Electrochemical aspects of electrospray and laser desorption/ionization for mass spectrometry

Annual Review of Analytical Chemistry

Volumn 3, Issue 1, 2010, Pages 231-254

  Abonnenc, Mélanie ^a   Qiao, Liang ^a,b   Liu, BaoHong ^b   Girault, Hubert H ^a  

^a EPFL   (Switzerland)

^b FUDAN UNIVERSITY   (China)

Author keywords

electrochemistry; electron transfer reaction; emitters; ion source; peptide analysis; proteomics

Indexed keywords

ANALYTICAL APPLICATIONS; ELECTROCHEMICAL REACTIONS; ELECTRODE REACTIONS; ELECTRON-TRANSFER REACTION; ELECTROSPRAYS; EMITTERS; GAS PHASE IONS; IONIZATION PRODUCTS; LASER DESORPTION/IONIZATION; PEPTIDE ANALYSIS; PHOTOELECTROCHEMICAL REACTION; PROTEOMICS; SOLID SUBSTRATES;

DESORPTION; ELECTROSPRAY IONIZATION; ION SOURCES; IONIZATION OF GASES; IONS; MASS SPECTROMETRY; MOLECULAR BIOLOGY; PEPTIDES; PHOTOOXIDATION;

ELECTROCHEMISTRY;

PEPTIDE;

CHEMISTRY; ELECTROCHEMICAL ANALYSIS; GAS; INSTRUMENTATION; MASS SPECTROMETRY; METHODOLOGY; REVIEW;

ELECTROCHEMICAL TECHNIQUES; GASES; PEPTIDES; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION;

EID: 78049371851     PISSN: 19361327     EISSN: 19361335     Source Type: Book Series    
DOI: 10.1146/annurev.anchem.111808.073740     Document Type: Article

References (115)

