-
1
-
-
0032600672
-
Beyond mere diversity: Tailoring combinatorial libraries for drug discovery
-
Martin, E.J. & Critchlow, R.E. Beyond mere diversity: tailoring combinatorial libraries for drug discovery. J. Comb. Chem. 1, 32-45 (1999).
-
(1999)
J. Comb. Chem.
, vol.1
, pp. 32-45
-
-
Martin, E.J.1
Critchlow, R.E.2
-
2
-
-
64349103355
-
Structure-activity relationship of new anti-hepatitis C virus agents: Heterobicycle-coumarin conjugates
-
Neyts, J. et al. Structure-activity relationship of new anti-hepatitis C virus agents: heterobicycle-coumarin conjugates. J. Med. Chem. 52, 1486-1490 (2009).
-
(2009)
J. Med. Chem.
, vol.52
, pp. 1486-1490
-
-
Neyts, J.1
-
3
-
-
33750227695
-
Inhibitors of Polo-like kinase reveal roles in spindle-pole maintenance
-
McInnes, C. et al. Inhibitors of Polo-like kinase reveal roles in spindle-pole maintenance. Nat. Chem. Biol. 2, 608-617 (2006).
-
(2006)
Nat. Chem. Biol.
, vol.2
, pp. 608-617
-
-
McInnes, C.1
-
4
-
-
61449229868
-
Novel non-peptide nociceptin/orphanin FQ receptor agonist, 1-[1-(1-methylcyclooctyl)-4-piperidinyl]-2-[(3R)-3-piperidinyl] -1H-benzimidazole: Design, synthesis, and structure-activity relationship of oral receptor occupancy in the brain for orally potent antianxiety drug
-
Hayashi, S. et al. Novel non-peptide nociceptin/orphanin FQ receptor agonist, 1-[1-(1-methylcyclooctyl)-4-piperidinyl]-2-[(3R)-3-piperidinyl]-1H- benzimidazole: design, synthesis, and structure-activity relationship of oral receptor occupancy in the brain for orally potent antianxiety drug. J. Med. Chem. 52, 610-625 (2009).
-
(2009)
J. Med. Chem.
, vol.52
, pp. 610-625
-
-
Hayashi, S.1
-
5
-
-
51849112827
-
Novel dual-targeting benzimidazole urea inhibitors of DNA gyrase and topoisomerase IV possessing potent antibacterial activity: Intelligent design and evolution through the judicious use of structure-guided design and structure-activity relationships
-
Charifson, P.S. et al. Novel dual-targeting benzimidazole urea inhibitors of DNA gyrase and topoisomerase IV possessing potent antibacterial activity: intelligent design and evolution through the judicious use of structure-guided design and structure-activity relationships. J. Med. Chem. 51, 5243-5263 (2008).
-
(2008)
J. Med. Chem.
, vol.51
, pp. 5243-5263
-
-
Charifson, P.S.1
-
6
-
-
49449095466
-
Synthesis of new arylpiperazinylalkylthiobenzimidazole, benzothiazole, or benzoxazole derivatives as potent and selective 5-HT1A serotonin receptor ligands
-
Siracusa, M.A. et al. Synthesis of new arylpiperazinylalkylthiobenzimidazole, benzothiazole, or benzoxazole derivatives as potent and selective 5-HT1A serotonin receptor ligands. J. Med. Chem. 51, 4529-4538 (2008).
-
(2008)
J. Med. Chem.
, vol.51
, pp. 4529-4538
-
-
Siracusa, M.A.1
-
7
-
-
64549100244
-
Discovery of 6-({4-[2-(4-tert-butylphenyl)-1H-benzimidazol-4-yl] piperazin-1-yl}methyl)quinoxaline (WAY-207024): An orally active antagonist of the gonadotropin releasing hormone receptor (GnRH-R)
-
Pelletier, J.C. et al. Discovery of 6-({4-[2-(4-tert-butylphenyl)-1H- benzimidazol-4-yl]piperazin-1-yl}methyl)quinoxaline (WAY-207024): an orally active antagonist of the gonadotropin releasing hormone receptor (GnRH-R). J. Med. Chem. 52, 2148-2152 (2009).
