Identification of neuronal target areas for nerve agents and specification of receptors for pharmacological treatment

NeuroToxicology

Volumn 31, Issue 6, 2010, Pages 629-638

  Myhrer, Trond ^a  

^a NORWEGIAN DEFENCE RESEARCH ESTABLISHMENT FFI   (Norway)

Author keywords

Anticonvulsants; Lesion studies; Microinfusion studies; Nerve agents; Pharmacological receptors; Seizures; Target areas; Treatment strategies

Indexed keywords

2 METHYL 6 (PHENYLETHYNYL)PYRIDINE; 4 AMINOBUTYRIC ACID RECEPTOR STIMULATING AGENT; 6 NITRO 7 SULFAMOYLBENZO[F]QUINOXALINE 2,3 DIONE; ALCOHOL; AMPA RECEPTOR ANTAGONIST; ATROPINE; BENACTYZINE; BENZODIAZEPINE RECEPTOR AFFECTING AGENT; BIPERIDEN; CARAMIPHEN; CHOLINERGIC RECEPTOR BLOCKING AGENT; CYCLOSARIN; DIAZEPAM; KETAMINE; METABOTROPIC RECEPTOR 2; METABOTROPIC RECEPTOR 3; METABOTROPIC RECEPTOR 5; MIDAZOLAM; MUSCIMOL; NERVE AGENT; NEUROTOXIN; PENTOBARBITAL; PHYSOSTIGMINE; PROCYCLIDINE; PROPOFOL; SARIN; SCOPOLAMINE; SOMAN; TABUN; UNCLASSIFIED DRUG; UNINDEXED DRUG;

AMYGDALOID NUCLEUS; ANTICONVULSANT ACTIVITY; BRAIN CORTEX; BRAIN REGION; CONVULSION; DISEASE CONTROL; DRUG EFFICACY; DRUG POTENCY; ENTORHINAL CORTEX; EPILEPTIC DISCHARGE; FOREBRAIN; HIPPOCAMPUS; HUMAN; MAGNOCELLULAR NUCLEUS; NONHUMAN; NUCLEUS ACCUMBENS; PRIORITY JOURNAL; PROPHYLAXIS; PYRIFORM CORTEX; REVIEW; RHOMBENCEPHALON; SEIZURE; TONIC CLONIC SEIZURE;

ANIMALS; ANTICONVULSANTS; CHEMICAL WARFARE AGENTS; HUMANS; NEURONS; RECEPTORS, CELL SURFACE; SEIZURES; TREATMENT OUTCOME;

RATTUS;

EID: 78049453570     PISSN: 0161813X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuro.2010.07.002     Document Type: Review

References (77)

