Trophic factors and their receptors in pain pathways

Synaptic Plasticity in Pain

Volumn , Issue , 2009, Pages 21-45

  Priestley, John V ^a  

^a QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 78149280322     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1007/978-1-4419-0226-9_2     Document Type: Chapter

References (162)

1. Abbadie C, Lindia JA, Cumiskey AM, Peterson LB, Mudgett JS, Bayne EK, DeMartino JA, MacIntyre DE, Forrest MJ (2003) Impaired neuropathic pain responses in mice lacking the chemokine receptor CCR2. Proc Natl Acad Sci USA 100:7947-7952.
2. Alvarez FJ, Morris HR, Priestley JV (1991) Sub-populations of smaller diameter trigeminal primary afferent neurons defined by expression of calcitonin gene-related peptide and the cell surface oligosaccharide recognized by monoclonal antibody LA4. J Neurocytol 20:716-731.
3. Amaya F, Shimosato G, Nagano M, Ueda M, Hashimoto S, Tanaka Y, Suzuki H, Tanaka M (2004) NGF and GDNF differentially regulate TRPV1 expression that contributes to development of inflammatory thermal hyperalgesia. Eur J Neurosci 20:2303-2310.
4. Apfel SC, Wright DE, Wiideman AM, Dormia C, Snider WD, Kessler JA (1996) Nerve growth-factor regulates the expression of brain-derived neurotrophic factor messenger-RNA in the peripheral nervous-system. Mol Cell Neurosci 7:134-142.
5. Arruda JL, Colburn RW, Rickman AJ, Rutkowski MD, DeLeo JA (1998) Increase of interleukin-6 mRNA in the spinal cord following peripheral nerve injury in the rat: potential role of IL-6 in neuropathic pain. Mol Brain Res 62:228-235.
6. Averill S, Inglis JJ, King VR, Thompson SW, Cafferty WB, Shortland PJ, Hunt SP, Kidd BL, Priestley JV (2008) Reg-2 expression in dorsal root ganglion neurons after adjuvantinduced monoarthritis. Neurosci 155:1227-1236.
7. Averill S, McMahon SB, Clary DO, Reichardt LF, Priestley JV (1995) Immunocytochemical localization of trkA receptors in chemically identified subgroups of adult rat sensory neurons. Eur J Neurosci 7:1484-1494.
8. Averill S, Michael GJ, Shortland PJ, Leavesley RC, King VR, Bradbury EJ, McMahon SB, Priestley JV (2004) NGF and GDNF ameliorate the increase in ATF3 expression which occurs in dorsal root ganglion cells in response to peripheral nerve injury. Eur J Neurosci 19:1437-1445.
9. Bandell M, Macpherson LJ, Patapoutian A (2007) From chills to chilis: mechanisms for thermosensation and chemesthesis via thermoTRPs. Curr Opin Neurobiol 17:490-497.
10. Bao L, Zhu Y, Elhassan AM, Wu Q, Xiao B, Zhu J, Lindgren JU (2001) Adjuvant-induced arthritis: IL-1 beta, IL-6 and TNF-alpha are up-regulated in the spinal cord. Neuroreport 12:3905-3908.
11. Barclay J, Patel S, Dorn G, Wotherspoon G, Moffatt S, Eunson L, Abdel'al S, Natt F, Hall J, Winter J, Bevan S, Wishart W, Fox A, Ganju P (2002) Functional downregulation of P2X3 receptor subunit in rat sensory neurons reveals a significant role in chronic neuropathic and inflammatory pain. J Neurosci 22:8139-8147.
12. Bauer S, Kerr BJ, Patterson PH (2007) The neuropoietic cytokine family in development, plasticity, disease and injury. Nat Rev Neurosci 8:221-232.
13. Bautista DM, Jordt SE, Nikai T, Tsuruda PR, Read AJ, Poblete J, Yamoah EN, Basbaum AI, Julius D (2006) TRPA1 mediates the inflammatory actions of environmental irritants and proalgesic agents. Cell 124:1269-1282.
14. Belvisi MG (2002) Overview of the innervation of the lung. Curr Opin Pharmacol 2:211-215.
15. Bennett DLH, Averill S, Clary DO, Priestley JV, McMahon SB (1996) Postnatal changes in the expression of the trkA high-affinity NGF receptor in primary sensory neurons. Eur J Neurosci 8:2204-2208.
16. Bennett DL, Boucher TJ, Armanini MP, Poulsen KT, Michael GJ, Priestley JV, Phillips HS, McMahon SB, Shelton DL (2000) The glial cell line-derived neurotrophic factor family receptor components are differentially regulated within sensory neurons after nerve injury. J Neurosci 20:427-437.
17. Bennett DL, Boucher TJ, Michael GJ, Popat RJ, Malcangio M, Averill SA, Poulsen KT, Priestley JV, Shelton DL, McMahon SB (2006) Artemin has potent neurotrophic actions on injured C-fibres. J Peripher Nerv Syst 11:330-345.
