35096019
-
Dhavan, R., and L.H. Tsai. 2001. A decade of CDK5. Nat. Rev. Mol. Cell Biol. 2:749-759. doi:10.1038/35096019
-
(2001)
Nat. Rev. Mol. Cell Biol.
, vol.2
, pp. 749-759
-
-
Dhavan, R.1
Tsai, L.H.2
-
14
-
-
0033553440
-
A coat protein on phagosomes involved in the intracellular survival of mycobacteria
-
doi:10.1016/S0092-8674(00)80754-0
-
Ferrari, G., H. Langen, M. Naito, and J. Pieters. 1999. A coat protein on phagosomes involved in the intracellular survival of mycobacteria. Cell. 97:435-447. doi:10.1016/S0092-8674(00)80754-0
-
(1999)
Cell
, vol.97
, pp. 435-447
-
-
Ferrari, G.1
Langen, H.2
Naito, M.3
Pieters, J.4
-
15
-
-
33747106194
-
Requirement for coronin 1 in T lymphocyte trafficking and cellular homeostasis
-
doi:10.1126/science.1130563
-
Föger, N., L. Rangell, D.M. Danilenko, and A.C. Chan. 2006. Requirement for coronin 1 in T lymphocyte trafficking and cellular homeostasis. Science. 313:839-842. doi:10.1126/science.1130563
-
(2006)
Science
, vol.313
, pp. 839-842
-
-
Föger, N.1
Rangell, L.2
Danilenko, D.M.3
Chan, A.C.4
-
16
-
-
2342483179
-
Cyclin-dependent kinase 5 phosphorylates signal transducer and activator of transcription 3 and regulates its transcriptional activity
-
doi:10.1073/pnas.0307606100
-
Fu, A.K., W.Y. Fu, A.K. Ng, W.W. Chien, Y.P. Ng, J.H. Wang, and N.Y. Ip. 2004. Cyclin-dependent kinase 5 phosphorylates signal transducer and activator of transcription 3 and regulates its transcriptional activity. Proc. Natl. Acad. Sci. USA. 101:6728-6733. doi:10.1073/pnas.0307606100
-
(2004)
Proc. Natl. Acad. Sci. USA
, vol.101
, pp. 6728-6733
-
-
Fu, A.K.1
Fu, W.Y.2
Ng, A.K.3
Chien, W.W.4
Ng, Y.P.5
Wang, J.H.6
Ip, N.Y.7
-
17
-
-
58149170170
-
Coronin: The double-edged sword of actin dynamics
-
doi:10.1007/978-0-387-09595-0-7
-
Gandhi, M., and B.L. Goode. 2008. Coronin: the double-edged sword of actin dynamics. Subcell. Biochem. 48:72-87. doi:10.1007/978-0-387-09595-0-7
-
(2008)
Subcell. Biochem.
, vol.48
, pp. 72-87
-
-
Gandhi, M.1
Goode, B.L.2
-
18
-
-
19644384351
-
Association of the leukocyte plasma membrane with the actin cytoskeleton through coiled coil-mediated trimeric coronin 1 molecules
-
doi:10.1091/mbc.E05-01-0042
-
Gatfield, J., I. Albrecht, B. Zanolari, M.O. Steinmetz, and J. Pieters. 2005. Association of the leukocyte plasma membrane with the actin cytoskeleton through coiled coil-mediated trimeric coronin 1 molecules. Mol. Biol. Cell. 16:2786-2798. doi:10.1091/mbc.E05-01-0042
-
(2005)
Mol. Biol. Cell.
