Influence of small doses of various drug vehicles on acetaminophen-induced liver injury

Canadian Journal of Physiology and Pharmacology

Volumn 88, Issue 10, 2010, Pages 960-967

  Kelava, Tomislav ^a   Ćavar, Ivan ^b   Čulo, Filip ^a,b  

^a UNIVERSITY OF ZAGREB   (Croatia)

^b UNIVERSITY OF MOSTAR   (Bosnia and Herzegovina)

Author keywords

Acetaminophen; Dimethylformamide; Dimethylsulfoxide; Ethanol; Liver injury; Propylene glycol; Tween 20

Indexed keywords

ALANINE AMINOTRANSFERASE; ALCOHOL; DIMETHYL SULFOXIDE; DRUG VEHICLE; GALACTOSAMINE; GLUTATHIONE; LIPOPOLYSACCHARIDE; N,N DIMETHYLFORMAMIDE; PARACETAMOL; PHENOBARBITAL; POLYSORBATE 20; PROPYLENE GLYCOL; SOLVENT; THIOL DERIVATIVE;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG INDUCED DISEASE; HISTOPATHOLOGY; LIVER HISTOLOGY; LIVER INJURY; LIVER NECROSIS; LIVER PROTECTION; LIVER TOXICITY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEPLETION;

EID: 77958521946     PISSN: 00084212     EISSN: 12057541     Source Type: Journal    
DOI: 10.1139/Y10-065     Document Type: Article

References (44)

