-
1
-
-
0032543207
-
Defective acidification in human breast tumor cells and implications for chemotherapy
-
Altan N, Chen Y, Schindler M, and Simon SM (1998) Defective acidification in human breast tumor cells and implications for chemotherapy. J Exp Med 187: 1583-1598.
-
(1998)
J Exp Med
, vol.187
, pp. 1583-1598
-
-
Altan, N.1
Chen, Y.2
Schindler, M.3
Simon, S.M.4
-
2
-
-
0032965433
-
Elevated lysosomal pH in Mucolipidosis type IV cells
-
Bach G, Chen CS, and Pagano RE (1999) Elevated lysosomal pH in Mucolipidosis type IV cells. Clin Chim Acta 280:173-179.
-
(1999)
Clin Chim Acta
, vol.280
, pp. 173-179
-
-
Bach, G.1
Chen, C.S.2
Pagano, R.E.3
-
3
-
-
0033044219
-
Characterization of intracellular pH gradients in human multidrug-resistant tumor cells by means of scanning microspectrofluorometry and dual-emission-ratio probes
-
Belhoussine R, Morjani H, Sharonov S, Ploton D, and Manfait M (1999) Characterization of intracellular pH gradients in human multidrug-resistant tumor cells by means of scanning microspectrofluorometry and dual-emission-ratio probes. Int J Cancer 81:81-89.
-
(1999)
Int J Cancer
, vol.81
, pp. 81-89
-
-
Belhoussine, R.1
Morjani, H.2
Sharonov, S.3
Ploton, D.4
Manfait, M.5
-
4
-
-
0016260069
-
Commentary. Lysosomotropic agents
-
de Duve C, de Barsy T, Poole B, Trouet A, Tulkens P, and Van Hoof F (1974) Commentary. Lysosomotropic agents. Biochem Pharmacol 23:2495-2531.
-
(1974)
Biochem Pharmacol
, vol.23
, pp. 2495-2531
-
-
de Duve, C.1
de Barsy, T.2
Poole, B.3
Trouet, A.4
Tulkens, P.5
Van Hoof, F.6
-
5
-
-
0033667814
-
20th-century advances in drug therapy in oncology-Part I
-
Dutcher JP, Novik Y, O'Boyle K, Marcoullis G, Secco C, and Wiernik PH (2000a) 20th-century advances in drug therapy in oncology-Part I. J Clin Pharmacol 40:1007-1024.
-
(2000)
J Clin Pharmacol
, vol.40
, pp. 1007-1024
-
-
Dutcher, J.P.1
Novik, Y.2
O'Boyle, K.3
Marcoullis, G.4
Secco, C.5
Wiernik, P.H.6
-
6
-
-
0033672861
-
20th-century advances in drug therapy in oncology-Part II
-
Dutcher JP, Novik Y, O'Boyle K, Marcoullis G, Secco C, and Wiernik PH (2000b) 20th-century advances in drug therapy in oncology-Part II. J Clin Pharmacol 40:1079-1092.
-
(2000)
J Clin Pharmacol
, vol.40
, pp. 1079-1092
-
-
Dutcher, J.P.1
Novik, Y.2
O'Boyle, K.3
Marcoullis, G.4
Secco, C.5
Wiernik, P.H.6
-
7
-
-
33845313861
-
A new approach for enhancing differential selectivity of drugs to cancer cells
-
Duvvuri M, Konkar S, Hong KH, Blagg BS, and Krise JP (2006) A new approach for enhancing differential selectivity of drugs to cancer cells. ACS Chem Biol 1:309-315.
-
(2006)
ACS Chem Biol
, vol.1
, pp. 309-315
-
-
Duvvuri, M.1
Konkar, S.2
Hong, K.H.3
Blagg, B.S.4
Krise, J.P.5
-
8
-
-
0021716521
-
Protective immune response to Plasmodium chabaudi, developed by mice after drug controlled infection or vaccination with parasite extracts: Analysis of stage specific antigens from the asexual blood cycle
-
Falanga PB, Franco da Silveira JF, and Pereira da Silva L (1984) Protective immune response to Plasmodium chabaudi, developed by mice after drug controlled infection or vaccination with parasite extracts: analysis of stage specific antigens from the asexual blood cycle. Parasite Immunol 6:529-543.
