Anticonvulsant effects of GABAA modulators microinfused into area tempestas or substantia nigra in rats exposed to soman

Archives of Toxicology

Volumn 80, Issue 8, 2006, Pages 502-507

  Myhrer, Trond ^a   Nguyen, Nga H T ^a   Enger, Siri ^a   Aas, Pål ^a  

^a NORWEGIAN DEFENCE RESEARCH ESTABLISHMENT FFI   (Norway)

Author keywords

Anticonvulsant effects; Area tempestas; GABAA modulators; Rats; Soman seizures; Substantia nigra

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR STIMULATING AGENT; ALCOHOL; ANTICONVULSIVE AGENT; AVIZAFONE; BENZODIAZEPINE; BICUCULLINE; CARBACHOL; CLONAZEPAM; DIAZEPAM; FLURAZEPAM; KAINIC ACID; LOPRAZOLAM; LORAZEPAM; METHYLENE BLUE; MIDAZOLAM; MUSCIMOL; NERVE GAS; PENTETRAZOLE; PENTOBARBITAL; PILOCARPINE; PROCYCLIDINE; PROGABIDE; PROPOFOL; SOMAN; UNCLASSIFIED DRUG; ZOLPIDEM;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTICONVULSANT ACTIVITY; ARTICLE; CONTROLLED STUDY; CONVULSION; DRUG EFFECT; ELECTROENCEPHALOGRAM; EPILEPSY; HISTOLOGY; MALE; MICROINJECTION; NEUROTOXICITY; NEUROTRANSMISSION; NONHUMAN; PRIORITY JOURNAL; RAT; SEIZURE; SUBSTANTIA NIGRA;

ANIMALS; ANTICONVULSANTS; CEREBRAL CORTEX; CHEMICAL WARFARE AGENTS; DIAZEPAM; DRUG THERAPY, COMBINATION; ETHANOL; GABA AGONISTS; INFUSION PUMPS; MALE; MICROINJECTIONS; MUSCIMOL; PROPOFOL; RATS; RATS, WISTAR; SEIZURES; SOMAN; SUBSTANTIA NIGRA;

EID: 33745529312     PISSN: 03405761     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00204-006-0070-8     Document Type: Article

References (29)

1. Deutsch SI, Norris DO, O'Connor DA, Novitzki MR, Lukas LG, Mastropaolo J (1992) Effects of milacemide, a glycine prodrug, on ethanol's antiseizure efficacy. Pharmacol Biochem Behav 41:263-266
2. Dybdal D, Gale K (2000) Postural and anticonvulsant effects of inhibition of the rat subthalamic nucleus. J Neurosci 20:6728-6733
3. Ekstrand JJ, Domroese ME, Johnson DMG, Feig SL, Knodel SM, Behan M, Haberly LB (2001) A new subdivision of anterior piriform cortex and associated deep nucleus with novel features of interest for olfaction and epilepsy. J Comp Neurol 434:289-307
4. Gale K (1988) Progression and generalization of seizure discharge: anatomical and neurochemical substrates. Epilepsia 29(Suppl 2):S15-S34
5. Gernert M, Löscher W (2001) Lack of robust anticonvulsant effects of muscimol microinfusions in the anterior substantia nigra of kindled rats. Eur J Pharmacol 432:35-41
6. Harris LW, McDonough JH Jr Stitcher DL, Lennox WJ (1984) Protection against both lethal and behavioral effects of soman. Drug Chem Toxicol 7:605-624
7. Jouvert P, Pain L, Aunis D, Zwiller J (2002) The anesthetics propofol and ketamine inhibit cocain-induced egr-1 gene expression in rat forebrain. Eur J Pharmacol 449:239-243
8. Kumari M, Ticku MK (2000) Regulation of NMDA receptors by ethanol. Prog Drug Res 54:152-189
9. Löscher W, Ebert U (1996) Basic mechanism of seizure propagation: Targets for rational drug design and rational polypharmacy. Epilepsy Res Suppl 11:17-43
10. Löscher W, Schwark WS (1985) Evaluation of different GABA receptor agonists in the kindled amygdala seizure model in rats. Exp Neurol 89:454-460
11. McDonough JH Jr, McMonagle J, Copeland T, Zoeffel D, Shih T-M (1999) Comparative evaluation of benzodiazepines for control of soman-induced seizures. Arch Toxicol 73:473-478
12. McDonough JH Jr, Shih T-M (1997) Neuropharmacological mechanisms of nerve agent-induced seizure and neuropathology. Neurosci Biobehav Rev 21:559-579
13. McNamara JO, Galloway MT, Rigsbee LC, Shin C (1984) Evidence implicating substantia nigra in regulation of kindled seizure threshold. J Neurosci 4:2410-2417
14. Mendelson WB (2001) The sleep-inducing effect of ethanol microinjection into the medial preoptic area is blocked by flumazenil. Brain Res 892:118-121
15. Moroni F, Forchetti MC, Krogsgaard-Larssen P, Guidotti A (1982) Relative disposition of the GABA agonists THIP and muscimol in the brain of the rat. J Pharm Pharmacol 34:676-678
16. Myhrer T, Andersen JM (2001) Interference with visual memory in rats following infusion of the functional NMDA receptor antagonist, HA-966, into temporal regions. Eur J Pharmacol 428:323-330
17. Myhrer T, Nguyen NHT, Andersen JM, Aas P (2004) Protection against soman-induced seizures: relationship among doses of prophylactics, soman, and adjuncts. Toxicol Appl Pharmacol 196:327-336
18. Myhrer T, Skymoen LR, Aas P (2003) Pharmacological agents, hippocampal EEG, and anticonvulsant effects on soman-induced seizures in rats. Neurotoxicology 24:357-367
19. Paxinos G, Watson C (1982) The rat brain in stereotaxic coordinates. Academic, Sidney
20. Peterson SL, Purvis RS, Griffith JW (2004) Differential neuroprotective effects of the NMDA receptor-associated glycine site partial agonist 1-aminocyclopropanecarboxiylic acid (ACPC) and D-cycloserine in lithium-pilocarpine status epilepticus. Neurotoxicology 25:835-847
21. Piredda S, Gale K (1985) A crucial epileptogenic site in the deep prepiriform cortex. Nature 317:623-625
22. Rang HP, Dale MM (1991) Pharmacology. Churchill Livingstone, London
23. A receptors: Influence on receptor subunits. J Pharmacol Exp Therap 274:353-360
24. Schmued LC, Hopkins KJ (2000) Fluoro-Jade B: a high affinity fluorescent marker for the localization of neuronal degeneration. Brain Res 874:123-130
25. Shih T-M, McDonough Jr JH, Koplovitz I (1999) Anticonvulsants for soman-induced seizure activity. J Biomed Sci 6:86-96
26. Turski L, Andrews JS, Löschmann PA, Bressler K, Bortolotto ZA, Calderazzo-Filho LS, Cavalheiro EA (1990) Substantia nigra regulates action of antiepileptic drugs. Brain Res 520:232-239
27. Velíšková J, Löscher W, Moshé SL (1998) Regional and age specific effects of zolpidem microinfusions in the substantia nigra on seizures. Epilepsy Res 30:107-114
28. Zhang H, Rosenberg HC, Tietz EI (1989) Injection of benzodiazepines but not GABA or muscimol into pars reticulata of substantia nigra suppresses pentylenetetrazol seizures. Brain Res 488:73-79
29. Zhang H, Rosenberg HC, Tietz EI (1991) Anticonvulsant actions and interaction of GABA agonists and a benzodiazepine in pars reticulata of substantia nigra. Epilepsy Res 8:11-20