1. Hawkridge AM, Muddiman DC. 2009. Mass spectrometry-based biomarker discovery: toward a global proteome index of individuality. Annu. Rev. Anal. Chem. 2:265-77
2. ChangHC. 2009. Ultrahigh-mass mass spectrometry of single biomolecules and bioparticles. Annu. Rev. Anal. Chem. 2:169-85
3. Burnum KE, Frappier SL, Caprioli RM. 2008. Matrix-assisted laser desorption/ionization imaging mass spectrometry for the investigation of proteins and peptides. Annu. Rev. Anal. Chem. 1:689-705
4. YamashitaM, Fenn JB. 1984. Eelectrospray ion-source-another variation on the free-jet theme. J. Phys. Chem. 88:4451-59
5. Karas M, Bachmann D, Bahr U, Hillenkamp F. 1987. Matrix-assisted ultraviolet-laser desorption of nonvolatile compounds. Int. J. Mass Spectrom. Ion Processes 78:53-68
6. Nollet JA. 1749. Recherches sur les causes particulìeres des pȟenom̀enes ̌electriques. Paris: Chez les Fr̀eres Guerin. 1st ed.
7. Zeleny J. 1914. The electrical discharge from liquid points, and a hydrostatic method of measuring the electric intensity at their surfaces. Phys. Rev. 3:69-91
8. Dole M, Mack LL, Hines RL, Chemistry DO, Mobley RC, et al. 1968. Molecular beams of macroions. J. Chem. Phys. 49:2240-49
9. Alexandrov ML, Gall LN, Krasnov NV, Nikolaev VI, Pavlenko VA, Shkurov VA. 1983. Short communication. Int. J. Mass Spectrom. Ion Processes 54:231-35
10. Cole RB. 1997. Electrospray Ionization Mass Spectrometry: Fundamentals, Instrumentation and Applications. New York: Wiley
11. Kebarle P, Tang L. 1993. From ions in solution to ions in the gas phase: The mechanism of electrospray mass spectrometry. Anal. Chem. 65:972-86A
12. Kebarle P, Peschke M. 2000.Onthemechanisms by which the charged droplets produced by electrospray lead to gas phase ions. Anal. Chim. Acta 406:11-35 (Pubitemid 30047022)
13. Kebarle P. 2000. A brief overview of the present status of the mechanisms involved in electrospray mass spectrometry. J. Mass Spectrom. 35:804-17 (Pubitemid 30479522)
14. Cole RB. 2000. Some tenets pertaining to electrospray ionization mass spectrometry. J. Mass Spectrom. 35:763-72 (Pubitemid 30479518)
15. Cech NB, Enke CG. 2001. Practical implications of some recent studies in electrospray ionization fundamentals. Mass Spectrom. Rev. 20:362-87
16. Mora J, Van Berkel GJ, Enke C, Cole R, Martinez-Sanchez M, Fenn JB. 2000. Electrochemical processes in electrospray ionization mass spectrometry. J. Mass Spectrom. 35:939-52
17. Van Berkel GJ, Kertesz V. 2007. Using the electrochemistry of the electrospray ion source. Anal. Chem. 79:5510-20 (Pubitemid 47229794)
18. Permentier HP, Bruins AP, Bischoff R. 2008. Electrochemistry-mass spectrometry in drug metabolism and protein research. Mini Rev. Med. Chem. 8:46-56 (Pubitemid 351320929)
19. Karst U. 2004. Electrochemistry/mass spectrometry (EC/MS)-a new tool to study drug metabolism and reaction mechanisms. Angew. Chem. Int. Ed. 43:2476-78 (Pubitemid 39257706)
20. Diehl G, Karst U. 2002. On-line electrochemistry-MS and related techniques. Anal. Bioanal. Chem. 373:390-98
21. Tanaka K, Waki H, Ido Y, Akita S, Yoshida Y, et al. 1988. Protein and polymer analyses up to m/z 100,000 by laser ionization time-of-flight mass spectrometry. Rapid Commun. Mass Spectrom. 2:151-53
22. StumpMJ, Fleming RC, Gong WH, Jaber AJ, Jones JJ, et al. 2002. Matrix-assisted laser desorption mass spectrometry. Appl. Spectrosc. Rev. 37:275-303 (Pubitemid 35328042)
23. Wei J, Buriak JM, Siuzdak G. 1999. Desorption-ionization mass spectrometry on porous silicon. Nature 399:243-46 (Pubitemid 29246449)
24. Peterson DS. 2007. Matrix-free methods for laser desorption/ionization mass spectrometry. Mass Spectrom. Rev. 26:19-34 (Pubitemid 46051811)
25. Karas M, Kruger R. 2003. Ion formation in MALDI: The cluster ionization mechanism. Chem. Rev. 103:427-39
26. Qiao L, Bi HY, Busnel JM, Waser J, Yang PY, et al. 2009. Photocatalytic redox reactions for in-source peptide fragmentation. Chem. A Eur. J. 15:6711-17
27. Taylor GI. 1964. Disintegration of water drops in an electric field. Proc. R. Soc. London Ser. A 280:383-97
28. Eyring CF, MacKeown SS, Millikan RA. 1928. Fields currents from points. Phys. Rev. 31:900-9
