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Volumn 9, Issue 4, 2010, Pages 570-579

Acetyl-L-carnitine protects yeast cells from apoptosis and aging and inhibits mitochondrial fission

Author keywords

Aging; Apoptosis; Carnitine; Mitochondria; S. Cerevisiae

Indexed keywords

CARNITINE; LEVACECARNINE; PROPIONYL L CARNITINE; UNCLASSIFIED DRUG; ACETIC ACID; ACETYLCARNITINE; CAFFEINE; HYDROGEN PEROXIDE; LSM4 PROTEIN, S CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEIN; SMALL NUCLEAR RIBONUCLEOPROTEIN;

EID: 78049451823     PISSN: 14749718     EISSN: 14749726     Source Type: Journal    
DOI: 10.1111/j.1474-9726.2010.00587.x     Document Type: Article
Times cited : (36)

References (51)
  • 1
    • 33746872880 scopus 로고    scopus 로고
    • Mitochondria and cancer: is there a morphological connection?
    • Alirol E, Martinou JC (2006) Mitochondria and cancer: is there a morphological connection? Oncogene 25, 4706-4716
    • (2006) Oncogene , vol.25 , pp. 4706-4716
    • Alirol, E.1    Martinou, J.C.2
  • 2
    • 13944278132 scopus 로고    scopus 로고
    • Mitochondria, oxidants, and aging
    • Balaban RS, Nemoto S, Finkel T (2005) Mitochondria, oxidants, and aging. Cell 120, 483-495.
    • (2005) Cell , vol.120 , pp. 483-495
    • Balaban, R.S.1    Nemoto, S.2    Finkel, T.3
  • 3
    • 29744462142 scopus 로고    scopus 로고
    • L-carnitine and neuroprotection in the animal model of mitochondrial dysfunction
    • Binienda Z, Przybyla-Zawislak B, Virmani A, Schmued L (2005) L-carnitine and neuroprotection in the animal model of mitochondrial dysfunction. Ann. N Y Acad. Sci. 1053, 174-182.
    • (2005) Ann. N Y Acad. Sci. , vol.1053 , pp. 174-182
    • Binienda, Z.1    Przybyla-Zawislak, B.2    Virmani, A.3    Schmued, L.4
  • 5
    • 0032579440 scopus 로고    scopus 로고
    • Designer deletion strains derived from Saccharomyces cerevisiae S288C: a useful set of strains and plasmids for PCR-mediated gene disruption and other applications
    • Brachmann CB, Davies A, Cost GJ, Caputo E, Li J, Hieter P, Boeke JD (1998) Designer deletion strains derived from Saccharomyces cerevisiae S288C: a useful set of strains and plasmids for PCR-mediated gene disruption and other applications. Yeast 14, 115-132.
    • (1998) Yeast , vol.14 , pp. 115-132
    • Brachmann, C.B.1    Davies, A.2    Cost, G.J.3    Caputo, E.4    Li, J.5    Hieter, P.6    Boeke, J.D.7
  • 10
    • 0036591533 scopus 로고    scopus 로고
    • Acetyl-L-carnitine protects against amyloid-beta neurotoxicity: roles of oxidative buffering and ATP levels
    • Dhitavat S, Ortiz D, Shea TB, Rivera ER (2002) Acetyl-L-carnitine protects against amyloid-beta neurotoxicity: roles of oxidative buffering and ATP levels. Neurochem. Res. 27, 501-505.
    • (2002) Neurochem. Res. , vol.27 , pp. 501-505
    • Dhitavat, S.1    Ortiz, D.2    Shea, T.B.3    Rivera, E.R.4
  • 11
    • 33747389446 scopus 로고    scopus 로고
    • Regulation of mitochondrial fusion by the F-box protein Mdm30 involves proteasome-independent turnover of Fzo1
    • Escobar-Henriques M, Westermann B, Langer T (2006) Regulation of mitochondrial fusion by the F-box protein Mdm30 involves proteasome-independent turnover of Fzo1. J. Cell Biol. 173, 645-650.