-
(1984)
Parasite Immunol
, vol.6
, pp. 529-543
-
-
Falanga, P.B.1
Franco da Silveira, J.F.2
Pereira da Silva, L.3
-
9
-
-
33745110220
-
Tumor pH controls the in vivo efficacy of weak acid and base chemotherapeutics
-
Gerweck LE, Vijayappa S, and Kozin S (2006) Tumor pH controls the in vivo efficacy of weak acid and base chemotherapeutics. Mol Cancer Ther 5:1275-1279.
-
(2006)
Mol Cancer Ther
, vol.5
, pp. 1275-1279
-
-
Gerweck, L.E.1
Vijayappa, S.2
Kozin, S.3
-
10
-
-
26444462561
-
Preclinical toxicity of a geldanamycin analog, 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin (17-DMAG), in rats and dogs: Potential clinical relevance
-
Glaze ER, Lambert AL, Smith AC, Page JG, Johnson WD, McCormick DL, Brown AP, Levine BS, Covey JM, Egorin MJ, et al. (2005) Preclinical toxicity of a geldanamycin analog, 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin (17-DMAG), in rats and dogs: potential clinical relevance. Cancer Chemother Pharmacol 56:637-647.
-
(2005)
Cancer Chemother Pharmacol
, vol.56
, pp. 637-647
-
-
Glaze, E.R.1
Lambert, A.L.2
Smith, A.C.3
Page, J.G.4
Johnson, W.D.5
McCormick, D.L.6
Brown, A.P.7
Levine, B.S.8
Covey, J.M.9
Egorin, M.J.10
-
11
-
-
0347379902
-
Separate roles for the Golgi apparatus and lysosomes in the sequestration of drugs in the multi-drug resistant human leukemic cell line HL-60
-
Gong Y, Duvvuri M, and Krise JP (2003) Separate roles for the Golgi apparatus and lysosomes in the sequestration of drugs in the multi-drug resistant human leukemic cell line HL-60. J Biol Chem 278:50234-50239.
-
(2003)
J Biol Chem
, vol.278
, pp. 50234-50239
-
-
Gong, Y.1
Duvvuri, M.2
Krise, J.P.3
-
12
-
-
77949696417
-
-
Houshmand P and Zlotnik A (2003) Targeting tumor cells. Curr Opin Cell Biol 15:640-644. Imai K and Takaoka A (2006) Comparing antibody and small-molecule therapies for cancer. Nat Rev Cancer 6:714-727.
-
Houshmand P and Zlotnik A (2003) Targeting tumor cells. Curr Opin Cell Biol 15:640-644. Imai K and Takaoka A (2006) Comparing antibody and small-molecule therapies for cancer. Nat Rev Cancer 6:714-727.
-
-
-
-
13
-
-
0025259555
-
Alkalinization of the lysosomes is correlated with ras transformation of murine and human fibroblasts
-
Jiang LW, Maher VM, McCormick JJ, and Schindler M (1990) Alkalinization of the lysosomes is correlated with ras transformation of murine and human fibroblasts. J Biol Chem 265:4775-4777.
-
(1990)
J Biol Chem
, vol.265
, pp. 4775-4777
-
-
Jiang, L.W.1
Maher, V.M.2
McCormick, J.J.3
Schindler, M.4
-
14
-
-
4544262273
-
Defective acidification of intracellular organelles results in aberrant secretion of cathepsin D in cancer cells
-
Kokkonen N, Rivinoja A, Kauppila A, Suokas M, Kellokumpu I, and Kellokumpu S (2004) Defective acidification of intracellular organelles results in aberrant secretion of cathepsin D in cancer cells. J Biol Chem 279:39982-39988.
-
(2004)
J Biol Chem
, vol.279
, pp. 39982-39988
-
-
Kokkonen, N.1
Rivinoja, A.2
Kauppila, A.3
Suokas, M.4
Kellokumpu, I.5
Kellokumpu, S.6
-
15
-
-
44449147036
-
Tumor cell metabolism: Cancer's Achilles' heel
-
Kroemer G and Pouyssegur J (2008) Tumor cell metabolism: cancer's Achilles' heel. Cancer Cell 13:472-482.