29. Girault HH. 2004. Electrified interfaces. In Analytical and Physical Chemistry, pp. 177-220. Lausanne: EPFL
30. Mack LL, Kralik P, Rheude A, Dole M. 1970. Molecular beams ofmacroions. II. J. Chem. Phys. 52:4977-86
31. Iribarne JV, Thomson BA. 1976. On the evaporation of small ions from charged droplets. J. Chem. Phys. 64:2287-94
32. Marcus RA. 2000. On the theory of ion transfer rates across the interface of two immiscible liquids. J. Chem. Phys. 113:1618-29
33. Blades AT, IkonomouMG, KebarleP. 1991. Mechanism of electrospraymass spectrometry. Electrospray as an electrolysis cell. Anal. Chem. 63:2109-14
34. Jackson G, Enke C. 1999. Electrical equivalence of electrospray ionization with conducting and nonconducting needles. Anal. Chem. 71:3777-84 (Pubitemid 129525468)
35. Van Berkel GJ, Zhou F. 1995. Characterization of an electrospray ion source as a controlled-current electrolytic cell. Anal. Chem. 67:2916-23
36. Van Berkel GJ, Zhou F, Aronson JT. 1997. Changes in bulk solution pH caused by the inherent controlled-current electrolytic process of an electrospray ion source. Int. J. Mass Spectrom. Ion Processes 162:55-67 (Pubitemid 127736986)
37. Konermann L, Silva EA, Sogbein OF. 2001. Electrochemically induced pH changes resulting in protein unfolding in the ion source of an electrospray mass spectrometer. Anal. Chem. 73:4836-44 (Pubitemid 32980105)
38. Pan P, Gunawardena HP, Xia Y, McLuckey SA. 2004. Nanoelectrospray ionization of protein mixtures: solution pH and protein pI. Anal. Chem. 76:1165-74 (Pubitemid 38235567)
39. Van Berkel GJ, McLuckey SA, Glish GL. 1992. Electrochemical origin of radical cations observed in electrospray ionization mass spectra. Anal. Chem. 64:1586-93
40. Xu X, Nolan SP, Cole RB. 1994. Electrochemical oxidation and nucleophilic addition reactions of metallocenes in electrospray mass spectrometry. Anal. Chem. 66:119-25 (Pubitemid 24985125)
41. Ochran R, Konermann L. 2004. Effects of ground loop currents on signal intensities in electrospray mass spectrometry. J. Am. Soc. Mass Spectrom. 15:1748-54 (Pubitemid 39602727)
42. Rohner TC, Rossier JS, Girault HH. 2002. On-line electrochemical tagging of cysteines in proteins during nanospray. Electrochem. Commun. 4:695-700
43. Roussel C, Dayon L, Lion N, Rohner TC, Josserand J, et al. 2004. Generation of mass tags by the inherent electrochemistry of electrospray for protein mass spectrometry. J. Am. Soc. Mass Spectrom. 15:1767-79 (Pubitemid 39602729)
44. Dayon L, Josserand J, Girault HH. 2005. Electrochemical multi-tagging of cysteinyl peptides during microspray mass spectrometry: numerical simulation of consecutive reactions in a microchannel. Phys. Chem. Chem. Phys. 7:4054-60
45. Dayon L, Roussel C, Prudent M, Lion N, Girault HH. 2005. On-line counting of cysteine residues in peptides during electrospray ionization by electrogenerated tags and their application to protein identification. Electrophoresis 26:238-47 (Pubitemid 40202141)
46. Dayon L, Roussel C, Girault HH. 2006. Probing cysteine reactivity in proteins by mass spectrometric EC-tagging. J. Proteome Res. 5:793-800
47. Van Berkel GJ, Kertesz V. 2009. Electrochemically initiated tagging of thiols using an electrospray ionization based liquid microjunction surface sampling probe two-electrode cell. Rapid Commun. Mass Spectrom. 23:1380-86
48. Van Berkel GJ. 1998. Electrolytic corrosion of a stainless-steel electrospray emitter monitored using an electrospray-photodiode array system. J. Anal. At. Spectrom. 13:603-7
49. Van Berkel GJ, Asano KG, Schnier PD. 2001. Electrochemical processes in a wire-in-a-capillary bulkloaded, nano-electrospray emitter. J. Am. Soc. Mass Spectrom. 12:853-62
50. Van Berkel GJ, Kertesz V. 2001. Redox buffering in an electrospray ion source using a copper capillary emitter. J. Mass Spectrom. 36:1125-32 (Pubitemid 33040766)
51. Mirza UA, Chalt BT. 1994. Effects of anions on the positive ion electrospray ionization mass spectra of peptides and proteins. Anal. Chem. 66:2898-904 (Pubitemid 24312397)
