메뉴 건너뛰기




Volumn 207, Issue 11, 2010, Pages 2507-2519

Cyclin-dependent kinase 5 activity is required for T cell activation and induction of experimental autoimmune encephalomyelitis

Author keywords

[No Author keywords available]

Indexed keywords

ACTIN; CORONIN 1A; CYCLIN DEPENDENT KINASE 5; MACROPHAGE INFLAMMATORY PROTEIN 3BETA; PROTEIN P35; REGULATOR PROTEIN; T LYMPHOCYTE RECEPTOR; THREONINE; UNCLASSIFIED DRUG;

EID: 78149352604     PISSN: 00221007     EISSN: 15409538     Source Type: Journal    
DOI: 10.1084/jem.20100876     Document Type: Article
Times cited : (56)

References (60)
  • 1
    • 0036687120 scopus 로고    scopus 로고
    • Functional expression of the lymphoid chemokines CCL19 (ECL) and CCL 21 (SLC) at the blood-brain barrier suggests their involvement in G-protein-dependent lymphocyte recruitment into the central nervous system during experimental autoimmune encephalomyelitis
    • DOI 10.1002/1521-4141(200208)32:8<2133::AID-IMMU2133>3.0.CO;2-W
    • Alt, C., M. Laschinger, and B. Engelhardt. 2002. Functional expression of the lymphoid chemokines CCL19 (ELC) and CCL 21 (SLC) at the blood-brain barrier suggests their involvement in G-protein-dependent lymphocyte recruitment into the central nervous system during experimental autoimmune encephalomyelitis. Eur. J. Immunol. 32:2133-2144. doi:10.1002/1521-4141(200208)32:8〈2133::AID- IMMU2133〉3.0.CO;2-W (Pubitemid 34965876)
    • (2002) European Journal of Immunology , vol.32 , Issue.8 , pp. 2133-2144
    • Alt, C.1    Laschinger, M.2    Engelhardt, B.3
  • 2
    • 33644798295 scopus 로고    scopus 로고
    • The crystal structure of murine coronin-1: A regulator of actin cytoskeletal dynamics in lymphocytes
    • doi:10.1016/j.str.2005.09.013
    • Appleton, B.A., P. Wu, and C. Wiesmann. 2006. The crystal structure of murine coronin-1: a regulator of actin cytoskeletal dynamics in lymphocytes. Structure. 14:87-96. doi:10.1016/j.str.2005.09.013
    • (2006) Structure , vol.14 , pp. 87-96
    • Appleton, B.A.1    Wu, P.2    Wiesmann, C.3
  • 3
    • 70349794451 scopus 로고    scopus 로고
    • Immune proteins in brain development and synaptic plasticity
    • doi:10.1016/j.neuron.2009.09.001
    • Boulanger, L.M. 2009. Immune proteins in brain development and synaptic plasticity. Neuron. 64:93-109. doi:10.1016/j.neuron.2009.09.001
    • (2009) Neuron , vol.64 , pp. 93-109
    • Boulanger, L.M.1
  • 4
    • 42649127027 scopus 로고    scopus 로고
    • The actin cytoskeleton in T cell activation
    • doi:10.1146/annurev.immunol.26.021607.090347
    • Burkhardt, J.K., E. Carrizosa, and M.H. Shaffer. 2008. The actin cytoskeleton in T cell activation. Annu. Rev. Immunol. 26:233-259. doi:10.1146/annurev.immunol.26.021607.090347
    • (2008) Annu. Rev. Immunol. , vol.26 , pp. 233-259
    • Burkhardt, J.K.1    Carrizosa, E.2    Shaffer, M.H.3
  • 5
    • 0031018336 scopus 로고    scopus 로고
    • Mice lacking p35, a neuronal specific activator of Cdk5, display cortical lamination defects, seizures, and adult lethality
    • doi:10.1016/S0896-6273(01)80044-1
    • Chae, T., Y.T. Kwon, R. Bronson, P. Dikkes, E. Li, and L.H. Tsai. 1997. Mice lacking p35, a neuronal specific activator of Cdk5, display cortical lamination defects, seizures, and adult lethality. Neuron. 18:29-42. doi:10.1016/S0896-6273(01)80044-1
    • (1997) Neuron , vol.18 , pp. 29-42
    • Chae, T.1    Kwon, Y.T.2    Bronson, R.3    Dikkes, P.4    Li, E.5    Tsai, L.H.6
  • 6
    • 0035877992 scopus 로고    scopus 로고
    • Expression of the neuronal cyclin-dependent kinase 5 activator p35Nck5a in human monocytic cells is associated with differentiation
    • doi:10.1182/blood.V97.12.3763
    • Chen, F., and G.P. Studzinski. 2001. Expression of the neuronal cyclin-dependent kinase 5 activator p35Nck5a in human monocytic cells is associated with differentiation. Blood. 97:3763-3767. doi:10.1182/blood.V97.12. 3763
    • (2001) Blood , vol.97 , pp. 3763-3767
    • Chen, F.1    Studzinski, G.P.2
  • 7
    • 58149142509 scopus 로고    scopus 로고
    • The coronin family of proteins
    • doi:10.1007/978-0-387-09595-0-1
    • Clemen, C.S., V. Rybakin, and L. Eichinger. 2008. The coronin family of proteins. Subcell. Biochem. 48:1-5. doi:10.1007/978-0-387-09595-0-1
    • (2008) Subcell. Biochem. , vol.48 , pp. 1-5
    • Clemen, C.S.1    Rybakin, V.2    Eichinger, L.3
  • 8
    • 0036527429 scopus 로고    scopus 로고
    • Protein kinases - The major drug targets of the twenty-first century?
