Turmeric: An overview of potential health benefits

Nutrition Today

Volumn 45, Issue 5, 2010, Pages 216-225

  Singletary, Keith ^a  

^a UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 77958514271     PISSN: 0029666X     EISSN: 15389839     Source Type: Journal    
DOI: 10.1097/NT.0b013e3181f1d72c     Document Type: Article

References (119)

1. Hatcher H, Planalp R, Cho J, Torti F, Torti S. Curcumin: from ancient medicine to current clinical trials. Cell Mol Life Sci. 2008;65:1631-1652.
2. Chaturvedi T. Uses of turmeric in dentistry: an update. Indian J Dent Res. 2009;20:107-109.
3. Tayyem R, Heath D, Al-Delaimy W, Rock C. Curcumin content of turmeric and curry powders. Nutr Cancer. 2006;55:126-131.
4. Pari L, Tewas D, Eckel J. Role of curcumin in health and disease. Arch Physiol Biochem. 2008;114:127-149.
5. Maheshwari R, Singh A, Gaddipati J, Srimal R. Multiple biological activities of curcumin: short review. Life Sci. 2006;78:2081-2087.
6. Gautam R, Jachak S. Recent developments in anti-inflammatory natural products. Med Res Rev. 2009; 29:767-820.
7. Anand P, Kunnumakkara A, Newman R, Aggarwal B. Bioavailability of curcumin: problems and promises. Mol Pharm. 2007;4:807-818.
8. Aggarwal B, Kumar A, Bharti A. Anticancer potential of curcumin: preclinical and clinical studies. Anticancer Res. 2003;23:363-398.
9. Lao C, Ruffin M, Normolle D, et al. Dose escalation of a curcuminoid formulation. BMC Complement Altern Med. 2006;6:10.
10. Cheng A, Hsu C, Lin J, et al. Phase I clinical trial of curcumin, a chemopreventive agent, in patients with high-risk or premalignant lesions. Anticancer Res. 2001;21: 2895-2900.
11. Shoba G, Joy D, Joseph T, Majeed M, Rajendran R, Srinivas P. Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers. Planta Med. 1998;64:353-356.
12. Hsu C, Cheng A. Clinical studies with curcumin. Adv Exp Med Biol. 2007;595:471-480.
13. Sharma R, Euden S, Platton S, et al. Phase I clinical trials of oral curcumin: biomarkers of systemic activity and compliance. Clin Cancer Res. 2004;10:6847-6854.
14. Aggarwal B, Surh Y, Sishodia S. Clinical studies with curcumin. Adv Exp Med Biol. 2007;595:471-480.
15. Yang C, Sang S, Lambert J, Lee M. Bioavailability issues in studying the health effects of plant polyphenolic compounds. Mol Nutr Food Res. 2008;52:139-151.
16. Garcea G, Jones D, Singh R, et al. Detection of curcumin and its metabolites in hepatic tissue and portal blood of patients following oral administration. Br J Cancer. 2004; 90:1011-1015.
17. Singh S. From exotic spice to modern drug?Cell. 2007;130:765-768.
18. Chin S, Iyer K, Saunders M, et al. Encapsulation and sustained release of curcumin using superparamagnetic silica reservoirs. Chem Eur J. 2009;15:5661-5665.
19. Aggarwal B, Sung B. Pharmacological basis for the role of curcumin in chronic diseases: an age-old spice with modern targets. Trends Pharmacol Sci. 2008;30:85-94.
20. Steward W, Gescher A. Curcumin in cancer management: recent results of analogue research and clinical studies and desirable future research. Mol Nutr Food Res. 2008; 52:1005-1009.
21. Aggarwal B, Sundaram C, Malani N, Ichikawa H. Curcumin: the Indian solid gold. Adv Exp Med Biol. 2007;595:1-75.
22. Menon V, Sudheer A. Antioxidant and anti-inflammatory properties of curcumin. Adv Exp Med Biol. 2007;595: 105-125.
23. Aggarwal B, Harikumar K. Potential therapeutic effects of curcumin, the anti-inflammatory agent in turmeric, against neurodegenerative, cardiovascular, pulmonary, metabolic, autoimmune and neoplastic diseases. Int J Biochem Cell Biol. 2009;41:40-59.
