Expression of IFNγR2 mutated in a dileucine internalization motif reinstates IFNγ signaling and apoptosis in human T lymphocytes

Immunology Letters

Volumn 134, Issue 1, 2010, Pages 17-25

  Boselli, Daniela ^a   Ragimbeau, Josiane ^b   Orlando, Luca ^a   Cappello, Paola ^a   Capello, Michela ^a   Ambrogio, Chiara ^a   Chiarle, Roberto ^a   Marsili, Giulia ^c   Battistini, Angela ^c   Giovarelli, Mirella ^a   Pellegrini, Sandra ^b   Novelli, Francesco ^a  

^a UNIVERSITY OF TURIN   (Italy)

^b CNRS   (France)

^c ISTITUTO SUPERIORE DI SANITÀ   (Italy)

Author keywords

Cytokine receptor; Internalization; Signal transduction; T cells

Indexed keywords

ALANINE; FAS ANTIGEN; FAS LIGAND; GAMMA INTERFERON; GAMMA INTERFERON RECEPTOR; GAMMA INTERFERON RECEPTOR R2 CHAIN; LENTIVIRUS VECTOR; LEUCINE; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MUTANT PROTEIN; RETROVIRUS VECTOR; STAT1 PROTEIN; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL SURFACE; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; GENE MUTATION; HUMAN; HUMAN CELL; INTERNALIZATION; INTRACELLULAR SIGNALING; LYMPHOCYTE PROLIFERATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN MOTIF; PROTEIN PHOSPHORYLATION; SCID MOUSE; T LYMPHOBLAST; T LYMPHOCYTE; TUMOR GROWTH; TUMOR VOLUME; VIRAL GENE DELIVERY SYSTEM; WILD TYPE;

AMINO ACID MOTIFS; ANIMALS; ANTIGENS, CD95; APOPTOSIS; BLOTTING, WESTERN; CELL LINE, TUMOR; DIPEPTIDES; ENDOCYTOSIS; FAS LIGAND PROTEIN; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; INTERFERON-GAMMA; JURKAT CELLS; LEUCINE; LYMPHOMA, T-CELL; MICE; MICE, SCID; MUTATION; PHOSPHORYLATION; RECEPTORS, INTERFERON; SIGNAL TRANSDUCTION; STAT1 TRANSCRIPTION FACTOR; T-LYMPHOCYTES; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 78049273169     PISSN: 01652478     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.imlet.2010.08.005     Document Type: Article

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