1. Bartsch, W., Sponer, G., Dietmann, K., and Fuchs, G. 1976. Acute toxicity of various solvents in the mouse and rat. LD50 of etha-nol, diethylacetamide, dimethylformamide, dimefhylsulfoxide, glycerine, N-mefhylpyrrolidone, polyethylene glycol 400, 1,2-propanediol and Tween 20. Arzneimittelforschung, 26(8): 1581-1583. PMID: 1036956.
2. Belardinelli, M.C., Pereira, F., Baldo, G., Vicente Tavares, A.M., Kieling, CO., da Silveira, T.R., et al. 2008. Adult derived mononuclear bone marrow cells improve survival in a model of acetaminophen-induced acute liver failure in rats. Toxicology, 247(1): 1-5. doi:10.1016/j.tox.2008.01.015. PMID:18336983.
3. Bradford, M.M. 1976. A rapid and sensitive method for the quanti-tation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72(1-2): 248-254. doi: 10.1016/0003-2697(76)90527-3. PMID:942051.
4. Chan, W.H., Liao, J.W., Chou, C.P., Chan, P.K., Wei, C.F., and Ueng, T.H. 2009. Induction of CYP1A1, 2B, 2E1 and 3A in rat liver by organochlorine pesticide dicofol. Toxicol. Lett. 190(2): 150-155. doi:10.1016/j.toxlet.2009.07.005. PMID:19595748.
5. Chen, C.P., Boyadjieva, N.I., Advis, J.P., and Sarkar, D.K. 2006. Ethanol suppression of the hypothalamic proopiomelanocortin level and the splenic NK cell cytolytic activity is associated with a reduction in the expression of proinflammatory cytokines but not anti-inflammatory cytokines in neuroendocrine and immune cells. Alcohol. Clin. Exp. Res. 30(11): 1925-1932. doi:10.1111/j.l530-0277.2006.00237.x. PMID: 17067358.
6. Denning, D.W., and Webster, A.D. 1987. Detrimental effect of pro-pylene glycol on natural killer cell and neutrophil function. J. Pharm. Pharmacol. 39(3): 236-238. PMID:2883293.
7. Donthamsetty, S., Bhave, V.S., Mitra, M.S., Latendresse, J.R., and Mehendale, H.M. 2008. Nonalcoholic steatohepatitic (NASH) mice are protected from higher hepatotoxicity of acetaminophen upon induction of PPARot with clofibrate.Toxicol. Appl. Pharmacol. 230(3): 327-337. doi:10.1016/j.taap.2008.02.031. PMID: 18501395.
8. Dunphy, G.B., Chen, G., and Webster, J.M. 2007. The antioxidants dimethylsulfoxide and dimethylthiourea affect the immediate adhesion responses of larval haemocytes from 3 lepidopteran insect species. Can. J. Microbiol. 53(12): 1330-1347. doi: 10. 1139/W07-096. PMID: 18059566.
9. El-Hassan, H., Anwar, K., Macanas-Pirard, P., Crabtree, M., Chow, S.C., Johnson, V.L., et al. 2003. Involvement of mitochondria in acetaminophen-induced apoptosis and hepatic injury: roles of cytochrome c, Bax, Bid, and caspases. Toxicol. Appl. Pharmacol. 191(2): 118-129. doi:10.1016/S0041-008X(03)00240-0. PMID: 12946648.
10. Ellman, G.L. 1959. Tissue sulfhydryl groups. Arch. Biochem. Bio-phys. 82(1): 70-77. doi:10.1016/0003-9861(59)90090-6. PMID: 13650640.
11. Ganey, P.E., Luyendyk, J.P., Newport, S.W., Eagle, T.M., Maddox, J.F., Mackman, N., and Roth, RA. 2007. Role of the coagulation system in acetaminophen-induced hepatotoxicity in mice. Hepatology, 46(4): 1177-1186. doi:10.1002/hep.21779. PMID: 17654741.
12. Guarner, F., Boughton-Smith, N.K., Blackwell, G.J., and Moncada, S. 1988. Reduction by prostacyclin of acetaminophen-induced liver toxicity in the mouse. Hepatology, 8(2): 248-253. doi:10. 1002/hep.1840080210. PMID:3281885.
13. Gunawan, B.K., and Kaplowitz, N. 2007. Mechanisms of drug-induced liver disease. Clin. Liver Dis. 11(3): 459-75. doi: 10. 1016/j.cld.2007.06.001. PMID: 17723915.
14. Harrill, A.H., Ross, P.K., Gatti, D.M., Threadgill, D.W., and Ru-syn, I. 2009. Population-based discovery of toxicogenomics bio-markers for hepatotoxicity using a laboratory strain diversity panel. Toxicol. Sci. 110(1): 235-243. doi:10.1093/toxsci/ kfp096. PMID:19420014.