18. Bennett DLH, Michael GJ, Ramachandran N, Munson JB, Averill S, Yan Q, McMahon SB, Priestley JV (1998) A distinct subgroup of small DRG cells express GDNF receptor components and GDNF is protective for these neurons after nerve injury. J Neurosci 18:3059-3072.
19. Blackshaw LA, Brookes SJ, Grundy D, Schemann M (2007) Sensory transmission in the gastrointestinal tract. Neurogastroenterol Motil 19:1-19.
20. Bogen O, Joseph EK, Chen X, Levine JD (2008) GDNF hyperalgesia is mediated by PLCgamma, MAPK/ERK, PI3K, CDK5 and Src family kinase signaling and dependent on the IB4-binding protein versican. Eur J Neurosci 28:12-19.
21. Boucher TJ, Okuse K, Bennett DL, Munson JB, Wood JN, McMahon SB (2000) Potent analgesic effects of GDNF in neuropathic pain states. Science 290:124-127.
22. Bradbury EJ, Burnstock G, McMahon SB (1998a) The expression of P2X3 purinoreceptors in sensory neurons: Effects of axotomy and glial-derived neurotrophic factor. Mol Cell Neurosci 12:256-268.
23. Bradbury EJ, King VR, Simmons LJ, Priestley JV, McMahon SB (1998b) NT-3, but not BDNF, prevents atrophy and death of axotomized spinal cord projection neurons. Eur J Neurosci 10:3058-3068.
24. Braz JM, Nassar MA, Wood JN, Basbaum AI (2005) Parallel "pain" pathways arise from subpopulations of primary afferent nociceptor. Neuron 47:787-793.
25. Breese NM, George AC, Pauers LE, Stucky CL (2005) Peripheral inflammation selectively increases TRPV1 function in IB4-positive sensory neurons from adult mouse. Pain 115:37-49.
26. Brown A, Ricci MJ, Weaver LC (2007) NGF mRNA is expressed in the dorsal root ganglia after spinal cord injury in the rat. Exp Neurol 205:283-286.
27. Cafferty WB, Gardiner NJ, Das P, Qiu J, McMahon SB, Thompson SW (2004) Conditioning injury-induced spinal axon regeneration fails in interleukin-6 knock-out mice. J Neurosci 24:4432-4443.
28. Cafferty WB, Gardiner NJ, Gavazzi I, Powell J, McMahon SB, Heath JK, Munson J, Cohen J, Thompson SW (2001) Leukemia inhibitory factor determines the growth status of injured adult sensory neurons. J Neurosci 21:7161-7170.
29. Cao Z, Gao Y, Bryson JB, Hou J, Chaudhry N, Siddiq M, Martinez J, Spencer T, Carmel J, Hart RB, Filbin MT (2006) The cytokine interleukin-6 is sufficient but not necessary to mimic the peripheral conditioning lesion effect on axonal growth. J Neurosci 26:5565-5573.
30. Charbel-Issa P, Lever IJ, Michael GJ, Bradbury EJ, Malcangio M (2001) Intrathecally delivered glial cell line-derived neurotrophic factor produces electrically evoked release of somatostatin in the dorsal horn of the spinal cord. J Neurochem 78:221-229.
31. Cho HJ, Kim SY, Park MJ, Kim DS, Kim JK, Chu MY (1997b) Expression of mRNA for brain-derived neurotrophic factor in the dorsal root ganglion following peripheral inflammation. Brain Res 749:358-362.
32. Cho HJ, Kim JK, Zhou XF, Rush RA (1997a) Increased brain-derived neurotrophic factor immunoreactivity in rat dorsal root ganglia and spinal cord following peripheral inflammation. Brain Res 764:269-272.
33. Corness J, Shi TJ, Xu ZQ, Brulet P, Hokfelt T (1996) Influence of leukemia inhibitory factor on galanin/GMAP and neuropeptide Y expression in mouse primary sensory neurons after axotomy. Exp Brain Res 112:79-88.
34. Coull JA, Beggs S, Boudreau D, Boivin D, Tsuda M, Inoue K, Gravel C, Salter MW, De Koninck Y (2005) BDNF from microglia causes the shift in neuronal anion gradient underlying neuropathic pain. Nature 438:1017-1021.
35. Crozier RA, Ajit SK, Kaftan EJ, Pausch MH (2007) MrgD activation inhibits KCNQ/M-currents and contributes to enhanced neuronal excitability. J Neurosci 27:4492-4496.
36. Cummins TR, Black JA, Dib-Hajj SD, Waxman SG (2000) Glial-derived neurotrophic factor upregulates expression of functional SNS and NaN sodium channels and their currents in axotomized dorsal root ganglion neurons. J Neurosci 20:8754-8761.
37. Cunha FQ, Poole S, Lorenzetti BB, Ferreira SH (1992) The pivotal role of tumour necrosis factor alpha in the development of inflammatory hyperalgesia. Br J Pharmacol 107:660-664.
38. De Jongh RF, Vissers KC, Meert TF, Booij LH, De Deyne CS, Heylen RJ (2003) The role of interleukin-6 in nociception and pain. Anesth Analg 96:1096-1103, table.
