Effects of pentoxifylline on Wnt/β-catenin signaling in mice chronically exposed to cigarette smoke

Chinese Medical Journal

Volumn 123, Issue 19, 2010, Pages 2688-2694

  Wang, Zheng ^a   Zhang, Jin Nong ^a   Hu, Xiao Fei ^a   Chen, Xue Lin ^a   Wang, Xiao Rong ^a   Zhao, Ting Ting ^a   Peng, Mei Jun ^a   Zou, Ping ^a  

^a UNION HOSPITAL   (China)

Author keywords

Pentoxifylline; Pulmonary emphysema; Pulmonary fibrosis; Wnt signaling pathway; Wnt catenin

Indexed keywords

BETA CATENIN; CIGARETTE SMOKE; CYCLIN D1; HYDROXYPROLINE; LYMPHOID ENHANCER FACTOR 1; MESSENGER RNA; PENTOXIFYLLINE; TRANSCRIPTION FACTOR 7; TRANSFORMING GROWTH FACTOR BETA1; WNT PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL COUNT; CELL NUCLEUS; CONTROLLED STUDY; CYTOPLASM; FORAGE; GENE EXPRESSION; HISTOPATHOLOGY; LONG TERM EXPOSURE; LUNG EMPHYSEMA; LUNG FIBROSIS; LUNG HOMOGENATE; LUNG SLICE; MALE; MORPHOMETRICS; MOUSE; NONHUMAN; PATHOGENESIS; PHENOTYPE; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN TRANSPORT; QUALITATIVE ANALYSIS; QUANTITATIVE ANALYSIS; SIGNAL TRANSDUCTION; TISSUE LEVEL;

ANIMALS; BETA CATENIN; BLOTTING, WESTERN; FEMALE; IMMUNOHISTOCHEMISTRY; MICE; MICE, INBRED BALB C; PENTOXIFYLLINE; PULMONARY EMPHYSEMA; PULMONARY FIBROSIS; RANDOM ALLOCATION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TOBACCO SMOKE POLLUTION; TRANSFORMING GROWTH FACTOR BETA1; WNT PROTEINS;

EID: 78149240579     PISSN: 03666999     EISSN: None     Source Type: Journal    
DOI: 10.3760/cma.j.issn.0366-6999.2010.19.013     Document Type: Article

References (38)