-
(2009)
J. Med. Chem.
, vol.52
, pp. 2148-2152
-
-
Pelletier, J.C.1
-
8
-
-
47749128453
-
Identifcation of a potent, selective, and orally active leukotriene A4 hydrolase inhibitor with anti-infammatory activity
-
Grice, C.A. et al. Identifcation of a potent, selective, and orally active leukotriene A4 hydrolase inhibitor with anti-infammatory activity. J. Med. Chem. 51, 4150-4169 (2008).
-
(2008)
J. Med. Chem.
, vol.51
, pp. 4150-4169
-
-
Grice, C.A.1
-
9
-
-
39749111209
-
Rh(I)-catalyzed arylation of heterocycles via C-H bond activation: Expanded scope through mechanistic insight
-
Lewis, J.C., Berman, A.M., Bergman, R.G. & Ellman, J.A. Rh(I)-catalyzed arylation of heterocycles via C-H bond activation: expanded scope through mechanistic insight. J. Am. Chem. Soc. 130, 2493-2500 (2008).
-
(2008)
J. Am. Chem. Soc.
, vol.130
, pp. 2493-2500
-
-
Lewis, J.C.1
Berman, A.M.2
Bergman, R.G.3
Ellman, J.A.4
-
10
-
-
63149091152
-
Design, selection, and characterization of thiofavin-based intercalation compounds with metal chelating properties for application in Alzheimer's disease
-
Rodriguez-Rodriguez, C. et al. Design, selection, and characterization of thiofavin-based intercalation compounds with metal chelating properties for application in Alzheimer's disease. J. Am. Chem. Soc. 131, 1436-1451 (2009).
-
(2009)
J. Am. Chem. Soc.
, vol.131
, pp. 1436-1451
-
-
Rodriguez-Rodriguez, C.1
-
11
-
-
64349094401
-
Synthesis, cytotoxicity, and DNA interactions of new cisplatin analogues containing substituted benzimidazole ligands
-
Gumus, F. et al. Synthesis, cytotoxicity, and DNA interactions of new cisplatin analogues containing substituted benzimidazole ligands. J. Med. Chem. 52, 1345-1357 (2009).
-
(2009)
J. Med. Chem.
, vol.52
, pp. 1345-1357
-
-
Gumus, F.1
-
12
-
-
67649518187
-
Effcient synthesis of regioisomerically pure bis(trifuoromethyl)- substituted 3,4,9,10-perylene tetracarboxylic bis(benzimidazole)
-
Yuan, Z., Xiao, Y., Li, Z. & Qian, X. Effcient synthesis of regioisomerically pure bis(trifuoromethyl)-substituted 3,4,9,10-perylene tetracarboxylic bis(benzimidazole). Org. Lett. 11, 2808-2811 (2009).
-
(2009)
Org. Lett.
, vol.11
, pp. 2808-2811
-
-
Yuan, Z.1
Xiao, Y.2
Li, Z.3
Qian, X.4
-
13
-
-
61549117103
-
Characterization of new benz-x-azole dye derivatives and metal complexes
-
Son, Y.-A., Kim, B.-S., Choi, M.-S. & Kim, S.-H. Characterization of new benz-x-azole dye derivatives and metal complexes. Mol. Cryst. Liq. Cryst. 498, 158-164 (2009).
-
(2009)
Mol. Cryst. Liq. Cryst.
, vol.498
, pp. 158-164
-
-
Son, Y.-A.1
Kim, B.-S.2
Choi, M.-S.3
Kim, S.-H.4
-
14
-
-
8144225722
-
Synthetic strategies towards benzoxazole ring systems: A review
-
Kumar, R.V. Synthetic strategies towards benzoxazole ring systems: a review. Asian J. Chem. 16, 1241-1260 (2004).
-
(2004)
Asian J. Chem.
