Thermodynamic analysis of mRNA cap binding by the human initiation factor eIF4E via free energy perturbations

Journal of the American Chemical Society

Volumn 131, Issue 50, 2009, Pages 18139-18146

  Guimarães, Cristiano R W ^a   Kopecky, David J ^a   Mihalic, Jeff ^a   Shen, Shanling ^a   Jeffries, Shawn ^a   Thibault, Stephen T ^a   Chen, Xiaoqi ^a   Walker, Nigel ^a   Cardozo, Mario ^a  

^a AMGEN INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALKYLATION; BINDING ENERGY; MONTE CARLO METHODS; POSITIVE IONS; PROTEINS; THERMOANALYSIS; VAN DER WAALS FORCES;

BINDING FREE ENERGY; BIOPHYSICAL STUDIES; CATION-PI INTERACTIONS; DIRECT INTERACTIONS; EUKARYOTIC TRANSLATION; FREE ENERGY PERTURBATION; THERMO DYNAMIC ANALYSIS; VAN DER WAALS INTERACTIONS;

FREE ENERGY;

7 DEAZAGUANOSINE 5' TRIPHOSPHATE; 7 METHYLDEAZAGUANOSINE 5' TRIPHOSPHATE; ANTINEOPLASTIC AGENT; CATION; GUANINE DERIVATIVE; GUANOSINE TRIPHOSPHATE; INITIATION FACTOR 4E; INITIATION FACTOR 4E INHIBITOR; MESSENGER RNA; METHYL GROUP; PHOSPHATE; PROTEIN INHIBITOR; SOLVENT; TRYPTOPHAN; UNCLASSIFIED DRUG;

ARTICLE; ATOM; BINDING AFFINITY; CALCULATION; CONTROLLED STUDY; ENERGY; ENVIRONMENT; METHYLATION; MONTE CARLO METHOD; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN BINDING; PROTON TRANSPORT; RNA BINDING; RNA CAPPING; SOLVATION; STRUCTURE ACTIVITY RELATION; THERMODYNAMICS;

EID: 72449154625     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja9064359     Document Type: Article

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