, vol.16
, pp. 2786-2798
-
-
Gatfield, J.1
Albrecht, I.2
Zanolari, B.3
Steinmetz, M.O.4
Pieters, J.5
-
19
-
-
0037431130
-
Cdk5-mediated inhibition of the protective effects of transcription factor MEF2 in neurotoxicity-induced apoptosis
-
doi:10.1016/S0896-6273(03)00191-0
-
Gong, X., X. Tang, M. Wiedmann, X. Wang, J. Peng, D. Zheng, L.A. Blair, J. Marshall, and Z. Mao. 2003. Cdk5-mediated inhibition of the protective effects of transcription factor MEF2 in neurotoxicity-induced apoptosis. Neuron. 38:33-46. doi:10.1016/S0896-6273(03)00191-0
-
(2003)
Neuron
, vol.38
, pp. 33-46
-
-
Gong, X.1
Tang, X.2
Wiedmann, M.3
Wang, X.4
Peng, J.5
Zheng, D.6
Blair, L.A.7
Marshall, J.8
Mao, Z.9
-
20
-
-
39849101009
-
Proteomic analysis of active multiple sclerosis lesions reveals therapeutic targets
-
doi:10.1038/nature06559
-
Han, M.H., S.I. Hwang, D.B. Roy, D.H. Lundgren, J.V. Price, S.S. Ousman, G.H. Fernald, B. Gerlitz, W.H. Robinson, S.E. Baranzini, et al. 2008. Proteomic analysis of active multiple sclerosis lesions reveals therapeutic targets. Nature. 451:1076-1081. doi:10.1038/nature06559
-
(2008)
Nature
, vol.451
, pp. 1076-1081
-
-
Han, M.H.1
Hwang, S.I.2
Roy, D.B.3
Lundgren, D.H.4
Price, J.V.5
Ousman, S.S.6
Fernald, G.H.7
Gerlitz, B.8
Robinson, W.H.9
Baranzini, S.E.10
-
21
-
-
37849023308
-
The lupus-related Lmb3 locus contains a disease-suppressing Coronin-1A gene mutation
-
doi:10.1016/j.immuni.2007.11.023
-
Haraldsson, M.K., C.A. Louis-Dit-Sully, B.R. Lawson, G. Sternik, M.L. Santiago-Raber, N.R. Gascoigne, A.N. Theofilopoulos, and D.H. Kono. 2008. The lupus-related Lmb3 locus contains a disease-suppressing Coronin-1A gene mutation. Immunity. 28:40-51. doi:10.1016/j.immuni.2007.11.023
-
(2008)
Immunity
, vol.28
, pp. 40-51
-
-
Haraldsson, M.K.1
Louis-Dit-Sully, C.A.2
Lawson, B.R.3
Sternik, G.4
Santiago-Raber, M.L.5
Gascoigne, N.R.6
Theofilopoulos, A.N.7
Kono, D.H.8
-
22
-
-
0033428894
-
Mammalian Cdk5 is a functional homologue of the budding yeast Pho85 cyclin-dependent protein kinase
-
doi:10.1073/pnas.96.25.14445
-
Huang, D., G. Patrick, J. Moffat, L.H. Tsai, and B. Andrews. 1999. Mammalian Cdk5 is a functional homologue of the budding yeast Pho85 cyclin-dependent protein kinase. Proc. Natl. Acad. Sci. USA. 96:14445-14450. doi:10.1073/pnas.96.25.14445
-
(1999)
Proc. Natl. Acad. Sci. USA
, vol.96
, pp. 14445-14450
-
-
Huang, D.1
Patrick, G.2
Moffat, J.3
Tsai, L.H.4
Andrews, B.5
-
23
-
-
0032530033
-
Chemokine regulation of experimental autoimmune encephalomyelitis: Temporal and spatial expression patterns govern disease pathogenesis
-
Karpus, W.J., and R.M. Ransohoff. 1998. Chemokine regulation of experimental autoimmune encephalomyelitis: temporal and spatial expression patterns govern disease pathogenesis. J. Immunol. 161:2667-2671.
-
(1998)
J. Immunol.
, vol.161
, pp. 2667-2671
-
-
Karpus, W.J.1
Ransohoff, R.M.2
-
24
-
-
33747482904
-
Phosphorylation of WAVE1 regulates actin polymerization and dendritic spine morphology
-
doi:10.1038/nature04976
-
Kim, Y., J.Y. Sung, I. Ceglia, K.W. Lee, J.H. Ahn, J.M. Halford, A.M. Kim, S.P. Kwak, J.B. Park, S. Ho Ryu, et al. 2006. Phosphorylation of WAVE1 regulates actin polymerization and dendritic spine morphology. Nature. 442:814-817. doi:10.1038/nature04976
-
(2006)
Nature
, vol.442
, pp. 814-817
-
-
Kim, Y.1
Sung, J.Y.2
Ceglia, I.3
Lee, K.W.4
Ahn, J.H.5
Halford, J.M.6
Kim, A.M.7
Kwak, S.P.8
Park, J.B.9
Ho Ryu, S.10
-
25
-
-
25644456097
-
Lipopolysaccharide-induced inflammation exacerbates tau pathology by a cyclin-dependent kinase 5-mediated pathway in a transgenic model of Alzheimer's disease
-
doi:10.1523/JNEUROSCI.2868-05.2005
-
Kitazawa, M., S. Oddo, T.R. Yamasaki, K.N. Green, and F.M. LaFerla. 2005. Lipopolysaccharide-induced inflammation exacerbates tau pathology by a cyclin-dependent kinase 5-mediated pathway in a transgenic model of Alzheimer's disease. J. Neurosci. 25:8843-8853. doi:10.1523/JNEUROSCI.2868-05.2005
-
(2005)