39. Del Fiacco M, Priestley JV (2001) Neurotrophins and adult somatosensory neurons. In: Neurobiology of the neurotrophins (Mocchetti I, ed), pp 205-236. Johnson City, TN: F. P. Graham Publishing.
40. DeLeo JA, Colburn RW, Nichols M, Malhotra A (1996) Interleukin-6-mediated hyperalgesia/allodynia and increased spinal IL-6 expression in a rat mononeuropathy model. J Interferon Cytokine Res 16:695-700.
41. Dirajlal S, Pauers LE, Stucky CL (2003) Differential response properties of IB4-positive and -negative unmyelinated sensory neurons to protons and capsaicin. J Neurophysiol 89:513-524.
42. Djouhri L, Lawson SN (2004) Abeta-fiber nociceptive primary afferent neurons: a review of incidence and properties in relation to other afferent A-fiber neurons in mammals. Brain Res Brain Res Rev 46:131-145.
43. Dong X, Han S, Zylka MJ, Simon MI, Anderson DJ (2001) A diverse family of GPCRs expressed in specific subsets of nociceptive sensory neurons. Cell 106:619-632.
44. Dong ZQ, Wang YQ, Ma F, Xie H, Wu GC (2006) Down-regulation of GFRalpha-1 expression by antisense oligodeoxynucleotide aggravates thermal hyperalgesia in a rat model of neuropathic pain. Neuropharmacology 50:393-403.
45. Dussor G, Zylka MJ, Anderson DJ, McCleskey EW (2008) Cutaneous sensory neurons expressing the mrgprd receptor sense extracellular ATP and are putative nociceptors. J Neurophysiol 99:1581-1589.
46. Elg S, Marmigere F, Mattsson JP, Ernfors P (2007) Cellular subtype distribution and developmental regulation of TRPC channel members in the mouse dorsal root ganglion. J Comp Neurol 503:35-46.
47. Elitt CM, McIlwrath SL, Lawson JJ, Malin SA, Molliver DC, Cornuet PK, Koerber HR, Davis BM, Albers KM (2006) Artemin overexpression in skin enhances expression of TRPV1 and TRPA1 in cutaneous sensory neurons and leads to behavioral sensitivity to heat and cold. J Neurosci 26:8578-8587.
48. Fang X, Djouhri L, McMullan S, Berry C, Waxman SG, Okuse K, Lawson SN (2006) Intense isolectin-B4 binding in rat dorsal root ganglion neurons distinguishes C-fiber nociceptors with broad action potentials and high Nav1.9 expression. J Neurosci 26:7281-7292.
49. Fang M, Wang Y, He QH, Sun YX, Deng LB, Wang XM, Han JS (2003) Glial cell linederived neurotrophic factor contributes to delayed inflammatory hyperalgesia in adjuvant rat pain model. Neurosci 117:503-512.
50. Fang M, Wang Y, Liu HX, Liu XS, Han JS (2000) Decreased GDNF mRNA expression in dorsal spinal cord of unilateral arthritic rat. Neuroreport 11:737-741.
51. Farinas I, Cano-Jaimez M, Bellmunt E, Soriano M (2002) Regulation of neurogenesis by neurotrophins in developing spinal sensory ganglia. Brain Res Bull 57:809-816.
52. Gardell LR, Wang R, Ehrenfels C, Ossipov MH, Rossomando AJ, Miller S, Buckley C, Cai AK, Tse A, Foley SF, Gong B, Walus L, Carmillo P, Worley D, Huang C, Engber T, Pepinsky B, Cate RL, Vanderah TW, Lai J, Sah DW, Porreca F (2003) Multiple actions of systemic artemin in experimental neuropathy. Nat Med 9:1383-1389.
53. Gardiner NJ, Cafferty WB, Slack SE, Thompson SW (2002) Expression of gp130 and leukaemia inhibitory factor receptor subunits in adult rat sensory neurones: regulation by nerve injury. J Neurochem 83:100-109.
54. Hammarberg H, Piehl F, Cullheim S, Fjell J, Hokfelt T, Fried K (1996) GDNF mRNA in Schwann cells and DRG satellite cells after chronic sciatic nerve injury. Neuroreport 7:857-860.
55. Hammarberg H, Piehl F, Risling M, Cullheim S (2000) Differential regulation of trophic factor receptor mRNAs in spinal motoneurons after sciatic nerve transection and ventral root avulsion in the rat. J Comp Neurol 426:587-601.
56. Hensellek S, Brell P, Schaible HG, Brauer R, Segond VB (2007) The cytokine TNFalpha increases the proportion of DRG neurones expressing the TRPV1 receptor via the TNFR1 receptor and ERK activation. Mol Cell Neurosci 36:381-391.
57. Hjerling-Leffler J, Alqatari M, Ernfors P, Koltzenburg M (2007) Emergence of functional sensory subtypes as defined by transient receptor potential channel expression. J Neurosci 27:2435-2443.
58. Hoane MR, Gulwadi AG, Morrison S, Hovanesian G, Lindner MD, Tao W (1999) Differential in vivo effects of neurturin and glial cell-line-derived neurotrophic factor. Exp Neurol 160:235-243.