24. Goel A, Ajaikumar B, Kunnumakkara B, Aggarwal B. Curcumin as "curecumin": from kitchen to clinic. Biochem Pharmacol. 2008;75:787-809.
25. Thomasset S, Berry D, Garcea G, Marczylo T, Steward W, Gescher A. Dietary polyphenolic phytochemicals-promising cancer chemopreventive agents in humans? A review of their clinical properties. Int J Cancer. 2006;120:451-458.
26. Strimpakos A, Sharma R. Curcumin: preventive and therapeutic properties in laboratory studies and clinical trials. Antioxid Redox Signal. 2008;10:511-545.
27. Saif M. Is there a role for herbal medicine in the treatment of pancreatic cancer?J Pancreas (Online). 2008;9:403-407.
28. Epelbaum R, Vizel B, Bar-Sela G. Phase II study of curcumin and gemcitabine in patients with advanced pancreatic cancer. J Clin Oncol. 2008;26:abstract 15619.
29. Villegas I, Sanchez-Fidalgo S, De La Lastra C. New mechanisms and the therapeutic potential of curcumin for colorectal cancer. Mol Nutr Food Res. 2008;52:1040-1061.
30. Anand P, Sundaram C, Jhurani S, Kunnumakkara A, Aggarwal B. Curcumin and cancer: an "old-age" disease with and "age-old" solution. Cancer Lett. 2008;267: 133-164.
31. Lopez-Lazaro M. Anticancer and carcinogenic properties of curcumin: considerations for its clinical development as a cancer chemopreventive and chemotherapeutic agent. Mol Nutr Food Res. 2008;52:103-127.
32. Narayanan N, Nargi D, Randolph C, Narayanan B. Liposome encapsulation of curcumin and resveratrol in combination reduces prostate cancer incidence in PTEN knockout mice. Int J Cancer. 2009;125:1-8.
33. Purkayastha S, Berliner A, Fernando S, et al. Curcumin blocks brain tumor formation. Brain Res. 2009;1266: 130-138.
34. Li Z, Ouyang K, Jiang X, Wang D, Hu Y. Curcumin induces apoptosis and inhibits growth of human Burkitt's lymphoma in xenograft mouse model. Mol Cells. 2009; 27:283-289.
35. Labbozzetta M, Notarbartolo M, Poma P, et al. Curcumin as a possible lead compound against hormone-independent, multidrug resistant breast cancer. Ann NY Acad Sci. 2009;1155:278-283.
36. Li J, Wang Y, Yang C, Wang P, et al. PEGylated curcumin conjugate inhibits pancreatic cancer cell growth through inactivation of Jab1. Mol Pharmacol. 2009;76:81-90.
37. Ganta S, Amiji M. Coadministration of paclitaxel and curcumin in nanoemulsion formulations to overcome multidrug resistance in tumor cells. Mol Pharmacol. 2009;6:928-939.
38. Cen L, Hutzen B, Ball S, et al. New structural analogues of curcumin exhibit potent growth suppressive activity in human colorectal carcinoma cells. BMC Cancer. 2009;9:99.
39. Dance-Barnes S, Kock N, Moore J, et al. Lung tumor promotion by curcumin. Carcinogenesis. 2009;30: 1016-1023.
40. Beevers C, Chen L, Liu L, Luo Y, Webster N, Huang S. Curcumin disrupts the mammalian target of rapamycin-raptor complex. Cancer Res. 2009;69: 1000-1008.
41. Kunnumakkara A, Anand P, Aggarwal B. Curcumin inhibits proliferation, invasion, angiogenesis, and metastasis of different cancers through interaction with multiple cell signaling proteins. Cancer Lett. 2008;269: 199-125.
42. Chainini-Wu N. Safety and anti-inflammatory activity of curcumin: a component of turmeric ( Curcuma longa). J Altern Complement Med. 2003;9:161-168.