J. Neurosci.
, vol.25
, pp. 8843-8853
-
-
Kitazawa, M.1
Oddo, S.2
Yamasaki, T.R.3
Green, K.N.4
LaFerla, F.M.5
-
26
-
-
46949104323
-
IL-12- and IL-23-modulated T cells induce distinct types of EAE based on histology, CNS chemokine profile, and response to cytokine inhibition
-
doi:10.1084/jem.20080159
-
Kroenke, M.A., T.J. Carlson, A.V. Andjelkovic, and B.M. Segal. 2008. IL-12- and IL-23-modulated T cells induce distinct types of EAE based on histology, CNS chemokine profile, and response to cytokine inhibition. J. Exp. Med. 205:1535-1541. doi:10.1084/jem.20080159
-
(2008)
J. Exp. Med.
, vol.205
, pp. 1535-1541
-
-
Kroenke, M.A.1
Carlson, T.J.2
Andjelkovic, A.V.3
Segal, B.M.4
-
27
-
-
61849141064
-
Tyrosine kinases and their substrates in B lymphocytes
-
doi:10.1111/j.1600-065X.2008.00748.x
-
Kurosaki, T., and M. Hikida. 2009. Tyrosine kinases and their substrates in B lymphocytes. Immunol. Rev. 228:132-148. doi:10.1111/j.1600-065X.2008.00748. x
-
(2009)
Immunol. Rev.
, vol.228
, pp. 132-148
-
-
Kurosaki, T.1
Hikida, M.2
-
28
-
-
34047251311
-
Cdk5 regulates STAT3 activation and cell proliferation in medullary thyroid carcinoma cells
-
doi:10.1074/jbc.M607234200
-
Lin, H., M.C. Chen, C.Y. Chiu, Y.M. Song, and S.Y. Lin. 2007. Cdk5 regulates STAT3 activation and cell proliferation in medullary thyroid carcinoma cells. J. Biol. Chem. 282:2776-2784. doi:10.1074/jbc.M607234200
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 2776-2784
-
-
Lin, H.1
Chen, M.C.2
Chiu, C.Y.3
Song, Y.M.4
Lin, S.Y.5
-
29
-
-
58149401207
-
STAT-3 and ERK 1/2 phosphorylation are critical for T-cell alloactivation and graft-versus-host disease
-
doi:10.1182/blood-2008-03-147322
-
Lu, S.X., O. Alpdogan, J. Lin, R. Balderas, R. Campos-Gonzalez, X. Wang, G.J. Gao, D. Suh, C. King, M. Chow, et al. 2008. STAT-3 and ERK 1/2 phosphorylation are critical for T-cell alloactivation and graft-versus-host disease. Blood. 112:5254-5258. doi:10.1182/blood-2008-03-147322
-
(2008)
Blood
, vol.112
, pp. 5254-5258
-
-
Lu, S.X.1
Alpdogan, O.2
Lin, J.3
Balderas, R.4
Campos-Gonzalez, R.5
Wang, X.6
Gao, G.J.7
Suh, D.8
King, C.9
Chow, M.10
-
30
-
-
34548368541
-
Variation in interleukin 7 receptor alpha chain (IL7R) influences risk of multiple sclerosis
-
doi:10.1038/ng2106
-
Lundmark, F., K. Duvefelt, E. Iacobaeus, I. Kockum, E. Wallström, M. Khademi, A. Oturai, L.P. Ryder, J. Saarela, H.F. Harbo, et al. 2007. Variation in interleukin 7 receptor alpha chain (IL7R) influences risk of multiple sclerosis. Nat. Genet. 39:1108-1113. doi:10.1038/ng2106
-
(2007)
Nat. Genet.