    • Cohen, P. 2002. Protein kinases-the major drug targets of the twenty-first century? Nat. Rev. Drug Discov. 1:309-315. doi:10.1038/nrd773 (Pubitemid 37361447)
    • (2002) Nature Reviews Drug Discovery , vol.1 , Issue.4 , pp. 309-315
    • Cohen, P.1
  • 9
    • 0037180757 scopus 로고    scopus 로고
    • Inflammation and cancer
    • doi:10.1038/nature01322
    • Coussens, L.M., and Z. Werb. 2002. Inflammation and cancer. Nature. 420:860-867. doi:10.1038/nature01322
    • (2002) Nature , vol.420 , pp. 860-867
    • Coussens, L.M.1    Werb, Z.2
  • 10
    • 4444262625 scopus 로고    scopus 로고
    • Cdk5 deregulation in the pathogenesis of Alzheimer's disease
    • doi:10.1016/j.molmed.2004.07.001
    • Cruz, J.C., and L.H. Tsai. 2004. Cdk5 deregulation in the pathogenesis of Alzheimer's disease. Trends Mol. Med. 10:452-458. doi:10.1016/j.molmed.2004.07. 001
    • (2004) Trends Mol. Med. , vol.10 , pp. 452-458
    • Cruz, J.C.1    Tsai, L.H.2
  • 11
    • 0037434789 scopus 로고    scopus 로고
    • Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain
    • doi:10.1038/nature01355
    • Cua, D.J., J. Sherlock, Y. Chen, C.A. Murphy, B. Joyce, B. Seymour, L. Lucian, W. To, S. Kwan, T. Churakova, et al. 2003. Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain. Nature. 421:744-748. doi:10.1038/nature01355
    • (2003) Nature , vol.421 , pp. 744-748
    • Cua, D.J.1    Sherlock, J.2    Chen, Y.3    Murphy, C.A.4    Joyce, B.5    Seymour, B.6    Lucian, L.7    To, W.8    Kwan, S.9    Churakova, T.10
  • 12
    • 0026041203 scopus 로고
    • Coronin, an actin binding protein of Dictyostelium discoideum localized to cell surface projections, has sequence similarities to G protein beta subunits
    • de Hostos, E.L., B. Bradtke, F. Lottspeich, R. Guggenheim, and G. Gerisch. 1991. Coronin, an actin binding protein of Dictyostelium discoideum localized to cell surface projections, has sequence similarities to G protein beta subunits. EMBO J. 10:4097-4104.
