Benefits of gene transduction of granulocyte macrophage colony-stimulating factor in cancer vaccine using genetically modified dendritic cells

International Journal of Oncology

Volumn 31, Issue 4, 2007, Pages 931-939

  Ojima, Toshiyasu ^a   Iwahashi, Makoto ^a   Nakamura, Masaki ^a   Matsuda, Kenji ^a   Nakamori, Mikihito ^a   Ueda, Kentaro ^a   Naka, Teiji ^a   Katsuda, Masahiro ^a   Miyazawa, Motoki ^a   Yamaue, Hiroki ^a  

^a WAKAYAMA MEDICAL UNIVERSITY   (Japan)

Author keywords

Adenoviral vector; Apoptosis; Dendritic cells; Granulocyte macrophage colony stimulating factor

Indexed keywords

CANCER VACCINE; CARCINOEMBRYONIC ANTIGEN; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR;

ADENOVIRUS; APOPTOSIS; ARTICLE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL LINE; CYTOTOXIC T LYMPHOCYTE; DENDRITIC CELL; ENZYME LINKED IMMUNOSORBENT ASSAY; FEASIBILITY STUDY; FLOW CYTOMETRY; GENE VECTOR; GENETIC TRANSDUCTION; GENETIC TRANSFECTION; GENETICS; HUMAN; IMMUNOLOGY; IMMUNOTHERAPY; METABOLISM; TRANSPLANTATION;

ADENOVIRIDAE; APOPTOSIS; CANCER VACCINES; CARCINOEMBRYONIC ANTIGEN; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CELL LINE; DENDRITIC CELLS; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEASIBILITY STUDIES; FLOW CYTOMETRY; GENETIC VECTORS; GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; HUMANS; IMMUNOTHERAPY; T-LYMPHOCYTES, CYTOTOXIC; TRANSDUCTION, GENETIC; TRANSFECTION;

EID: 35848940280     PISSN: 10196439     EISSN: 17912423     Source Type: Journal    
DOI: 10.3892/ijo.31.4.931     Document Type: Article

References (32)

