Genetically modified dendritic cells in cancer immunotherapy

Dendritic Cells in Cancer

Volumn , Issue , 2009, Pages 347-363

  Morrison, Brian J ^b,c   Steel, Jason C ^c   Gregory, Melissa ^a   Morris, John C ^c   Malyguine, Anatoli M ^a  

^a SAIC FREDERICK INC   (United States)

^b GRIFFITH UNIVERSITY   (Australia)

^c NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 77958458049     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1007/978-0-387-88611-4_23     Document Type: Chapter

References (53)

1. Antonia, S. J., Mirza, N., Fricke, I., Chiappori, A., Thompson, P., Williams, N., Bepler, G., Simon, G., Janssen, W., Lee, J. H., Menander, K., Chada, S. and Gabrilovich, D I 2006. Combination of p53 cancer vaccine with chemotherapy in patients with extensive stage small cell lung cancer. Clin Cancer Res 12:878-887
2. Arthur, J. F., Butterfield, L. H., Roth, M. D., Bui, L. A., Kiertscher, S. M., Lau, R., Dubinett, S., Glaspy, J., McBride, W. H. and Economou, J. S. 1997. A comparison of gene transfer methods in human dendritic cells. Cancer Gene Ther 4:17-25
3. Balkir,L., Tourkova, I. L.,Makarenkova, V. P., Shurin,G.V., Robbins, P. D.,Yin,X.M., Chatta, G. and Shurin, M. R. 2004. Comparative analysis of dendritic cells transduced with different anti-Apoptotic molecules: Sensitivity to tumor-induced apoptosis. J Gene Med 6:537-544
4. Bonehill, A., Tuyaerts, S., Van Nuffel, A. M., Heirman, C., Bos, T. J., Fostier, K., Neyns, B. and Thielemans, K. 2008. Enhancing the T-cell stimulatory capacity of human dendritic cells by co-electroporation with CD40L, CD70 and constitutively active TLR4 encoding mRNA. Mol Ther 16:1170-1180
5. Bontkes, H. J., Kramer, D., Ruizendaal, J. J., Meijer, C. J. and Hooijberg, E. 2008. Tumor associated antigen and interleukin-12 mRNA transfected dendritic cells enhance effector function of natural killer cells and antigen specific T-cells. Clin Immunol 127:375-384
6. Bronte, V., Kasic, T., Gri, G., Gallana, K., Borsellino, G., Marigo, I., Battistini, L., Iafrate, M., Prayer-Galetti, T., Pagano, F. and Viola, A. 2005. Boosting antitumor responses of T lymphocytes infiltrating human prostate cancers. J Exp Med 201:1257-1268
7. Caretti, E., Devarajan, K., Coudry, R., Ross, E., Clapper, M. L., Cooper, H. S. and Bellacosa, A. 2008. Comparison of RNA amplification methods and chip platforms for microarray analysis of samples processed by laser capture microdissection. J Cell Biochem 103:556-563
8. Chhabra, A., Chakraborty, N. G. and Mukherji, B. 2008. Silencing of endogenous IL-10 in human dendritic cells leads to the generation of an improved CTL response against human melanoma associated antigenic epitope, MART-1 27-35. Clin Immunol 126:251-259
9. Dannull, J., Su, Z., Rizzieri, D., Yang, B. K., Coleman, D., Yancey, D., Zhang, A., Dahm, P., Chao, N., Gilboa, E. and Vieweg, J. 2005. Enhancement of vaccine-mediated antitumor immunity in cancer patients after depletion of regulatory T cells. J Clin Invest 115:3623-3633
10. De Santo, C., Serafini, P., Marigo, I., Dolcetti, L., Bolla, M., Del Soldato, P., Melani, C., Guiducci, C., Colombo, M. P., Iezzi, M., Musiani, P., Zanovello, P. and Bronte, V. 2005. Nitroaspirin corrects immune dysfunction in tumor-bearing hosts and promotes tumor eradication by cancer vaccination. Proc Natl Acad Sci USA 102:4185-4190
11. Gilboa, E. 2007. DC-based cancer vaccines. J Clin Invest 117:1195-1203