    • (1991) EMBO J , vol.10 , pp. 4097-4104
    • De Hostos, E.L.1    Bradtke, B.2    Lottspeich, F.3    Guggenheim, R.4    Gerisch, G.5
  • 13
    • 0035489777 scopus 로고    scopus 로고
    • A decade of CDK5
    • doi:10.1038/35096019
    • Dhavan, R., and L.H. Tsai. 2001. A decade of CDK5. Nat. Rev. Mol. Cell Biol. 2:749-759. doi:10.1038/35096019
    • (2001) Nat. Rev. Mol. Cell Biol. , vol.2 , pp. 749-759
    • Dhavan, R.1    Tsai, L.H.2
  • 14
    • 0033553440 scopus 로고    scopus 로고
    • A coat protein on phagosomes involved in the intracellular survival of mycobacteria
    • doi:10.1016/S0092-8674(00)80754-0
    • Ferrari, G., H. Langen, M. Naito, and J. Pieters. 1999. A coat protein on phagosomes involved in the intracellular survival of mycobacteria. Cell. 97:435-447. doi:10.1016/S0092-8674(00)80754-0
    • (1999) Cell , vol.97 , pp. 435-447
    • Ferrari, G.1    Langen, H.2    Naito, M.3    Pieters, J.4
  • 15
    • 33747106194 scopus 로고    scopus 로고
    • Requirement for coronin 1 in T lymphocyte trafficking and cellular homeostasis
    • doi:10.1126/science.1130563
    • Föger, N., L. Rangell, D.M. Danilenko, and A.C. Chan. 2006. Requirement for coronin 1 in T lymphocyte trafficking and cellular homeostasis. Science. 313:839-842. doi:10.1126/science.1130563
    • (2006) Science , vol.313 , pp. 839-842
    • Föger, N.1    Rangell, L.2    Danilenko, D.M.3    Chan, A.C.4
  • 16
    • 2342483179 scopus 로고    scopus 로고
    • Cyclin-dependent kinase 5 phosphorylates signal transducer and activator of transcription 3 and regulates its transcriptional activity
    • doi:10.1073/pnas.0307606100
    • Fu, A.K., W.Y. Fu, A.K. Ng, W.W. Chien, Y.P. Ng, J.H. Wang, and N.Y. Ip. 2004. Cyclin-dependent kinase 5 phosphorylates signal transducer and activator of transcription 3 and regulates its transcriptional activity. Proc. Natl. Acad. Sci. USA. 101:6728-6733. doi:10.1073/pnas.0307606100
    • (2004) Proc. Natl. Acad. Sci. USA , vol.101 , pp. 6728-6733
    • Fu, A.K.1    Fu, W.Y.2    Ng, A.K.3    Chien, W.W.4    Ng, Y.P.5    Wang, J.H.6    Ip, N.Y.7
  • 17
    • 58149170170 scopus 로고    scopus 로고
    • Coronin: The double-edged sword of actin dynamics
    • doi:10.1007/978-0-387-09595-0-7
    • Gandhi, M., and B.L. Goode. 2008. Coronin: the double-edged sword of actin dynamics. Subcell. Biochem. 48:72-87. doi:10.1007/978-0-387-09595-0-7
    • (2008) Subcell. Biochem. , vol.48 , pp. 72-87
    • Gandhi, M.1    Goode, B.L.2
  • 18
    • 19644384351 scopus 로고    scopus 로고
    • Association of the leukocyte plasma membrane with the actin cytoskeleton through coiled coil-mediated trimeric coronin 1 molecules
    • doi:10.1091/mbc.E05-01-0042
    • Gatfield, J., I. Albrecht, B. Zanolari, M.O. Steinmetz, and J. Pieters. 2005. Association of the leukocyte plasma membrane with the actin cytoskeleton through coiled coil-mediated trimeric coronin 1 molecules. Mol. Biol. Cell. 16:2786-2798. doi:10.1091/mbc.E05-01-0042
    • (2005) Mol. Biol. Cell. , vol.16 , pp. 2786-2798
    • Gatfield, J.1    Albrecht, I.2    Zanolari, B.3    Steinmetz, M.O.4    Pieters, J.5
  • 19
    • 0037431130 scopus 로고    scopus 로고
    • Cdk5-mediated inhibition of the protective effects of transcription factor MEF2 in neurotoxicity-induced apoptosis
    • doi:10.1016/S0896-6273(03)00191-0
    • Gong, X., X. Tang, M. Wiedmann, X. Wang, J. Peng, D. Zheng, L.A. Blair, J. Marshall, and Z. Mao. 2003. Cdk5-mediated inhibition of the protective effects of transcription factor MEF2 in neurotoxicity-induced apoptosis. Neuron. 38:33-46. doi:10.1016/S0896-6273(03)00191-0
    • (2003) Neuron , vol.38 , pp. 33-46
    • Gong, X.1    Tang, X.2    Wiedmann, M.3    Wang, X.4    Peng, J.5    Zheng, D.6    Blair, L.A.7    Marshall, J.8    Mao, Z.9
  • 22
    • 0033428894 scopus 로고    scopus 로고
    • Mammalian Cdk5 is a functional homologue of the budding yeast Pho85 cyclin-dependent protein kinase
    • doi:10.1073/pnas.96.25.14445
    • Huang, D., G. Patrick, J. Moffat, L.H. Tsai, and B. Andrews. 1999. Mammalian Cdk5 is a functional homologue of the budding yeast Pho85 cyclin-dependent protein kinase. Proc. Natl. Acad. Sci. USA. 96:14445-14450. doi:10.1073/pnas.96.25.14445
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 14445-14450
    • Huang, D.1    Patrick, G.2    Moffat, J.3    Tsai, L.H.4    Andrews, B.5
  • 23
    • 0032530033 scopus 로고    scopus 로고
    • Chemokine regulation of experimental autoimmune encephalomyelitis: Temporal and spatial expression patterns govern disease pathogenesis
    • Karpus, W.J., and R.M. Ransohoff. 1998. Chemokine regulation of experimental autoimmune encephalomyelitis: temporal and spatial expression patterns govern disease pathogenesis. J. Immunol. 161:2667-2671.