, vol.16
, pp. 1241-1260
-
-
Kumar, R.V.1
-
15
-
-
42449103107
-
General and practical synthesis of benzothiazoles
-
Mase, T. & Itoh, T. General and practical synthesis of benzothiazoles. Pure Appl. Chem. 80, 707-715 (2008).
-
(2008)
Pure Appl. Chem.
, vol.80
, pp. 707-715
-
-
Mase, T.1
Itoh, T.2
-
16
-
-
50949127251
-
Synthesis reactivity and biological activity of benzimidazoles
-
Alamgir, M., Black, D.St.C. & Kumar, N. Synthesis, reactivity and biological activity of benzimidazoles. Top. Heterocycl. Chem. 9, 87-118 (2007).
-
(2007)
Top. Heterocycl. Chem.
, vol.9
, pp. 87-118
-
-
Alamgir, M.1
Black, D.St.C.2
Kumar, N.3
-
17
-
-
57749092640
-
Synthesis of 5-and 6-substituted 2-(4-dimethylaminophenyl)-1,3- benzoxazoles and their in vitro and in vivo evaluation as imaging agents for amyloid plaque
-
Hausner, S.H. et al. Synthesis of 5-and 6-substituted 2-(4-dimethylaminophenyl)-1,3-benzoxazoles and their in vitro and in vivo evaluation as imaging agents for amyloid plaque. Bioorg. Med. Chem. Lett. 19, 543-545 (2009).
-
(2009)
Bioorg. Med. Chem. Lett.
, vol.19
, pp. 543-545
-
-
Hausner, S.H.1
-
18
-
-
34347380861
-
Phenylpropanoic acid derivatives bearing a benzothiazole ring as PPAR?-selective agonists
-
Fujieda, H. et al. Phenylpropanoic acid derivatives bearing a benzothiazole ring as PPAR?-selective agonists. Bioorg. Med. Chem. Lett. 17, 4351-4357 (2007).
-
(2007)
Bioorg. Med. Chem. Lett.
, vol.17
, pp. 4351-4357
-
-
Fujieda, H.1
-
19
-
-
58249096372
-
Formation and structures of Pd(II) N,S-heterocyclic carbene-pyridyl mixed-ligand complexes
-
Yen, S.K., Koh, L.L., Huynh, H.V. & Andy Hor, T.S. Formation and structures of Pd(II) N,S-heterocyclic carbene-pyridyl mixed-ligand complexes. J. Organomet. Chem. 694, 332-338 (2009).
-
(2009)
J. Organomet. Chem.
, vol.694
, pp. 332-338
-
-
Yen, S.K.1
Koh, L.L.2
Huynh, H.V.3
Andy Hor, T.S.4
-
20
-
-
58249118877
-
Palladium-catalyzed direct arylations of heteroarenes with tosylates and mesylates
-
Ackermann, L., Althammer, A. & Fenner, S. Palladium-catalyzed direct arylations of heteroarenes with tosylates and mesylates. Angew. Chem. Int. Ed. 48, 201-204 (2009).
-
(2009)
Angew. Chem. Int. Ed.
, vol.48
, pp. 201-204
-
-
Ackermann, L.1
Althammer, A.2
Fenner, S.3
-
21
-
-
0033524753
-
Synthesis of 2-alkylaminobenzimidazoles
-
Perkins, J.J., Zartman, A.E. & Meissner, R.S. Synthesis of 2-alkylaminobenzimidazoles. Tetrahedron Lett. 40, 1103-1106 (1999).
-
(1999)
Tetrahedron Lett.
, vol.40
, pp. 1103-1106
-
-
Perkins, J.J.1
Zartman, A.E.2
Meissner, R.S.3
-
22
-
-
0016426884
-
New facile synthesis of 2-substituted aminobenzimidazoles
-
Mohsen, A., Omar, M.E., Sams El-Dine, S.H.A. & Hazzam, A.A.B. New facile synthesis of 2-substituted aminobenzimidazoles. Pharmazie 30, 85-86 (1975).