12. Gilboa, E. and Vieweg, J. 2004. Cancer immunotherapy with mRNA-Transfected dendritic cells. Immunol Rev 199:251-263
13. Gonzá lez-Carmona, M., Märten, A., Hoffmann, P., Schneider, C., Sievers, E., Schmidt-Wolf, I., Sauerbruch, T. and Caselmann, W. 2006. Patient-Derived dendritic cells transduced with an a-fetoprotein-encoding adenovirus and co-cultured with autologous cytokineinduced lymphocytes induce a specific and strong immune response against hepatocellular carcinoma cells. Liver Int 26:369-379
14. Grunebach, F., Kayser, K., Weck, M. M., Muller, M. R., Appel, S. and Brossart, P. 2005. Cotransfection of dendritic cells withRNAcoding forHER-2/neu and 4-1BBL increases the induction of tumor antigen specific cytotoxic T lymphocytes. Cancer Gene Ther 12:749-756
15. Heiser, A., Coleman, D., Dannull, J., Yancey, D., Maurice, M. A., Lallas, C. D., Dahm, P., Niedzwiecki, D., Gilboa, E. and Vieweg, J. 2002. Autologous dendritic cells transfected with prostate-specific antigen RNA stimulate CTL responses against metastatic prostate tumors. J Clin Invest 109:409-417
16. Hirano, F., Kaneko, K., Tamura, H., Dong, H.,Wang, S., Ichikawa, M., Rietz, C., Flies, D. B., Lau, J. S., Zhu, G., Tamada, K. and Chen, L. 2005. Blockade of B7-H1 and PD-1 by monoclonal antibodies potentiates cancer therapeutic immunity. Cancer Res 65:1089-1096
17. Kikuchi, T. 2006. Genetically modified dendritic cells for therapeutic immunity. Tohoku J Exp Med 208:1-8
18. Lizee, G., RadVanyi, L. G., Overwijk, W. W. and Hwu, P. 2006. Improving antitumor immune responses by circumventing immunoregulatory cells and mechanisms. Clin Cancer Res 12:4794-4803
19. Manto Vani, A., Romero, P, Palucka, AK, Marincola, FM 2008. Tumour immunity: Effector response to tumour and role of the microenvironment. Lancet 371:771-783
20. Mao, C. P., Hung, C. F. and Wu, T. C. 2007. Immunotherapeutic strategies employing RNA interference technology for the control of cancers. J Biomed Sci 14:15-29
21. Mazzolini, G., Alfaro, C., Sangro, B., Feijoo, E., Ruiz, J., Benito, A., Tirapu, I., Arina, A., Sola, J., Herraiz, M., Lucena, F., Olague, C., Subtil, J., Quiroga, J., Herrero, I., Sadaba, B., Bendandi, M., Qian, C., Prieto, J. and Melero, I. 2005. Intratumoral injection of dendritic cells engineered to secrete interleukin-12 by recombinant adenovirus in patients with metastatic gastrointestinal carcinomas. J Clin Oncol 23:999-1010
22. Melero, I., Duarte, M., Ruiz, J., Sangro, B., Galofre, J., Mazzolini, G., Bustos, M., Qian, C. and Prieto, J. 1999. Intratumoral injection of bone-marrow derived dendritic cells engineered to produce interleukin-12 induces complete regression of established murine transplantable colon adenocarcinomas. Gene Ther 6:1779-1784
23. Ménard, C., Martin, F., Apetoh, L., Bouyer, F. and Ghiringhelli, F. 2008. Cancer chemotherapy: Not only a direct cytotoxic effect, but also an adjuVant for antitumor immunity. Cancer Immunol Immunother. Epub ahead of print
24. Metharom, P., Ellem, K. A., Schmidt, C. and Wei, M. Q. 2001. Lentiviral vector-mediated tyrosinase-related protein 2 gene transfer to dendritic cells for the therapy of melanoma. Hum Gene Ther 12:2203-2213
25. Midgley, R. and Kerr, D. 2005. Bevacizumab-current status and future directions. Ann Oncol 16:999-1004
26. Morandi, F., Chiesa, S., Bocca, P., Millo, E., Salis, A., Solari, M., Pistoia, V. and Prigione, I. 2006. Tumor mRNA-Transfected dendritic cells stimulate the generation of CTL that recognize neuroblastoma-Associated antigens and kill tumor cells: Immunotherapeutic implications. Neoplasia 8:833-842