    • (1998) J. Immunol. , vol.161 , pp. 2667-2671
    • Karpus, W.J.1    Ransohoff, R.M.2
  • 24
    • 33747482904 scopus 로고    scopus 로고
    • Phosphorylation of WAVE1 regulates actin polymerization and dendritic spine morphology
    • doi:10.1038/nature04976
    • Kim, Y., J.Y. Sung, I. Ceglia, K.W. Lee, J.H. Ahn, J.M. Halford, A.M. Kim, S.P. Kwak, J.B. Park, S. Ho Ryu, et al. 2006. Phosphorylation of WAVE1 regulates actin polymerization and dendritic spine morphology. Nature. 442:814-817. doi:10.1038/nature04976
    • (2006) Nature , vol.442 , pp. 814-817
    • Kim, Y.1    Sung, J.Y.2    Ceglia, I.3    Lee, K.W.4    Ahn, J.H.5    Halford, J.M.6    Kim, A.M.7    Kwak, S.P.8    Park, J.B.9    Ho Ryu, S.10
  • 25
    • 25644456097 scopus 로고    scopus 로고
    • Lipopolysaccharide-induced inflammation exacerbates tau pathology by a cyclin-dependent kinase 5-mediated pathway in a transgenic model of Alzheimer's disease
    • doi:10.1523/JNEUROSCI.2868-05.2005
    • Kitazawa, M., S. Oddo, T.R. Yamasaki, K.N. Green, and F.M. LaFerla. 2005. Lipopolysaccharide-induced inflammation exacerbates tau pathology by a cyclin-dependent kinase 5-mediated pathway in a transgenic model of Alzheimer's disease. J. Neurosci. 25:8843-8853. doi:10.1523/JNEUROSCI.2868-05.2005
    • (2005) J. Neurosci. , vol.25 , pp. 8843-8853
    • Kitazawa, M.1    Oddo, S.2    Yamasaki, T.R.3    Green, K.N.4    LaFerla, F.M.5
  • 26
    • 46949104323 scopus 로고    scopus 로고
    • IL-12- and IL-23-modulated T cells induce distinct types of EAE based on histology, CNS chemokine profile, and response to cytokine inhibition
    • doi:10.1084/jem.20080159
    • Kroenke, M.A., T.J. Carlson, A.V. Andjelkovic, and B.M. Segal. 2008. IL-12- and IL-23-modulated T cells induce distinct types of EAE based on histology, CNS chemokine profile, and response to cytokine inhibition. J. Exp. Med. 205:1535-1541. doi:10.1084/jem.20080159
    • (2008) J. Exp. Med. , vol.205 , pp. 1535-1541
    • Kroenke, M.A.1    Carlson, T.J.2    Andjelkovic, A.V.3    Segal, B.M.4
  • 27
    • 61849141064 scopus 로고    scopus 로고
    • Tyrosine kinases and their substrates in B lymphocytes
    • doi:10.1111/j.1600-065X.2008.00748.x
    • Kurosaki, T., and M. Hikida. 2009. Tyrosine kinases and their substrates in B lymphocytes. Immunol. Rev. 228:132-148. doi:10.1111/j.1600-065X.2008.00748. x
    • (2009) Immunol. Rev. , vol.228 , pp. 132-148
    • Kurosaki, T.1    Hikida, M.2
  • 28
    • 34047251311 scopus 로고    scopus 로고
    • Cdk5 regulates STAT3 activation and cell proliferation in medullary thyroid carcinoma cells
    • doi:10.1074/jbc.M607234200
    • Lin, H., M.C. Chen, C.Y. Chiu, Y.M. Song, and S.Y. Lin. 2007. Cdk5 regulates STAT3 activation and cell proliferation in medullary thyroid carcinoma cells. J. Biol. Chem. 282:2776-2784. doi:10.1074/jbc.M607234200
    • (2007) J. Biol. Chem. , vol.282 , pp. 2776-2784
    • Lin, H.1    Chen, M.C.2    Chiu, C.Y.3    Song, Y.M.4    Lin, S.Y.5
  • 29
    • 58149401207 scopus 로고    scopus 로고
    • STAT-3 and ERK 1/2 phosphorylation are critical for T-cell alloactivation and graft-versus-host disease
    • doi:10.1182/blood-2008-03-147322
    • Lu, S.X., O. Alpdogan, J. Lin, R. Balderas, R. Campos-Gonzalez, X. Wang, G.J. Gao, D. Suh, C. King, M. Chow, et al. 2008. STAT-3 and ERK 1/2 phosphorylation are critical for T-cell alloactivation and graft-versus-host disease. Blood. 112:5254-5258. doi:10.1182/blood-2008-03-147322
    • (2008) Blood , vol.112 , pp. 5254-5258