1. Zhou Y, Wang C, Yao W, Chen P, Kang J, Huang S, et al. COPD in Chinese nonsmokers. Eur Respir J 2009; 33: 509-518.
2. Yoshida T, Tuder RM. Pathobiology of cigarette smoke-induced chronic obstructive pulmonary disease. Physiol Rev 2007; 87: 1047-1082.
3. Weiss W. Smoking and pulmonary fibrosis. J Occup Med 1988; 30: 33-39.
4. Baumgartner KB, Samet JM, Stidley CA, Colby TV, Waldron JA. Cigarette smoking: a risk factor for idiopathic pulmonary fibrosis. Am J Respir Crit Care Med 1997; 155: 242-248.
5. Elias JA, Kang MJ, Crothers K, Homer R, Lee CG. State of the art. Mechanistic heterogeneity in chronic obstructive pulmonary disease: insights from transgenic mice. Proc Am Thorac Soc 2006; 3: 494-498.
6. Hogg JC, Chu F, Utokaparch S, Woods R, Elliott WM, Buzatu L, et al. The nature of small-airway obstruction in chronic obstructive pulmonary disease. N Engl J Med 2004; 350: 2645-2653.
7. Demedts M, Costabel U. ATS/ERS international multidisciplinary consensus classification of the idiopathic interstitial pneumonias. Eur Respir J 2002; 19: 794-796.
8. Wang ZL. Advances in understanding of idiopathic pulmonary fibrosis. Chin Med J 2009; 122: 844-857.
9. Wynn TA. Cellular and molecular mechanisms of fibrosis. J Pathol 2008; 214: 199-210.
10. Zhang JN, Zheng L, Bai M. Dynamic expression of tumor necrosis factor-alpha and vascular endothelial growth factor in rat model of pulmonary emphysema induced by smoke exposure. J Huazhong Univ Sci Technolog Med Sci 2007; 27: 505-507.
11. Suzuki M, Betsuyaku T, Nagai K, Fuke S, Nasuhara Y, Kaga K, et al. Decreased airway expression of vascular endothelial growth factor in cigarette smoke-induced emphysema in mice and COPD patients. Inhal Toxicol 2008; 20: 349-359.
12. Magno F, Di Stefano A. Contribution of bronchial biopsies in the evaluation of pathogenesis and progression of COPD. Monaldi Arch Chest Dis 2007; 67: 229-233.
13. Tsoumakidou M, Demedts IK, Brusselle GG, Jeffery PK. Dendritic cells in chronic obstructive pulmonary disease: new players in an old game. Am J Respir Crit Care Med 2008; 177: 1180-1186.
14. Grubstein A, Bendayan D, Schactman I, Cohen M, Shitrit D, Kramer MR. Concomitant upper-lobe bullous emphysema, lower-lobe interstitial fibrosis and pulmonary hypertension in heavy smokers: report of eight cases and review of the literature. Respir Med 2005; 99: 948-954.
15. Cottin V, Nunes H, Brillet PY, Delaval P, Devouassoux G, Tillie-Leblond I, et al. Combined pulmonary fibrosis and emphysema: a distinct underrecognised entity. Eur Respir J 2005; 26: 586-593.
16. Fan Chung K. Phosphodiesterase inhibitors in airways disease. Eur J Pharmacol 2006; 533: 110-117.
17. Zhang JN, Tao XN, Xie JM, Xiang M, Fu W. Prophylactic anti-inflammation inhibits cigarette smoke-induced emphysema in guinea pigs. J Huazhong Univ Sci Technolog Med Sci 2003; 23: 365-368.
18. Martorana PA, Beume R, Lucattelli M, Wollin L, Lungarella G. Roflumilast fully prevents emphysema in mice chronically exposed to cigarette smoke. Am J Respir Crit Care Med 2005; 172: 848-853.
19. Zhang JN, Wang Z, Shi W, Wang XR, Zhao TT, Xiang M, et al. Mechanism responsible for pulmonary fibrosis induced by concomitant chronic smoke exposure and pentoxifylline administration. Chin J Pathophysiol (Chin) 2009; 25: 333-337.
20. Desmouliere A, Xu G, Costa AM, Yousef IM, Gabbiani G, Tuchweber B. Effect of pentoxifylline on early proliferation and phenotypic modulation of fibrogenic cells in two rat models of liver fibrosis and on cultured hepatic stellate cells. J Hepatol 1999; 30: 621-631.
21. Xiong LJ, Zhu JF, Luo DD, Zen LL, Cai SQ. Effects of pentoxifylline on the hepatic content of TGF-beta1 and collagen in Schistosomiasis japonica mice with liver fibrosis. World J Gastroenterol 2003; 9: 152-154.
22. Ng YY, Chen YM, Tsai TJ, Lan XR, Yang WC, Lan HY. Pentoxifylline inhibits transforming growth factor-beta signaling and renal fibrosis in experimental crescentic glomerulonephritis in rats. Am J Nephrol 2009; 29: 43-53.
23. Konigshoff M, Eickelberg O. WNT signaling in lung disease: a failure or a regeneration signal? Am J Respir Cell Mol Biol 2010; 42: 21-31.
24. Liu L, Carron B, Yee HT, Yie TA, Hajjou M, Rom W. Wnt pathway in pulmonary fibrosis in the bleomycin mouse model. J Environ Pathol Toxicol Oncol 2009; 28: 99-108.
25. Kim K, Lu Z, Hay ED. Direct evidence for a role of beta-catenin/LEF-1 signaling pathway in induction of EMT. Cell Biol Int 2002; 26: 463-476.
26. Kalluri R, Weinberg RA. The basics of epithelial- mesenchymal transition. J Clin Invest 2009; 119: 1420-1428.
27. Chilosi M, Poletti V, Zamo A, Lestani M, Montagna L, Piccoli P, et al. Aberrant Wnt/beta-catenin pathway activation in idiopathic pulmonary fibrosis. Am J Pathol 2003; 162: 1495-1502.
28. Konigshoff M, Kramer M, Balsara N, Wilhelm J, Amarie OV, Jahn A, et al. WNT1-inducible signaling protein-1 mediates pulmonary fibrosis in mice and is upregulated in humans with idiopathic pulmonary fibrosis. J Clin Invest 2009; 119: 772-787.
29. He W, Dai C, Li Y, Zeng G, Monga SP, Liu Y. Wnt/beta-catenin signaling promotes renal interstitial fibrosis. J Am Soc Nephrol 2009; 20: 765-776.
30. Surendran K, Schiavi S, Hruska KA. Wnt-dependent beta-catenin signaling is activated after unilateral ureteral obstruction, and recombinant secreted frizzled-related protein 4 alters the progression of renal fibrosis. J Am Soc Nephrol 2005; 16: 2373-2384.
31. Cheng JH, She H, Han YP, Wang J, Xiong S, Asahina K, et al. Wnt antagonism inhibits hepatic stellate cell activation and liver fibrosis. Am J Physiol Gastrointest Liver Physiol 2008; 294: G39-G49.
32. Douglas IS, Diaz del Valle F, Winn RA, Voelkel NF. Beta-catenin in the fibroproliferative response to acute lung injury. Am J Respir Cell Mol Biol 2006; 34: 274-285.
33. Willinger T, Freeman T, Herbert M, Hasegawa H, McMichael AJ, Callan MF. Human naive CD8 T cells down-regulate expression of the WNT pathway transcription factors lymphoid enhancer binding factor 1 and transcription factor 7 (T cell factor-1) following antigen encounter in vitro and in vivo. J Immunol 2006; 176: 1439-1446.
34. Ashcroft T, Simpson JM, Timbrell V. Simple method of estimating severity of pulmonary fibrosis on a numerical scale. J Clin Pathol 1988; 41: 467-470.
35. Nelson WJ, Nusse R. Convergence of Wnt, beta-catenin, and cadherin pathways. Science 2004; 303: 1483-1487.
36. Konigshoff M, Balsara N, Pfaff EM, Kramer M, Chrobak I, Seeger W, et al. Functional Wnt signaling is increased in idiopathic pulmonary fibrosis. PLoS One 2008; 3: e2142.
37. Shen F, Fan X, Liu B, Jia X, Gao A, Du H, et al. Downregulation of cyclin D1-CDK4 protein in human embryonic lung fibroblasts (HELF) induced by silica is mediated through the ERK and JNK pathway. Cell Biol Int 2008; 32: 1284-1292.
38. Watts KL, Cottrell E, Hoban PR, Spiteri MA. RhoA signaling modulates cyclin D1 expression in human lung fibroblasts; implications for idiopathic pulmonary fibrosis. Respir Res 2006; 7: 88.