-
(2008)
Cancer Cell
, vol.13
, pp. 472-482
-
-
Kroemer, G.1
Pouyssegur, J.2
-
16
-
-
0022261161
-
Ectromelia virus-induced changes in primary cultures of mouse hepatocytes
-
Lees DN and Stephen J (1985) Ectromelia virus-induced changes in primary cultures of mouse hepatocytes. J Gen Virol 66:2171-2181.
-
(1985)
J Gen Virol
, vol.66
, pp. 2171-2181
-
-
Lees, D.N.1
Stephen, J.2
-
17
-
-
0141786825
-
Tumor acidity, ion trapping and chemotherapeutics. I. Acid pH affects the distribution of chemotherapeutic agents in vitro
-
Mahoney BP, Raghunand N, Baggett B, and Gillies RJ (2003) Tumor acidity, ion trapping and chemotherapeutics. I. Acid pH affects the distribution of chemotherapeutic agents in vitro. Biochem Pharmacol 66:1207-1218.
-
(2003)
Biochem Pharmacol
, vol.66
, pp. 1207-1218
-
-
Mahoney, B.P.1
Raghunand, N.2
Baggett, B.3
Gillies, R.J.4
-
18
-
-
0028525202
-
Molecular weight dependent tissue accumulation of dextrans: In vivo studies in rats
-
Mehvar R, Robinson MA, and Reynolds JM (1994) Molecular weight dependent tissue accumulation of dextrans: in vivo studies in rats. J Pharm Sci 83:1495-1499.
-
(1994)
J Pharm Sci
, vol.83
, pp. 1495-1499
-
-
Mehvar, R.1
Robinson, M.A.2
Reynolds, J.M.3
-
19
-
-
0024565575
-
Human neoplasm pH and response to radiation therapy: P-31 MR spectroscopy studies in situ
-
Ng TC, Majors AW, Vijayakumar S, Baldwin NJ, Thomas FJ, Koumoundouros I, Taylor ME, Grundfest SF, Meaney TF, and Tubbs RR (1989) Human neoplasm pH and response to radiation therapy: P-31 MR spectroscopy studies in situ. Radiology 170:875-878.
-
(1989)
Radiology
, vol.170
, pp. 875-878
-
-
Ng, T.C.1
Majors, A.W.2
Vijayakumar, S.3
Baldwin, N.J.4
Thomas, F.J.5
Koumoundouros, I.6
Taylor, M.E.7
Grundfest, S.F.8
Meaney, T.F.9
Tubbs, R.R.10
-
20
-
-
17144421250
-
Analysis of cytosolic and lysosomal pH in apoptotic cells by flow cytometry
-
Nilsson C, Kågedal K, Johansson U, and Öllinger K (2003) Analysis of cytosolic and lysosomal pH in apoptotic cells by flow cytometry. Meth Cell Sci 25:185-194.
-
(2003)
Meth Cell Sci
, vol.25
, pp. 185-194
-
-
Nilsson, C.1
Kågedal, K.2
Johansson, U.3
Öllinger, K.4
-
21
-
-
2642714342
-
Fluorescence probe measurement of the intralysosomal pH in living cells and the perturbation of pH by various agents
-
Ohkuma S and Poole B (1978) Fluorescence probe measurement of the intralysosomal pH in living cells and the perturbation of pH by various agents. Proc Natl Acad Sci U S A 75:3327-3331.
-
(1978)
Proc Natl Acad Sci U S A
, vol.75
, pp. 3327-3331
-
-
Ohkuma, S.1
Poole, B.2
-
22
-
-
39649094514
-
The current state of serum biomarkers of hepatotoxicity
-
Ozer J, Ratner M, Shaw M, Bailey W, and Schomaker S (2008) The current state of serum biomarkers of hepatotoxicity. Toxicology 245:194-205.
-
(2008)
Toxicology
, vol.245
, pp. 194-205
-
-
Ozer, J.1
Ratner, M.2
Shaw, M.3
Bailey, W.4
Schomaker, S.5
-
23
-
-
0019866088
-
Effect of weak bases on the intralysosomal pH in mouse peritoneal macrophages
-
Poole B and Ohkuma S (1981) Effect of weak bases on the intralysosomal pH in mouse peritoneal macrophages. J Cell Biol 90:665-669.