    • Lu, S.X.1    Alpdogan, O.2    Lin, J.3    Balderas, R.4    Campos-Gonzalez, R.5    Wang, X.6    Gao, G.J.7    Suh, D.8    King, C.9    Chow, M.10
  • 32
    • 33646148511 scopus 로고    scopus 로고
    • The role of serine/threonine kinases in T-cell activation
    • doi:10.1016/j.coi.2006.03.006
    • Matthews, S.A., and D.A. Cantrell. 2006. The role of serine/threonine kinases in T-cell activation. Curr. Opin. Immunol. 18:314-320. doi:10.1016/j.coi.2006.03.006
    • (2006) Curr. Opin. Immunol. , vol.18 , pp. 314-320
    • Matthews, S.A.1    Cantrell, D.A.2
  • 33
    • 34948888764 scopus 로고    scopus 로고
    • LINGO-1 antagonist promotes spinal cord remyelination and axonal integrity in MOG-induced experimental autoimmune encephalomyelitis
    • doi:10.1038/nm1664
    • Mi, S., B. Hu, K. Hahm, Y. Luo, E.S. Kam Hui, Q. Yuan, W.M. Wong, L. Wang, H. Su, T.H. Chu, et al. 2007. LINGO-1 antagonist promotes spinal cord remyelination and axonal integrity in MOG-induced experimental autoimmune encephalomyelitis. Nat. Med. 13:1228-1233. doi:10.1038/nm1664
    • (2007) Nat. Med. , vol.13 , pp. 1228-1233
    • Mi, S.1    Hu, B.2    Hahm, K.3    Luo, Y.4    Kam Hui, E.S.5    Yuan, Q.6    Wong, W.M.7    Wang, L.8    Su, H.9    Chu, T.H.10
  • 34
    • 51149123070 scopus 로고    scopus 로고
    • Cdk5 phosphorylation of WAVE2 regulates oligodendrocyte precursor cell migration through nonreceptor tyrosine kinase Fyn
    • doi:10.1523/JNEUROSCI.1482-08.2008
    • Miyamoto, Y., J. Yamauchi, and A. Tanoue. 2008. Cdk5 phosphorylation of WAVE2 regulates oligodendrocyte precursor cell migration through nonreceptor tyrosine kinase Fyn. J. Neurosci. 28:8326-8337. doi:10.1523/JNEUROSCI.1482-08. 2008
    • (2008) J. Neurosci. , vol.28 , pp. 8326-8337
    • Miyamoto, Y.1    Yamauchi, J.2    Tanoue, A.3
  • 35
  • 36
    • 0032504964 scopus 로고    scopus 로고
    • The p35/Cdk5 kinase is a neuron-specific Rac effector that inhibits Pak1 activity
    • doi:10.1038/26034
    • Nikolic, M., M.M. Chou, W. Lu, B.J. Mayer, and L.H. Tsai. 1998. The p35/Cdk5 kinase is a neuron-specific Rac effector that inhibits Pak1 activity. Nature. 395:194-198. doi:10.1038/26034
    • (1998) Nature , vol.395 , pp. 194-198
    • Nikolic, M.1    Chou, M.M.2    Lu, W.3    Mayer, B.J.4    Tsai, L.H.5
  • 38
    • 0029768093 scopus 로고    scopus 로고
    • Targeted disruption of the cyclin-dependent kinase 5 gene results in abnormal corticogenesis, neuronal pathology and perinatal death
    • doi:10.1073/pnas.93.20.11173
    • Ohshima, T., J.M. Ward, C.G. Huh, G. Longenecker, Veeranna, H.C. Pant, R.O. Brady, L.J. Martin, and A.B. Kulkarni. 1996. Targeted disruption of the cyclin-dependent kinase 5 gene results in abnormal corticogenesis, neuronal pathology and perinatal death. Proc. Natl. Acad. Sci. USA. 93:11173-11178. doi:10.1073/pnas.93.20.11173
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 11173-11178
    • Ohshima, T.1    Ward, J.M.2    Huh, C.G.3    Longenecker, G.4    Veeranna5    Pant, H.C.6    Brady, R.O.7    Martin, L.J.8    Kulkarni, A.B.9
  • 40
    • 33846293924 scopus 로고    scopus 로고
    • Cyclin-dependent kinase 5 modulates nociceptive signaling through direct phosphorylation of transient receptor potential vanilloid 1
    • doi:10.1073/pnas.0609916104
    • Pareek, T.K., J. Keller, S. Kesavapany, N. Agarwal, R. Kuner, H.C. Pant, M.J. Iadarola, R.O. Brady, and A.B. Kulkarni. 2007. Cyclin-dependent kinase 5 modulates nociceptive signaling through direct phosphorylation of transient receptor potential vanilloid 1. Proc. Natl. Acad. Sci. USA. 104:660-665. doi:10.1073/pnas.0609916104
