Synthesis of 2-(alkylamino)benzimidazoles

Tetrahedron Letters

Volumn 40, Issue 6, 1999, Pages 1103-1106

  Perkins, James J ^a   Zartman, Amy E ^a   Meissner, Robert S ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARGININE; BENZIMIDAZOLE DERIVATIVE; GUANIDINE;

ARTICLE; CHEMICAL REACTION; DRUG SYNTHESIS; MASS SPECTROMETRY; PROTON NUCLEAR MAGNETIC RESONANCE;

EID: 0033524753     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(98)02592-1     Document Type: Article

References (11)

1. 1. a) Rastogi, R.; Sharm, S. Synthesis 1983, 861.
2. b) Simonov, A. M.; Anisimova, V. A. Chem. Heterocycl. Compd. 1979, 15, 705.
3. 2. a) Janssens, F.; Torremans, J.; Janssen, M.; Stokbroekx, R.; Luyckx, M.; Janssen, P. A. J. J. Med. Chem. 1985, 28, 1925.
4. b) Povstyanoi, M. V.; Kruglenko, V. P.; Fedosenko, E. N.; Klyuev, N. A. Khim. Geterotsikl. Sodein. 1990, 8, 1065.
5. 3. a) Stedman, R. J. U.S. Patent 3455948 1969; C.A. 71, 81369 1969.
6. b) Chow, A. W. U.S. Patent 3468888 1969; C.A. 72, 3489 1970.
7. c) Kifter, D.; Levy, C. R. Acad. Sci. Paris Ser. C 1968, 267, 1730.
8. 4. Other reagents, such as MeI or sodium dithionate can be used: a) Ojha, V.; Singh, J.; Bhakuni, D. S.; Singh, S. N.; Fatma, N.; Chatterjee, R. K. Indian J. Chem. Sect. B 32 1993, 3, 394.
9. b) Omar, M. E.; Mohsen, A. Synthesis 1974, 41.
10. c) Bera, T.; Belsare, D. P. Indian J. Chem. Sect. B 31 1992, 6, 370.
11. 5. The pKa's were measured on a Sirius Model PCA-101 pKa titrator.