15. Henderson, C.J., Otto, D.M., Carrie, D., Magnuson, M.A., McLaren, A.W., Rosewell, I., and Wolf, C.R. 2003. Inactivation of the hepatic cytochrome P450 system by conditional deletion of hepatic cytochrome P450 reductase. J. Biol. Chem. 278(15): 13480-13486. doi:10.1074/jbc.M212087200. PMID: 12566435.
16. Hughes, R.D., Gove, CD., and Williams, R. 1991. Protective effects of propylene glycol, a solvent used pharmaceutically, against paracetamol-induced liver injury in mice. Biochem. Pharmacol. 42(3): 710-713. doi:10.1016/0006-2952(91)90339-7. PMID:1859476.
17. Iida, C, Fujii, K., Koga, E., Washino, Y., Ichi, I., and Kojo, S. 2007. Inhibitory effect of dimethyl sulfoxide (DMSO) on necrosis and oxidative stress caused by D-galactosamine in the rat liver. J. Nutr. Sci. Vitaminol. (Tokyo), 53(2): 160-165. doi:10. 3177/jnsv.53.160. PMID: 17616004.
18. Imbriani, M., Ghittori, S., Prestinoni, A., Longoni, P., Cascone, G., and Gamba, G. 1986. Effects of dimethylformamide (DMF) on coagulation and platelet activity. Arch. Environ. Health, 41(2): 90-93. PMID:3718008.
19. Jaeschke, H., Cover, C, and Bajt, M.L. 2006. Role of caspases in acetaminophen-induced liver injury. Life Sci. 78(15): 1670-1676. doi:10.1016/j.lfs.2005.07.003. PMID: 16226279.
20. Jeffery, E.H., Arndt, K., and Haschek, W.M. 1988. Mechanism of inhibition of hepatic bioactivation of paracetamol by dimethyl sulfoxide. Drug Metabol. Drug Interact. 6(3-4): 413-124. PMID:3271647.
21. Jodynis-Liebert, J., Matlawska, I., Bylka, W., and Murias, M. 2005. Protective effect of Aquilegia vulgaris (L.) on APAP-induced oxidative stress in rats. J. Ethnopharmacol. 97(2): 351-358. doi:10.1016/jjep.2004.11.027. PMID:15707775.
22. Kamanaka, Y., Kawabata, A., Matsuya, H., Taga, C, Sekiguchi, F., and Kawao, N. 2003. Effect of a potent iNOS inhibitor (ONO-1714) on acetaminophen-induced hepatotoxicity in the rat. Life Sci. 74(6): 793-802. doi:10.1016/j.lfs.2003.09.036. PMID: 14654171.
23. Kunze, M. 1975. Production of interferon in the white mouse by dimethyl sulfoxide. Ann. N. Y. Acad. Sci. 243(1): 308-310. doi:10.1111/j. 1749-6632.1975.tb25370.x. PMID: 1055550.
24. Laine, J.E., Auriola, S., Pasanen, M., and Juvonen, R.O. 2009. Acetaminophen bioactivation by human cytochrome P450 enzymes and animal microsomes. Xenobiotica, 39(1): 11-21. doi:10.1080/00498250802512830. PMID: 19219744.
25. Lee, W.M. 2004. Acetaminophen and the U.S. Acute Liver Failure Study Group: lowering the risks of hepatic failure. Hepatology, 40(1): 6-9. doi:10.1002/hep.20293. PMID: 15239078.
26. Lee, S.M., Cho, T.S., Kim, D.J., and Cha, Y.N. 1999. Protective effect of ethanol against acetaminophen-induced hepatotoxicity in mice: role of NADH:quinone reductase. Biochem. Pharmacol. 58(10): 1547-1555. doi:10.1016/S0006-2952(99)00248-8. PMID:10535745.
27. Liu, Z.X., Govindarajan, S., and Kaplowitz, N. 2004. Innate immune system plays a critical role in determining the progression and severity of acetaminophen hepatotoxicity. Gastroenterology, 127(6): 1760-1774. doi:10.1053/j.gastro.2004.08.053. PMID: 15578514.
28. Marotta, F., Yadav, H., Gumaste, U., Helmy, A., Jain, S., and Minelli, E. 2009. Protective effect of a phytocompound on oxidative stress and DNA fragmentation against paracetamol-induced liver damage. Ann. Hepatol. 8(1): 50-56. PMID: 19221534.
29. Masson, M.J., Carpenter, L.D., Graf, ML., and Pohl, L.R. 2008. Pathogenic role of natural killer T and natural killer cells in acetaminophen-induced liver injury in mice is dependent on the presence of dimethyl sulfoxide. Hepatology, 48(3): 889-897. doi:10.1002/hep.22400. PMID: 18712839.