59. Holstege JC, Jongen JLM, Kennis JHH, van Rooyen-Boot AAMA, Vecht CJ (1998) Immunocytochemical localization of GDNF in primary afferents of the lumbar dorsal horn. Neuroreport 9:2893-2897.
60. Hucho TB, Dina OA, Levine JD (2005) Epac mediates a cAMP-to-PKC signaling in inflammatory pain: an isolectin B4 (+) neuron-specific mechanism. J Neurosci 25:6119-6126.
61. Inserra MM, Yao M, Murray R, Terris DJ (2000) Peripheral nerve regeneration in interleukin 6-deficient mice. Arch Otolaryngol Head Neck Surg 126:1112-1116.
62. Ito Y, Yamamoto M, Li M, Mitsuma N, Tanaka F, Doyu M, Suzumura A, Mitsuma T, Sobue G (2000) Temporal expression of mRNAs for neuropoietic cytokines, interleukin-11 (IL-11), oncostatin M (OSM), cardiotrophin-1 (CT-1) and their receptors (IL-11Ralpha and OSMRbeta) in peripheral nerve injury [In Process Citation]. Neurochem Res 25:1113-1118.
63. Jeon SM, Lee KM, Park ES, Jeon YH, Cho HJ (2008) Monocyte chemoattractant protein-1 immunoreactivity in sensory ganglia and hindpaw after adjuvant injection. Neuroreport 19:183-186.
64. Jia Y, Lee LY (2007) Role of TRPV receptors in respiratory diseases. Biochim Biophys Acta 1772:915-927.
65. Jongen JL, Haasdijk ED, Sabel-Goedknegt H, van der BJ, Vecht C, Holstege JC (2005) Intrathecal injection of GDNF and BDNF induces immediate early gene expression in rat spinal dorsal horn. Exp Neurol 194:255-266.
66. Jongen JL, Jaarsma D, Hossaini M, Natarajan D, Haasdijk ED, Holstege JC (2007) Distribution of RET immunoreactivity in the rodent spinal cord and changes after nerve injury. J Comp Neurol 500:1136-1153.
67. Jordt SE, Bautista DM, Chuang HH, McKemy DD, Zygmunt PM, Hogestatt ED, Meng ID, Julius D (2004) Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1. Nature 427:260-265.
68. Josephson A, Widenfalk J, Trifunovski A, Widmer HR, Olson L, Spenger C (2001) GDNF and NGF family members and receptors in human fetal and adult spinal cord and dorsal root ganglia. J Comp Neurol 440:204-217.
69. Ju G, Hokfelt T, Brodin E, Fahrenkrug J, Fischer JA, Frey P, Elde RP, Brown JC (1987) Primary sensory neurons of the rat showing calcitonin gene-related peptide immunoreactivity and their relation to substance P-, somatostatin-, galanin-, vasoactive intestinal polypeptide- and cholecystokinin-immunoreactive ganglion cells. Cell Tissue Res 247:417-431.
70. Karchewski LA, Kim FA, Johnston J, McKnight RM, Verge VM (1999) Anatomical evidence supporting the potential for modulation by multiple neurotrophins in the majority of adult lumbar sensory neurons. J Comp Neurol 413:327-341.
71. Kashiba H, Uchida Y, Senba E (2001) Difference in binding by isolectin B4 to trkA and c-ret mRNA-expressing neurons in rat sensory ganglia. Mol Brain Res 95:18-26.
72. Kashiba H, Uchida Y, Senba E (2003) Distribution and colocalization of NGF and GDNF family ligand receptor mRNAs in dorsal root and nodose ganglion neurons of adult rats. Brain Res Mol Brain Res 110:52-62.
73. Kerr BJ, Bradbury EJ, Bennett DLH, Trivedi PM, Dassan P, French J, Shelton DB, McMahon SB, Thompson SWN (1999) Brain-derived neurotrophic factor modulates nociceptive sensory inputs and NMDA-evoked responses in the rat spinal cord. J Neurosci 19:5138-5148.
74. Kidd BL, Urban LA (2001) Mechanisms of inflammatory pain. Br J Anaesth 87:3-11.
75. King VR, Michael GJ, Joshi RK, Priestley JV (1999) TrkA, trκB, and trkC messenger RNA expression by bulbospinal cells of the rat. Neurosci 92:935-944.
76. Kobayashi K, Fukuoka T, Obata K, Yamanaka H, Dai Y, Tokunaga A, Noguchi K (2005) Distinct expression of TRPM8, TRPA1, and TRPV1 mRNAs in rat primary afferent neurons with adelta/c-fibers and colocalization with trk receptors. J Comp Neurol 493:596-606.
77. Kurek JB, Austin L, Cheema SS, Bartlett PF, Murphy M (1996) Up-regulation of leukaemia inhibitory factor and interleukin-6 in transected sciatic nerve and muscle following denervation. Neuromuscul Disord 6:105-114.
