Novel EGF pathway regulators modulate C. Elegans healthspan and lifespan via EGF receptor, PLC-γ, and IP3R activation

Aging Cell

Volumn 9, Issue 4, 2010, Pages 490-505

  Iwasa, Hiroaki ^a   Yu, Simon ^b   Xue, Jian ^b   Driscoll, Monica ^b  

^a TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

^b RUTGERS UNIVERSITY   (United States)

Author keywords

Aging; Behavioral decline; EGF signaling; IP3 signaling; Lipofuscin; Sarcopenia

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR; INSULIN RECEPTOR; LIPOFUSCIN; PHOSPHOLIPASE C GAMMA; CAENORHABDITIS ELEGANS PROTEIN; EPIDERMAL GROWTH FACTOR; INOSITOL 1,4,5 TRISPHOSPHATE RECEPTOR; INSULIN;

AGING; ARTICLE; CAENORHABDITIS ELEGANS; CONTROLLED STUDY; DIET RESTRICTION; GENE; HIGH PERFORMANCE IN ADVANCED AGE 1 GENE; HIGH PERFORMANCE IN ADVANCED AGE 2 PROTEIN; LIFESPAN; LOCOMOTION; NONHUMAN; PRIORITY JOURNAL; RNA INTERFERENCE; ANIMAL; BIOLOGICAL MODEL; CALORIC RESTRICTION; DIET; ENZYME ACTIVATION; ENZYMOLOGY; GENETICS; HEALTH; LONGEVITY; METABOLISM; PHYSIOLOGY; SIGNAL TRANSDUCTION;

ANIMALS; CAENORHABDITIS ELEGANS; CAENORHABDITIS ELEGANS PROTEINS; CALORIC RESTRICTION; DIET; ENZYME ACTIVATION; EPIDERMAL GROWTH FACTOR; GENES, HELMINTH; HEALTH; INOSITOL 1,4,5-TRISPHOSPHATE RECEPTORS; INSULIN; LOCOMOTION; LONGEVITY; MODELS, BIOLOGICAL; PHOSPHOLIPASE C GAMMA; RECEPTOR, EPIDERMAL GROWTH FACTOR; RNA INTERFERENCE; SIGNAL TRANSDUCTION;

EID: 78049441103     PISSN: 14749718     EISSN: 14749726     Source Type: Journal    
DOI: 10.1111/j.1474-9726.2010.00575.x     Document Type: Article

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