    • (2006) J. Cell Biol. , vol.173 , pp. 645-650
    • Escobar-Henriques, M.1    Westermann, B.2    Langer, T.3
  • 13
    • 0347917233 scopus 로고    scopus 로고
    • The S. cerevisiae HtrA-like protein Nma111p is a nuclear serine protease that mediates yeast apoptosis
    • Fahrenkrog B, Sauder U, Aebi U (2004) The S. cerevisiae HtrA-like protein Nma111p is a nuclear serine protease that mediates yeast apoptosis. J. Cell Sci. 117, 115-126.
    • (2004) J. Cell Sci. , vol.117 , pp. 115-126
    • Fahrenkrog, B.1    Sauder, U.2    Aebi, U.3
  • 15
    • 44349152327 scopus 로고    scopus 로고
    • Carnitine and carnitine acetyltransferases in the yeast Saccharomyces cerevisiae: a role for carnitine in stress protection
    • Franken J, Kroppenstedt S, Swiegers JH, Bauer FF (2008) Carnitine and carnitine acetyltransferases in the yeast Saccharomyces cerevisiae: a role for carnitine in stress protection. Curr. Genet. 53, 347-360.
    • (2008) Curr. Genet. , vol.53 , pp. 347-360
    • Franken, J.1    Kroppenstedt, S.2    Swiegers, J.H.3    Bauer, F.F.4
  • 17
    • 30544455318 scopus 로고    scopus 로고
    • Antioxidant and antiradical activities of L-carnitine
    • Gulcin I (2006) Antioxidant and antiradical activities of L-carnitine. Life Sci. 78, 803-811.
    • (2006) Life Sci , vol.78 , pp. 803-811
    • Gulcin, I.1
  • 18
    • 33745736330 scopus 로고    scopus 로고
    • Mitochondrial membrane dynamics, cristae remodelling and apoptosis
    • Heath-Engel HM, Shore GC (2006) Mitochondrial membrane dynamics, cristae remodelling and apoptosis. Biochim. Biophys. Acta 1763, 549-560.
    • (2006) Biochim. Biophys. Acta , vol.1763 , pp. 549-560
    • Heath-Engel, H.M.1    Shore, G.C.2
  • 19
    • 34250204271 scopus 로고    scopus 로고
    • The machines that divide and fuse mitochondria
    • Hoppins S, Lackner L, Nunnari J (2007) The machines that divide and fuse mitochondria. Annu. Rev. Biochem. 76, 751-780.
    • (2007) Annu. Rev. Biochem. , vol.76 , pp. 751-780
    • Hoppins, S.1    Lackner, L.2    Nunnari, J.3
  • 21
    • 13944278072 scopus 로고    scopus 로고
    • DRP-1-mediated mitochondrial fragmentation during EGL-1-induced cell death in C. elegans
    • Jagasia R, Grote P, Westermann B, Conradt B (2005) DRP-1-mediated mitochondrial fragmentation during EGL-1-induced cell death in C. elegans. Nature 433, 754-760.
    • (2005) Nature , vol.433 , pp. 754-760
    • Jagasia, R.1    Grote, P.2    Westermann, B.3    Conradt, B.4
  • 22
    • 6344274848 scopus 로고    scopus 로고
    • Roles of the mammalian mitochondrial fission and fusion mediators Fis1, Drp1, and Opa1 in apoptosis
    • Lee YJ, Jeong SY, Karbowski M, Smith CL, Youle RJ (2004) Roles of the mammalian mitochondrial fission and fusion mediators Fis1, Drp1, and Opa1 in apoptosis. Mol. Biol. Cell 15, 5001-5011.
    • (2004) Mol. Biol. Cell , vol.15 , pp. 5001-5011
    • Lee, Y.J.1    Jeong, S.Y.2    Karbowski, M.3    Smith, C.L.4    Youle, R.J.5
  • 25
    • 0030667206 scopus 로고    scopus 로고
    • A yeast mutant showing diagnostic markers of early and late apoptosis
    • Madeo F, Frohlich E, Frohlich KU (1997) A yeast mutant showing diagnostic markers of early and late apoptosis. J. Cell Biol. 139, 729-734.
