Discovery of 6-({4-[2-(4-tert-Butylphenyl)-1H-benzimidazol-4-yl]piperazin- 1-yl}methyl)quinoxaline(WAY-207024): An orally active antagonist of the gonadotropin releasing hormone receptor (GnRH-R)

Journal of Medicinal Chemistry

Volumn 52, Issue 7, 2009, Pages 2148-2152

  Pelletier, Jeffrey C ^a   Chengalvala, Murty V ^a   Cottom, Joshua E ^a   Feingold, Irene B ^a   Green, Daniel M ^a   Hauze, Diane B ^a   Huselton, Christine A ^a   Jetter, James W ^a   Kopf, Gregory S ^a   Lundquist, Joseph T ^a   Magolda, Ronald L ^a   Mann, Charles W ^a   Mehlmann, John F ^a   Rogers, John F ^a   Shanno, Linda K ^a   Adams, William R ^a   Tio, Cesario O ^a   Wrobel, Jay E ^a  

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

6 [4 [2 (4 TERT BUTYLPHENYL) 1H BENZIMIDAZOL 4 YL]PIPERAZIN 1 YL]METHYL QUINOXALINE; GONADORELIN ANTAGONIST; GONADORELIN RECEPTOR; LUTEINIZING HORMONE; QUINOXALINE DERIVATIVE; UNCLASSIFIED DRUG; WAY 207024;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG HALF LIFE; DRUG MECHANISM; DRUG METABOLISM; DRUG STRUCTURE; HORMONE BLOOD LEVEL; NONHUMAN; PHARMACOPHORE; RAT;

ADMINISTRATION, ORAL; ANIMALS; BENZIMIDAZOLES; BINDING, COMPETITIVE; BIOLOGICAL AVAILABILITY; HALF-LIFE; HUMANS; LUTEINIZING HORMONE; MALE; MICROSOMES, LIVER; ORCHIECTOMY; PITUITARY GLAND; QUINOXALINES; RADIOLIGAND ASSAY; RATS; RECEPTORS, LHRH; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 64549100244     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm801572m     Document Type: Article

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