GDNF and NGF family members and receptors in human fetal and adult spinal cord and dorsal root ganglia

Journal of Comparative Neurology

Volumn 440, Issue 2, 2001, Pages 204-217

  Josephson, Anna ^a   Widenfalk, Johan ^a   Trifunovski, Alexandra ^a   Widmer, Hans Ruedi ^b   Olson, Lars ^a   Spenger, Christian ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b UNIVERSITY OF BERN   (Switzerland)

Author keywords

GFR alpha; Neurotrophin; Neurturin; p75 receptor; Persephin; trk

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR; GROWTH FACTOR RECEPTOR; LIGAND; MESSENGER RNA; NERVE GROWTH FACTOR; NERVE GROWTH FACTOR RECEPTOR; NEUROTROPHIN; NEUROTROPHIN 3; NEURTURIN; PERSEPHIN; PROTEIN P75; PROTEIN TYROSINE KINASE INHIBITOR;

ADULT; ARTICLE; CELL SIZE; COMPARATIVE STUDY; FETUS; FETUS CELL; GENE EXPRESSION; HUMAN; HUMAN TISSUE; IN SITU HYBRIDIZATION; NEWBORN; PRIORITY JOURNAL; PROTEIN FAMILY; SPINAL CORD; SPINAL GANGLION;

ADULT; AGING; BRAIN-DERIVED NEUROTROPHIC FACTOR; CELL SIZE; DROSOPHILA PROTEINS; FEMALE; FETUS; GANGLIA, SPINAL; GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR; GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR RECEPTORS; HUMANS; IN SITU HYBRIDIZATION; MEMBRANE GLYCOPROTEINS; MIDDLE AGED; MOTOR NEURONS; NERVE GROWTH FACTORS; NERVE TISSUE PROTEINS; NEURONS, AFFERENT; NEUROTROPHIN 3; POSTERIOR HORN CELLS; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-RET; RECEPTOR PROTEIN-TYROSINE KINASES; RECEPTOR, NERVE GROWTH FACTOR; RECEPTOR, TRKB; RECEPTOR, TRKC; RECEPTORS, CELL SURFACE; RECEPTORS, NERVE GROWTH FACTOR; RNA, MESSENGER; SPINAL CORD;

EID: 0035851290     PISSN: 00219967     EISSN: None     Source Type: Journal    
DOI: 10.1002/cne.1380     Document Type: Article

References (96)