1. Alexander G.M., Godwin D.W. Metabotropic glutamate receptors as a strategic target for the treatment of epilepsy. Epilepsy Res 2006, 71:1-22.
2. Aultman J.M., Moghaddam B. Distinct contributions of glutamate and dopamine receptors to temporal aspects of rodent working memory using a clinically relevant task. Neuropharmacology 2001, 53:353-364.
3. Baxter C.F., Oh C.C., Wasterlain C.G., Ozaki L.K. Alterations of GABA metabolism and seizure susceptibility in the substantia nigra of the kindled rat acclimating to changes in osmotic state. Neurochem Res 1991, 16:269-278.
4. Browning R.A., Nelson D.K. Modification of electroshock and pentylenetetrazol seizure patterns in rats after precollicular transections. Exp Neurol 1986, 93:546-556.
5. Burwell R.D., Amaral D.G. Cortical afferents of the perirhinal, postrhinal, and entorhinal cortices of the rat. J Comp Neurol 1998, 398:179-205.
6. Campbell U.C., Lalwani K., Hernandez L., Kinney G.G., Conn P.J., Bristow L.J. The mGluR5 antagonist 2-methyl-6-(phenylethynyl)-pyridine (MPEP) potentiates PCP-induced cognitive deficits in rats. Psychopharmacology 2004, 175:310-318.
7. Carpentier P., Foquin A., Kamenka J.-M., Rondouin G., Lerner-Natoli M., de Groot D.M.G., et al. Effects of thienylphencyclidine (TCP) on seizure activity and brain damage produced by soman in guinea-pigs: ECoG correlates of neurotoxicity. Neurotoxicology 2001, 22:13-28.
8. Chen J.W.Y., Wasterlain C.G. Status epilepticus: pathophysiology and management in adults. Lancet Neurol 2006, 5:246-256.
9. Denoyer M., Lallement G., Collet A., Pernot-Marino I., Séréno D., Blanchet G. Influence of medial septal cholinoceptive cells on c-Fos-like proteins induced by soman. Brain Res 1992, 592:157-162.
10. Doherty J., Gale K., Eagles D.A. Evoked epileptiform discharges in the rat anterior piriform cortex: generation and local propagation. Brain Res 2000, 861:77-87.
11. Dybdal D., Gale K. Postural and anticonvulsant effects of inhibition of the rat subthalamic nucleus. J Neurosci 2000, 20:6728-6733.
12. Ebert U., Löscher W. Strong induction of c-fos in the piriform cortex during focal seizures evoked from different limbic sites. Brain Res 1995, 671:338-344.
13. Ekstrand J.J., Domroese M.E., Johnson D.M.G., Feig S.L., Knodel S.M., Behan M., et al. A new subdivision of anterior piriform cortex and associated deep nucleus with novel features of interest for olfaction and epilepsy. J Comp Neurol 2001, 434:289-307.
14. Fonnum F. Glutamate: a neurotransmitter in mammalian brain. J Neurochem 1984, 42:1-11.
15. Gale K. Progression and generalization of seizure discharge: anatomical and neurochemical substrates. Epilepsia 1988, 29(Suppl 2):S15-S34.
16. Garrido-Sanabria E.R., Otalora P., Arshadmansab M.F., Herrera B., Francisco S., Ermolinsky B.S. Impaired expression and function of group II metabotropic glutamate receptors in pilocarpine-treated chronically epileptic rats. Brain Res 2008, 1240:165-176.
17. Giorgi F., Ferrucci M., Lazzeri G., Pizzanelli C., Lenzi P., Alessandrl M.G., et al. A damage to locus coeruleus neurons converts sporadic seizures into self-sustaining limbic status epilepticus. Eur J Neurosci 2003, 17:2593-2601.
18. Halonen T., Tortorella A., Zrebeet H., Gale K. Posterior piriform and perirhinal cortex relay seizures evoked from the area tempestas; role of excitatory and inhibitory amino acid receptors. Brain Res 1994, 652:145-148.
19. Hedner J., Hedner T., Jonason J., Lundberg D. GABAergic mechanisms in central respiratory control in the anesthetized rat. Vaunyn-Schmiedeberg's Arch Pharmacol 1981, 317:315-320.
20. Imamura S.-i., Tanaka S., Tojo H., Fukumoto S.-i., Uetsuhara K., Kuratsu J.-i., et al. Kainic acid-induced perirhinal cortical seizures in rats. Brain Res 1998, 800:323-327.
21. Jesse C.R., Savegnago L., Rocha J.B.T., Nogueira C.W. Neuroprotective effect caused by MPEP, an antagonist of metabotropic glutamate receptor mGluR5, on seizures induced by pilocarpine in 21-day-old rats. Brain Res 2008, 1198:197-203.
22. Jouvert P., Pain L., Aunis D., Zwiller J. The anesthetics propofol and ketamine inhibit cocaine-induced egr-1 gene expression in rat forebrain. Eur J Pharmacol 2002, 449:239-243.
23. Kaminski R.M., Matagne A., Patsalos P.N., Klitgaard H. Benefit of combination therapy in epilepsy: a review of preclinical evidence with levetiracetam. Epilepsia 2009, 50:387-397.
24. Kashiwagi M., Okada Y., Kuwana S.-i., Sakuraba S., Ochiai R., Takeda J. A neuronal mechanism of propofol-induced central respiratory depression in newborn rats. Anesth Analg 2004, 99:49-55.
25. Kelly M.E., McIntyre D.C. Perirhinal cortex involvement in limbic kindled seizures. Epilepsy Res 1996, 26:233-243.
