Selectively targeting T- and B-cell lymphomas: A benzothiazole antagonist of α 4β 1integrin

Journal of Medicinal Chemistry

Volumn 52, Issue 1, 2009, Pages 14-19

  Carpenter, Richard D ^a   Andrei, Mirela ^b   Aina, Olulanu H ^b   Lau, Edmond Y ^c   Lightstone, Felice C ^c   Liu, Ruiwu ^b   Lam, Kit S ^b   Kurth, Mark J ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c LAWRENCE LIVERMORE NATIONAL LABORATORY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA4BETA1 INTEGRIN ANTAGONIST; BENZOTHIAZOLE DERIVATIVE; CYANINE DYE 5; CYANINE DYE CY5.5; UNCLASSIFIED DRUG; VERY LATE ACTIVATION ANTIGEN 4; BENZOTHIAZOLE; MOLEPHANTIN; SESQUITERPENE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; B CELL LYMPHOMA; CELL ADHESION; CONTROLLED STUDY; DRUG POTENCY; DRUG SELECTIVITY; DRUG SOLUBILITY; DRUG TARGETING; FEMALE; HUMAN; IC 50; MALE; MOUSE; NONHUMAN; PHARMACOPHORE; PHYSICAL CHEMISTRY; STRUCTURE ANALYSIS; T CELL LYMPHOMA; ANIMAL; CHEMICAL STRUCTURE; CHEMISTRY; DRUG ANTAGONISM; DRUG EFFECT; DRUG SCREENING; ENZYME SPECIFICITY; METABOLISM; NUDE MOUSE; PATHOLOGY; STRUCTURE ACTIVITY RELATION; SYNTHESIS; TUMOR CELL LINE;

ANIMALS; BENZOTHIAZOLES; CELL ADHESION; CELL LINE, TUMOR; FEMALE; HUMANS; INHIBITORY CONCENTRATION 50; INTEGRIN ALPHA4BETA1; LYMPHOMA, B-CELL; LYMPHOMA, T-CELL; MALE; MICE; MICE, NUDE; MOLECULAR STRUCTURE; SESQUITERPENES; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 59449093689     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm800313f     Document Type: Article

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