78. Lawson SN (1992) Morphological and biochemical cell types of sensory neurons. In: Sensory neurons. Diversity, Development, and Plasticity (Scott SA, ed), pp 27-59. New York: OUP.
79. Lawson SN (2002) Phenotype and function of somatic primary afferent nociceptive neurones with C-, Adelta- or Aalpha/beta-fibres. Exp Physiol 87:239-244.
80. Lawson SN, Crepps BA, Perl ER (1997) Relationship of substance P to afferent characteristics of dorsal root ganglion neurones in guinea-pig. J Physiol 505:177-191.
81. Lawson SN, Crepps B, Perl ER (2002) Calcitonin gene-related peptide immunoreactivity and afferent receptive properties of dorsal root ganglion neurones in guinea-pigs. J Physiol 540:989-1002.
82. Lawson JJ, McIlwrath SL, Woodbury CJ, Davis BM, Koerber HR (2008) TRPV1 unlike TRPV2 is restricted to a subset of mechanically insensitive cutaneous nociceptors responding to heat. J Pain 9:298-308.
83. Lawson SN, Waddell PJ (1991) Soma neurofilament immunoreactivity is related to cell size and fibre conduction velocity in rat primary sensory neurons. J Physiol 435:41-63.
84. Leffler A, Cummins TR, Dib-Hajj SD, Hormuzdiar WN, Black JA, Waxman SG (2002) GDNF and NGF reverse changes in repriming of TTX-sensitive Na (+) currents following axotomy of dorsal root ganglion neurons. J Neurophysiol 88:650-658.
85. Lever IJ, Bradbury EJ, Cunningham JR, Adelson DW, Jones MG, McMahon SB, Marvizon JC, Malcangio M (2001) Brain-derived neurotrophic factor is released in the dorsal horn by distinctive patterns of afferent fiber stimulation. J Neurosci 21:4469-4477.
86. Liu HX, Hokfelt T (2002) The participation of galanin in pain processing at the spinal level. Trends Pharmacol Sci 23:468-474.
87. Liu Q, Vrontou S, Rice FL, Zylka MJ, Dong X, Anderson DJ (2007) Molecular genetic visualization of a rare subset of unmyelinated sensory neurons that may detect gentle touch. Nat Neurosci 10:946-948.
88. Liu M, Willmott NJ, Michael GJ, Priestley JV (2004) Differential pH and capsaicin responses of Griffonia simplicifolia IB4 (IB4)-positive and IB4-negative small sensory neurons. Neurosci 127:659-672.
89. Lorenzo LE, Ramien M, St Louis M, De Koninck Y, Ribeiro-da-Silva A (2008) Postnatal changes in the Rexed lamination and markers of nociceptive afferents in the superficial dorsal horn of the rat. J Comp Neurol 508:592-604.
90. Lu J, Zhou XF, Rush RA (2001) Small primary sensory neurons innervating epidermis and viscera display differential phenotype in the adult rat. Neurosci Res 41:355-363.
91. Macpherson LJ, Xiao B, Kwan KY, Petrus MJ, Dubin AE, Hwang S, Cravatt B, Corey DP, Patapoutian A (2007) An ion channel essential for sensing chemical damage. J Neurosci 27:11412-11415.
92. Malcangio M, Getting SJ, Grist J, Cunningham JR, Bradbury EJ, Charbel-Issa P, Lever IJ, Pezet S, Perretti M (2002) A novel control mechanism based on GDNF modulation of somatostatin release from sensory neurones. FASEB J 16:730-732.
93. Malin SA, Molliver DC, Koerber HR, Cornuet P, Frye R, Albers KM, Davis BM (2006) Glial cell line-derived neurotrophic factor family members sensitize nociceptors in vitro and produce thermal hyperalgesia in vivo. J Neurosci 26:8588-8599.
94. Marchand F, Perretti M, McMahon SB (2005) Role of the immune system in chronic pain. Nat Rev Neurosci 6:521-532.
95. Marmigere F, Ernfors P (2007) Specification and connectivity of neuronal subtypes in the sensory lineage. Nat Rev Neurosci 8:114-127.
96. Matsuoka I, Nakane A, Kurihara K (1997) Induction of LIF-mRNA by TGF-beta 1 in Schwann cells. Brain Res 776:170-180.
97. McMahon SB, Armanini MP, Ling LH, Phillips HS (1994) Expression and coexpression of trk receptors in subpopulations of adult primary sensory neurons projecting to identified peripheral targets. Neuron 12:1161-1171.
98. McMahon SB, Priestley JV (2005) Nociceptor plasticity. In: The Neurobiology of Pain (Hunt SP, Koltzenburg M, eds), pp 35-64. Oxford: Oxford University Press.
99. Michael GJ, Averill S, Nitkunan A, Rattray M, Bennett DLH, Yan Q, Priestley JV (1997a) Nerve growth factor treatment increases brain-derived neurotrophic factor selectively in trkA-expressing dorsal root ganglion cells and in their central terminations within the spinal cord. J Neurosci 17:8476-8490.