    • (1997) J. Cell Biol. , vol.139 , pp. 729-734
    • Madeo, F.1    Frohlich, E.2    Frohlich, K.U.3
  • 28
    • 0038433337 scopus 로고    scopus 로고
    • Acetyl-L-carnitine cytoprotection against 1-methyl-4-phenylpyridinium toxicity in neuroblastoma cells
    • Mazzio E, Yoon KJ, Soliman KF (2003) Acetyl-L-carnitine cytoprotection against 1-methyl-4-phenylpyridinium toxicity in neuroblastoma cells. Biochem. Pharmacol. 66, 297-306.
    • (2003) Biochem. Pharmacol. , vol.66 , pp. 297-306
    • Mazzio, E.1    Yoon, K.J.2    Soliman, K.F.3
  • 29
    • 0034740527 scopus 로고    scopus 로고
    • Isolation and study of KlLSM4, a Kluyveromyces lactis gene homologous to the essential gene LSM4 of Saccharomyces cerevisiae
    • Mazzoni C, Falcone C (2001) Isolation and study of KlLSM4, a Kluyveromyces lactis gene homologous to the essential gene LSM4 of Saccharomyces cerevisiae. Yeast 18, 1249-1256.
    • (2001) Yeast , vol.18 , pp. 1249-1256
    • Mazzoni, C.1    Falcone, C.2
  • 30
    • 46549090119 scopus 로고    scopus 로고
    • Caspase-dependent apoptosis in yeast
    • Mazzoni C, Falcone C (2008) Caspase-dependent apoptosis in yeast. Biochim. Biophys. Acta 1783, 1320-1327.
    • (2008) Biochim. Biophys. Acta , vol.1783 , pp. 1320-1327
    • Mazzoni, C.1    Falcone, C.2
  • 31
    • 0037326056 scopus 로고    scopus 로고
    • A truncated form of KlLsm4p and the absence of factors involved in mRNA decapping trigger apoptosis in yeast
    • Mazzoni C, Mancini P, Verdone L, Madeo F, Serafini A, Herker E, Falcone C (2003) A truncated form of KlLsm4p and the absence of factors involved in mRNA decapping trigger apoptosis in yeast. Mol. Biol. Cell 14, 721-729.
    • (2003) Mol. Biol. Cell , vol.14 , pp. 721-729
    • Mazzoni, C.1    Mancini, P.2    Verdone, L.3    Madeo, F.4    Serafini, A.5    Herker, E.6    Falcone, C.7
  • 33
    • 27744538945 scopus 로고    scopus 로고
    • HIR1, the co-repressor of histone gene transcription of Saccharomyces cerevisiae, acts as a multicopy suppressor of the apoptotic phenotypes of the LSM4 mRNA degradation mutant
    • Mazzoni C, Palermo V, Torella M, Falcone C (2005b) HIR1, the co-repressor of histone gene transcription of Saccharomyces cerevisiae, acts as a multicopy suppressor of the apoptotic phenotypes of the LSM4 mRNA degradation mutant. FEMS Yeast Res. 5, 1229-1235.
    • (2005) FEMS Yeast Res , vol.5 , pp. 1229-1235
    • Mazzoni, C.1    Palermo, V.2    Torella, M.3    Falcone, C.4
  • 34
    • 60749092787 scopus 로고    scopus 로고
    • PGK1, the gene encoding the glycolitic enzyme phosphoglycerate kinase, acts as a multicopy suppressor of apoptotic phenotypes in S. cerevisiae
    • Mazzoni C, Torella M, Petrera A, Palermo V, Falcone C (2009) PGK1, the gene encoding the glycolitic enzyme phosphoglycerate kinase, acts as a multicopy suppressor of apoptotic phenotypes in S. cerevisiae. Yeast 26, 31-37.
    • (2009) Yeast , vol.26 , pp. 31-37
    • Mazzoni, C.1    Torella, M.2    Petrera, A.3    Palermo, V.4    Falcone, C.5
  • 35
    • 0034676096 scopus 로고    scopus 로고
    • Dnm1p GTPasemediated mitochondrial fission is a multi-step process requiring the novel integral membrane component Fis1p
    • Mozdy AD, McCaffery JM, Shaw JM (2000) Dnm1p GTPasemediated mitochondrial fission is a multi-step process requiring the novel integral membrane component Fis1p. J. Cell Biol. 151, 367-380.