, vol.39
, pp. 1108-1113
-
-
Lundmark, F.1
Duvefelt, K.2
Iacobaeus, E.3
Kockum, I.4
Wallström, E.5
Khademi, M.6
Oturai, A.7
Ryder, L.P.8
Saarela, J.9
Harbo, H.F.10
-
31
-
-
13444253813
-
Mechanism of CDK5/p25 binding by CDK inhibitors
-
doi:10.1021/jm049323m
-
Mapelli, M., L. Massimiliano, C. Crovace, M.A. Seeliger, L.H. Tsai, L. Meijer, and A. Musacchio. 2005. Mechanism of CDK5/p25 binding by CDK inhibitors. J. Med. Chem. 48:671-679. doi:10.1021/jm049323m
-
(2005)
J. Med. Chem.
, vol.48
, pp. 671-679
-
-
Mapelli, M.1
Massimiliano, L.2
Crovace, C.3
Seeliger, M.A.4
Tsai, L.H.5
Meijer, L.6
Musacchio, A.7
-
32
-
-
33646148511
-
The role of serine/threonine kinases in T-cell activation
-
doi:10.1016/j.coi.2006.03.006
-
Matthews, S.A., and D.A. Cantrell. 2006. The role of serine/threonine kinases in T-cell activation. Curr. Opin. Immunol. 18:314-320. doi:10.1016/j.coi.2006.03.006
-
(2006)
Curr. Opin. Immunol.
, vol.18
, pp. 314-320
-
-
Matthews, S.A.1
Cantrell, D.A.2
-
33
-
-
34948888764
-
LINGO-1 antagonist promotes spinal cord remyelination and axonal integrity in MOG-induced experimental autoimmune encephalomyelitis
-
doi:10.1038/nm1664
-
Mi, S., B. Hu, K. Hahm, Y. Luo, E.S. Kam Hui, Q. Yuan, W.M. Wong, L. Wang, H. Su, T.H. Chu, et al. 2007. LINGO-1 antagonist promotes spinal cord remyelination and axonal integrity in MOG-induced experimental autoimmune encephalomyelitis. Nat. Med. 13:1228-1233. doi:10.1038/nm1664
-
(2007)
Nat. Med.
, vol.13
, pp. 1228-1233
-
-
Mi, S.1
Hu, B.2
Hahm, K.3
Luo, Y.4
Kam Hui, E.S.5
Yuan, Q.6
Wong, W.M.7
Wang, L.8
Su, H.9
Chu, T.H.10
-
34
-
-
51149123070
-
Cdk5 phosphorylation of WAVE2 regulates oligodendrocyte precursor cell migration through nonreceptor tyrosine kinase Fyn
-
doi:10.1523/JNEUROSCI.1482-08.2008
-
Miyamoto, Y., J. Yamauchi, and A. Tanoue. 2008. Cdk5 phosphorylation of WAVE2 regulates oligodendrocyte precursor cell migration through nonreceptor tyrosine kinase Fyn. J. Neurosci. 28:8326-8337. doi:10.1523/JNEUROSCI.1482-08. 2008
-
(2008)
J. Neurosci.
, vol.28
, pp. 8326-8337
-
-
Miyamoto, Y.1
Yamauchi, J.2
Tanoue, A.3
-
35
-
-
40949165216
-
Regulation of T cell survival through coronin-1-mediated generation of inositol-1,4,5-trisphosphate and calcium mobilization after T cell receptor triggering
-
doi:10.1038/ni1570
-
Mueller, P., J. Massner, R. Jayachandran, B. Combaluzier, I. Albrecht, J. Gatfield, C. Blum, R. Ceredig, H.R. Rodewald, A.G. Rolink, and J. Pieters. 2008. Regulation of T cell survival through coronin-1-mediated generation of inositol-1,4,5-trisphosphate and calcium mobilization after T cell receptor triggering. Nat. Immunol. 9:424-431. doi:10.1038/ni1570
-
(2008)
Nat. Immunol.
