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Volumn 2, Issue 4, 2010, Pages 219-231

Increased Plp1 gene expression leads to massive microglial cell activation and inflammation throughout the brain

Author keywords

Inflammation; Microglia; Myelin; Oligodendrocyte; Pelizaeus merzbacher disease; Proteolipid protein

Indexed keywords

CYTOKINE; INTERLEUKIN 6; PROTEOLIPID PROTEIN; PROTEOLIPID PROTEIN 1; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

EID: 77958457229     PISSN: None     EISSN: 17590914     Source Type: Journal    
DOI: 10.1042/AN20100016     Document Type: Article
Times cited : (45)

References (73)
  • 2
    • 0033554297 scopus 로고    scopus 로고
    • Distinct phenotypes associated with increasing dosage of the PLP gene: Implications for CMT1A due to PMP22 gene duplication
    • Anderson TJ, Klugmann M, Thomson CE, Schneider A, Readhead C, Nave KA, Griffiths IR (1999) Distinct phenotypes associated with increasing dosage of the PLP gene: implications for CMT1A due to PMP22 gene duplication. Ann NY Acad Sci 883:234-246.
    • (1999) Ann NY Acad Sci , vol.883 , pp. 234-246
    • Anderson, T.J.1    Klugmann, M.2    Thomson, C.E.3    Schneider, A.4    Readhead, C.5    Nave, K.A.6    Griffiths, I.R.7
  • 3
    • 0842308448 scopus 로고    scopus 로고
    • Investigation of cytokine (tumor necrosis factor alpha, interleukin-6, interleukin-10) concentrations in the cerebrospinal fluid of female patients with multiple sclerosis and systemic lupus erythematosus
    • Baraczka K, Nékám K, Pozsonyi T, Szüts I, Ormos G (2004) Investigation of cytokine (tumor necrosis factor alpha, interleukin-6, interleukin-10) concentrations in the cerebrospinal fluid of female patients with multiple sclerosis and systemic lupus erythematosus. Eur J Neurol 11:37-42.
    • (2004) Eur J Neurol , vol.11 , pp. 37-42
    • Baraczka, K.1    Nékám, K.2    Pozsonyi, T.3    Szüts, I.4    Ormos, G.5
  • 5
    • 0032956016 scopus 로고    scopus 로고
    • High-resolution in situ hybridization and TUNEL staining with free-floating brain sections
    • Bessert DA, Skoff RP (1999) High-resolution in situ hybridization and TUNEL staining with free-floating brain sections. J Histochem Cytochem 47:693-702.
    • (1999) J Histochem Cytochem , vol.47 , pp. 693-702
    • Bessert, D.A.1    Skoff, R.P.2
  • 6
    • 24144453087 scopus 로고    scopus 로고
    • Microglia and inflammation-mediated neurodegeneration: Multiple triggers with a common mechanism
    • Block ML, Hong JS (2005) Microglia and inflammation-mediated neurodegeneration: multiple triggers with a common mechanism. Prog Neurobiol 76:77-98.
    • (2005) Prog Neurobiol , vol.76 , pp. 77-98
    • Block, M.L.1    Hong, J.S.2
  • 8
    • 0029127508 scopus 로고
    • Adhesive properties of proteolipid protein are responsible for the compaction of CNS myelin sheaths
    • Boison D, Büssow H, D'Urso D, Müller HW, Stoffel W (1995) Adhesive properties of proteolipid protein are responsible for the compaction of CNS myelin sheaths. J Neurosci 15:5502-5513.
    • (1995) J Neurosci , vol.15 , pp. 5502-5513
    • Boison, D.1    Büssow, H.2    D'Urso D3    Müller, H.W.4    Stoffel, W.5
  • 10
    • 0032900037 scopus 로고    scopus 로고
    • Transgenic Lewis rats overexpressing the proteolipid protein gene: Myelin degeneration and its effect on T cell-mediated experimental autoimmune encephalomyelitis
    • Bradl M, Bauer J, Inomata T, Zielasek J, Nave KA, Toyka K, Lassmann H, Wekerle H (1999) Transgenic Lewis rats overexpressing the proteolipid protein gene: myelin degeneration and its effect on T cell-mediated experimental autoimmune encephalomyelitis. Acta Neuropathol 97:595-606.