1. A BDNF autocrine loop in adult sensory neurons prevents cell death
2. Truncated and catalytic isoforms of trkB are co-expressed in neurons of rat and mouse CNS
3. Increase in nerve growth factor-like immunoreactivity and decrease in choline acetyltransferase following contusive spinal cord injury
4. TrnR2, a novel receptor that mediates neurturin and GDNF signaling through Ret
5. GFRalpha3 is an orphan member of the GDNF/neurturin/persephin receptor family
6. Artemin, a novel member of the GDNF ligand family, supports peripheral and central neurons and signals through the GFRalpha3-RET receptor complex
7. The GDNF family ligands and receptors - Implications for neural development
8. GDNF and its receptor component Ret in injured human nerves and dorsal root ganglia
9. What, if anything, is a neurotrophic factor?
10. Positive and negative interactions of GDNF, NTN and ART in developing sensory neuron subpopulations, and their collaboration with neurotrophins
11. A distinct subgroup of small DRG cells express GDNF receptor components and GDNF is protective for these neurons after nerve injury
12. The glial cell linederived neurotrophic factor family receptor components are differently regulated within sensory neurons after nerve injury
13. Effects of aging and axotomy on the expression of neurotrophin receptors in primary sensory neurons
14. Signaling complexes and protein-protein interactions involved in the activation of the Ras and phosphatidylinositol 3-kinase pathways by the c-Ret receptor tyrosine kinase
15. Neurotrophins: Key regulators of cell fate and cell shape in the vertebrate nervous system
16. GDNF and neublastin protect against NMDA-induced excitotoxicity in hippocampal slice cultures
17. Neurotrophin expression by spinal motoneurons in adult and developing rats
18. Dorsal root ganglion neurons expressing trk are selectively sensitive to NGF deprivation in utero
19. Sensitive mRNA detection using unfixed tissue: Combined radioactive and non-radioactive in situ hybridization histochemistry
20. Timing and site of nerve growth factor synthesis in developing skin in relation to innervation and expression of the receptor
21. Expression of neurotrophins in the adult spinal cord in vivo
22. Embryonic sensory development: Local expression of neurotrophin-3 and target expression of nerve growth factor
23. Developmentally regulated expression of HDNF/NT3 mRNA in rat spinal cord motoneurons and expression of BDNF mRNA in embryonic dorsal root ganglion
24. Expression of nerve growth factor receptor mRNA is developmentally regulated and increased after axotomy in rat spinal cord motoneurons
25. Identification of cells in rat brain and peripheral tissues expressing mRNA for members of the nerve growth factor family
26. Cells expressing mRNA for neurotrophins and their receptors during embryonic rat development
27. Expression of mRNAs for neurotrophin receptors in the dorsal root ganglion and spinal cord during development and fol]owing following peripheral or central axotomy
28. Regulation of neurotrophin receptor expression during embryonic and postnatal development
29. A mathematical model for the estimation of human embryonic and fetal age
30. Sexual dimorphism in human and canine spinal cord: Role of early androgen
31. BDNF and NT-4/5 exert neurotrophic influences on injured adult spinal motor neurons
32. Increased levels of trkB mRNA and trkB protein-like immunoreactivity in the injured rat and cat spinal cord
33. Limbic seizures increase neuronal production of messenger RNA for nerve growth factor
34. Cellular delivery of neurotrophin-3 promotes corticospinal axonal growth and partial functional recovery after spinal cord injury
35. Characterization of the human melanoma nerve growth factor receptor
36. GDNF mRNA in Schwann cells and DRG satellite cells after chronic sciatic nerve injury
37. Neurotrophic factor therapy for nervous system degenerative diseases
38. GDNF: A potent survival factor for motoneurons present in peripheral nerve and muscle
39. Structure and organization of the human TRKA gene encoding a high affinity receptor for nerve growth factor
40. The expression profiles of neurotrophins and their receptors in rat and chicken tissues during development
41. Mammalian neurotrophin-4: Structure, chromosomal localization, tissue distribution, and receptor specificity
42. GDNF-induced activation of the ret protein tyrosine kinase is mediated by GDNFR-alpha, a novel receptor for GDNF
43. Central nervous system and peripheral nerve growth factor provide trophic support critical to mature sensory neuronal survival
44. NOGO mRNA expression in adult and fetal human and rat nervous tissue and in weight drop injury
45. Anatomical evidence supporting the potential for modulation by multiple neurotrophins in the majority of adult lumbar sensory neurons
46. Changes in truncated trkB and p75 receptor expression in the rat spinal cord following spinal cord hemisection and spinal cord hemisection plus neurotrophin treatment
47. BDNF and NT-4/5 prevent atrophy of rat rubrospinal neurons after cervical axotomy, stimulate GAP-43 and Talpha1-tubulin mRNA expression, and promote axonal regeneration
48. Evidence that brain-derived neurotrophic factor is a trophic factor for motor neurons in vivo
49. Motor neurons in Onuf's nucleus and its rat homologues express the p75 nerve growth factor receptor: Sexual dimorphism and regulation by axotomy