-
(1975)
Pharmazie
, vol.30
, pp. 85-86
-
-
Mohsen, A.1
Omar, M.E.2
Sams El-Dine, S.H.A.3
Hazzam, A.A.B.4
-
23
-
-
64949123222
-
Diversity oriented synthesis of benzimidazole and benzoxa/(thia)zole libraries through polymer-supported hypervalent iodine reagent
-
Kumar, A., Maurya, R.A. & Ahmad, P. Diversity oriented synthesis of benzimidazole and benzoxa/(thia)zole libraries through polymer-supported hypervalent iodine reagent. J. Comb. Chem. 11, 198-201 (2009).
-
(2009)
J. Comb. Chem.
, vol.11
, pp. 198-201
-
-
Kumar, A.1
Maurya, R.A.2
Ahmad, P.3
-
24
-
-
56449089532
-
Effcient aerobic oxidative synthesis of 2-substituted benzoxazoles, benzothiazoles, and benzimidazoles catalyzed by 4-methoxy-TEMPO
-
Chen, Y.-X., Qian, L.-F., Zhang, W. & Han, B. Effcient aerobic oxidative synthesis of 2-substituted benzoxazoles, benzothiazoles, and benzimidazoles catalyzed by 4-methoxy-TEMPO. Angew. Chem. Int. Ed. 47, 9330-9333 (2008).
-
(2008)
Angew. Chem. Int. Ed.
, vol.47
, pp. 9330-9333
-
-
Chen, Y.-X.1
Qian, L.-F.2
Zhang, W.3
Han, B.4
-
25
-
-
0020363114
-
2-(2-Benzimidazolylamin o)benzothiazoles and 2-(2imidazolidinylidenamino) benzothiazoles
-
Merchan, F.L., Garin, J., Melendez, E. & Tejero, T. 2-(2-Benzimidazolylamin o)benzothiazoles and 2-(2imidazolidinylidenamino) benzothiazoles. Synthesis 1066-1067 (1982).
-
(1982)
Synthesis
, pp. 1066-1067
-
-
Merchan, F.L.1
Garin, J.2
Melendez, E.3
Tejero, T.4
-
26
-
-
84986438897
-
A facile synthesis of dimethyl N-aryldithiocarbonimidates and 2-arylaminobenzimidazoles
-
Garin, J., Melendez, E., Merchan, F.L., Tejel, C. & Tejero, T. A facile synthesis of dimethyl N-aryldithiocarbonimidates and 2- arylaminobenzimidazoles. Synthesis 375-376 (1983).
-
(1983)
Synthesis
, pp. 375-376
-
-
Garin, J.1
Melendez, E.2
Merchan, F.L.3
Tejel, C.4
Tejero, T.5
-
27
-
-
33646080577
-
A one-pot method for the synthesis of 2-aminobenzimidazoles and related heterocycles
-
Cee, V.J. & Downing, N.S. A one-pot method for the synthesis of 2-aminobenzimidazoles and related heterocycles. Tetrahedron Lett. 47, 3747-3750 (2006).
-
(2006)
Tetrahedron Lett.
, vol.47
, pp. 3747-3750
-
-
Cee, V.J.1
Downing, N.S.2
-
28
-
-
70349765825
-
Effcient one-step synthesis of benzazoles in aqueous media
-
Boeini, H.Z. & Najafabadi, K.H. Effcient one-step synthesis of benzazoles in aqueous media. Eur. J. Org. Chem. 2009, 4926-4929 (2009).
-
(2009)
Eur. J. Org. Chem.
, vol.2009
, pp. 4926-4929
-
-
Boeini, H.Z.1
Najafabadi, K.H.2
-
29
-
-
57349191553
-
Desulfurization mediated by hypervalent iodine(III): A novel strategy for the construction of heterocycles
-
Ghosh, H., Yella, R., Nath, J. & Patel, B.K. Desulfurization mediated by hypervalent iodine(III): a novel strategy for the construction of heterocycles. Eur. J. Org. Chem. 2008, 6189-6196 (2008).