    • (2000) J. Cell Biol. , vol.151 , pp. 367-380
    • Mozdy, A.D.1    McCaffery, J.M.2    Shaw, J.M.3
  • 36
    • 21644455319 scopus 로고    scopus 로고
    • Activated mitofusin 2 signals mitochondrial fusion, interferes with Bax activation, and reduces susceptibility to radical induced depolarization
    • Neuspiel M, Zunino R, Gangaraju S, Rippstein P, McBride H (2005) Activated mitofusin 2 signals mitochondrial fusion, interferes with Bax activation, and reduces susceptibility to radical induced depolarization. J. Biol. Chem. 280, 25060-25070.
    • (2005) J. Biol. Chem. , vol.280 , pp. 25060-25070
    • Neuspiel, M.1    Zunino, R.2    Gangaraju, S.3    Rippstein, P.4    McBride, H.5
  • 37
    • 0037424239 scopus 로고    scopus 로고
    • Loss of OPA1 perturbates the mitochondrial inner membrane structure and integrity, leading to cytochrome c release and apoptosis
    • Olichon A, Baricault L, Gas N, Guillou E, Valette A, Belenguer P, Lenaers G (2003) Loss of OPA1 perturbates the mitochondrial inner membrane structure and integrity, leading to cytochrome c release and apoptosis. J. Biol. Chem. 278, 7743-7746.
    • (2003) J. Biol. Chem. , vol.278 , pp. 7743-7746
    • Olichon, A.1    Baricault, L.2    Gas, N.3    Guillou, E.4    Valette, A.5    Belenguer, P.6    Lenaers, G.7
  • 38
    • 37649023789 scopus 로고    scopus 로고
    • Apoptosis and aging in mitochondrial morphology mutants of S. cerevisiae
    • Palermo V, Falcone C, Mazzoni C (2007) Apoptosis and aging in mitochondrial morphology mutants of S. cerevisiae. Folia. Microbiol. (Praha) 52, 479-483.
    • (2007) Folia. Microbiol. (Praha) , vol.52 , pp. 479-483
    • Palermo, V.1    Falcone, C.2    Mazzoni, C.3
  • 39
    • 33745742159 scopus 로고    scopus 로고
    • Mitochondrial fission and apoptosis: an ongoing trial
    • Parone PA, Martinou JC (2006) Mitochondrial fission and apoptosis: an ongoing trial. Biochim. Biophys. Acta 1763, 522-530.
    • (2006) Biochim. Biophys. Acta , vol.1763 , pp. 522-530
    • Parone, P.A.1    Martinou, J.C.2
  • 40
    • 18844439697 scopus 로고    scopus 로고
    • Reduction of apoptosis through the mitochondrial pathway by the administration of acetyl-L-carnitine to mouse fibroblasts in culture
    • Pillich RT, Scarsella G, Risuleo G (2005) Reduction of apoptosis through the mitochondrial pathway by the administration of acetyl-L-carnitine to mouse fibroblasts in culture. Exp. Cell Res. 306, 1-8.
    • (2005) Exp. Cell Res. , vol.306 , pp. 1-8
    • Pillich, R.T.1    Scarsella, G.2    Risuleo, G.3
  • 42
    • 0029064219 scopus 로고
    • The membrane of peroxisomes in Saccharomyces cerevisiae is impermeable to NAD(H) and acetyl-CoA under in vivo conditions
    • van Roermund CW, Elgersma Y, Singh N, Wanders RJ, Tabak HF (1995) The membrane of peroxisomes in Saccharomyces cerevisiae is impermeable to NAD(H) and acetyl-CoA under in vivo conditions. EMBO J. 14, 3480-3486.
    • (1995) EMBO J , vol.14 , pp. 3480-3486
    • van Roermund, C.W.1    Elgersma, Y.2    Singh, N.3    Wanders, R.J.4    Tabak, H.F.5
  • 43
    • 0027772068 scopus 로고
    • The ethanol-inducible YAT1 gene from yeast encodes a presumptive mitochondrial outer carnitine acetyltransferase
    • Schmalix W, Bandlow W (1993) The ethanol-inducible YAT1 gene from yeast encodes a presumptive mitochondrial outer carnitine acetyltransferase. J. Biol. Chem. 268, 27428-27439.