100. Michael GJ, Averill S, Shortland PJ, Yan Q, Priestley JV (1999) Axotomy results in major changes in BDNF expression by dorsal root ganglion cells: BDNF expression in large trκB and trkC cells, in pericellular baskets, and in projections to deep dorsal horn and dorsal column nuclei. Eur J Neurosci 11:3539-3551.
101. Michael GJ, Kaya E, Averill S, Rattray M, Clary DO, Priestley JV (1997b) TrkA immunoreactive neurones in the rat spinal cord. J Comp Neurol 385:441-455.
102. Michael GJ, Priestley JV (1999) Differential expression of the mRNA for the vanilloid receptor subtype 1 in cells of the adult rat dorsal root and nodose ganglia and its downregulation by axotomy. J Neurosci 19:1844-1854.
103. Miletic G, Hanson EN, Miletic V (2004) Brain-derived neurotrophic factor-elicited or sciatic ligation-associated phosphorylation of cyclic AMP response element binding protein in the rat spinal dorsal horn is reduced by block of tyrosine kinase receptors. Neurosci Lett 361:269-271.
104. Mizuno M, Kondo E, Nishimura M, Ueda Y, Yoshiya I, Tohyama M, Kiyama H (1997) Localization of molecules involved in cytokine receptor signaling in the rat trigeminal ganglion. Mol Brain Res 44:163-166.
105. Molliver DC, Wright DE, Leitner ML, Parsadanian AS, Doster K, Wen D, Yan Q, Snider WD (1997) IB4-binding DRG neurons switch from NGF to GDNF dependence in early postnatal life. Neuron 19:849-861.
106. Moran MM, Xu H, Clapham DE (2004) TRP ion channels in the nervous system. Curr Opin Neurobiol 14:362-369.
107. Morikawa Y, Tamura S, Minehata K, Donovan PJ, Miyajima A, Senba E (2004) Essential function of oncostatin m in nociceptive neurons of dorsal root ganglia. J Neurosci 24:1941-1947.
108. Murphy PG, Borthwick LA, Altares M, Gauldie J, Kaplan D, Richardson PM (2000) Reciprocal actions of interleukin-6 and brain-derived neurotrophic factor on rat and mouse primary sensory neurons. Eur J Neurosci 12:1891-1899.
109. Murphy PG, Grondin J, Altares M, Richardson PM (1995) Induction of interleukin-6 in axotomized sensory neurons. J Neurosci 15:5130-5138.
110. Murphy PG, Ramer MS, Borthwick L, Gauldie J, Richardson PM, Bisby MA (1999) Endogenous interleukin-6 contributes to hypersensitivity to cutaneous stimuli and changes in neuropeptides associated with chronic nerve constriction in mice. Eur J Neurosci 11:2243-2253.
111. Nagano M, Sakai A, Takahashi N, Umino M, Yoshioka K, Suzuki H (2003) Decreased expression of glial cell line-derived neurotrophic factor signaling in rat models of neuropathic pain. Br J Pharmacol 140:1252-1260.
112. Orozco OE, Walus L, Sah DW, Pepinsky RB, Sanicola M (2001) GFRalpha3 is expressed predominantly in nociceptive sensory neurons. Eur J Neurosci 13:2177-2182.
113. Petruska JC, Napaporn J, Johnson RD, Cooper BY (2002) Chemical responsiveness and histochemical phenotype of electrophysiologically classified cells of the adult rat dorsal root ganglion. Neurosci 115:15-30.
114. Pezet S, Malcangio M, Lever IJ, Perkinton MS, Thompson SW, Williams RJ, McMahon SB (2002) Noxious stimulation induces Trk receptor and downstream ERK phosphorylation in spinal dorsal horn. Mol Cell Neurosci 21:684-695.
115. Pezet S, McMahon SB (2006) Neurotrophins: mediators and modulators of pain. Annu Rev Neurosci 29:507-538.
116. Priestley JV (2008) Neuropeptides - sensory systems. In: The New Encyclopedia of Neuroscience (Squire LR, ed), Amsterdam: Elsevier.
117. Priestley JV, Michael GJ, Averill S, Liu M, Willmott N (2002) Regulation of nociceptive neurons by nerve growth factor and glial cell line derived neurotrophic factor. Can J Physiol Pharmacol 80:495-505.
118. Qiu L, Towle MF, Bernd P, Fukada K (1997) Distribution of cholinergic neuronal differentiation factor/leukemia inhibitory factor binding sites in the developing and adult rat nervous system in vivo. J Neurobiol 32:163-192.
119. Raghavendra V, Tanga FY, DeLeo JA (2004) Complete Freunds adjuvant-induced peripheral inflammation evokes glial activation and proinflammatory cytokine expression in the CNS. Eur J Neurosci 20:467-473.
120. Ramer MS, Bradbury EJ, Michael GJ, Lever IJ, McMahon SB (2003) Glial cell line-derived neurotrophic factor increases calcitonin gene-related peptide immunoreactivity in sensory and motoneurons in vivo. Eur J Neurosci 18:2713-2721.
121. Ramer MS, Murphy PG, Richardson PM, Bisby MA (1998) Spinal nerve lesion-induced mechanoallodynia and adrenergic sprouting in sensory ganglia are attenuated in interleukin-6 knockout mice. Pain 78:115-121.