43. Jagtap S, Meganathan K, Wagh V, Winkler J, Hescheler J, Sachinidis A. Chemoprotective mechanism of the natural compounds epigallocatechin-3- O-gallate, quercetin and curcumin against cancer and cardiovascular diseases. Curr Med Chem. 2009;16:1451-1462.
44. Tsvetkov P, Asher G, Reiss V, Shaul Y, Sachs L, Loten J. Inhibition of NAD(P)H:quinine oxidoreductase 1 activity and induction of p53 degradation by the natural phenolic compound curcumin. Proc Natl Acad Sci U S A. 2005;102: 5535-5540.
45. Moos P, Edes K, Mullally J, Fitzpatrick F. Curcumin impairs tumour suppressor p53 function in colon cancer cells. Carcinogenesis. 2004;25:1611-1617.
46. Siddiqui R, Hassan S, Harvey K, et al. Attenuation of proteolysis and muscle wasting by curcumin C3 complex in MAC16 colon tumor-bearing mice. Br J Nutr. 2009; 27:1-9.
47. Alamdari N, O'Neal P, Hasselgren P. Curcumin and muscle wasting-a new role for an old drug? Nutrition. 2009;25:125-129.
48. Holt P, Katz S, Kirshoff R. Curcumin therapy in inflammatory bowel disease: a pilot study. Dig Dis Sci. 2005;50:2191-2193.
49. Ng S, Kamm M. Therapeutic strategies for the management of ulcerative colitis. Inflamm Bowel Dis. 2009;15:935-950.
50. Hanai H, Iida T, Takeuchi K, et al. Curcumin maintenance therapy for ulcerative colitis: randomized, multicenter, double-blind, placebo-controlled trial. Clin Gastroenterol Hepatol. 2006;4:1502-1506.
51. Arafa H, Hemuda R, El-Bahrawy A, Hamada F. Prophylactic role of curcumin in dextran sulfate sodium (DSS)-induced ulcerative colitis murine model. Food Chem Toxicol. 2009;47:1311-1317.
52. Yaday V, Suresh S, Devi K, Yadav S. Novel formulation of solid lipid microparticles of curcumin for anti-angiogenic and anti-inflammatory activity for optimization of therapy of inflammatory bowel disease. J Pharm Pharmacol. 2009;61:311-321.
53. Chiu J, Khan Z, Farhangkhoee H, Chakrabati S. Curcumin prevents diabetes-associated abnormalities in the kidneys by inhibiting p300 and nuclear factor-kappaB. Nutrition. 2009;25:964-972.
54. Ejaz A, Wu D, Kwan P, Meydani M. Curcumin inhibits adipogenesis in 3T3-L1 adipocytes and angiogenesis and obesity in C57/BL mice. J Nutr. 2009;139:919-925.
55. Balamurugan A, Akhov L, Selvarai G, Pugazhenthi S. Induction of antioxidant enzymes by curcumin and its analogues in human islets: implications in transplantation. Pancreas. 2009;38:454-460.
56. Srinivasan M. Effect of curcumin on blood sugar as seen in a diabetic subject. Indian J Med Sci. 1972;26:269-270.
57. Ushatani P, Mateen A, Naidu M, Raju Y, Chandon N. Effect of NCB-02, atorvastatin and placebo on endothelial function, oxidative stress and inflammatory markers in patients with type 2 diabetes mellitus: a randomized, parallel-group, placebo-controlled, 8-week study. Drugs Res Design. 2008;9:243-250.
58. Srivastava G, Mehta J. Currying the heart: curcumin and cardioprotection. J Cardiovascul Pharmacol Ther. 2009; 14:22-27.
59. Ali M, Maidagal M, Goli D. Cardioprotective effect of tetrahydrocurcumin and rutin on lipid peroxides and antioxidants in experimentally-induced myocardial infarction in rats. Pharmazie. 2009;64:132-136.
60. Wongcharoen W, Phrommintikul A. The protective role of curcumin in cardiovascular diseases. Int J Cardiol. 2009;133:145-151.