-
(2008)
Eur. J. Org. Chem.
, vol.2008
, pp. 6189-6196
-
-
Ghosh, H.1
Yella, R.2
Nath, J.3
Patel, B.K.4
-
30
-
-
68049084761
-
TBAF-assisted copper-catalyzed N-arylation and benzylation of benzazoles with aryl and benzyl halides under the ligand/base/solvent-free conditions
-
Lee, H.-G. et al. TBAF-assisted copper-catalyzed N-arylation and benzylation of benzazoles with aryl and benzyl halides under the ligand/base/solvent-free conditions. J. Org. Chem. 74, 5675-5678 (2009).
-
(2009)
J. Org. Chem.
, vol.74
, pp. 5675-5678
-
-
Lee, H.-G.1
-
31
-
-
4644226156
-
A convenient method for the synthesis of 2-amino substituted aza-heterocycles from N,N′-disubstituted thioureas using TsCl/NaOH
-
Heinelt, U. et al. A convenient method for the synthesis of 2-amino substituted aza-heterocycles from N,N′-disubstituted thioureas using TsCl/NaOH. Tetrahedron 60, 9883-9888 (2004).
-
(2004)
Tetrahedron
, vol.60
, pp. 9883-9888
-
-
Heinelt, U.1
-
32
-
-
34347250848
-
Rapid preparation of the mitotic kinesin Eg5 inhibitor monastrol using controlled microwave-assisted synthesis
-
Dallinger, D. & Kappe, C.O. Rapid preparation of the mitotic kinesin Eg5 inhibitor monastrol using controlled microwave-assisted synthesis. Nat. Protoc. 2, 317-321 (2007).
-
(2007)
Nat. Protoc.
, vol.2
, pp. 317-321
-
-
Dallinger, D.1
Kappe, C.O.2
-
33
-
-
34548493472
-
Automated generation of a dihydropyrimidine compound library using microwave-assisted processing
-
Dallinger, D. & Kappe, C.O. Automated generation of a dihydropyrimidine compound library using microwave-assisted processing. Nat. Protoc. 2, 1713-1721 (2007).
-
(2007)
Nat. Protoc.
, vol.2
, pp. 1713-1721
-
-
Dallinger, D.1
Kappe, C.O.2
-
34
-
-
38449099548
-
Rapid solid-phase synthesis of a calmodulin-binding peptide using controlled microwave irradiation
-
Bacsa, B. & Kappe, C.O. Rapid solid-phase synthesis of a calmodulin-binding peptide using controlled microwave irradiation. Nat. Protoc. 2, 2222-2227 (2007).
-
(2007)
Nat. Protoc.
, vol.2
, pp. 2222-2227
-
-
Bacsa, B.1
Kappe, C.O.2
-
35
-
-
33845242284
-
Carbodiimide-based benzimidazole library method
-
Carpenter, R.D., DeBerdt, P.B., Lam, K.S. & Kurth, M.J. Carbodiimide-based benzimidazole library method. J. Comb. Chem. 8, 907-914 (2006).
-
(2006)
J. Comb. Chem.
, vol.8
, pp. 907-914
-
-
Carpenter, R.D.1
Deberdt, P.B.2
Lam, K.S.3
Kurth, M.J.4
-
37
-
-
0031980058
-
Contact hypersensitivity to dicyclohexylcarbodiimide and diisopropylcarbodiimide in female B6C3F1 mice
-
Hayes, B.B., Gerber, P.C., Griffey, S.S. & Meade, B.J. Contact hypersensitivity to dicyclohexylcarbodiimide and diisopropylcarbodiimide in female B6C3F1 mice. Drug Chem. Toxicol. 1, 195-206 (1998).
-
(1998)
Drug Chem. Toxicol.