27. Morse, M. A., Clay, T. M., Hobeika, A. C., Osada, T., Khan, S., Chui, S., Niedzwiecki, D., Panicali, D., Schlom, J. and Lyerly, H. K. 2005. Phase I study of immunization with dendritic cells modified with fowlpox encoding carcinoembryonic antigen and costimulatory molecules. Clin Cancer Res 11:3017-3024
28. Morse, M. A., Nair, S. K., Mosca, P. J., Hobeika, A. C., Clay, T. M., Deng, Y., Boczkowski, D., Proia, A., Neidzwiecki, D., Clavien, P. A., Hurwitz, H. I., Schlom, J., Gilboa, E. and Lyerly, H. K. 2003. Immunotherapy with autologous, human dendritic cells transfected with carcinoembryonic antigen mRNA. Cancer Invest 21:341-349
29. Nencioni, A., Grunebach, F., Schmidt, S., Muller, M., Boy, D., Patrone, F., Ballestrero, A. and Brossart, P. 2008. The use of dendritic cells in cancer immunotherapy. Crit Rev Oncol Hematol 65:191-199
30. Ni, X., Richmond, H. M., Liao, X. M., Decker, W. K., Shiue, L. H., Shpall, E. J. and Duvic, M. 2008. Induction of T-cell responses against cutaneous T-cell lymphomas ex vivo by autologous dendritic cells transfected with amplified tumor mRNA. J Invest Dermatol 128:2631-2639
31. Ojima, T., Iwahashi, M., Nakamura, M., Matsuda, K., Nakamori, M., Ueda, K., Naka, T., Ishida, K., Primus, F. J. and Yamaue, H. 2007a. Successful cancer vaccine therapy for carcinoembryonic antigen (CEA)-expressing colon cancer using genetically modified dendritic cells that express CEA and T helper-Type 1 cytokines in CEA transgenic mice. Int J Cancer 120:585-593
32. Ojima, T., Iwahashi, M., Nakamura, M., Matsuda, K., Nakamori, M., Ueda, K., Naka, T., Katsuda, M., Miyazawa, M. and Yamaue, H. 2007b. Benefits of gene transduction of granulocyte macrophage colony-stimulating factor in cancer vaccine using genetically modified dendritic cells. Int J Oncol 31:931-939
33. Osada, T., Chong, G., Tansik, R., Hong, T., Spector, N., Kumar, R., Hurwitz, H. I., Dev, I., Nixon, A. B., Lyerly, H. K., Clay, T. and Morse, M. A. 2008. The effect of anti-VEGF therapy on immature myeloid cell and dendritic cells in cancer patients. Cancer Immunol Immunother 57:1115-1124
34. Osada, T., Clay, T., Hobeika, A., Lyerly, H. K. and Morse, M. A. 2006. NKcell activation by dendritic cell vaccine: A mechanism of action for clinical activity. Cancer Immunol Immunother 55:1122-1131
35. Palucka, A. K., Ueno, H., Fay, J. W. and Banchereau, J. 2007. Taming cancer by inducing immunity via dendritic cells. Immunol Rev 220:129-150
36. Phan, G. Q., Yang, J. C., Sherry, R. M., Hwu, P., Topalian, S. L., Schwartzentruber, D. J., Restifo, N. P., Haworth, L. R., Seipp, C. A., Freezer, L. J., Morton, K. E., Mavroukakis, S. A., Duray, P. H., Steinberg, S. M., Allison, J. P., Davis, T. A. and Rosenberg, S. A. 2003. Cancer regression and autoimmunity induced by cytotoxic T lymphocyte-Associated antigen 4 blockade in patients with metastatic melanoma. Proc Natl Acad Sci USA 100:8372-8377
37. Rabinovich, G. A., Gabrilovich, D. and Sotomayor, E. M. 2007. Immunosuppressive strategies that are mediated by tumor cells. Annu Rev Immunol 25:267-296
38. Ribas, A. 2005. Genetically modified dendritic cells for cancer immunotherapy. Cur Gene Ther 5:619-628
39. Rosenberg, S. A., Restifo, N. P., Yang, J. C., Morgan, R. A. and Dudley, M. E. 2008. Adoptive cell transfer: A clinical path to effective cancer immunotherapy. Nat Rev Cancer 8:299-308
