Green tea improves metabolic biomarkers, not weight or body composition: A pilot study in overweight breast cancer survivors

Journal of Human Nutrition and Dietetics

Volumn 23, Issue 6, 2010, Pages 590-600

  Stendell Hollis, N R ^a   Thomson, C A ^a,b   Thompson, P A ^a,b   Bea, J W ^b   Cussler, E C ^c   Hakim, I A ^a,b  

^a UNIVERSITY OF ARIZONA   (United States)

^b UNIVERSITY OF ARIZONA   (United States)

^c UNIVERSITY OF ARIZONA COLLEGE OF MEDICINE   (United States)

Author keywords

Breast cancer survivors; Green tea; Overweight

Indexed keywords

BIOLOGICAL MARKER; CAENORHABDITIS ELEGANS PROTEIN; DIE 1 PROTEIN, C ELEGANS; DIE-1 PROTEIN, C ELEGANS; INSULIN; LIPID; PLACEBO; TRANSCRIPTION FACTOR;

AGED; ARTICLE; BLOOD; BODY COMPOSITION; BREAST TUMOR; CALORIC INTAKE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; ENERGY METABOLISM; EXERCISE; FEMALE; GLUCOSE BLOOD LEVEL; HUMAN; MIDDLE AGED; OBESITY; PATHOPHYSIOLOGY; PHYTOTHERAPY; PILOT STUDY; RANDOMIZED CONTROLLED TRIAL; TEA; WEIGHT REDUCTION;

AGED; BIOLOGICAL MARKERS; BLOOD GLUCOSE; BODY COMPOSITION; BREAST NEOPLASMS; CAENORHABDITIS ELEGANS PROTEINS; DOUBLE-BLIND METHOD; ENERGY INTAKE; ENERGY METABOLISM; EXERCISE; FEMALE; HUMANS; INSULIN; LIPIDS; MIDDLE AGED; OVERWEIGHT; PHYTOTHERAPY; PILOT PROJECTS; PLACEBOS; TEA; TRANSCRIPTION FACTORS; WEIGHT LOSS;

EID: 78049359517     PISSN: 09523871     EISSN: 1365277X     Source Type: Journal    
DOI: 10.1111/j.1365-277X.2010.01078.x     Document Type: Article

References (67)