26. Kelly M.E., Staines W.A., McIntyre D.C. Secondary generalization of hippocampal kindled seizures: examination of the role of the piriform cortex. Brain Res 2002, 957:152-161.
27. Kumari M., Ticku M. Regulation of NMDA receptors by ethanol. Prog Drug Res 2000, 54:152-189.
28. Lallement G., Baubichon D., Clarençon D., Gallonier M., Peoc'h M., Carpentier P. Review of the value of gacyclidine (GK-11) as adjuvant medication to conventional treatments of organophosphate poisoning: primate experiments mimicking various scenarios of military of terrorist attack by soman. Neurotoxicology 1999, 20:675-684.
29. Lallement G., Denoyer M., Collet A., Pernot-Marino I., Baubichon D., Monmaur P., et al. Changes in hippocampal acetylcholine and glutamate extracellular levels during soman-induced seizures; influence of septal cholinoceptive cells. Neurosci Lett 1992, 139:104-107.
30. Lallement G., Pernot-Marino I., Baubichon D., Burckhart M.-F., Carpentier P., Blanchet G. Modulation of soman-induced neuropathology with an anticonvulsant regimen. Neuroreport 1994, 5:2265-2268.
31. Lallement G., Pernot-Marino I., Foquin-Tarricone A., Baubichon D., Piras A., Blanchet G., et al. Coadministration of atropine, NBQX, and TCP against soman-induced seizures. Neuroreport 1994, 5:1113-1117.
32. Löscher W., Ebert U. Basic mechanisms of seizure propagation: targets for rational drug design and rational polypharmacy. Epilepsy Res Suppl 1996, 11:17-43.
33. McCaffery B., Cho K., Bortolotto Z.A., Aggleton J.P., Brown M.W., Conquet F., et al. Synaptic depression induced by pharmacological activation of metabotropic glutamate receptors in the perirhinal cortex in vitro. Neuroscience 1999, 93:977-984.
34. McDonough J.H., Dochterman W., Smith C.D., Shih T.-M. Protection against nerve agent-induced neuropathology, but not cardiac pathology, is associated with the anticonvulsant action of drug treatment. Neurotoxicology 1995, 15:123-132.
35. McDonough J.H., McLeod C.G., Nipwoda T. Direct microinjection of soman or VX into the amygdala produces repetitive limbic convulsions and neuropathology. Brain Res 1987, 435:123-137.
36. McDonough J.H., McMonagle J., Copeland T., Zoeffel D., Shih T.-M. Comparative evaluation of benzodiazepines for control of soman-induced seizures. Arch Toxicol 1999, 73:473-478.
37. McDonough J.H., Shih T.-M. Neuropharmacological mechanisms of nerve agent-induced seizure and neuropathology. Neurosci Biobehav Rev 1997, 21:559-579.
38. McDonough J.H., Van Shura K.E., LaMont J.C., McMonagle J.D., Shih T.-M. Comparison of the intramuscular, intranasal or sublingual routes of midazolam administration for control of soman-induced seizures. Basic Clin Pharmacol Toxicol 2008, 104:27-34.
39. McIntyre D.C. The kindling phenomenon. Models of seizures and epilepsy 2006, 351-363. Elsevier, Amsterdam. A. Pitkänan, P.A. Schwartzkroin, S.L. Moshé (Eds.).
40. McIntyre D.C., Kelly M.E. The parahippocampal cortices and kindling. Ann NY Acad Sci 2000, 911:343-354.
41. McIntyre D.C., Kelly M.E., Armstrong J.N. Kindling in the perirhinal cortex. Brain Res 1993, 615:1-6.
42. McIntyre D.C., Kelly M.E., Staines W.A. Efferent projections of the anterior perirhinal cortex in the rat. J Comp Neurol 1996, 369:302-318.
43. Mizuno T., Kimura F. Medial septal injection of naloxone elevates acetylcholine release in the hippocampus and induces behavioral seizures in rats. Brain Res 1996, 713:1-7.
44. Moghaddam B., Adams B.W. Reversal of phencyclidine effects by a group II metabotropic glutamate receptor agonists in rats. Science 1998, 281:1349-1352.
45. Mraovitch S., Calando Y. Interactions between limbic, thalamo-striatal-cortical, and central autonomic pathways during epileptic seizure progression. J Comp Neurol 1999, 411:145-161.
46. Myhrer T. Neurotransmitter systems involved in learning and memory in the rat: a meta-analysis based on studies of four behavioral tasks. Brain Res Rev 2003, 41:268-287.
47. Myhrer T. Neuronal structures involved in the induction and propagation of seizures caused by nerve agents: implications for medical treatment. Toxicology 2007, 239:1-14.
48. Myhrer T. Prophylactic and therapeutic measures in nerve agent poisoning. Handbook of toxicology of chemical warfare agents 2009, 965-975. Academic Press/Elsevier Inc., Amsterdam. R.C. Gupta (Ed.).
49. Myhrer T., Andersen J.M. Interference with visual memory in rats following infusion of the functional NMDA receptor antagonist, HA-966, into temporal regions. Eur J Pharmacol 2001, 428:323-330.
50. Myhrer T., Enger S., Aas P. Pharmacological therapies against soman-induced seizures in rats 30min following onset and anticonvulsant impact. Eur J Pharmacol 2006, 548:83-89.
51. Myhrer T., Enger S., Aas P. Anticonvulsant effects of damage to structures involved in seizure induction in rats exposed to soman. Neurotoxicology 2007, 28:819-828.