, vol.1
, pp. 195-206
-
-
Hayes, B.B.1
Gerber, P.C.2
Griffey, S.S.3
Meade, B.J.4
-
38
-
-
0032932094
-
Induction of micronucleated erythrocytes in rodents by diisopropylcarbodiimide and dicyclohexylcarbodiimide: Dependence on exposure protocol
-
Witt, K.L., Tice, R.R., Shelby, M.D., Chhabra, R.S. & Zeiger, E. Induction of micronucleated erythrocytes in rodents by diisopropylcarbodiimide and dicyclohexylcarbodiimide: dependence on exposure protocol. Environ. Mol. Mutagen. 33, 65-74 (1999).
-
(1999)
Environ. Mol. Mutagen.
, vol.33
, pp. 65-74
-
-
Witt, K.L.1
Tice, R.R.2
Shelby, M.D.3
Chhabra, R.S.4
Zeiger, E.5
-
40
-
-
84987322826
-
Methods for preparing benzimidazo[2,1-b] quinazolin-12-ones and related compounds
-
Lunn, W.H.W. & Harper, R.W. Methods for preparing benzimidazo[2,1-b] quinazolin-12-ones and related compounds. J. Heterocycl. Chem. 8, 141-147 (1971).
-
(1971)
J. Heterocycl. Chem.
, vol.8
, pp. 141-147
-
-
Lunn, W.H.W.1
Harper, R.W.2
-
41
-
-
33846044053
-
Microwave-mediated heterocyclization to benzimidazo[2,1-b]quinazolin- 12(5H)-ones
-
Carpenter, R.D., Lam, K.S. & Kurth, M.J. Microwave-mediated heterocyclization to benzimidazo[2,1-b]quinazolin-12(5H)-ones. J. Org. Chem. 72, 284-287 (2007).
-
(2007)
J. Org. Chem.
, vol.72
, pp. 284-287
-
-
Carpenter, R.D.1
Lam, K.S.2
Kurth, M.J.3
-
42
-
-
33644853780
-
The impact of microwave synthesis on drug discovery
-
Kappe, C.O. & Dallinger, D. The impact of microwave synthesis on drug discovery. Nat. Rev. Drug Discov. 5, 51-63 (2006).
-
(2006)
Nat. Rev. Drug Discov.
, vol.5
, pp. 51-63
-
-
Kappe, C.O.1
Dallinger, D.2
-
43
-
-
34047184163
-
Contrasting chemoselectivities in the ultrasound and microwave assisted bromination reactions of substituted alkylaromatics with N-bromosuccinimide
-
Heropoulos, G.A., Cravotto, G., Screttas, C.G. & Steele, B.R. Contrasting chemoselectivities in the ultrasound and microwave assisted bromination reactions of substituted alkylaromatics with N-bromosuccinimide. Tetrahedron Lett. 48, 3247-3250 (2007).
-
(2007)
Tetrahedron Lett.
, vol.48
, pp. 3247-3250
-
-
Heropoulos, G.A.1
Cravotto, G.2
Screttas, C.G.3
Steele, B.R.4
-
44
-
-
77954374488
-
Halogenated benzimidazole carboxamides target integrin alpha4 beta1 on T and B cell lymphomas
-
Carpenter, R.D. et al. Halogenated benzimidazole carboxamides target integrin alpha4 beta1 on T and B cell lymphomas. Cancer Res. 70, 5448-5456 (2010).
-
(2010)
Cancer Res.
, vol.70
, pp. 5448-5456
-
-
Carpenter, R.D.1
-
45
-
-
78049361773
-
-
accessed on July 2010
-
http://www.mrl.ucsb.edu/mrl/centralfacilities/polymer/mconditions-1.html (accessed on July 2010).
-
-
-
-
46
-
-
84932242838
-
New synthesis of aromatic isothiocyanates
-
Jochims, J.C. Carbodiimides. IV. New synthesis of aromatic isothiocyanates. Chem. Ber. 101, 1746-1752 (1968).
-
(1968)
Chem. Ber.
, vol.101
, pp. 1746-1752
-
-
Jochims, J.C.1
Carbodiimides., I.V.2
|