    • (1993) J. Biol. Chem. , vol.268 , pp. 27428-27439
    • Schmalix, W.1    Bandlow, W.2
  • 44
    • 26444463430 scopus 로고    scopus 로고
    • Proteins that fuse and fragment mitochondria in apoptosis: con-fissing a deadly con-fusion?
    • Scorrano L (2005) Proteins that fuse and fragment mitochondria in apoptosis: con-fissing a deadly con-fusion? J. Bioenerg. Biomembr. 37, 165-170.
    • (2005) J Bioenerg. Biomembr. , vol.37 , pp. 165-170
    • Scorrano, L.1
  • 45
    • 0033451992 scopus 로고    scopus 로고
    • Synergistic roles for Pim-1 and c-Myc in STAT3-mediated cell cycle progression and antiapoptosis
    • Shirogane T, Fukada T, Muller JM, Shima DT, Hibi M, Hirano T (1999) Synergistic roles for Pim-1 and c-Myc in STAT3-mediated cell cycle progression and antiapoptosis. Immunity 11, 709-719.
    • (1999) Immunity , vol.11 , pp. 709-719
    • Shirogane, T.1    Fukada, T.2    Muller, J.M.3    Shima, D.T.4    Hibi, M.5    Hirano, T.6
  • 46
    • 34548615053 scopus 로고    scopus 로고
    • Calorie restriction extends the chronological lifespan of Saccharomyces cerevisiae independently of the Sirtuins
    • Smith DLJ, McClure JM, Matecic M, Smith JS (2007) Calorie restriction extends the chronological lifespan of Saccharomyces cerevisiae independently of the Sirtuins. Aging Cell 6, 649-662.
    • (2007) Aging Cell , vol.6 , pp. 649-662
    • Smith, D.L.J.1    McClure, J.M.2    Matecic, M.3    Smith, J.S.4
  • 47
    • 0031785750 scopus 로고    scopus 로고
    • The facC gene of Aspergillus nidulans encodes an acetate-inducible carnitine acetyltransferase
    • Stemple CJ, Davis MA, Hynes MJ (1998) The facC gene of Aspergillus nidulans encodes an acetate-inducible carnitine acetyltransferase. J. Bacteriol. 180, 6242-6251.
    • (1998) J. Bacteriol. , vol.180 , pp. 6242-6251
    • Stemple, C.J.1    Davis, M.A.2    Hynes, M.J.3
  • 48
    • 10644296253 scopus 로고    scopus 로고
    • Fzo1, a protein involved in mitochondrial fusion, inhibits apoptosis
    • Sugioka R, Shimizu S, Tsujimoto Y (2004) Fzo1, a protein involved in mitochondrial fusion, inhibits apoptosis. J. Biol. Chem. 279, 52726-52734.
    • (2004) J. Biol. Chem. , vol.279 , pp. 52726-52734
    • Sugioka, R.1    Shimizu, S.2    Tsujimoto, Y.3
  • 49
    • 0033672549 scopus 로고    scopus 로고
    • Mitochondria-targeted green fluorescent proteins: convenient tools for the study of organelle biogenesis in Saccharomyces cerevisiae
    • Westermann B, Neupert W (2000) Mitochondria-targeted green fluorescent proteins: convenient tools for the study of organelle biogenesis in Saccharomyces cerevisiae. Yeast 16, 1421-1427.
    • (2000) Yeast , vol.16 , pp. 1421-1427
    • Westermann, B.1    Neupert, W.2
  • 51
    • 41149160642 scopus 로고    scopus 로고
    • Combined treatment with L-carnitine and a pan-caspase inhibitor effectively reverses amiodarone-induced injury in cultured human lung epithelial cells
    • Yano T, Itoh Y, Yamada M, Egashira N, Oishi R (2008) Combined treatment with L-carnitine and a pan-caspase inhibitor effectively reverses amiodarone-induced injury in cultured human lung epithelial cells. Apoptosis 13, 543-552.
    • (2008) Apoptosis , vol.13 , pp. 543-552
    • Yano, T.1    Itoh, Y.2    Yamada, M.3    Egashira, N.4    Oishi, R.5


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