    • (2007) Proc. Natl. Acad. Sci. USA , vol.104 , pp. 660-665
    • Pareek, T.K.1    Keller, J.2    Kesavapany, S.3    Agarwal, N.4    Kuner, R.5    Pant, H.C.6    Iadarola, M.J.7    Brady, R.O.8    Kulkarni, A.B.9
  • 41
    • 0031457622 scopus 로고    scopus 로고
    • Signaling through scaffold, anchoring, and adaptor proteins
    • DOI 10.1126/science.278.5346.2075
    • Pawson, T., and J.D. Scott. 1997. Signaling through scaffold, anchoring, and adaptor proteins. Science. 278:2075-2080. doi:10.1126/science.278.5346.2075 (Pubitemid 28028310)
    • (1997) Science , vol.278 , Issue.5346 , pp. 2075-2080
    • Pawson, T.1    Scott, J.D.2
  • 42
    • 24944548652 scopus 로고    scopus 로고
    • Historical descriptions of multiple sclerosis
    • doi:10.1159/000087387
    • Pearce, J.M. 2005. Historical descriptions of multiple sclerosis. Eur. Neurol. 54:49-53. doi:10.1159/000087387
    • (2005) Eur. Neurol. , vol.54 , pp. 49-53
    • Pearce, J.M.1
  • 43
    • 61849142482 scopus 로고    scopus 로고
    • The Tec kinases Itk and Rlk regulate conventional versus innate T-cell development
    • doi:10.1111/j.1600-065X.2008.00746.x
    • Prince, A.L., C.C. Yin, M.E. Enos, M. Felices, and L.J. Berg. 2009. The Tec kinases Itk and Rlk regulate conventional versus innate T-cell development. Immunol. Rev. 228:115-131. doi:10.1111/j.1600-065X.2008.00746.x
    • (2009) Immunol. Rev. , vol.228 , pp. 115-131
    • Prince, A.L.1    Yin, C.C.2    Enos, M.E.3    Felices, M.4    Berg, L.J.5
  • 44
    • 47249131563 scopus 로고    scopus 로고
    • The use of chemokine antagonists in EAE models
    • doi:10.1016/j.jneuroim.2008.04.007
    • Proudfoot, A.E., A.L. de Souza, and V. Muzio. 2008. The use of chemokine antagonists in EAE models. J. Neuroimmunol. 198:27-30. doi:10.1016/j.jneuroim. 2008.04.007
    • (2008) J. Neuroimmunol. , vol.198 , pp. 27-30
    • Proudfoot, A.E.1    De Souza, A.L.2    Muzio, V.3
  • 45
    • 0035966018 scopus 로고    scopus 로고
    • Phosphorylation of Pak1 by the p35/Cdk5 kinase affects neuronal morphology
    • doi:10.1074/jbc.M105599200
    • Rashid, T., M. Banerjee, and M. Nikolic. 2001. Phosphorylation of Pak1 by the p35/Cdk5 kinase affects neuronal morphology. J. Biol. Chem. 276:49043-49052. doi:10.1074/jbc.M105599200
    • (2001) J. Biol. Chem. , vol.276 , pp. 49043-49052
    • Rashid, T.1    Banerjee, M.2    Nikolic, M.3
  • 46
    • 33750014263 scopus 로고    scopus 로고
    • Extraneuronal roles of cyclin-dependent kinase 5
    • doi:10.1002/bies.20473
    • Rosales, J.L., and K.Y. Lee. 2006. Extraneuronal roles of cyclin-dependent kinase 5. Bioessays. 28:1023-1034. doi:10.1002/bies.20473
    • (2006) Bioessays , vol.28 , pp. 1023-1034
    • Rosales, J.L.1    Lee, K.Y.2
  • 47
    • 61849128182 scopus 로고    scopus 로고
    • T-cell receptor proximal signaling via the Src-family kinases, Lck and Fyn, influences T-cell activation, differentiation, and tolerance
    • doi:10.1111/j.1600-065X.2008.00745.x
    • Salmond, R.J., A. Filby, I. Qureshi, S. Caserta, and R. Zamoyska. 2009. T-cell receptor proximal signaling via the Src-family kinases, Lck and Fyn, influences T-cell activation, differentiation, and tolerance. Immunol. Rev. 228:9-22. doi:10.1111/j.1600-065X.2008.00745.x
    • (2009) Immunol. Rev. , vol.228 , pp. 9-22
    • Salmond, R.J.1    Filby, A.2    Qureshi, I.3    Caserta, S.4    Zamoyska, R.5
  • 49