52. Enke CG. 1997. A predictive model for matrix and analyte effects in electrospray ionization of singlycharged ionic analytes. Anal. Chem. 69:4885-93 (Pubitemid 127485141)
53. Rohner TC, Girault HH. 2005. Study of peptide on-line complexation with transition-metal ions generated from sacrificial electrodes in thin-chip polymer microsprays. Rapid Commun. Mass Spectrom. 19:1183-90
54. Prudent M, Roussel C, Girault HH. 2007. Electrochemical generation of Cu(I) complexes in aqueous solutions studied by on-line mass spectrometry. Electrochem. Commun. 9:2067-74 (Pubitemid 47069115)
55. Prudent M, Girault HH. 2008. On-line electrogeneration of copper-peptide complexes in microspray mass spectrometry. J. Am. Soc. Mass Spectrom. 19:560-68
56. Prudent M, Rossier JS, LionN,Girault HH. 2008. Microfabricated dual sprayer for on-linemass tagging of phosphopeptides. Anal. Chem. 80:2531-38 (Pubitemid 351499837)
57. Kertesz V, Van Berkel GJ. 2006. Expanded use of a battery-powered two-electrode emitter cell for electrospray mass spectrometry. J. Am. Soc. Mass Spectrom. 17:953-61 (Pubitemid 43928607)
58. Xu X, Lu W, Cole RB. 1996. On-line probe for fast electrochemistry/ electrospray mass spectrometry. Investigation of polycyclic aromatic hydrocarbons. Anal. Chem. 68:4244-53 (Pubitemid 126682605)
59. Van Berkel GJ, Asano KG, Granger MC. 2004. Controlling analyte electrochemistry in an electrospray ion source with a three-electrode emitter cell. Anal. Chem. 76:1493-99 (Pubitemid 38280499)
60. Kertesz V, Van Berkel GJ, Granger MC. 2005. Study and application of a controlled-potential electrochemistry-electrospray emitter for electrospray mass spectrometry. Anal. Chem. 77:4366-73 (Pubitemid 41542254)
61. Liu BH, Lee YT, Wang YS. 2009. Incoherent production reactions of positive and negative ions in matrix-assisted laser desorption/ionization. J. Am. Soc. Mass Spectrom. 20:1078-86
62. KarasM,Gluckmann M, Schafer J. 2000. Ionization inmatrix-assisted laser desorption/ionization: Singly charged molecular ions are the lucky survivors. J. Mass Spectrom. 35:1-12 (Pubitemid 30060147)
63. LehmannE,Knochenmuss R, Zenobi R. 1997. Ionizationmechanisms in matrix-assisted laser desorption ionizationmass spectrometry: contribution of preformed ions. Rapid Commun. Mass Spectrom. 11:1483-92
64. Sarver A, Scheffler NK, Shetlar MD, Gibson BW. 2001. Analysis of peptides and proteins containing nitrotyrosine bymatrix-assisted laser desorption/ionizationmass spectrometry. J. Am. Soc.Mass Spectrom. 12:439-48 (Pubitemid 34546613)
65. Petersson AS, Steen H, Kalume DE, Caidahl K, Roepstorff P. 2001. Investigation of tyrosine nitration in proteins by mass spectrometry. J. Mass Spectrom. 36:616-25 (Pubitemid 32624621)
66. Kaneko R, Wada Y. 2003. Decomposition of protein nitrosothiols in matrix-assisted laser desorption/ ionization and electrospray ionization mass spectrometry. J. Mass Spectrom. 38:526-30 (Pubitemid 36665539)
67. Frankevich VE, Zhang J, Friess SD, Dashtiev M, Zenobi R. 2003. Role of electrons in laser desorption/ionization mass spectrometry. Anal. Chem. 75:6063-67 (Pubitemid 37420595)
68. Frankevich V, Knochenmuss R, Zenobi R. 2002. The origin of electrons in MALDI and their use for sympathetic cooling of negative ions in FTICR. Int. J. Mass Spectrom. 220:11-19
69. Gorshkov MV, Frankevich VE, Zenobi R. 2002. Characteristics of photoelectrons emitted in matrixassisted laser desorption/ionization Fourier transform ion cyclotron resonance experiments. Eur. J. Mass Spectrom. 8:67-69
70. Knochenmuss R, McCombie G, Faderl M. 2006. Ion yields of thin MALDI samples: dependence on matrix and metal substrate and implications for models. J. Phys. Chem. A 110:12728-33 (Pubitemid 46065648)
71. Gruszecka A, Szymanska-Chargot M, Smolira A, Cytawa J, Michalak L. 2008. Role of the support material on laser desorption/ionization mass spectra. Rapid Commun. Mass Spectrom. 22:925-29 (Pubitemid 351468244)
72. Frankevich V, Zhang J, Dashtiev M, Zenobi R. 2003. Production and fragmentation of multiply charged ions in electron-free matrix-assisted laser desorption/ionization. Rapid Commun. Mass Spectrom. 17:2343-48 (Pubitemid 37243320)