1. Abrahamson, P.E., Gammon, M.D., Lund, M.J., Flagg, E.W., Porter, P.L., Stevens, J., Swanson, C.A., Brinton, L.A., Eley, J.W. & Coates, R.J. (2006) General and abdominal obesity and survival among young women with breast cancer. Cancer Epidemiol. Biomarkers Prev. 15, 1871-1877.
2. Anderson, R.A. & Polansky, M.M. (2002) Tea enhances insulin activity. J. Agric. Food. Chem. 50, 7182-7186.
3. Auvichayapat, P., Prapochanung, M., Tunkamnerdthai, O., Sripanidkulchai, B.O., Auvichayapat, N., Thinkhamrop, B., Kunhasura, S., Wongpratoom, S., Sinawat, S. & Hongprapas, P. (2008) Effectiveness of green tea on weight reduction in obese Thais: a randomised, controlled trial. Physiol. Behav. 93, 486-491.
4. Bakris, G.L., Fonseca, V., Katholi, R.E., McGill, J.B., Messerli, F.H., Phillips, R.A., Raskin, P., Wright, J.T., Oakes, R., Lukas, M.A., Anderson, K.M. & Bell, D.S. (2004) Metabolic effects of carvedilol vs metoprolol in patients with type 2 diabetes mellitus and hypertension: a randomised controlled trial. JAMA 292, 2227-2236.
5. Bonora, E., Targher, G., Alberiche, M., Bonadonna, R.C., Saggiani, F., Zenere, M.B., Monauni, T. & Muggeo, M. (2000) Homeostasis model assessment closely mirrors the glucose clamp technique in the assessment of insulin sensitivity: studies in subjects with various degrees of glucose tolerance and insulin sensitivity. Diabetes Care 23, 57-63.
6. Caan, B.J., Emond, J.A., Natarajan, L., Castillo, A., Gunderson, E.P., Habel, L., Jones, L., Newman, V.A., Rock, C.L., Slattery, M.L., Stefanick, M.L., Sternfeld, B., Thomson, C.A. & Pierce, J.P. (2006) Post-diagnosis weight gain and breast cancer recurrence in women with early stage breast cancer. Breast Cancer Res. Treat. 99, 47-57.
7. Cabrera, C., Artacho, R. & Giménez, R. (2006) Beneficial effects of green tea - a review. J. Am. Coll. Nutr. 25, 79-99.
8. Chan, C.C., Koo, M.W., Ng, E.H., Tang, O.S., Yeung, W.S. & Ho, P.C. (2006) Effects of Chinese green tea on weight, and hormonal and biochemical profiles in obese patients with polycystic ovary syndrome - a randomised placebo-controlled trial. J. Soc. Gynecol. Investig. 13, 63-68.
9. Chantre, P. & Lairon, D. (2002) Recent findings of green tea extract AR25 (Exolise) and its activity for the treatment of obesity. Phytomedicine 9, 3-8.
10. Chow, H.S., Hakim, I.A., Vining, D.R., Crowell, J.A., Tome, M.E., Ranger-Moore, J., Cordova, C.A., Mikhael, D.M., Briehl, M.M. & Alberts, D.S. (2007) Modulation of human glutathione S-transferases by polyphenon E intervention. Cancer Epidemiol. Biomarkers Prev. 16, 1662-1666.
11. Coates, R.J., Uhler, R.J., Hall, H.I., Potischman, N., Brinton, L.A., Ballard-Barbash, R., Gammon, M.D., Brogan, D.R., Daling, J.R., Malone, K.E., Schoenberg, J.B. & Swanson, C.A. (1999) Risk of breast cancer in young women in relation to body size and weight gain in adolescence and early adulthood. Br. J. Cancer 81, 167-174.
12. Collins, Q., Liu, H.Y., Pi, J., Liu, Z., Quon, M.J. & Cao, W. (2007) Epigallocatechin-3-gallate (EGCG), a green tea polyphenol, suppresses hepatic gluconeogenesis through 5'-AMP-activated protein kinase. J. Biol. Chem. 282, 30143-30149.
13. Diepvens, K., Kovacs, E.M., Vogels, N. & Westerterp-Plantenga, M.S. (2006) Metabolic effects of green tea and of phases of weight loss. Physiol. Behav. 87, 185-191.
14. Diepvens, K., Westerterp, K.R. & Westerterp-Plantenga, M.S. (2007) Obesity and thermogenesis related to the consumption of caffeine, ephedrine, capsaicin, and green tea. Am. J. Physiol. Regul. Integr. Comp. Physiol. 292, R77-R85.