-
(1981)
J Cell Biol
, vol.90
, pp. 665-669
-
-
Poole, B.1
Ohkuma, S.2
-
24
-
-
0141740718
-
Tumor acidity, ion trapping and chemotherapeutics. II. pH-dependent partition coefficients predict importance of ion trapping on pharmacokinetics of weakly basic chemotherapeutic agents
-
Raghunand N, Mahoney BP, and Gillies RJ (2003) Tumor acidity, ion trapping and chemotherapeutics. II. pH-dependent partition coefficients predict importance of ion trapping on pharmacokinetics of weakly basic chemotherapeutic agents. Biochem Pharmacol 66:1219-1229.
-
(2003)
Biochem Pharmacol
, vol.66
, pp. 1219-1229
-
-
Raghunand, N.1
Mahoney, B.P.2
Gillies, R.J.3
-
25
-
-
0019276096
-
Prodrugs and site-specific drug delivery
-
Stella VJ and Himmelstein KJ (1980) Prodrugs and site-specific drug delivery. J Med Chem 23:1275-1282.
-
(1980)
J Med Chem
, vol.23
, pp. 1275-1282
-
-
Stella, V.J.1
Himmelstein, K.J.2
-
26
-
-
37349119391
-
Antimetastatic effect of a smallmolecule vacuolar H+-ATPase inhibitor in in vitro and in vivo preclinical studies
-
Supino R, Petrangolini G, Pratesi G, Tortoreto M, Favini E, Bo LD, Casalini P, Radaelli E, Croce AC, Bottiroli G, et al. (2008) Antimetastatic effect of a smallmolecule vacuolar H+-ATPase inhibitor in in vitro and in vivo preclinical studies. J Pharmacol Exp Ther 324:15-22.
-
(2008)
J Pharmacol Exp Ther
, vol.324
, pp. 15-22
-
-
Supino, R.1
Petrangolini, G.2
Pratesi, G.3
Tortoreto, M.4
Favini, E.5
Bo, L.D.6
Casalini, P.7
Radaelli, E.8
Croce, A.C.9
Bottiroli, G.10
-
28
-
-
0029998292
-
Involvement of the vacuolar proton-translocating ATPase in multiple steps of the endo-lysosomal system and in the contractile vacuole system of Dictyostelium discoideum
-
Temesvari LA, Rodriguez-Paris JM, Bush JM, Zhang L, and Cardelli JA (1996) Involvement of the vacuolar proton-translocating ATPase in multiple steps of the endo-lysosomal system and in the contractile vacuole system of Dictyostelium discoideum. J Cell Sci 109:1479-1495.
-
(1996)
J Cell Sci
, vol.109
, pp. 1479-1495
-
-
Temesvari, L.A.1
Rodriguez-Paris, J.M.2
Bush, J.M.3
Zhang, L.4
Cardelli, J.A.5
-
29
-
-
4544337503
-
Synthesis and biological activities of novel 17-aminogeldanamycin derivatives
-
Tian ZQ, Liu Y, Zhang D, Wang Z, Dong SD, Carreras CW, Zhou Y, Rastelli G, Santi DV, and Myles DC (2004) Synthesis and biological activities of novel 17-aminogeldanamycin derivatives. Bioorg Med Chem 12:5317-5329.
-
(2004)
Bioorg Med Chem
, vol.12
, pp. 5317-5329
-
-
Tian, Z.Q.1
Liu, Y.2
Zhang, D.3
Wang, Z.4
Dong, S.D.5
Carreras, C.W.6
Zhou, Y.7
Rastelli, G.8
Santi, D.V.9
Myles, D.C.10
-
30
-
-
0035939668
-
Hsp90: A specialized but essential proteinfolding tool
-
Young JC, Moarefi I, and Hartl FU (2001) Hsp90: a specialized but essential proteinfolding tool. J Cell Biol 154:267-273.
-
(2001)
J Cell Biol
, vol.154
, pp. 267-273
-
-
Young, J.C.1
Moarefi, I.2
Hartl, F.U.3
|