52. Myhrer T., Enger S., Aas P. Anticonvulsant efficacy of drugs with cholinergic and/or glutamatergic antagonism microinfused into area tempestas of rats exposed to soman. Neurochem Res 2008, 33:348-354.
53. Myhrer T., Enger S., Aas P. Anticonvulsant impact of lesions in the ventrolateral forebrain of rats challenged with soman. Brain Res 2008, 1226:241-247.
54. Myhrer T., Enger S., Aas P. Antiparkinson drugs used as prophylactics for nerve agents: studies of cognitive side effects in rats. Pharmacol Biochem Behav 2008, 89:633-638.
55. Myhrer T., Enger E., Aas P. Anticonvulsant efficacy of pharmacological agents microinfused into medial septum of rats exposed to soman. J Med CBR Defense 2009, 7:1-14.
56. Myhrer T., Enger S., Aas P. Roles of perirhinal and posterior piriform cortices in control and generation of seizures: a microinfusion study in rats exposed to soman. Neurotoxicology 2010, 31:147-153.
57. Myhrer T., Enger S., Aas P. Modulators of metabotropic glutamate receptors microinfused into perirhinal cortex: anticonvulsant effects in rats challenged with soman. Eur J Pharmacol 2010, 636:82-87.
58. Myhrer T., Enger S., Aas P. Behavioral side effects in rats treated with acetylcholinesterase inhibitors suggested used as prophylactics against nerve agents. Pharmacol Biochem Behav 2010, 95:338-343.
59. A modulators microinfused into area tempestas or substantia nigra in rats exposed to soman. Arch Toxicol 2006, 80:502-507.
60. Myhrer T., Skymoen L.R., Aas P. Pharmacological agents, hippocampal EEG, and anticonvulsant effects on soman-induced seizures in rats. Neurotoxicology 2003, 24:357-367.
61. Paxinos G., Watson C. The rat brain in stereotaxic coordinates 1982, Academic Press, Sydney.
62. Philippens I., Jongsma M., Joosen M., Bouwman G., Vanwersch R. Prophylaxis against nerve agent toxicity: physiological, behavioral, and neuroprotection aspects of current and novel treatments 2007, NATO/HFM, Edinburgh, p. 16-1-15.
63. Philippens I.H.C.H.M., Jongsma M., Vanwersch R.A.P. Efficacy of pretreatment and treatment against soman intoxication. Medical treatment of intoxications and decontamination of chemical agents in the area of terrorist attack 2006, 113-121. Springer, Amsterdam. C. Dishovsky (Ed.).
64. Piredda S., Gale K. A crucial epileptogenic site in the deep prepiriform cortex. Nature 1985, 317:623-625.
65. Racine R.J., Paxinos G., Mosher J.M., Kairiss E.W. The effects of various lesions and knife-cuts on septal and amygdala kindling in the rat. Brain Res 1988, 454:264-274.
66. Rang H.P., Dale M.M. Pharmacology 1991, Churchill Livingstone, London.
67. Raveh L., Chapman S., Cohen G., Alkalay D., Gilat E., Rabinovitz I., et al. The involvement of the NMDA receptor complex in the protective effect of anticholinergic drugs against soman poisoning. Neurotoxicology 1999, 20:551-560.
68. Raveh L., Weissman B.A., Cohen G., Alkalay D., Rabinovitz I., Sonego H., et al. Caramiphen and scopolamine prevent soman-induced brain damage and cognitive dysfunction. Neurotoxicology 2002, 23:7-17.
69. Shih T.-M., Dunibo S.M., McDonough J.H. Control of nerve agent-induced seizures is critical for neuroprotection and survival. Toxicol Appl Pharmacol 2003, 188:69-80.
70. Shih T.-M., McDonough J.H. Efficacy of biperiden and atropine as anticonvulsant treatment for organophosphorus nerve agent intoxication. Arch Toxicol 2000, 74:165-172.
71. Skovira J.W., McDonough J.H., Shih T.-M. Protection against sarin-induced seizures in rats by direct brain microinjection of scopolamine, midazolam or MK-801. J Mol Neurosci 2010, 40:56-62.
72. Swinyard E. Assay of antiepileptic drug activity in experimental animals: standard tests. Anticonvulsant drugs 1973, 47-65. Pergamon Press, Oxford. J. Mercier (Ed.).
73. Taylor P. Anticholinesterase agents. The pharmacological basis of therapeutics 2001, 175-191. McGraw-Hill Companies, Inc., New York. J.G. Hardman, L.E. Limbird, A.G. Gilman (Eds.).
74. Tortorella A., Halonen T., Sahibzada N., Gale K. A crucial role of the amino-3-hydroxy-5-methylisoxazole-4-propionic acid subtype of glutamate receptors in piriform and perirhinal cortex for the initiation and propagation of limbic motor seizures. J Pharmacol Exp Therap 1997, 280:1401-1405.
75. Weissman B.A., Raveh L. Therapy against organophosphate poisoning: the importance of anticholinergic drugs with antiglutamatergic properties. Toxicol Appl Pharmacol 2008, 232:351-358.
76. Woolf N.J., Eckenstein F., Butcher L.L. Cholinergic systems in the rat brain. I. Projections to the limbic telencephalon. Brain Res Bull 1984, 13:751-784.
77. Zimmer L.A., Ennis M., El-Etri M., Shipley M.T. Anatomical localization and time course of Fos expression following soman-induced seizures. J Comp Neurol 1997, 378:468-481.