61. Miriyala S, Panchatcharam M, Rengarajulu P. Cardioprotective effects of curcumin. Adv Exp Med Biol. 2007;595:359-377.
62. Pongchaidecha A, Lailerd N, Boonprasert W, Chattipakorn N. Effects of curcuminoid supplements on cardiac autonomic status in high fat-induced obese rats. Nutrition. 2009;25:1-9.
63. Wakade C, King M, Laird M, Alleyne C, Dhandapani K. Curcumin attenuates vascular inflammation and cerebral vasospasm after subarachnoid hemorrhage in mice. Antioxid Redox Signal. 2009;11:35-45.
64. Ovbiagele B. Potential role of curcumin in stroke prevention. Exp Rev Neurother. 2008;8:1175-1176.
65. Dohare P, Garg P, Jain V, Nath C, Ray M. Dose dependence and therapeutic window for the neuroprotective effects of curcumin in thromboembolic model of rat. Behav Brain Res. 2008;193:289-297.
66. Ringman J, Frautschy S, Cole G, Masterman D, Cummings J. A potential role of the curry spice curcumin in Alzheimer's disease. Curr Alzheimers Res. 2005;2: 131-136.
67. Kelley B, Knopman D. Alternative medicine and Alzheimer's disease. Neurologist. 2008;14:299-306.
68. Cashman J, Ghirmai S, Abel K, Fiala M. Immune defects in Alzheimer's disease: new medications development. BMC Neuroscience. 2008;9(suppl 2):S13.
69. Garcia-Alloza M, Borrelli L, Rozkalne A, Hyman B, Bacskai B. Curcumin labels amyloid pathology in vivo, disrupts existing plaques, and partially restores distorted neuritis in an Alzheimer mouse model. J Neurochem. 2007;102:1095-1104.
70. Ahmed T, Gilani A. Inhibitory effect of curcuminoids on acetylcholinesterase activity and attenuation of scopolamine-induced amnesia may explain medicinal use of turmeric in Alzheimer's disease. Pharmacol Biochem Behav. 2009;91:554-559.
71. Li Y, Wang F, Pan Y, Qiang L, Cheng G, Zhang W, Kong L. Antidepressant-like effects of curcumin on serotoninergic receptor-coupled AC-cAMP pathway in chronic unpredictable mild stress of rats. Prog Neuropsychopharmacol Biol Psychiatry. 2009;33:435-449.
72. Tang H, Lu D, Pan R, Qin X, Xiong H, Dong J. Curcumin improves spatial memory impairment induced by human immunodeficiency virus type 1 glycoprotein 120 -3 loop peptide in rats. Life Sci. 2009;85:1-10.
73. Conbay L, Foley A, O'Boyle N, et al. Curcumin-induced degradation of PKC delta is associated with enhanced dentate NCAM PSA expression and spatial learning in adult and aged Wistar rats. Biochem Pharmacol. 2009; 77:1254-1265.
74. Isik A, Celik T, Ulusoy G, et al. Curcumin ameliorates impaired insulin/IGF signaling and memory deficit in a streptozotocin-treated rat model. Age (Dordr). 2009;31: 39-49.
75. Thomas P, Wang Y, Zhong J, et al. Grape seed polyphenol and curcumin reduce genomic instability events in a transgenic mouse model for Alzheimer's disease. Mutat Res. 2009;661:25-34.
76. Ishrat T, Hoda M, Khan M, et al. Amelioration of cognitive deficits and neurodegeneration by curcumin in rat model of sporadic dementia of Alzheimer's type (SDAT). Eur Neuropsychopharmacol. 2009;19:636-647.
77. Wu A, Ying Z, Gomez-Pinilla F. Dietary curcumin counteracts the outcome of traumatic brain injury on oxidative stress synaptic plasticity and cognition. Exp Neurol. 2006;197:309-317.
78. Sharma S, Zhuang Y, Ying Z, Gomez-Pinilla F. Dietary curcumin supplementation counteracts reduction in levels of molecules involved in energy homeostasis after brain trauma. Neuroscience. 2009;161:1037-1044.