    • 1642269125 scopus 로고    scopus 로고
    • Cyclin-dependent kinase-5 in neurodegeneration
    • doi:10.1111/j.1471-4159.2003.02328.x
    • Shelton, S.B., and G.V. Johnson. 2004. Cyclin-dependent kinase-5 in neurodegeneration. J. Neurochem. 88:1313-1326. doi:10.1111/j.1471-4159.2003. 02328.x
    • (2004) J. Neurochem. , vol.88 , pp. 1313-1326
    • Shelton, S.B.1    Johnson, G.V.2
  • 50
    • 54549117897 scopus 로고    scopus 로고
    • The actin regulator coronin 1A is mutant in a thymic egress-deficient mouse strain and in a patient with severe combined immunodeficiency
    • doi:10.1038/ni.1662
    • Shiow, L.R., D.W. Roadcap, K. Paris, S.R. Watson, I.L. Grigorova, T. Lebet, J. An, Y. Xu, C.N. Jenne, N. Föger, et al. 2008. The actin regulator coronin 1A is mutant in a thymic egress-deficient mouse strain and in a patient with severe combined immunodeficiency. Nat. Immunol. 9:1307-1315. doi:10.1038/ni.1662
    • (2008) Nat. Immunol. , vol.9 , pp. 1307-1315
    • Shiow, L.R.1    Roadcap, D.W.2    Paris, K.3    Watson, S.R.4    Grigorova, I.L.5    Lebet, T.6    An, J.7    Xu, Y.8    Jenne, C.N.9    Föger, N.10
  • 51
    • 63249106283 scopus 로고    scopus 로고
    • Severe combined immunodeficiency (SCID) and attention deficit hyperactivity disorder (ADHD) associated with a Coronin-1A mutation and a chromosome 16p11.2 deletion
    • doi:10.1016/j.clim.2008.11.002
    • Shiow, L.R., K. Paris, M.C. Akana, J.G. Cyster, R.U. Sorensen, and J.M. Puck. 2009. Severe combined immunodeficiency (SCID) and attention deficit hyperactivity disorder (ADHD) associated with a Coronin-1A mutation and a chromosome 16p11.2 deletion. Clin. Immunol. 131:24-30. doi:10.1016/j.clim.2008. 11.002
    • (2009) Clin. Immunol. , vol.131 , pp. 24-30
    • Shiow, L.R.1    Paris, K.2    Akana, M.C.3    Cyster, J.G.4    Sorensen, R.U.5    Puck, J.M.6
  • 52
    • 33747875152 scopus 로고    scopus 로고
    • Cyclin-dependent kinase 5 activity controls cell motility and metastatic potential of prostate cancer cells
    • doi:10.1158/0008-5472.CAN-05-3048
    • Strock, C.J., J.I. Park, E.K. Nakakura, G.S. Bova, J.T. Isaacs, D.W. Ball, and B.D. Nelkin. 2006. Cyclin-dependent kinase 5 activity controls cell motility and metastatic potential of prostate cancer cells. Cancer Res. 66:7509-7515. doi:10.1158/0008-5472.CAN-05-3048
    • (2006) Cancer Res , vol.66 , pp. 7509-7515
    • Strock, C.J.1    Park, J.I.2    Nakakura, E.K.3    Bova, G.S.4    Isaacs, J.T.5    Ball, D.W.6    Nelkin, B.D.7
  • 53
    • 0037299465 scopus 로고    scopus 로고
    • The neuronal cyclin-dependent kinase 5 activator p35Nck5a and Cdk5 activity in monocytic cells
    • doi:10.1080/1042819021000030009
    • Studzinski, G.P., and J.S. Harrison. 2003. The neuronal cyclin-dependent kinase 5 activator p35Nck5a and Cdk5 activity in monocytic cells. Leuk. Lymphoma. 44:235-240. doi:10.1080/1042819021000030009
    • (2003) Leuk. Lymphoma. , vol.44 , pp. 235-240
    • Studzinski, G.P.1    Harrison, J.S.2
  • 54
    • 0028824975 scopus 로고
    • Molecular mechanism of T-cell activation: Role of protein tyrosine kinases in antigen receptor-mediated signal transduction
    • doi:10.1016/0923-2494(96)80263-X
    • Thome, M., and O. Acuto. 1995. Molecular mechanism of T-cell activation: role of protein tyrosine kinases in antigen receptor-mediated signal transduction. Res. Immunol. 146:291-307. doi:10.1016/0923-2494(96)80263-X
    • (1995) Res. Immunol. , vol.146 , pp. 291-307
    • Thome, M.1    Acuto, O.2
  • 55