122. Rind HB, von Bartheld CS (2002) Anterograde axonal transport of internalized GDNF in sensory and motor neurons. Neuroreport 13:659-664.
123. Rubio N (1997) Mouse astrocytes store and deliver brain-derived neurotrophic factor using the non-catalytic gp95 (trkb) receptor. Eur J Neurosci 9:1847-1853.
124. Rutkowski JL, Tuite GF, Lincoln PM, Boyer PJ, Tennekoon GI, Kunkel SL (1999) Signals for proinflammatory cytokine secretion by human Schwann cells. J Neuroimmunol 101:47-60.
125. Sah DW, Ossipov MH, Rossomando A, Silvian L, Porreca F (2005) New approaches for the treatment ofpain: the GDNF family of neurotrophic growth factors. Curr Top Med Chem 5:577-583.
126. Salio C, Averill S, Priestley JV, Merighi A (2007) Costorage of BDNF and neuropeptides within individual dense-core vesicles in central and peripheral neurons. Dev Neurobiol 67:326-338.
127. Scott RL, Gurusinghe AD, Rudvosky AA, Kozlakivsky V, Murray SS, Satoh M, Cheema SS (2000) Expression of leukemia inhibitory factor receptor mRNA in sensory dorsal root ganglion and spinal motor neurons of the neonatal rat. Neurosci Lett 295:49-53.
128. Shinohara T, Harada M, Ogi K, Maruyama M, Fujii R, Tanaka H, Fukusumi S, Komatsu H, Hosoya M, Noguchi Y, Watanabe T, Moriya T, Itoh Y, Hinuma S (2004) Identification of a G protein-coupled receptor specifically responsive to beta-alanine. J Biol Chem 279:23559-23564.
129. Shortland PJ, Baytug B, Krzyzanowska A, McMahon SB, Priestley JV, Averill S (2006) ATF3 expression in L4 dorsal root ganglion neurons after L5 spinal nerve transection. Eur J Neurosci 23:365-373.
130. Silverman JD, Kruger L (1990) Selective neuronal glycoconjugate expression in sensory and autonomic ganglia: relation of lectin reactivity to peptide and enzyme markers. J Neurocytol 19:789-801.
131. Slack SE, Grist J, Mac Q, McMahon SB, Pezet S (2005) TrκB expression and phospho-ERK activation by brain-derived neurotrophic factor in rat spinothalamic tract neurons. J Comp Neurol 489:59-68.
132. Slack SE, Pezet S, McMahon SB, Thompson SW, Malcangio M (2004) Brain-derived neurotrophic factor induces NMDA receptor subunit one phosphorylation via ERK and PKC in the rat spinal cord. Eur J Neurosci 20:1769-1778.
133. Snider WD, McMahon SB (1998) Tackling pain at the source: new ideas about nociceptors. Neuron 20:629-632.
134. Story GM, Peier AM, Reeve AJ, Eid SR, Mosbacher J, Hricik TR, Earley TJ, Hergarden AC, Andersson DA, Hwang SW, McIntyre P, Jegla T, Bevan S, Patapoutian A (2003) ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures. Cell 112:819-829.
135. Stucky CL, Lewin GR (1999) Isolectin B4-positive and -negative nociceptors are functionally distinct. J Neurosci 19:6497-6505.
136. Subang MC, Richardson PM (2001) Influenceofinjury and cytokines onsynthesis ofmonocyte chemoattractant protein-1 mRNAin peripheral nervous tissue. Eur J Neurosci 13:521-528.
137. Summer GJ, Romero-Sandoval EA, Bogen O, Dina OA, Khasar SG, Levine JD (2008) Proinflammatory cytokines mediating burn-injury pain. Pain 135:98-107.
138. Sun Y, Zigmond RE (1996) Leukemia inhibitory factor-induced in the sciatic-nerve after axotomy is involved in the induction of galanin in sensory neurons. Eur J Neurosci 8:2213-2220.
139. Szallasi A, Cortright DN, Blum CA, Eid SR (2007) The vanilloid receptor TRPV1:10 years from channel cloning to antagonist proof-of-concept. Nat Rev Drug Discov 6:357-372.
140. Tamura S, Morikawa Y, Miyajima A, Senba E (2003) Expression of oncostatin M receptor beta in a specific subset of nociceptive sensory neurons. Eur J Neurosci 17:2287-2298.
141. Tamura S, Morikawa Y, Senba E (2005) TRPV2, a capsaicin receptor homologue, is expressed predominantly in the neurotrophin-3-dependent subpopulation of primary sensory neurons. Neurosci 130:223-228.
142. Thacker MA, Clark AK, Bishop T, Grist J, Yip PK, Moon LD, Thompson SW, Marchand F, McMahon SB (2009) CCL2 is a key mediator of microglia activation in neuropathic pain states. Eur J Pain 13:263-272.