, vol.9
, pp. 424-431
-
-
Mueller, P.1
Massner, J.2
Jayachandran, R.3
Combaluzier, B.4
Albrecht, I.5
Gatfield, J.6
Blum, C.7
Ceredig, R.8
Rodewald, H.R.9
Rolink, A.G.10
Pieters, J.11
-
36
-
-
0032504964
-
The p35/Cdk5 kinase is a neuron-specific Rac effector that inhibits Pak1 activity
-
doi:10.1038/26034
-
Nikolic, M., M.M. Chou, W. Lu, B.J. Mayer, and L.H. Tsai. 1998. The p35/Cdk5 kinase is a neuron-specific Rac effector that inhibits Pak1 activity. Nature. 395:194-198. doi:10.1038/26034
-
(1998)
Nature
, vol.395
, pp. 194-198
-
-
Nikolic, M.1
Chou, M.M.2
Lu, W.3
Mayer, B.J.4
Tsai, L.H.5
-
37
-
-
0034727066
-
Multiple sclerosis
-
doi:10.1056/NEJM200009283431307
-
Noseworthy, J.H., C. Lucchinetti, M. Rodriguez, and B.G. Weinshenker. 2000. Multiple sclerosis. N. Engl. J. Med. 343:938-952. doi:10.1056/ NEJM200009283431307
-
(2000)
N. Engl. J. Med.
, vol.343
, pp. 938-952
-
-
Noseworthy, J.H.1
Lucchinetti, C.2
Rodriguez, M.3
Weinshenker, B.G.4
-
38
-
-
0029768093
-
Targeted disruption of the cyclin-dependent kinase 5 gene results in abnormal corticogenesis, neuronal pathology and perinatal death
-
doi:10.1073/pnas.93.20.11173
-
Ohshima, T., J.M. Ward, C.G. Huh, G. Longenecker, Veeranna, H.C. Pant, R.O. Brady, L.J. Martin, and A.B. Kulkarni. 1996. Targeted disruption of the cyclin-dependent kinase 5 gene results in abnormal corticogenesis, neuronal pathology and perinatal death. Proc. Natl. Acad. Sci. USA. 93:11173-11178. doi:10.1073/pnas.93.20.11173
-
(1996)
Proc. Natl. Acad. Sci. USA
, vol.93
, pp. 11173-11178
-
-
Ohshima, T.1
Ward, J.M.2
Huh, C.G.3
Longenecker, G.4
Veeranna5
Pant, H.C.6
Brady, R.O.7
Martin, L.J.8
Kulkarni, A.B.9
-
39
-
-
31444436004
-
Cyclin-dependent kinase 5 activity regulates pain signaling
-
doi:10.1073/pnas.0510405103
-
Pareek, T.K., J. Keller, S. Kesavapany, H.C. Pant, M.J. Iadarola, R.O. Brady, and A.B. Kulkarni. 2006. Cyclin-dependent kinase 5 activity regulates pain signaling. Proc. Natl. Acad. Sci. USA. 103:791-796. doi:10.1073/pnas. 0510405103
-
(2006)
Proc. Natl. Acad. Sci. USA
, vol.103
, pp. 791-796
-
-
Pareek, T.K.1
Keller, J.2
Kesavapany, S.3
Pant, H.C.4
Iadarola, M.J.5
Brady, R.O.6
Kulkarni, A.B.7
-
40
-
-
33846293924
-
Cyclin-dependent kinase 5 modulates nociceptive signaling through direct phosphorylation of transient receptor potential vanilloid 1
-
doi:10.1073/pnas.0609916104
-
Pareek, T.K., J. Keller, S. Kesavapany, N. Agarwal, R. Kuner, H.C. Pant, M.J. Iadarola, R.O. Brady, and A.B. Kulkarni. 2007. Cyclin-dependent kinase 5 modulates nociceptive signaling through direct phosphorylation of transient receptor potential vanilloid 1. Proc. Natl. Acad. Sci. USA. 104:660-665. doi:10.1073/pnas.0609916104
-
(2007)
Proc. Natl. Acad. Sci. USA
, vol.104
, pp. 660-665
-
-
Pareek, T.K.1
Keller, J.2
Kesavapany, S.3
Agarwal, N.4
Kuner, R.5
Pant, H.C.6
Iadarola, M.J.7
Brady, R.O.8
Kulkarni, A.B.9
-
41
-
-
0031457622
-
Signaling through scaffold, anchoring, and adaptor proteins
-
DOI 10.1126/science.278.5346.2075
-
Pawson, T., and J.D. Scott. 1997. Signaling through scaffold, anchoring, and adaptor proteins. Science. 278:2075-2080. doi:10.1126/science.278.5346.2075 (Pubitemid 28028310)
-
(1997)
Science
, vol.278
, Issue.5346
, pp. 2075-2080
-
-
Pawson, T.1
Scott, J.D.2
-
42
-
-
24944548652
-
Historical descriptions of multiple sclerosis
-
doi:10.1159/000087387
-
Pearce, J.M. 2005. Historical descriptions of multiple sclerosis. Eur. Neurol. 54:49-53. doi:10.1159/000087387
-
(2005)
Eur. Neurol.