15. Dignam, J.J., Wieand, K., Johnson, K.A., Raich, P., Anderson, S.J., Somkin, C. & Wickerham, D.L. (2006) Effects of obesity and race on prognosis in lymph node-negative, estrogen receptor-negative breast cancer. Breast Cancer Res. Treat. 97, 245-254.
16. Dona, M., Dell'Aica, I., Calabrese, F., Benelli, R., Morini, M., Albini, A. & Garbisa, S. (2003) Neutrophil restraint by green tea: inhibition of inflammation, associated angiogenesis, and pulmonary fibrosis. J. Immunol. 170, 4335-4341.
17. Dulloo, A.G., Rohrer, D., Girardier, L., Mensi, N., Fathi, M., Chantre, P. & Vandermander, J. (1999) Efficacy of a green tea extract rich in catechin polyphenols and caffeine in increasing 24-h energy expenditure and fat oxidation in humans. Am. J. Clin. Nutr. 70, 1040-1045.
18. Dulloo, A.G., Seudoux, J., Girardier, L., Chantre, P. & Vandermander, J. (2000) Green tea and thermogenesis: interactions between catechin-polyphenols, caffeine, and sympathetic activity. Int. J. Obes. Relat. Metab. Disord. 24, 252-258.
19. Fox, C., Pencina, M.J., Meigs, J.B., Vasan, R.S., Levitzky, Y.S. & D'Agostino, R.B. (2006) Trends in the incidence of type 2 diabetes mellitus from the 1970s to the 1990s: the Framingham Heart Study. Circulation 113, 2914-2918.
20. Garcia-Estevez, D., Araujo-Vilar, D., Fiestras-Janeiro, G., Saavedra-Gonzalez, A. & Cabezas-Cerrato, J. (2003) Comparison of several insulin sensitivity indices derived from basal plasma insulin and glucose levels with minimal model indices. Horm. Metab. Res. 35, 13-17.
21. Haffner, S.M., Kennedy, E., Gonzalez, C., Stern, M.P. & Miettinen, H. (1996) A prospective analysis of the HOMA model. The Mexico City Diabetes Study. Diabetes Care 19, 1138-1141.
22. Herman, D.R., Ganz, P., Petersen, L. & Greendale, G.A. (2005) Obesity and cardiovascular risk factors in young breast cancer survivors: the Cancer and Menopause Study (CAMS). Breast Cancer Res. Treat. 93, 13-23.
23. Van Het Hof, K.H., De Boer, H.S., Wiseman, S.A., Lien, N., Westrate, J.A. & Tijburg, L.B. (1997) Consumption of green or black tea does not increase resistance of low-density lipoprotein to oxidation in humans. Am. J. Clin. Nutr. 66, 1125-1132.
24. Hsu, C.H., Tsai, T.H., Kao, Y.H., Hwang, K.C., Tseng, T.Y. & Chou, P. (2008) Effect of green tea extract on obese women: a randomised, double-blind, placebo-controlled clinical trial. Clin. Nutr. 27, 363-370.
25. Inami, S., Takano, M., Yamamoto, M., Murakami, D., Tajika, K., Yodogawa, K., Yokoyama, S., Ohno, N., Ohba, T., Sano, J., Ibuki, C., Seino, Y. & Mizuno, K. (2007) Tea catechin consumption reduces circulating oxidised low-density lipoprotein. Int. Heart J. 48, 725-732.
26. Islam, M.S. & Choi, H. (2007) Green tea, anti-diabetic or diabetogenic: a dose response study. Biofactors 29, 45-53.
27. Iso, H., Date, C., Wakai, K., Fukui, M. & Tamakoshi, A. (2006) The relationship between green tea and total caffeine intake and risk for self-reported type 2 diabetes among Japanese adults. Ann. Intern. Med. 144, 554-562.
28. Jayagopal, V., Kilpatrick, E.S., Jennings, P.E., Hepburn, D.A. & Atkin, S.L. (2002) Biological variation of homeostasis model assessment-derived insulin resistance in type 2 diabetes. Diabetes Care 25, 2022-2025.
29. Jochmann, N., Baumann, G. & Stangl, V. (2008) Green tea and cardiovascular disease: from molecular targets towards human health. Curr. Opin. Clin. Nutr. Metab. Care 11, 758-765.
30. Kao, Y.H., Hiipakka, R.A. & Liao, S. (2000) Modulation of endocrine systems and food intake by green tea epigallocatechin gallate. Endocrinology 141, 980-987.