73. Zhang J, Frankevich V, Knochenmuss R, Friess SD, Zenobi R. 2003. Reduction of Cu(II) in matrixassisted laser desorption/ionization mass spectrometry. J. Am. Soc. Mass Spectrom. 14:42-50 (Pubitemid 36875974)
74. Okuno S, NakanoM,Matsubayashi G, Arakawa R, Wada Y. 2004. Reduction of organic dyes in matrixassisted laser desorption/ionization and desorption/ionization on porous silicon. Rapid Commun. Mass Spectrom. 18:2811-17 (Pubitemid 39576823)
75. Brown RS, Lennon JJ. 1995. Sequence-specific fragmentation of matrix-assisted laser-desorbed protein peptide ions. Anal. Chem. 67:3990-99
76. Yalcin T, Schriemer DC, Li L. 1997. Matrix-assisted laser desorption ionization time-of-flight mass spectrometry for the analysis of polydienes. J. Am. Soc. Mass Spectrom. 8:1220-29 (Pubitemid 28487047)
77. Wong CKL, Chan TWD. 1997. Cationization processes in matrix-assisted laser desorption/ionization mass spectrometry: attachment of divalent and trivalent metal ions. Rapid Commun. Mass Spectrom. 11:513-19
78. MasselonC, Salih B, Zenobi R. 1999. Matrix-assisted laser desorption/ionization Fourier transform mass spectrometry of luteinizing hormone releasing hormone-metal ion complexes. J. Am. Soc.Mass Spectrom.10:19-26 (Pubitemid 34450232)
79. +. J. Mass Spectrom. 32:1037-49 (Pubitemid 27454248)
80. Salih B, Masselon C, Zenobi R. 1998. Matrix-assisted laser desorption/ionization mass spectrometry of noncovalent protein transition metal ion complexes. J. Mass Spectrom. 33:994-1002 (Pubitemid 28499668)
81. Kosevich MV, Chagovets VV, Shmigol IV, Snegir SV, Boryak OA, et al. 2008. Sensitivity of redox reactions of dyes to variations of conditions created in mass spectrometric experiments. J. Mass Spectrom. 43:1402-12
82. Sachon E, Clodic G, Blasco T, Bolbach G. 2007. Protein desolvation in UV matrix-assisted laser desorption/ ionization (MALDI). J. Am. Soc. Mass Spectrom. 18:1880-90 (Pubitemid 47432851)
83. Hardouin J. 2007. Protein sequence information by matrix-assisted laser desorption/ionization in-source decay mass spectrometry. Mass Spectrom. Rev. 26:672-82 (Pubitemid 47280717)
84. Demeure K, Quinton L, Gabelica V, De Pauw E. 2007. Rational selection of the optimum MALDI matrix for top-down proteomics by in-source decay. Anal. Chem. 79:8678-85 (Pubitemid 350171379)
85. Gao JL, Tsugita A, Takayama M, Xu L. 2002. A programmable fragmentation analysis of proteins by in-source decay in MALDI-TOF mass spectrometry. Anal. Chem. 74:1449-57 (Pubitemid 34233339)
86. Schnaible V, Wefing S, Resemann A, Suckau D, Bucker A, et al. 2002. Screening for disulfide bonds in proteins by MALDI in-source decay and LIFT-TOF/TOF-MS. Anal. Chem. 74:4980-88
87. Reiber DC, Grover TA, Brown RS. 1998. Identifying proteins using matrix-assisted laser desorption/ ionization in-source fragmentation data combined with database searching. Anal. Chem. 70:673-83 (Pubitemid 128496249)
88. Takayama M. 2001. In-source decay characteristics of peptides in matrix-assisted laser desorption/ ionization time-of-flight mass spectrometry. J. Am. Soc. Mass Spectrom. 12:420-27 (Pubitemid 34546611)
89. Brown RS, Carr BL, Lennon JJ. 1996. Factors that influence the observed fast fragmentation of peptides in matrix-assisted laser desorption. J. Am. Soc. Mass Spectrom. 7:225-32
90. Brown RS, Feng JH, Reiber DC. 1997. Further studies of in-source fragmentation of peptides inmatrixassisted laser desorption-ionization. Int. J. Mass Spectrom. 169:1-18
91. Marzilli LA,Golden TR, Cotter RJ, Woods AS. 2000. Peptide sequence information derived by pronase digestion and ammonium sulfate in-source decay matrix-assisted laser desorption/ionization time-offlight mass spectrometry. J. Am. Soc. Mass Spectrom. 11:1000-8
92. Katta V, Chow DT, Rohde MF. 1998. Applications of in-source fragmentation of protein ions for direct sequence analysis by delayed extraction MALDI-TOF mass spectrometry. Anal. Chem. 70:4410-16 (Pubitemid 128484792)
93. Kocher T, Engstrom A, Zubarev RA. 2005. Fragmentation of peptides in MALDI in-source decay mediated by hydrogen radicals. Anal. Chem. 77:172-77 (Pubitemid 40096683)