, vol.54
, pp. 49-53
-
-
Pearce, J.M.1
-
43
-
-
61849142482
-
The Tec kinases Itk and Rlk regulate conventional versus innate T-cell development
-
doi:10.1111/j.1600-065X.2008.00746.x
-
Prince, A.L., C.C. Yin, M.E. Enos, M. Felices, and L.J. Berg. 2009. The Tec kinases Itk and Rlk regulate conventional versus innate T-cell development. Immunol. Rev. 228:115-131. doi:10.1111/j.1600-065X.2008.00746.x
-
(2009)
Immunol. Rev.
, vol.228
, pp. 115-131
-
-
Prince, A.L.1
Yin, C.C.2
Enos, M.E.3
Felices, M.4
Berg, L.J.5
-
44
-
-
47249131563
-
The use of chemokine antagonists in EAE models
-
doi:10.1016/j.jneuroim.2008.04.007
-
Proudfoot, A.E., A.L. de Souza, and V. Muzio. 2008. The use of chemokine antagonists in EAE models. J. Neuroimmunol. 198:27-30. doi:10.1016/j.jneuroim. 2008.04.007
-
(2008)
J. Neuroimmunol.
, vol.198
, pp. 27-30
-
-
Proudfoot, A.E.1
De Souza, A.L.2
Muzio, V.3
-
45
-
-
0035966018
-
Phosphorylation of Pak1 by the p35/Cdk5 kinase affects neuronal morphology
-
doi:10.1074/jbc.M105599200
-
Rashid, T., M. Banerjee, and M. Nikolic. 2001. Phosphorylation of Pak1 by the p35/Cdk5 kinase affects neuronal morphology. J. Biol. Chem. 276:49043-49052. doi:10.1074/jbc.M105599200
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 49043-49052
-
-
Rashid, T.1
Banerjee, M.2
Nikolic, M.3
-
46
-
-
33750014263
-
Extraneuronal roles of cyclin-dependent kinase 5
-
doi:10.1002/bies.20473
-
Rosales, J.L., and K.Y. Lee. 2006. Extraneuronal roles of cyclin-dependent kinase 5. Bioessays. 28:1023-1034. doi:10.1002/bies.20473
-
(2006)
Bioessays
, vol.28
, pp. 1023-1034
-
-
Rosales, J.L.1
Lee, K.Y.2
-
47
-
-
61849128182
-
T-cell receptor proximal signaling via the Src-family kinases, Lck and Fyn, influences T-cell activation, differentiation, and tolerance
-
doi:10.1111/j.1600-065X.2008.00745.x
-
Salmond, R.J., A. Filby, I. Qureshi, S. Caserta, and R. Zamoyska. 2009. T-cell receptor proximal signaling via the Src-family kinases, Lck and Fyn, influences T-cell activation, differentiation, and tolerance. Immunol. Rev. 228:9-22. doi:10.1111/j.1600-065X.2008.00745.x
-
(2009)
Immunol. Rev.
, vol.228
, pp. 9-22
-
-
Salmond, R.J.1
Filby, A.2
Qureshi, I.3
Caserta, S.4
Zamoyska, R.5
-
48
-
-
11244309560
-
Hyperphosphorylation and aggregation of tau in experimental autoimmune encephalomyelitis
-
doi:10.1074/jbc.M409954200
-
Schneider, A., G.W. Araújo, K. Trajkovic, M.M. Herrmann, D. Merkler, E.M. Mandelkow, R. Weissert, and M. Simons. 2004. Hyperphosphorylation and aggregation of tau in experimental autoimmune encephalomyelitis. J. Biol. Chem. 279:55833-55839. doi:10.1074/jbc.M409954200
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 55833-55839
-
-
Schneider, A.1
Araújo, G.W.2
Trajkovic, K.3
Herrmann, M.M.4
Merkler, D.5
Mandelkow, E.M.6
Weissert, R.7
Simons, M.8
-
49
-
-
1642269125
-
Cyclin-dependent kinase-5 in neurodegeneration
-
doi:10.1111/j.1471-4159.2003.02328.x
-
Shelton, S.B., and G.V. Johnson. 2004. Cyclin-dependent kinase-5 in neurodegeneration. J. Neurochem. 88:1313-1326. doi:10.1111/j.1471-4159.2003. 02328.x
-
(2004)