31. Khosla, T. & Lowe, C.R. (1967) Indices of obesity derived from body weight and height. Br. J. Prev. Soc. Med. 21, 122-128.
32. Kuriyama, S., Shimazu, T., Ohmori, K., Kikuchi, N., Nakaya, N., Nishino, Y., Tsubono, Y. & Tsuji, I. (2006) Green tea consumption and mortality due to cardiovascular disease, cancer, and all causes in Japan: the Ohsaki study. JAMA 296, 1255-1265.
33. Lean, M.E., Han, T.S. & Morrison, C.E. (1995) Waist circumference as a measure for indicating need for weight management. BMJ 311, 158-164.
34. Lin, J.K. & Lin-Shiau, S.Y. (2006) Mechanisms of hypolipidemic and anti-obesity effects of tea and tea polyphenols. Mol. Nutr. Food Res. 50, 211-217.
35. Lipscombe, L.L., Goodwin, P.J., Zinman, B., McLaughlin, J.R. & Hux, J.E. (2008) The impact of diabetes on survival following breast cancer. Breast Cancer Res. Treat. 109, 389-395.
36. Mackenzie, T., Leary, L. & Brooks, W.B. (2007) The effect of an extract of green and black tea on glucose control in adults with type 2 diabetes mellitus: double-blind randomised study. Metabolism 56, 1340-1344.
37. Matsumoto, N., Ishigaki, F., Ishigaki, A., Iwashina, H. & Hard, Y. (1993) Reduction of blood glucose levels by tea catechins. Biosci. Biotechnol. Biochem. 57, 525-527.
38. McTiernan, A. (2005) Obesity and cancer: the risks, science, and potential management strategies. Oncology 19, 871-881.
39. Moon, H.S., Lee, H.G., Choi, Y.J., Kim, T.G. & Cho, C.S. (2007) Proposed mechanisms of (-)-epigallocatechin-3-gallate for anti-obesity. Chem. Biol. Interact. 167, 85-89.
40. Moyers, S.B. & Kumar, N.B. (2004) Green tea polyphenols and cancer chemoprevention: multiple mechanisms and endpoints for phase II trials. Nutr. Rev. 62, 204-211.
41. Nagao, T., Hase, T. & Tokimitsu, I. (2007) A green tea extract high in catechins reduces body fat and cardiovascular risks in humans. Obesity (Silver Spring) 15, 1473-1483.
42. Nagao, T., Meguro, S., Hase, T., Otsuka, K., Komikado, M., Tokimitsu, I., Yamamoto, T. & Yamamoto, K. (2009) A catechin-rich beverage improves obesity and blood glucose control in patients with type 2 diabetes. Obesity (Silver Spring) 17, 310-317.
43. Nantz, M.P., Rowe, C.P., Bukowski, J.F. & Percival, S.S. (2009) Standardized capsule of Camellia sinensis lowers cardiovascular risk factors in a randomised, double-blind, placebo-controlled study. Nutrition 25, 147-154.
44. Osada, K., Takahashi, M., Hoshina, S., Nakamura, M., Nakamura, S. & Sugano, M. (2001) Tea catechins inhibit cholesterol oxidation accompanying oxidation of low density lipoprotein in vitro. Comp. Biochem. Physiol. C Toxicol. Pharmacol. 128, 153-164.
45. Pasanisi, P., Berrino, F., De Petris, M., Venturelli, E., Mastroianni, A. & Panico, S. (2006) Metabolic syndrome as a prognostic factor for breast cancer recurrences. Int. J. Cancer 119, 236-238.
46. Ritenbaugh, C., Aickin, M., Taren, D., Teufel, N., Graver, E., Woolf, K. & Alberts, D.S. (1997) Use of a food frequency questionnaire to screen for dietary eligibility in a randomised cancer prevention phase III trial. Cancer Epidemiol. Biomarkers Prev. 6, 347-354.
47. Rock, C.L. & Demark-Wahnefried, W. (2002) Nutrition and survival after the diagnosis of breast cancer: a review of the evidence. J. Clin. Oncol. 20, 3302-3316.
48. Sabu, M.C., Smitha, K. & Kuttan, R. (2002) Anti-diabetic activity of green tea polyphenols and their role in reducing oxidative stress in experimental diabetes. J. Ethnopharmacol. 83, 109-116.