79. Ng T, Chian P, Lee T, Chua H, Lim L, Kua E. Curry consumption and cognitive function in the eldrly. Am J Epidemiol. 2006;164:898-906.
80. Baum L, Lam C, Cheung S, et al. Six month, randomized, placebo-controlled, pilot clinical trial of curcumin in patients with Alzheimer's disease. J Clin Psychopharmacol. 2008;28:110-113.
81. Khanna D, Sethi G, Ahn K, et al. Natural products as a gold mine for arthritis treatment. Curr Opin Pharmacol. 2007;7:344-351.
82. Jaqetia G, Aggarwal B. "Spicing up" of the immune system by curcumin. J Clin Immunol. 2007;27:19-35.
83. Cheung K, Khor T, Kong A. Synergistic effect of combination of phenethylisothiocyanate and sulforaphane or curcumin and sulforaphane in the inhibition of inflammation. Pharm Res. 2009;26:224-231.
84. Innes J, Fuller C, Grover E, Kelly A, Burn J. Randomised, double-blind, placebo-controlled parallel group study of P54FP for the treatment of dogs with osteoarthritis. Vet Rec. 2003;152:457-460.
85. Gregory P, Sperry M, Friedman A. Dietary supplements for osteoarthritis (clinical report). Am Fam Physician. 2008;77:177-184.
86. Gautam S, Gao X, Dulchavsky S. Immunomodulation by curcumin. Adv Exp Med Biol. 2007;595:327-341.
87. Lev-Ari S, Lichtenberg D, Arber N. Compositions for treatment of cancer and inflammation. Recent Pat Anticancer Drug Discov. 2008;3:55-62.
88. Kurup V, Barrio C. Immunomodulatory effects of curcumin in allergy. Mol Nutr Food Res. 2008;52:1031-1039.
89. Suzuki M, Betsuyaki T, Ito Y, et al. Curcumin attenuates elastase- and cigarette smoke-induced pulmonary emphysema in mice. Am J Physiol Lung Cell Mol Physiol. 2009;296:L614-623.
90. Conteas C, Panossian A, Tran T, Singh H. Treatment of HIV-associated diarrhea with curcumin. Dig Dis Sci. 2009;54:2188-2191.
91. Agarwal D, Saikla D, Tiwari R, et al. Demethoxycurcumin and its semisynthetic analogues as antitubercular agents. Plant Med. 2008;74:1828-1831.
92. De R, Kundu P, Swarnakar S, et al. Antimicrobial activity of curcumin against Indian Helicobacter pylori and also during mice infection. Antimicrob Agents Chemother. 2009;53:1592-1597.
93. Allam G. Immunomodulatory effects of curcumin treatment on murine schistosomiasis treatment. Immunobiology. 2009;214:712-727.
94. Ji H, Shen L. Interactions of curcumin with PfATP6 model and implications for its antimalarial mechanism. Biiorg Med Chem Lett. 2009;19:2453-2455.
95. Mishra K, Dash A, Swain B, Dey N. Anti-malarial activities of Andrographis paniculata and Hedyotis corymbosa extracts and their combination with curcumin. Malar J. 2009;8:26.
96. Mishra S, Karmodiya K, Surolia N, Surolia A. Synthesis and exploration of novel curcumin analogues as anti-malarial agents. Bioorg Med Chem. 2008;16: 2894-2902.
97. Thanapazham R, Sharma A, Maheshwari R. Beneficial role of curcumin in skin diseases. Adv Exp Med Biol. 2007; 595:343-357.
98. Kurd S, Smith N, Van-orhees A, et al. Oral curcumin in the treatment of moderate to severe psoriasis vulgaris: a prospective clinical trial. J Am Dermatol. 2008;58: 625-631.
99. Baumann L. Botanical ingredients in cosmeceuticals. J Drugs Dermatol. 2007;6:1084-1088.
100. Shoskes D, Lapierre C, Cruz-Corerra, et al. Beneficial effects of the bioflavonoids curcumin and quercetin on early function in cadaveric renal transplantation: a randomized placebo-controlled trial. Transplantation. 2005;80:1556-1559.