J. Neurochem.
, vol.88
, pp. 1313-1326
-
-
Shelton, S.B.1
Johnson, G.V.2
-
50
-
-
54549117897
-
The actin regulator coronin 1A is mutant in a thymic egress-deficient mouse strain and in a patient with severe combined immunodeficiency
-
doi:10.1038/ni.1662
-
Shiow, L.R., D.W. Roadcap, K. Paris, S.R. Watson, I.L. Grigorova, T. Lebet, J. An, Y. Xu, C.N. Jenne, N. Föger, et al. 2008. The actin regulator coronin 1A is mutant in a thymic egress-deficient mouse strain and in a patient with severe combined immunodeficiency. Nat. Immunol. 9:1307-1315. doi:10.1038/ni.1662
-
(2008)
Nat. Immunol.
, vol.9
, pp. 1307-1315
-
-
Shiow, L.R.1
Roadcap, D.W.2
Paris, K.3
Watson, S.R.4
Grigorova, I.L.5
Lebet, T.6
An, J.7
Xu, Y.8
Jenne, C.N.9
Föger, N.10
-
51
-
-
63249106283
-
Severe combined immunodeficiency (SCID) and attention deficit hyperactivity disorder (ADHD) associated with a Coronin-1A mutation and a chromosome 16p11.2 deletion
-
doi:10.1016/j.clim.2008.11.002
-
Shiow, L.R., K. Paris, M.C. Akana, J.G. Cyster, R.U. Sorensen, and J.M. Puck. 2009. Severe combined immunodeficiency (SCID) and attention deficit hyperactivity disorder (ADHD) associated with a Coronin-1A mutation and a chromosome 16p11.2 deletion. Clin. Immunol. 131:24-30. doi:10.1016/j.clim.2008. 11.002
-
(2009)
Clin. Immunol.
, vol.131
, pp. 24-30
-
-
Shiow, L.R.1
Paris, K.2
Akana, M.C.3
Cyster, J.G.4
Sorensen, R.U.5
Puck, J.M.6
-
52
-
-
33747875152
-
Cyclin-dependent kinase 5 activity controls cell motility and metastatic potential of prostate cancer cells
-
doi:10.1158/0008-5472.CAN-05-3048
-
Strock, C.J., J.I. Park, E.K. Nakakura, G.S. Bova, J.T. Isaacs, D.W. Ball, and B.D. Nelkin. 2006. Cyclin-dependent kinase 5 activity controls cell motility and metastatic potential of prostate cancer cells. Cancer Res. 66:7509-7515. doi:10.1158/0008-5472.CAN-05-3048
-
(2006)
Cancer Res
, vol.66
, pp. 7509-7515
-
-
Strock, C.J.1
Park, J.I.2
Nakakura, E.K.3
Bova, G.S.4
Isaacs, J.T.5
Ball, D.W.6
Nelkin, B.D.7
-
53
-
-
0037299465
-
The neuronal cyclin-dependent kinase 5 activator p35Nck5a and Cdk5 activity in monocytic cells
-
doi:10.1080/1042819021000030009
-
Studzinski, G.P., and J.S. Harrison. 2003. The neuronal cyclin-dependent kinase 5 activator p35Nck5a and Cdk5 activity in monocytic cells. Leuk. Lymphoma. 44:235-240. doi:10.1080/1042819021000030009
-
(2003)
Leuk. Lymphoma.
, vol.44
, pp. 235-240
-
-
Studzinski, G.P.1
Harrison, J.S.2
-
54
-
-
0028824975
-
Molecular mechanism of T-cell activation: Role of protein tyrosine kinases in antigen receptor-mediated signal transduction
-
doi:10.1016/0923-2494(96)80263-X
-
Thome, M., and O. Acuto. 1995. Molecular mechanism of T-cell activation: role of protein tyrosine kinases in antigen receptor-mediated signal transduction. Res. Immunol. 146:291-307. doi:10.1016/0923-2494(96)80263-X
-
(1995)
Res. Immunol.
