A crucial role of the α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid subtype of glutamate receptors in piriform and perirhinal cortex for the initiation and propagation of limbic motor seizures

Journal of Pharmacology and Experimental Therapeutics

Volumn 280, Issue 3, 1997, Pages 1401-1405

  Tortorella, Alfonso ^a,b   Halonen, Toivo ^a,c   Sahibzada, Niaz ^a,d   Gale, Karen ^a  

^a GEORGETOWN UNIVERSITY MEDICAL CENTER   (United States)

^b UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^c UNIVERSITY OF EASTERN FINLAND   (Finland)

^d UNIVERSITY OF THE DISTRICT OF COLUMBIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 AMINO 7 PHOSPHONOHEPTANOIC ACID; 6 NITRO 7 SULFAMOYLBENZO[F]QUINOXALINE 2,3 DIONE; ALPHA AMINO 3 HYDROXY 5 METHYL 4 ISOXAZOLEPROPIONIC ACID; AMPA RECEPTOR; BICUCULLINE METHIODIDE; GLUTAMATE RECEPTOR; KAINIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTICONVULSANT ACTIVITY; ARTICLE; BRAIN CORTEX; COMPLEX PARTIAL SEIZURE; CONTROLLED STUDY; DISEASE SEVERITY; DOSE RESPONSE; DRUG POTENCY; INTRACEREBRAL DRUG ADMINISTRATION; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; NONHUMAN; PRIORITY JOURNAL; PYRIFORM CORTEX; RAT; SUBCUTANEOUS DRUG ADMINISTRATION;

ANIMALS; MALE; MOTOR CORTEX; QUINOXALINES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, AMPA; SEIZURES;

EID: 0030905432     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (18)

1. CASSIDY, R., FORNAI, F., KIM, C. AND GALE, K.: The mediodorsal thalamic nucleus plays a critical role in seizures evoked from area tempestas. Epilepsia 35: 37, 1994.
2. CHAPMAN, A. G., AL-ZUBAIDY, Z. AND MELDRUM, B. S.: Aniracetam reverses the anticonvulsant action of NBQX and GYKI 52466 in DBA/2 mice. Eur. J. Pharmacol. 231: 301-303, 1993.
3. CHAPMAN, A. G., SMITH, S. E. AND MELDRUM, B. S.: The anticonvulsant effect of the non-NMDA antagonists, NBQX and GYKI 52466, in mice. Epilepsy Res. 9: 92-96, 1991.
4. DURMULLER, N., CRAGGS, M. AND MELDRUM, B. S.: The effect of the non-NMDA receptor antagonists GYKI 52466 and NBQX and the competitive NMDA receptor antagonist d-CPPENE on the development of amygdala kindling and on amygdala-kindled seizures. Epilepsy Res. 17: 167-174, 1994.
5. HALONEN, T., TORTORELLA, A., ZREBEET, H. AND GALE, K.: Posterior piriform and perirhinal cortex relay seizures evoked from the area tempestas: role of excitatory and inhibitory amino acid receptors. Brain Res. 652: 145-148, 1994.
6. HONORE, T., DAVIES, S. N., DREJER, J., FLETCHER, E. J., JACOBSON, LODGE, D. AND NIELSON, F.: Quinoxalinediones: Potent competitive non-NMDA glutamate receptor antagonists. Science 70: 240-242, 1988.
7. LOSCHER, W. AND HONACK, D.: Over-additive anticonvulsant effect of memantine and NBQX in kindled rats. Eur. J. Pharmacol. 259: 113-115, 1994.
8. MCALLISTER, K. H.: Antagonism of non-NMDA receptors inhibits handling-induced, strychnine-potentiated convulsions. Eur. J. Pharmacol. 231: 309-312, 1993.
9. MELDRUM, B. S., CRAGGS, M. D., DURMULLER, N., SMITH, S. E. AND CHAPMAN, A. G.: The effects of AMPA receptor antagonists on kindled seizures and on reflex epilepsy in rodents and primates. Epilepsy Res. Suppl. 9: 307-311, 1992.
10. NAMBA, T., MORIMOTO, K., SATO, K., YAMADA, N. AND KURODA, S.: Antiepileptogenic and anticonvulsant effects of NBQX, a selective AMPA receptor antagonist, in the rat kindling model of epilepsy. Brain Res. 638: 36-14, 1994.
11. PELLEGRINO, L. V., PELLEGRINO, A. S. AND CUSHMAN, A. J.: A Stereotaxic Atlas of the Rat Brain, Appleton-Century-Crofts, New York, 1979.
12. PIREDDA, S. AND GALE, K.: Evidence that the deep prepiriform cortex contains a crucial epileptogenic site. Nature 317: 623-625, 1985.
13. PIREDDA, S. AND GALE, K.: Role of excitatory amino acid transmission in the genesis of seizures elicited from the deep prepiriform cortex. Brain Res. 377: 205-210, 1986.
14. SHEARDOWN, M. J., NIELSEN, E. O., HANSEN, A. J., JACOBSEN, P. AND HONORE, T.: 2,3-Dihydroxy-6-nitro-7-sulfamoyl-benzo (f) quinoxaline: A neuroprotectant for cerebral ischemia. Science 247: 571-574, 1990.
15. SMITH, S. E., DURMULLER, N. AND MELDRUM, B. S.: The non-N-methyl-D-aspartate receptor antagonists, GYKI 52466 and NBQX are anticonvulsant in two animal models of reflex epilepsy. Eur. J. Pharmacol. 201: 179-183, 1991.
16. TORTORELLA, A., FORNAI, F., CASSIDY, R. AND GALE, K.: Role of muscarinic and non-NMDA receptors in area tempestas for focally evoked status epilepticus. Soc. Neurosci. Abst. 19: 1469, 599.15, 1993.
17. YAMAGUCHI, S., DONEVAN, S. D. AND ROGAWSKI, M. A.: Anticonvulsant activity of AMPA/kainate antagonists: comparison of GYKI 52466 and NBQX in maximal electroshock and chemoconvulsant seizure models. Epilepsy Res. 15: 179-184, 1993.
18. ZARNOWSKI, T., KLEINROK, Z., TURSKI, W. A. AND CZUCZWAR, S. J.: 2,3-Dihydroxy-6-nitro-7-sulfamoylbenzo (F) quinoxaline enhances the protective activity of common antiepileptic drugs against maximal electroshock-induced seizures in mice. Neuropharmacology 32: 895-900, 1993.