50. Nerve growth factor supply for sensory neurons: Site of origin and competition with the sympathetic nervous system
51. Neurturin, a relative of glial-cell-line-derived neurotrophic factor
52. Therapeutic potentials for glial cell line-derived neurotrophic factor (GDNF) based upon pharmacological activities in the CNS
53. Expression of nerve growth factor in the dorsal root ganglion after peripheral nerve injury
54. Loss of brain-derived neurotrophic factor-dependent neural crest-derived sensory neurons in neurotrophin-4 mutant mice
55. GDNF: A glial cell line-derived neurotrophic factor for midbrain dopaminergic neurons
56. Neurotrophic growth factors and neurodegenerative diseases: Therapeutic potential of the neurotrophins and ciliary neurotrophic factor
57. Transplants of fibroblasts genetically modified to express BDNF promote regeneration of adult rat rubrospinal axons and recovery of forelimb function
58. Human and rat brain-derived neurotrophic factor and neurotrophin-3: Gene structures, distributions, and chromosomal localizations
59. Molecular cloning, expression and tissue distribution of glial-cell-line-derived neurotrophic factor family receptor alpha-3 (GFRalpha-3)
60. Molecular cloning of the cDNA for human TrkC (NTRK3), chromosomal assignment, and evidence for a splice variant
61. Schwann cells genetically modified to secrete human BDNF promote enhanced axonal regrowth across transected adult rat spinal cord
62. Nerve growth factor treatment increases brain-derived neurotrophic factor selectively in TrkA-expressing dorsal root ganglion cells and in their central terminations within the spinal cord
63. TrkA immunoreactive neurones in the rat spinal cord
64. A dynamic regulation of GDNF-family receptors correlates with a specific trophic dependency of cranial motor neuron subpopulations during development
65. Persephin, a novel neurotrophic factor related to GDNF and neurturin
66. Renal and neuronal abnormalities in mice lacking GDNF
67. Expression of trk receptors in the developing and adult human central and peripheral nervous system
68. Differences in neurotrophic factor gene expression profiles between neonate and adult rat spinal cord after injury
69. Expression and regulation of GFRalpha3, a glial cell line-derived neurotrophic factor family receptor
70. Brain-derived neurotrophic factor mRNA is expressed in the developing taste bud-bearing tongue papillae of rat
71. Notes on the arrangement and function of the cell groups in the sacral region of the spinal cord
72. Developing motor neurons rescued from programmed and axotomy-induced cell death by GDNF
73. Requirement of nerve growth factor for development of substance P-containing sensory neurones
74. Renal agenesis and the absence of enteric neurons in mice lacking GDNF
75. Glial cell line-derived neurotrophic factor-dependent RET activation can be mediated by two different cell-surface accessory proteins
76. Glial cell-line derived neurotrophic factor (GDNF) mRNA upregulation in striatum and cortical areas after pilocarpine-induced status epilepticus in rats
77. Neurotrophin-3 enhances sprouting of corticospinal tract during development and after adult spinal cord lesion
78. Determinants of ligand binding specificity in the glial cell line-derived neurotrophic factor family receptor alpha s
79. Expression of mRNA for neurotrophic factors and their receptors in the rat dorsal root ganglion and sciatic nerve following nerve injury
80. Human trks: Molecular cloning, tissue distribution, and expression of extracellular domain immunoadhesins
81. Expression of neurotrophin mRNAs in the dorsal root ganglion after spinal nerve injury
82. Long-term survival of dopaminergic neurones in free-floating roller tube cultures of human fetal ventral mesencephaion
83. Expression of GDNF mRNA in rat and human nervous tissue
84. Ret transforming gene encodes a fusion protein homologous to tyrosine kinases
85. Nerve growth factor
86. Developmental regulation of brain-derived neurotrophic factor messenger RNAs transcribed from different promoters in the rat brain
87. Peripheral expression and biological activities of GDNF, a new neurotrophic factor for avian and mammalian peripheral neurons
88. Ret-dependent and -independent mechanisms of glial cell line-derived neurotrophic factor signaling in neuronal cells
89. Sequence homology of human and mouse beta-NGF subunit genes
90. Neuronal and nonneuronal expression of neurotrophins and their receptors in sensory and sympathetic ganglia suggest new intercellular trophic interactions
91. Neurturin and glial cell line-derived neurotrophic factor receptor-beta (GDNFR-beta), novel proteins related to GDNF and GDNFR-alpha with specific cellular patterns of expression suggesting roles in the developing and adult nervous system and in peripheral organs
92. GFRalpha-3, a protein related to GFRalpha-1, is expressed in developing peripheral neurons and ensheathing cells
93. GDNF, RET and GFRalpha-1-3 mRNA expression in the developing human spinal cord and ganglia
94. Neurotrophic factors and receptors in the immature and adult spinal cord after mechanical injury or kainic acid
95. Expression of mRNAs for neurotrophic factors (NGF, BDNF, NT-3, and GDNF) and their receptors (p75NGFR, trkA, trkB, and trkC) in the adult human peripheral nervous system and nonneural tissues
96. Expression of GDNF family receptor components during development: Implications in the mechanisms of interaction