, vol.146
, pp. 291-307
-
-
Thome, M.1
Acuto, O.2
-
55
-
-
57449107298
-
Cell cycle regulatory protein 5 (Cdk5) is a novel downstream target of ERK in carboplatin induced death of breast cancer cells
-
doi:10.2174/156800908786733405
-
Upadhyay, A.K., A.K. Ajay, S. Singh, and M.K. Bhat. 2008. Cell cycle regulatory protein 5 (Cdk5) is a novel downstream target of ERK in carboplatin induced death of breast cancer cells. Curr. Cancer Drug Targets. 8:741-752. doi:10.2174/156800908786733405
-
(2008)
Curr. Cancer Drug Targets
, vol.8
, pp. 741-752
-
-
Upadhyay, A.K.1
Ajay, A.K.2
Singh, S.3
Bhat, M.K.4
-
56
-
-
44049105823
-
Transcription factor Mef2c is required for B cell proliferation and survival after antigen receptor stimulation
-
doi:10.1038/ni.1609
-
Wilker, P.R., M. Kohyama, M.M. Sandau, J.C. Albring, O. Nakagawa, J.J. Schwarz, and K.M. Murphy. 2008. Transcription factor Mef2c is required for B cell proliferation and survival after antigen receptor stimulation. Nat. Immunol. 9:603-612. doi:10.1038/ni.1609
-
(2008)
Nat. Immunol.
, vol.9
, pp. 603-612
-
-
Wilker, P.R.1
Kohyama, M.2
Sandau, M.M.3
Albring, J.C.4
Nakagawa, O.5
Schwarz, J.J.6
Murphy, K.M.7
-
57
-
-
0036685522
-
Inflammation in neurodegenerative disease - A double-edged sword
-
doi:10.1016/S0896-6273(02)00794-8
-
Wyss-Coray, T., and L. Mucke. 2002. Inflammation in neurodegenerative disease - a double-edged sword. Neuron. 35:419-432. doi:10.1016/S0896-6273(02) 00794-8
-
(2002)
Neuron
, vol.35
, pp. 419-432
-
-
Wyss-Coray, T.1
Mucke, L.2
-
58
-
-
0042329506
-
Serine 732 phosphorylation of FAK by Cdk5 is important for microtubule organization, nuclear movement, and neuronal migration
-
doi:10.1016/S0092-8674(03)00605-6
-
Xie, Z., K. Sanada, B.A. Samuels, H. Shih, and L.H. Tsai. 2003. Serine 732 phosphorylation of FAK by Cdk5 is important for microtubule organization, nuclear movement, and neuronal migration. Cell. 114:469-482. doi:10.1016/S0092-8674(03)00605-6
-
(2003)
Cell
, vol.114
, pp. 469-482
-
-
Xie, Z.1
Sanada, K.2
Samuels, B.A.3
Shih, H.4
Tsai, L.H.5
-
59
-
-
0031438929
-
Sequence-specific and phosphorylation-dependent proline isomerization: A potential mitotic regulatory mechanism
-
doi:10.1126/science.278.5345.1957
-
Yaffe, M.B., M. Schutkowski, M. Shen, X.Z. Zhou, P.T. Stukenberg, J.U. Rahfeld, J. Xu, J. Kuang, M.W. Kirschner, G. Fischer, et al. 1997. Sequence-specific and phosphorylation-dependent proline isomerization: a potential mitotic regulatory mechanism. Science. 278:1957-1960. doi:10.1126/science.278.5345.1957
-
(1997)
Science
, vol.278
, pp. 1957-1960
-
-
Yaffe, M.B.1
Schutkowski, M.2
Shen, M.3
Zhou, X.Z.4
Stukenberg, P.T.5
Rahfeld, J.U.6
Xu, J.7
Kuang, J.8
Kirschner, M.W.9
Fischer, G.10
-
60
-
-
0038392934
-
Increased ezrin expression and activation by CDK5 coincident with acquisition of the senescent phenotype
-
doi:10.1016/S1097-2765(03)00135-7
-
Yang, H.S., and P.W. Hinds. 2003. Increased ezrin expression and activation by CDK5 coincident with acquisition of the senescent phenotype. Mol. Cell. 11:1163-1176. doi:10.1016/S1097-2765(03)00135-7
-
(2003)
Mol. Cell.
, vol.11
, pp. 1163-1176
-
-
Yang, H.S.1
Hinds, P.W.2
|