    • 57449107298 scopus 로고    scopus 로고
    • Cell cycle regulatory protein 5 (Cdk5) is a novel downstream target of ERK in carboplatin induced death of breast cancer cells
    • doi:10.2174/156800908786733405
    • Upadhyay, A.K., A.K. Ajay, S. Singh, and M.K. Bhat. 2008. Cell cycle regulatory protein 5 (Cdk5) is a novel downstream target of ERK in carboplatin induced death of breast cancer cells. Curr. Cancer Drug Targets. 8:741-752. doi:10.2174/156800908786733405
    • (2008) Curr. Cancer Drug Targets , vol.8 , pp. 741-752
    • Upadhyay, A.K.1    Ajay, A.K.2    Singh, S.3    Bhat, M.K.4
  • 56
    • 44049105823 scopus 로고    scopus 로고
    • Transcription factor Mef2c is required for B cell proliferation and survival after antigen receptor stimulation
    • doi:10.1038/ni.1609
    • Wilker, P.R., M. Kohyama, M.M. Sandau, J.C. Albring, O. Nakagawa, J.J. Schwarz, and K.M. Murphy. 2008. Transcription factor Mef2c is required for B cell proliferation and survival after antigen receptor stimulation. Nat. Immunol. 9:603-612. doi:10.1038/ni.1609
    • (2008) Nat. Immunol. , vol.9 , pp. 603-612
    • Wilker, P.R.1    Kohyama, M.2    Sandau, M.M.3    Albring, J.C.4    Nakagawa, O.5    Schwarz, J.J.6    Murphy, K.M.7
  • 57
    • 0036685522 scopus 로고    scopus 로고
    • Inflammation in neurodegenerative disease - A double-edged sword
    • doi:10.1016/S0896-6273(02)00794-8
    • Wyss-Coray, T., and L. Mucke. 2002. Inflammation in neurodegenerative disease - a double-edged sword. Neuron. 35:419-432. doi:10.1016/S0896-6273(02) 00794-8
    • (2002) Neuron , vol.35 , pp. 419-432
    • Wyss-Coray, T.1    Mucke, L.2
  • 58
    • 0042329506 scopus 로고    scopus 로고
    • Serine 732 phosphorylation of FAK by Cdk5 is important for microtubule organization, nuclear movement, and neuronal migration
    • doi:10.1016/S0092-8674(03)00605-6
    • Xie, Z., K. Sanada, B.A. Samuels, H. Shih, and L.H. Tsai. 2003. Serine 732 phosphorylation of FAK by Cdk5 is important for microtubule organization, nuclear movement, and neuronal migration. Cell. 114:469-482. doi:10.1016/S0092-8674(03)00605-6
    • (2003) Cell , vol.114 , pp. 469-482
    • Xie, Z.1    Sanada, K.2    Samuels, B.A.3    Shih, H.4    Tsai, L.H.5
  • 59
    • 0031438929 scopus 로고    scopus 로고
    • Sequence-specific and phosphorylation-dependent proline isomerization: A potential mitotic regulatory mechanism
    • doi:10.1126/science.278.5345.1957
    • Yaffe, M.B., M. Schutkowski, M. Shen, X.Z. Zhou, P.T. Stukenberg, J.U. Rahfeld, J. Xu, J. Kuang, M.W. Kirschner, G. Fischer, et al. 1997. Sequence-specific and phosphorylation-dependent proline isomerization: a potential mitotic regulatory mechanism. Science. 278:1957-1960. doi:10.1126/science.278.5345.1957
    • (1997) Science , vol.278 , pp. 1957-1960
    • Yaffe, M.B.1    Schutkowski, M.2    Shen, M.3    Zhou, X.Z.4    Stukenberg, P.T.5    Rahfeld, J.U.6    Xu, J.7    Kuang, J.8    Kirschner, M.W.9    Fischer, G.10
  • 60
    • 0038392934 scopus 로고    scopus 로고
    • Increased ezrin expression and activation by CDK5 coincident with acquisition of the senescent phenotype
    • doi:10.1016/S1097-2765(03)00135-7
    • Yang, H.S., and P.W. Hinds. 2003. Increased ezrin expression and activation by CDK5 coincident with acquisition of the senescent phenotype. Mol. Cell. 11:1163-1176. doi:10.1016/S1097-2765(03)00135-7
    • (2003) Mol. Cell. , vol.11 , pp. 1163-1176
    • Yang, H.S.1    Hinds, P.W.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.