30. Mitchell, J.R., Jollow, D.J., Potter, W.Z., Davis, D.C., Gillette, J.R., and Brodie, B.B. 1973. Acetaminophen-induced hepatic necrosis. I. Role of drug metabolism. J. Pharmacol. Exp. Ther. 187(1): 185-194. PMID:4746326.
31. Nelson, S.D. 1982. Metabolic activation and drug toxicity. J. Med. Chem. 25(7): 753-765. doi:10.1021/jm00349a001. PMID: 7050382.
32. Norris, W., Paredes, A.H., and Lewis, J.H. 2008. Drug-induced liver injury in 2007. Curr. Opin. Gastroenterol. 24(3): 287-297. doi:10.1097/MOG.0b013e3282f9764b. PMID: 18408456.
33. Oshiro, T.T., Teixeira, C.F., and Oga, S. 1990. Propylene glycol enhances anti-inflammatory effects of phenylbutazone. Gen. Pharmacol. 21(1): 131-134. PMID:2298384.
34. Oz, H.S., and Chen, T.S. 2008. Green-tea polyphenols downregu-late cyclooxygenase and Bcl-2 activity in acetaminophen-induced hepatotoxicity. Dig. Dis. Sci. 53(11): 2980-2988. doi:10. 1007/sl0620-008-0239-5. PMID: 18373199.
35. Pan, H.N., Sun, R., Jaruga, B., Hong, F., Kim, W.H., and Gao, B. 2006. Chronic ethanol consumption inhibits hepatic natural killer cell activity and accelerates murine cytomegalovirus-in-duced hepatitis. Alcohol. Clin. Exp. Res. 30(9): 1615-1623. doi:10.1111/j.l530-0277.2006.00194.x. PMID: 16930225.
36. Piel, M.T., Aldrete, J.A., and Jones, G. 1969. Influence of enzyme induction on the sleeping time of rats. Can. Anaesth. Soc. J. 16(6): 538-546. doi:10.1007/BF03004547. PMID:5346844.
37. Prescott, L.F. 2000. Paracetamol, alcohol and the liver. Br. J. Clin. Pharmacol. 49(4): 291-301. doi:10.1046/j. 1365-2125.2000. 00167.x. PMID: 10759684.
38. Reisman, S.A., Aleksunes, L.M., and Klaassen, CD. 2009. Oleano-lic acid activates Nrf2 and protects from acetaminophen hepatotoxicity via Nrf2-dependent and Nrf2-independent processes. Biochem. Pharmacol. 77(7): 1273-1282. doi:10.1016/j.bcp.2008. 12.028. PMID: 19283895.
39. Renić, M., Culo, F., Bilić, A., Bukovec, Z., Sabolović, D., and Zu-panović, Z. 1993. The effect of interleukin 1 a on acetaminophen-induced hepatotoxicity. Cytokine, 5(3): 192-197. doi:10. 1016/1043-4666(93)90004-0. PMID:8218930.
40. Thomsen, M.S., Loft, S., Roberts, D.W., and Poulsen, HE. 1995. Cytochrome P4502E1 inhibition by propylene glycol prevents acetaminophen (paracetamol) hepatotoxicity in mice without cytochrome P4501A2 inhibition. Pharmacol. Toxicol. 76(6): 395-399. doi:10.1111/j.1600-0773.1995.tb00168.x. PMID:7479582.
41. Tolando, R., Zanovello, A., Ferrara, R., Iley, J.N., and Manno, M. 2001. Inactivation of rat liver cytochrome P450 (P450) by N,N-dimethylformamide and AgV-dimefhylacetamide. Toxicol. Lett. 124(1-3): 101-111. doi:10.1016/S0378-4274(01)00384-8. PMID: 11684362.
42. Yamasaki, T., Klein, G., Ljunggren, H.G., Hoglund, P., Ohlen, C, Petersson, M.G., and Karre, K. 1988. Effects of dimethyl sulfoxide treatment on H-2 expression and susceptibility to NK or cy-totoxic T-lymphocyte-mediated lysis of the YAC-1 lymphoma and its p 2-microglobulin-deficient variant. J. Natl. Cancer Inst. 80(4): 263-269. doi:10.1093/jnci/80.4.263. PMID:3127594.
43. Yoon, MY., Kim, S.J., Lee, B.H., Chung, J.H., and Kim, Y.C. 2006. Effects of dimethylsulfoxide on metabolism and toxicity of acetaminophen in mice. Biol. Pharm. Bull. 29(8): 1618-1624. doi:10.1248/bpb.29.1618. PMID: 16880615.
44. Zaher, H., Buters, J.T., Ward, J.M., Bruno, M.K., Lucas, A.M., Stern, S.T., et al. 1998. Protection against acetaminophen toxicity in CYP1A2 and CYP2E1 double-null mice. Toxicol. Appl. Pharmacol. 152(1): 193-199. doi:10.1006/taap.1998.8501. PMID:9772215.