Human Acyl-CoA:Cholesterol acyltransferase-inhibiting dammarane triterpenes from Rhus chinensis

Journal of Applied Biological Chemistry

Volumn 53, Issue 4, 2010, Pages 417-421

  Kim, Geum Soog ^a   Jeong, Tae Sook ^b   Kim, Young Ock ^a   Baek, Nam In ^c   Cha, Seon Woo ^a   Lee, Jong Won ^d   Song, Kyung Sik ^e  

^a Rural Development Administration   (South Korea)

^b Korea Research Institute of Bioscience and Biotechnology (KRIBB)   (South Korea)

^c Kyung Hee University   (South Korea)

^d Catholic University of Daegu   (South Korea)

^e Kyungpook National University   (South Korea)

Author keywords

Atherosclerosis; hACAT; Hydroxydammarenone; Hypercholesterolemia; Rhus chinensis; Semialactone

Indexed keywords

HEDERA; RATTUS; RHUS CHINENSIS;

EID: 78049370714     PISSN: 19760442     EISSN: None     Source Type: Journal    
DOI: 10.3839/jksabc.2010.064     Document Type: Article

References (23)

1. Brecher P and Chan CT (1980) Properties of Acyl-CoA: cholesterol O-acyltransferase in aortic microsomes from atherosclerotic rabbits. Biochim Biophys Acta- Lipids and Lipid Metabolism 617, 458-471.
2. Cha BC, Lee SB, Rhim TJ, and Lee KH (2000) Constituents of antioxidative activity and free radical scavenging effect from Galla rhois (Rhus javanica Linne). Korean J Pharmacogn 31, 185-189.
3. Cho KH, An S, Lee WS, Paik YK, Kim YK, and Jeong TS (2003) Mass-production of human ACAT-1 and ACAT-2 to screen isoform-specific inhibitor: a different substrate specificity and inhibitory regulation. Biochem Biophys Res Commun 309, 864-872.
4. Choi I (2003) Antimicrobial activity of Rhus javanica extracts against animal husbandry disease-related bacteria. J Korean Soc Food Sci Nutr 32, 1214-1220.
5. Chung SC, Hwang BY, Oh GJ, Kang SJ, Kim MJ, Choi WH, Lee KS, and Ro JS (1999) Chemical components from the stem bark of Rhus javanica L. Korean J Pharmacogn 30, 295-300.
6. Hua DH, Huang XD, Tamura M, Chen Y, Woltkamp M, Jin LW, Perchellet EM, Perchellet JP, Chiang PK, Namatame I, and Tomoda H (2003) Syntheses and bioactivities of tricyclic pyrones. Tetrahedron 59, 4795-4803.
7. Hutter-Paier B, Huttunen HJ, Puglielli L, Eckman CB, Kim DY, Hofmeister A, Moir RD, Domnitz SB, Frosch MP, Windisch M, and Kovacs DM (2004) The ACAT inhibitor CP-113,818 markedly reduces amyloid pathology in a mouse model of Alzheimer's disease. Neuron 44, 227-238.
8. Jeong TS, Kim SU, Son KH, Kwon BM, Kim YK, Choi MU, and Bok SH (1995) GERI-BP001 compounds, new inhibitors of acyl-CoA: Cholesterol acyltransferase from Aspergillus fumigatus F37. J Antibio 48, 751-756.
9. Kim HJ, Jang DI, and Choi SW (1997) Inhibitors of tyrosinase and melanogenesis from Galla rhois. J Food Sci Nutr 2, 285-290.
10. Kurokawa M, Nakano M, Ohyama H, Hozumi T, Kageyama S, Namba T, and Shiraki K (1997) Prophylactic efficacy of traditional herbal medicines against recurrent herpes simplex virus type 1 infection from latently infected ganglia in mice. J Dermatol Sci 14, 76-84.
11. Lawrence LR and Gregory SS (2000) Cholesterol esters and atherosclerosis-a game of ACAT and mouse. Nat Med 6, 1341-1347.
12. Lee DY, Jung L, Lyu HN, Jeong TS, Lee YH, and Baek NI (2009) Triterpenoids from the Fruits of Cornus kousa Burg as Human Acyl-CoA: Cholesterol Acyltransferase Inhibitors. Food Sci Biotechnol 18, 223-227.
13. Lee IS, Oh SR, Ahn KS, and Lee HK (2001) Semialactone, isofouquierone peroxide and fouquierone, three new dammarane triterpenes from Rhus javanica. Chem Pharm Bull (Tokyo) 49, 1024-1026.
14. Lee WS, Im KR, Park YD, Sung ND, and Jeong TS (2006) Human ACAT-1 and ACAT-2 Inhibitory Activities of pentacyclic triterpenes from the leaves of Lycopus lucidus TURCZ. Biol Pharm Bull 29, 382-384.
15. Lee YJ, Shin DH, Chang YS, and Kang WS (1993) Antioxidative effect of Rhus javanica Linne extract by various solvents. Korean J Food Sci Technol 25, 677-682.
16. Liu J, Sun HB, Wang, XF, Mu DY, Liao H, and Zhang L (2007) Effects of oleanolic acid and maslinic acid on hyperlipidemia. Drug Dev Res 68, 261-266.
17. Nishimura K, Miyase T, and Noguchi H (1999) Triterpenoid saponins from Ilex kudincha. J Nat Prod 62, 1128-1133.
18. Puglielli L, Konopka G, Pack-Chung E, Ingano LAM, Berezovska O, Hyman BT, Chang TY, Tanzi RE, and Kovacs DM (2001) Acyl-coenzyme A: cholesterol acyltransferase modulates the generation of the amyloid β-peptide. Nat Cell Biol 3, 905-912.
19. Puglielli L, Tanzi RE, and Kovacs DM (2003) Alzheimer's disease: the cholesterol connection. Nat Neurosci 6, 345-351.
20. Rudel LL, Lee RG, and Cockman TL (2001) Acyl coenzyme A: cholesterol acyltransferase types 1 and 2: structure and function in atherosclerosis. Curr Opin Lipidol 12, 121-127.
21. Runz H, Rietdorf J, Tomic I, de Bernard M, Beyreuther K, Pepperkok R, and Hartmann T (2002). Inhibition of intracellular cholesterol transport alters presenilin localization and amyloid precursor protein processing in neuronal cells. J Neurosci 22, 1679-1689.
22. Shim YJ, Do HK, Ah SY, Kim YS, Seong JK, Park IS, and Min BH (2003) Inhibitory effect of aqueous extract from the gall of Rhus chinensis on alpha-glucosidase activity and postprandial blood glucose. J Ethnopharmacol 85, 283-287.
23. Wahrle S, Das P, Nyborg AC, McLendon C, Shoji M, Kawarabayashi T, Younkin LH, Younkin SG, and Golde TE (2002) Cholesterol-dependent γ-secretase activity in buoyant cholesterol-rich membrane microdomains. Neurobiol Dis 9, 11-23.