Combined treatment with L-carnitine and a pan-caspase inhibitor effectively reverses amiodarone-induced injury in cultured human lung epithelial cells

Apoptosis

Volumn 13, Issue 4, 2008, Pages 543-552

  Yano, Takahisa ^a   Itoh, Yoshinori ^b   Yamada, Masahiro ^a   Egashira, Nobuaki ^a   Oishi, Ryozo ^a  

^a KYUSHU UNIVERSITY HOSPITAL   (Japan)

^b GIFU UNIVERSITY HOSPITAL   (Japan)

Author keywords

Amiodarone; Apoptosis; Caspases; Mitochondria; Necrosis; Pulmonary

Indexed keywords

ADENOSINE TRIPHOSPHATE; AMIODARONE; BENZYLOXYCARBONYLASPARTYLGLUTAMYLVALYLASPARTYL FLUOROMETHYL KETONE; BENZYLOXYCARBONYLISOLEUCYLGLUTAMYLTHREONYLASPARTYL FLUOROMETHYL KETONE; BENZYLOXYCARBONYLLEUCYLGLUTAMYLHISTIDYLASPARTYL FLUOROMETHYL KETONE; BENZYLOXYCARBONYLVALYLALANYLASPARTYL FLUOROMETHYL KETONE; BENZYLOXYCARBONYLVALYLASPARTYLVALYLALANYLASPARTYL FLUOROMETHYL KETONE; CARNITINE; CASPASE 2; CASPASE 3; CASPASE 8; CASPASE 9; CASPASE INHIBITOR; LEVACECARNINE; LIPOCORTIN 5; PROPIDIUM IODIDE; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL CULTURE; CELL DAMAGE; CELL DEATH; CELL DIFFERENTIATION; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; HUMAN; HUMAN CELL; LUNG ALVEOLUS EPITHELIUM; MEMBRANE DEPOLARIZATION; MITOCHONDRIAL MEMBRANE; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; PRIORITY JOURNAL;

ADENOSINE TRIPHOSPHATE; AMINO ACID CHLOROMETHYL KETONES; AMIODARONE; ANNEXIN A5; APOPTOSIS; CARNITINE; CASPASES; CELL SURVIVAL; CELLS, CULTURED; DRUG THERAPY, COMBINATION; EPITHELIAL CELLS; HUMANS; L-LACTATE DEHYDROGENASE; MEMBRANE POTENTIAL, MITOCHONDRIAL; MICROSCOPY, FLUORESCENCE; PROPIDIUM; PULMONARY ALVEOLI; RESPIRATORY DISTRESS SYNDROME, ADULT; TETRAZOLIUM SALTS;

EID: 41149160642     PISSN: 13608185     EISSN: 1573675X     Source Type: Journal    
DOI: 10.1007/s10495-008-0186-9     Document Type: Article

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