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Volumn 66, Issue 48, 2010, Pages 9461-9467

Synthesis of quinoline thioethers as novel small molecule enhancers of monoclonal antibody production in mammalian cell culture

Author keywords

Hybridoma; IgG; Monoclonal antibody; Quinoline thioether; Small molecule enhancer

Indexed keywords

2 [2 [2 [2 (2 AMINOETHOXY)ETHOXY]ETHYLCARBAMOYL] 6 BROMOQUINOLIN 4 YL]THIOBENZOIC ACID; 3 [2 [2 [2 (2 AMINOETHOXY)ETHOXY]ETHYLCARBAMOYL] 6 BROMOQUINOLIN 4 YLTHIO]PROPANOIC ACID TRIFLUOROACETATE SALT; 4 [2 [2 [2 (2 AMINOETHOXY)ETHOXY]ETHYLCARBAMOYL] 6 BROMOQUINOLIN 4 YLTHIO]BENZOIC ACID; IMMUNOGLOBULIN G; MONOCLONAL ANTIBODY; N [2 [2 (2 AMINOETHOXY)ETHOXY]ETHYL] 6 BROMO 4 (4 HYDROXYPHENYLTHIO)QUINOLINE 2 CARBOXAMIDE TRIFLUOROACETATE SALT; N [2 [2 (2 AMINOETHOXY)ETHOXY]ETHYL] 6 BROMO 4 (ISOPROPYLTHIO)QUINOLINE 2 CARBOXAMIDE TRIFLUOROACETATE SALT; N [2 [2 (2 AMINOETHOXY)ETHOXY]ETHYL] 6 BROMO 4 (METHYLTHIO)QUINOLINE 2 CARBOXAMIDE; N [2 [2 (2 AMINOETHOXY)ETHOXY]ETHYL] 6 BROMO 4 (PHENYLTHIO)QUINOLINE 2 CARBOXAMIDE TRIFLUOROACETATE SALT; N [2 [2 (2 AMINOETHOXY)ETHOXY]ETHYL] 6 BROMO 4 (PROPYLTHIO)QUINOLINE 2 CARBOXAMIDE TRIFLUOROACETATE SALT; N [2 [2 (2 AMINOETHOXY)ETHOXY]ETHYL] 6 BROMO 4 [2 (TERT BUTYLAMINO)ETHYLTHIO]QUINOLINE 2 CARBOXAMIDE; N [2 [2 (2 AMINOETHOXY)ETHOXY]ETHYL] 6 BROMO 4 HYDROXYQUINOLINE 2 CARBOXAMIDE; QUINOLINE DERIVATIVE; UNCLASSIFIED DRUG;

EID: 78049464979     PISSN: 00404020     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tet.2010.09.020     Document Type: Article
Times cited : (11)

References (24)
  • 24
    • 78049483600 scopus 로고    scopus 로고
    • note
    • 1H decoupled) NMR experiment using spiked sample of trifluoroethanol as reference and found to contain 1:1 ratio of TFA as salt. As a consequence, on a weight basis the lowest effective concentrations that the active compounds 8b, 8c, 8d, and 8h were assayed as free quinoline compounds were ∼20% lower than 80 nM, i.e., 67 nM.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.