143. Thompson SWN, Priestley JV, Southall A (1998) Gp130 cytokines, leukemia inhibitory factor and interleukin-6, induce neuropeptide expression in intact adult rat sensory neurons in vivo: time course, specificity and comparison with sciatic nerve axotomy. Neurosci 84:1247-1255.
144. Thompson SWN, Vernallis AB, Heath JK, Priestley JV (1997) Leukaemia inhibitory factor is retrogradely transported by a distinct population of adult rat sensory neurons: co-localization with trka and other neurochemical markers. Eur J Neurosci 9:1244-1251.
145. Trevisani M, Siemens J, Materazzi S, Bautista DM, Nassini R, Campi B, Imamachi N, Andre E, Patacchini R, Cottrell GS, Gatti R, Basbaum AI, Bunnett NW, Julius D, Geppetti P (2007) 4-Hydroxynonenal, an endogenous aldehyde, causes pain and neurogenic inflammation through activation of the irritant receptor TRPA1. Proc Natl Acad Sci USA 104:13519-13524.
146. Vellani V, Zachrisson O, McNaughton PA (2004) Functional bradykinin B1 receptors are expressed in nociceptive neurones and are upregulated by the neurotrophin GDNF. J Physiol 560:391-401.
147. Verge VM, Richardson PM, Wiesenfeld-Hallin Z, Hokfelt T (1995) Differential influence of nerve growth factor on neuropeptide expression in vivo: a novel role in peptide suppression in adult sensory neurons. J Neurosci 15:2081-2096.
148. Villar MJ, Cortes R, Theodorsson E, Wiesenfeld-Hallin Z, Schalling M, Fahrenkrug J, Emson PC, Hokfelt T (1989) Neuropeptide expression in rat dorsal root ganglion cells and spinal cord after peripheral nerve injury with special reference to galanin. Neurosci 33:587-604.
149. Vulchanova L, Olson TH, Stone LS, Riedl MS, Elde R, Honda CN (2001) Cytotoxic targeting of isolectin IB4-binding sensory neurons. Neurosci 108:143-155.
150. Vydyanathan A, Wu ZZ, Chen SR, Pan HL (2005) A-type voltage-gated K+ currents influence firing properties of isolectin B4-positive but not isolectin B4-negative primary sensory neurons. J Neurophysiol 93:3401-3409.
151. Wang R, Guo W, Ossipov MH, Vanderah TW, Porreca F, Lai J (2003) Glial cell line-derived neurotrophic factor normalizes neurochemical changes in injured dorsal root ganglion neurons and prevents the expression of experimental neuropathic pain. Neurosci 121:815-824.
152. Woodbury CJ, Ritter AM, Koerber HR (2000) On the problem of lamination in the superficial dorsal horn of mammals: a reappraisal of the substantia gelatinosa in postnatal life. J Comp Neurol 417:88-102.
153. Woodbury CJ, Zwick M, Wang S, Lawson JJ, Caterina MJ, Koltzenburg M, Albers KM, Koerber HR, Davis BM (2004) Nociceptors lacking TRPV1 and TRPV2 have normal heat responses. J Neurosci 24:6410-6415.
154. Woolf CJ, Costigan M (1999) Transcriptional and posttranslational plasticity and the generation of inflammatory pain. Proc Natl Acad Sci USA 96:7723-7730.
155. Woolf CJ, Safieh-Garabedian B, Ma QP, Crilly P, Winter J (1994) Nerve growth factor contributes to the generation of inflammatory sensory hypersensitivity. Neurosci 62:327-331.
156. Wotherspoon G, Winter J (2000) Bradykinin B1 receptor is constitutively expressed in the rat sensory nervous system. Neurosci Lett 294:175-178.
157. Wu D, Zhang Y, Bo X, Huang W, Xiao F, Zhang X, Miao T, Magoulas C, Subang MC, Richardson PM (2007) Actions of neuropoietic cytokines and cyclic AMP in regenerative conditioning of rat primary sensory neurons. Exp Neurol 204:66-76.
158. Wynick D, Thompson SW, McMahon SB (2001) The role of galanin as a multi-functional neuropeptide in the nervous system. Curr Opin Pharmacol 1:73-77.
159. Zhong J, Dietzel ID, Wahle P, Kopf M, Heumann R (1999) Sensory impairments and delayed regeneration of sensory axons in interleukin-6-deficient mice. J Neurosci 19:4305-4313.
160. Zhu M, Oishi K, Lee SC, Patterson PH (2001) Studies using leukemia inhibitory factor (LIF) knockout mice and a LIF adenoviral vector demonstrate a key anti-inflammatory role for this cytokine in cutaneous inflammation. J Immunol 166:2049-2054.
161. Zwick M, Davis BM, Woodbury CJ, Burkett JN, Koerber HR, Simpson JF, Albers KM (2002) Glial cell line-derived neurotrophic factor is a survival factor for isolectin B4-positive, but not vanilloid receptor 1-positive, neurons in the mouse. J Neurosci 22:4057-4065.
162. Zylka MJ, Rice FL, Anderson DJ (2005) Topographically distinct epidermal nociceptive circuits revealed by axonal tracers targeted to Mrgprd. Neuron 45:17-25.