101. Cekmen M, Ilbey Y, Ozbek E, Simsek A, Somay A, Ersoz C. Curcumin prevents oxidative renal damage induced by acetaminophen in rats. Food Chem Toxicol. 2009;47:1480-1484.
102. Ghosh S, Massey H, Krieg R, et al. Curcumin ameliorates renal failure in 5/6 nephrectomized rats: role of inflammation. Am J Physiol Renal Physiol. 2009;296: 1146-1157.
103. Swarnakar S, Paul S. Curcumin arrests endometriosis by down regulation of matrix metalloproteinase-9 activity. Indian J Biochem Biophys. 2009;46:59-65.
104. Bright J. Curcumin and autoimmune disease. Adv Exp Med Biol. 2007;595:425-451.
105. Biswas T, Mukherjee B. Plant medicines of Indian origin for wound healing activity. Int J Low Extrem Wounds. 2003;2:25-39.
106. Sidhu G, Singh D, Thaloor D, et al. Enhancement of wound healing by curcumin in animals. Wound Repair Regen. 1998;6:167-177.
107. Bishnoi M, Chopra K, Kulkarni S. Protective effect of curcumin, the active principle of turmeric (Curcuma longa) in haloperidol-induced orofacial dyskinesia and associated behavioral, biochemical and neurochemical changes in rat brain. Pharmacol Biochem Behav. 2008; 88:511-522.
108. Gupta A, Vij G, sharma S, Tirkey N, Rishi P, Chopra K. Curcumin, a polyphenolic antioxidant, attenuates chronic fatigue syndrome in murine water immersion stress model. Immunobiology. 2009;214:33-39.
109. Sharma R, Steward W, Gescher A. Pharmacokinetics and pharmacodynamics of curcumin. Adv Exp Med Biol. 2007;595:453-470.
110. National Toxicology Program. NTP toxicology and carcinogenesis studies of turmeric oleoresin (CAS no. 8024-37-1) (major component 79%-85% curcumin CAS no. 458-37-7) in F344/N rats and B6C3F1 mice (feed studies). Natl Toxicol Program Tech Rep Ser. 1993;427:1-275.
111. Ganiger S, Malleshappa H, Krishnappa H, Rajashekhar G, Ramakrishar-Rao V, Sullivan F. A two generation reproductive toxicity study with curcumin, turmeric yellow in Wistar rats. Food Chem Toxicol. 2007;45:64-69.
112. Shankar T, Shantha N, Ramesh H, Murthy I, Murthy V. Toxicity studies on turmeric ( Curcuma longa): acute toxicity studies in rats, guinea pigs and monkeys. India J Exp Biol. 1980;18:73-75.
113. Bayes M, Rabasseda X, Prous J. Gateways to clinical trials. Meth Find Exp Clin Pharmacol. 2007;29:697-735. (Pubitemid 351255461)
114. Joshi J, Ghaisas S, Vaidya A, et al. Early human safety study of turmeric oil ( Curcuma longa oil) administered orally in healthy volunteers. J Assoc Physic India. 2003;51:1055-1060.
115. Dhillon N, Aggarwal B, Newman R, et al. Curcumin and pancreatic cancer: phase II clinical trial experience. J Clin Oncol. 2007;25:(18 suppl):Abstract 4599.
116. Tang N, Larson-Meyer D, Liebman M. Effects of cinnamon and turmeric on urinary oxalate excretion, plasma lipids, and plasma glucose in healthy subjects. Am J Clin Nutr. 2008;87:1262-1267.
117. He J, Terhaag B, Zang C, et al. Unexpected effect of concomitantly administered curcumin on the pharmacokinetics of talinol in healthy Chinese volunteers. Eur J Clin Pharmacol. 2007;63:663-668.
118. Corson T, Crews C. Molecular understanding and modern application of traditional medicines: triumphs and trials. Cell. 2007;130:769-774.
119. Talalay P, Talalay P. The importance of using scientific principles in the development of medicinal agents from plants. Acad Med. 2001;76:238-247.