49. Shimazu, T., Kuriyama, S., Hozawa, A., Ohmori, K., Sato, Y., Nakaya, N., Nishino, Y., Tsubono, Y. & Tsuji, I. (2007) Dietary patterns and cardiovascular disease mortality in Japan: a prospective cohort study. Int. J. Epidemiol. 36, 600-609.
50. Shimizu, M., Kobayashi, Y., Suzuki, M., Satsu, H. & Miyamoto, Y. (2000) Regulation of intestinal glucose transport by tea catechins. Biofactors 13, 61-65.
51. Shixian, Q., VanCrey, B., Shi, J., Kakuda, Y. & Jiang, Y. (2006) Obesity and thermogenesis related to the consumption of caffeine, ephedrine, capsaicin, and green tea. J. Med. Food. 9, 451-458.
52. Sinagra, D., Amato, C., Scarpilta, A.M., Brigandì, M., Amato, M., Saura, G., Latteri, M.A. & Caimi, G. (2002) Metabolic syndrome and breast cancer risk. Eur. Rev. Med. Pharmacol. Sci. 6, 55-59.
53. Staten, L.K., Taren, D.L., Howell, W.H., Tobar, M., Poehlman, E.T., Hill, A., Reid, P.M. & Ritenbaugh, C. (2001) Validation of the Arizona Activity Frequency Questionnaire using doubly labeled water. Med. Sci. Sports Exerc. 33, 1959-1967.
54. Taylor, H.L., Jacobs, D.R., Schucker, B., Knudsen, J., Leon, A.S. & Debacker, G. (1978) A questionnaire for the assessment of leisure time physical activities. J. Chronic Dis. 31, 741-755.
55. Thomson, C.A., Giuliano, A., Rock, C.L., Ritenbaugh, C.K., Flatt, S.W., Faerber, S., Newman, V., Caan, B., Graver, E., Hartz, V., Whitacre, R., Parker, F., Pierce, J.P. & Marshall, J.R. (2003) Measuring dietary change in a diet intervention trial: comparing food frequency questionnaire and dietary recalls. Am. J. Epidemiol. 157, 754-762.
56. Tsuchida, T., Itakura, H. & Nakamura, H. (2002) Reduction of body fat in humans by long-term ingestion of catechins. Prog. Med. 22, 2189-2203.
57. US Department of Agriculture (2000) Continuous Survey of Food Intakes by Individuals (CSFII) 1994-1996, 1998. Beltsville, MD: Beltsville Human Nutrition Research Center.
58. Venables, M.C., Hulston, C.J., Cox, H.R. & Jeukendrup, A.E. (2008) Green tea extract ingestion, fat oxidation, and glucose tolerance in healthy humans. Am. J. Clin. Nutr. 87, 778-784.
59. Wallace, T.M., Levy, J.C. & Matthews, D.R. (2004) Use and abuse of HOMA modeling. Diabetes Care 27, 1487-1495.
60. Westerterp-Plantenga, M., Diepvens, K., Joosen, A.M., Bérubé-Parent, S. & Tremblay, A. (2006) Metabolic effects of spices, teas, and caffeine. Physiol. Behav. 89, 85-91.
61. Whiteman, M.K., Hillis, S.D., Curtis, K.M., McDonald, J.A., Wingo, P.A. & Marchbanks, P.A. (2005) Body mass and mortality after breast cancer diagnosis. Cancer Epidemiol. Biomarkers Prev. 14, 2009-2014.
62. Wolfram, S. (2007) Effects of green tea and EGCG on cardiovascular and metabolic health. J. Am. Coll. Nutr. 26, 373S-388S.
63. Wolfram, S., Wang, Y. & Thielecke, F. (2006) Anti-obesity effects of green tea: from bedside to bench. Mol. Nutr. Food Res. 50, 176-187.
64. Yang, Y.C., Lu, F.H., Wu, J.S., Wu, C.H. & Chang, C.J. (2004) The protective effect of habitual tea consumption on hypertension. Arch. Intern. Med. 164, 1534-1540.
65. Zaveri, N. (2006) Green tea and its polyphenolic catechins: medicinal uses in cancer and noncancer applications. Life Sci. 78, 2073-2080.
66. Zhang, R., Xiao, W., Wang, X., Wu, X. & Tian, W. (2006) Novel inhibitors of fatty-acid synthase from green tea (Camellia sinensis Xihu Longjing) with high activity and a new reacting site. Biotechnol. Appl. Biochem. 43, 1-7.
67. Zhong, L., Furne, J.K. & Levitt, M.D. (2006) An extract of black, green, and mulberry teas causes malabsorption of carbohydrate but not of triacylglycerol in healthy volunteers. Am. J. Clin. Nutr. 84, 551-555.