The H63D HFE gene variant promotes activation of the intrinsic apoptotic pathway via mitochondria dysfunction following β-amyloid peptide exposure

Journal of Neuroscience Research

Volumn 88, Issue 14, 2010, Pages 3079-3089

  Mairuae, Nootchanat ^a   Hall II, Eric C ^b   Cheepsunthorn, Poonlarp ^a   Lee, Sang Y ^b   Connor, James R ^b  

^a CHULALONGKORN UNIVERSITY   (Thailand)

^b PENN STATE COLLEGE OF MEDICINE   (United States)

Author keywords

Alzheimer's disease; Apoptosis; APP; HFE; Iron; Mitochondria

Indexed keywords

AMYLOID BETA PROTEIN[1-42]; AMYLOID BETA PROTEIN[25-35]; AMYLOID PRECURSOR PROTEIN; CASPASE 3; CASPASE 9; CYTOCHROME C; HFE PROTEIN; PROTEIN BAX;

APOPTOSIS; ARTICLE; CELL STRESS; CELL VIABILITY; CYTOSOL; DISEASE ASSOCIATION; ENZYME INDUCTION; GENE EXPRESSION; GENE TRANSLOCATION; GENETIC POLYMORPHISM; GENETIC RISK; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; HUMAN; HUMAN CELL; MITOCHONDRION; NEUROBLASTOMA CELL; OXIDATIVE STRESS; PRIORITY JOURNAL;

ALLELES; ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; AMYLOID BETA-PROTEIN PRECURSOR; APOPTOSIS; CELL LINE, TUMOR; GENETIC PREDISPOSITION TO DISEASE; GENETIC VARIATION; HISTOCOMPATIBILITY ANTIGENS CLASS I; HUMANS; MEMBRANE PROTEINS; MITOCHONDRIA; NEURONS; PEPTIDE FRAGMENTS;

EID: 78149347778     PISSN: 03604012     EISSN: 10974547     Source Type: Journal    
DOI: 10.1002/jnr.22466     Document Type: Article

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