94. Takayama M. 2001. N-C-αbond cleavage of the peptide backbone via hydrogen abstraction. J. Am. Soc. Mass Spectrom. 12:1044-49
95. Go EP, Apon JV, Luo G, Saghatelian A, Daniels RH, et al. 2005. Desorption/ionization on silicon nanowires. Anal. Chem. 77:1641-46 (Pubitemid 40396256)
96. Trauger SA, Go EP, Shen ZX, Apon JV, Compton BJ, et al. 2004. High sensitivity and analyte capture with desorption/ionization mass spectrometry on silylated porous silicon. Anal. Chem. 76:4484-89
97. LewisWG, Shen ZX, Finn MG, Siuzdak G. 2003. Desorption/ionization on silicon (DIOS) mass spectrometry: background and applications. Int. J. Mass Spectrom. 226:107-16 (Pubitemid 36582839)
98. Shen ZX, Thomas JJ, Averbuj C, Broo KM, Engelhard M, et al. 2001. Porous silicon as a versatile platform for laser desorption/ionization mass spectrometry. Anal. Chem. 73:612-19 (Pubitemid 32116454)
99. Thomas JJ, Shen ZX, Crowell JE, Finn MG, Siuzdak G. 2001. Desorption/ionization on silicon (DIOS): a diverse mass spectrometry platform for protein characterization. Proc. Natl. Acad. Sci. USA 98:4932-37 (Pubitemid 32397060)
100. Chen CT, Chen YC. 2004. Molecularly imprinted TiO2-matrix-assisted laser desorption/ionization mass spectrometry for selectively detecting α-cyclodextrin. Anal. Chem. 76:1453-57
101. Chen CT, Chen YC. 2004. Desorption/ionization mass spectrometry on nanocrystalline titania sol-geldeposited films. Rapid Commun. Mass Spectrom. 18:1956-64
102. LinYS, Chen YC. 2002. Laser desorption/ionization time-of-flight mass spectrometry on sol-gel-derived 2,5-dihydroxybenzoic acid film. Anal. Chem. 74:5793-98 (Pubitemid 35364834)
103. Sunner J, Dratz E, Chen YC. 1995. Graphite surface assisted laser desorption/ionization time-of-flight mass spectrometry of prptides and proteins from liquid solutions. Anal. Chem. 67:4335-42
104. Chen YC, Shiea J, Sunner J. 1998. Thin-layer chromatography mass spectrometry using activated carbon, surface-assisted laser desorption/ ionization. J. Chromatogr. A 826:77-86 (Pubitemid 28515637)
105. Han M, Sunner J. 2000. An activated carbon substrate surface for laser desorption mass spectrometry. J. Am. Soc. Mass Spectrom. 11:644-49 (Pubitemid 34525070)
106. Xu SY, Li YF, Zou HF, Qiu JS, Guo Z, Guo BC. 2003. Carbon nanotubes as assisted matrix for laser desorption/ionization time-of-flight mass spectrometry. Anal. Chem. 75:6191-95 (Pubitemid 37420612)
107. Qiao L, Roussel C, Wan JJ, Kong J, Yang PY, et al. 2008. MALDI in-source photooxidation reactions for online peptide tagging. Angew. Chem. Int. Ed. 47:2646-48
108. Qiao L, Bi HY, Busnel JM, Liu BH, Girault HH. 2008. In-source photocatalytic reduction of disulfide bonds during laser desorption ionization. Chem. Commun. 2008:6357-59
109. Sechi S, Chait BT. 1998. Modification of cysteine residues by alkylation. A tool in peptide mapping and protein identification. Anal. Chem. 70:5150-58 (Pubitemid 128669977)
110. Shkrob IA, Sauer MC, Gosztola D. 2004. Efficient, rapid photooxidation of chemisorbed polyhydroxyl alcohols and carbohydrates by TiO2 nanoparticles in an aqueous solution. J. Phys. Chem. B 108:12512-17
111. Kjeldsen F, Silivra OA, Ivonin IA, Haselmann KF, Gorshkov M, Zubarev RA. 2005. C-α-C backbone fragmentation dominates in electron detachment dissociation of gas-phase polypeptide polyanions. Chem. Eur. J. 11:1803-12 (Pubitemid 40379844)
112. Haselmann KF, Budnik BA, Kjeldsen F,Nielsen ML,Olsen JV, Zubarev RA. 2002. Electronic excitation gives informative fragmentation of polypeptide cations and anions. Eur. J. Mass Spectrom. 8:117-21
113. Budnik BA, Haselmann KF, Zubarev RA. 2001. Electron detachment dissociation of peptide di-anions: an electron-hole recombination phenomenon. Chem. Phys. Lett. 342:299-302
114. Okuno S, Arakawa R, Wada Y. 2004. Reduction of Cu(II) and riboflavin in DIOS mass spectrometry. J. Mass Spectrom. Soc. Jpn. 52:13-20
115. Fukuyama Y, Iwamoto S,TanakaK. 2006. Rapid sequencing and disulfide mapping of peptides containing disulfide bonds by using 1,5-diaminonaphthalene as a reductive matrix. J. Mass Spectrom. (Pubitemid 43260160)