1. Banchereau J and Steinman RM: Dendritic cells and the control of immunity. Nature 392: 245-252, 1998.
2. Thompson JA, Grunert F and Zimmermann W: Carcino-embryonic antigen gene family: molecular biology and clinical perspectives. J Clin Lab Anal 5: 344-366, 1991.
3. Matsuda K, Tsunoda T, Tanaka H, et al: Enhancement of cytotoxic T-lymphocyte responses in patients with gastrointestinal malignancies following vaccination with CEA peptide-pulsed dendritic cells. Cancer Immunol Immunother 53: 609-616, 2004.
4. Nakamura M, Iwahashi M, Nakamori M, et al: Dendritic cells transduced with tumor-associated antigen gene elicit potent therapeutic antitumor immunity: comparison with immunodominant peptide-pulsed DCs. Oncology 68: 163-170, 2005.
5. Cho HI, Kim HJ, Oh ST and Kim TG: In vitro induction of carcinoembryonic antigen (CEA)-specific cytotoxic T lymphocytes by dendritic cells transduced with recombinant adenoviruses. Vaccine 22: 224-236, 2003.
6. Oh ST, Kim CH, Park MY, et al: Dendritic cells transduced with recombinant adenoviruses induce more efficient anti-tumor immunity than dendritic cells pulsed with peptide. Vaccine 24: 2860-2868, 2006.
7. Sallusto F and Lanzavecchia A: Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor ?. J Exp Med 179: 1109-1118, 1994. (Pubitemid 24091769)
8. Nakamura M, Iwahashi M, Nakamori M, Ueda K, Matsuura I, Noguchi K and Yamaue H: Dendritic cells genetically engineered to simultaneously express endogenous tumor antigen and granulocyte macrophage colony-stimulating factor elicit potent therapeutic antitumor immunity. Clin Cancer Res 8: 2742-2749, 2002.
9. Ojima T, Iwahashi M, Nakamura M, et al: Successful cancer vaccine therapy for carcinoembryonic antigen (CEA)-expressing colon cancer using genetically modified dendritic cells expressing CEA and T helper-type 1 cytokines in CEA transgenic mice. Int J Cancer 120: 585-593, 2007.
10. Markowicz S and Engleman EG: Granulocyte-macrophage colony-stimulating factor promotes differentiation and survival of human peripheral blood dendritic cells in vitro. J Clin Invest 85: 955-961, 1990. (Pubitemid 20087502)
11. Vasilijic S, Colic M and Vucevic D: Granulocyte-macrophage colony stimulating factor is an anti-apoptotic cytokine for thymic dendritic cells and a significant modulator of their accessory function. Immunol Lett 86: 99-112, 2003.
12. Eastman A and Rigas JR: Modulation of apoptosis signaling pathways and cell cycle regulation. Semin Oncol 26: 7-16, 1999.
13. Ito M, Minamiya Y, Kawai H, et al: Tumor-derived TGF beta-1 induces dendritic cell apoptosis in the sentinel lymph node. J Immunol 176: 5637-5643, 2006.
14. Roskrow MA, Suzuki N, Gan Y, et al: Epstein-Barr virus (EBV)-specific cytotoxic T lymphocytes for the treatment of patients with EBV-positive relapsed Hodgkin's disease. Blood 91: 2925-2934, 1998.
15. Romani N, Gruner S, Brang D, et al: Proliferating dendritic cell progenitors in human blood. J Exp Med 180: 83-93, 1994. (Pubitemid 24181058)
16. Ueda K, Iwahashi M, Nakamori M, Nakamura M, Matsuura I, Yamaue H and Tanimura H: Carcinoembryonic antigen-specific suicide gene therapy of cytosine deaminase/5-fluorocytosine enhanced by the Cre/loxP system in the orthotopic gastric carcinoma model. Cancer Res 61: 6158-6162, 2001.
17. Nishimura N, Nishioka Y, Shinohara T and Sone S: Enhanced efficiency by centrifugal manipulation of adenovirus-mediated interleukin 12 gene transduction into human monocyte-derived dendritic cells. Hum Gene Ther 12: 333-346, 2001. (Pubitemid 32186646)
18. Ogihara T, Iinuma H and Okinaga K: Usefulness of immunomodulators for maturation of dendritic cells. Int J Oncol 25: 453-459, 2004.
19. Ojima T, Iwahashi M, Nakamura M, et al: The boosting effect of co-transduction with cytokine genes on cancer vaccine therapy using genetically modified dendritic cells expressing tumor-associated antigen. Int J Oncol 28: 947-953, 2006.
20. Kianmanesh A, Hackett NR, Lee JM, Kikuchi T, Korst RJ and Crystal RG: Intratumoral administration of low doses of an adenovirus vector encoding tumor necrosis factor alpha together with naive dendritic cells elicits significant suppression of tumor growth without toxicity. Hum Gene Ther 12: 2035-2049, 2001.
21. Witmer-Pack MD, Olivier W, Valinsky J, Schuler G and Steinman RM: Granulocyte/macrophage colony-stimulating factor is essential for the viability and function of cultured murine epidermal Langerhans cells. J Exp Med 166: 1484-1498, 1987. (Pubitemid 18051438)
22. L is critical for dendritic cell survival in vivo. J Immunol 173: 4425-4432, 2004.
23. Faderl S, Harris D, Van Q, Kantarjian HM, Talpaz M and Estrov Z: Granulocyte-macrophage colony-stimulating factor (GM-CSF) induces antiapoptotic and proapoptotic signals in acute myeloid leukemia. Blood 102: 630-637, 2003.
24. Vander Heiden MG and Thompson CB: Bcl-2 proteins: regulators of apoptosis or of mitochondrial homeostasis? Nat Cell Biol 1: E209-E216, 1999.
25. L escape negative selection and are tolerized by clonal anergy and receptor editing. Immunity 9: 35-45, 1998.
26. Hou WS and Van Parijs L: A Bcl-2-dependent molecular timer regulates the lifespan and immunogenicity of dendritic cells. Nat Immunol 5: 583-589, 2004.
27. Ardeshna KM, Pizzey AR, Devereux S and Khwaja A: The PI3 kinase, p38 SAP kinase, and NF-kappaB signal transduction pathways are involved in the survival and maturation of lipopolysaccharide-stimulated human monocyte-derived dendritic cells. Blood 96: 1039-1046, 2000.
28. Park Y, Lee SW and Sung YC: Cutting Edge: CpG DNA inhibits dendritic cell apoptosis by up-regulating cellular inhibitor of apoptosis proteins through the phospha-tidylinositide-3′-OH kinase pathway. J Immunol 168: 5-8, 2002. (Pubitemid 34014095)
29. Pirtskhalaishvili G, Shurin GV, Esche C, et al: Cytokine-mediated protection of human dendritic cells from prostate cancer-induced apoptosis is regulated by the Bcl-2 family of proteins. Br J Cancer 83: 506-513, 2000.
30. Jang MH, Sougawa N, Tanaka T, et al: CCR7 is critically important for migration of dendritic cells in intestinal lamina propria to mesenteric lymph nodes. J Immunol 176: 803-810, 2006.
31. Sanchez-Sanchez N, Riol-Blanco L and Rodriguez-Fernandez JL: The multiple personalities of the chemokine receptor CCR7 in dendritic cells. J Immunol 176: 5153-5159, 2006.
32. Sanchez-Sanchez N, Riol-Blanco L, De la Rosa G, et al: Chemokine receptor CCR7 induces intracellular signaling that inhibits apoptosis of mature dendritic cells. Blood 104: 619-625, 2004. (Pubitemid 38970552)