40. Rosenberg, S. A., Yang, J. C. and Restifo, N. P. 2004. Cancer immunotherapy: Moving beyond current vaccines. Nat Med 10:909-915
41. Sakai, Y., Morrison, B. J., Burke, J. D., Park, J. M., Terabe, M., Janik, J. E., Forni, G., Berzofsky, J. A. and Morris, J. C. 2004. Vaccination by genetically modified dendritic cells expressing a truncated neu oncogene prevents development of breast cancer in transgenic mice. Cancer Res 64:8022-8028
42. Su, Z., Dannull, J., Yang, B. K., Dahm, P., Coleman, D., Yancey, D., Sichi, S., Niedzwiecki, D., Boczkowski, D., Gilboa, E. and Vieweg, J. 2005. Telomerase mRNA-Transfected dendritic cells stimulate antigen-specific CD8+ and CD4+ T-cell responses in patients with metastatic prostate cancer. J Immunol 174:3798-3807
43. Tong, X. M., Zheng, S. E., Bader, A., Yao, H. P., Wu, N. P., Altmeyer, P., Brockmeyer, N. H. and Jin, J. 2008. Construction of expression vector of hTERT-hIL18 fusion gene and induction of cytotoxic T lymphocyte response against hTERT. Eur J Med Res 13:7-14
44. Tyagi, P. 2005. First-line treatment with bevacizumab and paclitaxel prolongs progressionfree survival in metastatic breast cancer. Clin Breast Cancer 6:105-107
45. Van Tendeloo, V. F., Ponsaerts, P., Lardon, F., Nijs, G., Lenjou, M., Van Broeckhoven, C., Van Bockstaele, D. R. and Berneman, Z. N. 2001. Highly efficient gene delivery bymRNA electroporation in human hematopoietic cells: Superiority to lipofection and passive pulsing of mRNA and to electroporation of plasmid cDNA for tumor antigen loading of dendritic cells. Blood 98:49-56
46. Vujanovic, L., Ranieri, E., Gambotto, A., Olson, W. C., Kirkwood, J. M. and Storkus, W. J. 2006. IL-12p70 and IL-18 gene-modified dendritic cells loaded with tumor antigen-Derived peptides or recombinant protein effectively stimulate specific Type-1 CD4+ T-cell responses from normal donors and melanoma patients in vitro. Cancer Gene Ther 13:798-805
47. Vulink, A., Radford, K. J., Melief, C. and Hart, D. N. 2008. Dendritic cells in cancer immunotherapy. Adv Cancer Res 99:363-407
48. Wargo, J., Schumacher, L., Comin-Anduix, B., Dissette, V., Glaspy, J., McBride, W., Butterfield, L., Economou, J. and Ribas, A. 2005. Natural killer cells play a critical role in the immune response following immunization with melanoma-Antigen-engineered dendritic cells. Cancer Gene Ther 12:516-527
49. Woo, C. Y., Clay, T. M., Lyerly, H. K., Morse, M. A. and Osada, T. 2006. Role of natural killer cell function in dendritic cell-based vaccines. Expert Rev Vaccines 5:55-65
50. Woo, E. Y., Yeh, H., Chu, C. S., Schlienger, K., Carroll, R. G., Riley, J. L., Kaiser, L. R. and June, C. H. 2002. Cutting edge: Regulatory T cells from lung cancer patients directly inhibit autologous T cell proliferation. J Immunol 168:4272-4276
51. Yamanaka, R., Zullo, S. A., Ramsey, J., Yajima, N., Tsuchiya, N., Tanaka, R., Blaese, M. and Xanthopoulos, K. G. 2002. Marked enhancement of antitumor immune responses in mouse brain tumor models by genetically modified dendritic cells producing Semliki Forest virus-mediated interleukin-12. J Neurosurg 97:611-618
52. Zhang, H. M., Zhang, L. W., Ren, J., Fan, L., Si, X. M. and Liu, W. C. 2006. Induction of alpha-fetoprotein-specific CD4-And CD8-mediated T-cell response using RNA-Transfected dendritic cells. Cell Immunol 239:144-150
53. Zhong, H., Shurin, M. R. and Han, B. 2007. Optimizing dendritic cell-based immunotherapy for cancer. Expert Rev Vaccines 6:333-345