    • (1999) Acta Neuropathol , vol.97 , pp. 595-606
    • Bradl, M.1    Bauer, J.2    Inomata, T.3    Zielasek, J.4    Nave, K.A.5    Toyka, K.6    Lassmann, H.7    Wekerle, H.8
  • 11
    • 77955085839 scopus 로고    scopus 로고
    • Inflammatory neurodegeneration and mechanisms of microglial killing of neurons
    • Brown GC, Neher JJ (2010) Inflammatory neurodegeneration and mechanisms of microglial killing of neurons. Mol Neurobiol 41:242-247.
    • (2010) Mol Neurobiol , vol.41 , pp. 242-247
    • Brown, G.C.1    Neher, J.J.2
  • 12
    • 0035194637 scopus 로고    scopus 로고
    • The pathobiology of myelin mutants reveal novel biological functions of the MBP and PLP genes
    • Campagnoni AT, Skoff RP (2001) The pathobiology of myelin mutants reveal novel biological functions of the MBP and PLP genes. Brain Pathol 11:74-91.
    • (2001) Brain Pathol , vol.11 , pp. 74-91
    • Campagnoni, A.T.1    Skoff, R.P.2
  • 13
    • 0035469764 scopus 로고    scopus 로고
    • Differential expression of apoptotic markers in jimpy and in Plp overexpressors: Evidence for different apoptotic pathways
    • Cerghet M, Bessert DA, Nave KA, Skoff RP (2001) Differential expression of apoptotic markers in jimpy and in Plp overexpressors: evidence for different apoptotic pathways. J Neurocytol 30:841-855.
    • (2001) J Neurocytol , vol.30 , pp. 841-855
    • Cerghet, M.1    Bessert, D.A.2    Nave, K.A.3    Skoff, R.P.4
  • 14
    • 56849129516 scopus 로고    scopus 로고
    • Interleukin-1beta and tumor necrosis factor-alpha are expressed by different subsets of microglia and macrophages after ischemic stroke in mice
    • Clausen BH, Lambertsen KL, Babcock AA, Holm TH, Dagnaes-Hansen F, Finsen B (2008) Interleukin-1beta and tumor necrosis factor-alpha are expressed by different subsets of microglia and macrophages after ischemic stroke in mice. J Neuroinflammation 5:46.
    • (2008) J Neuroinflammation , vol.5 , pp. 46
    • Clausen, B.H.1    Lambertsen, K.L.2    Babcock, A.A.3    Holm, T.H.4    Dagnaes-Hansen, F.5    Finsen, B.6
  • 17
    • 34748885573 scopus 로고    scopus 로고
    • Axonal lesion-induced microglial proliferation and microglial cluster formation in the mouse
    • Dissing-Olesen L, Ladeby R, Nielsen H, Toft-Hansen H, Dalmau I, Finsen B (2007) Axonal lesion-induced microglial proliferation and microglial cluster formation in the mouse. Neurosci 149:112-122.
    • (2007) Neurosci , vol.149 , pp. 112-122
    • Dissing-Olesen, L.1    Ladeby, R.2    Nielsen, H.3    Toft-Hansen, H.4    Dalmau, I.5    Finsen, B.6
  • 18
    • 0023404814 scopus 로고
    • Abnormal compact myelin in the myelin-deficient rat: Absence of proteolipid protein correlates with a defect in the intraperiod line
    • Duncan I, Hammang J, Trapp B (1987) Abnormal compact myelin in the myelin-deficient rat: absence of proteolipid protein correlates with a defect in the intraperiod line. Proc Natl Acad Sci USA 84:6287-6291.
    • (1987) Proc Natl Acad Sci USA , vol.84 , pp. 6287-6291
    • Duncan, I.1    Hammang, J.2    Trapp, B.3
  • 22
    • 0032942060 scopus 로고    scopus 로고
    • Microglia as mediators of inflammatory and degenerative diseases
    • Gonzalez-Scarano, F. and G. Baltuch (1999) Microglia as mediators of inflammatory and degenerative diseases. Annu Rev Neurosci 22:219-40.
    • (1999) Annu Rev Neurosci , vol.22 , pp. 219-240
    • Gonzalez-Scarano, F.1    Baltuch, G.2
  • 24
    • 0032559544 scopus 로고    scopus 로고
    • Disrupted proteolipid protein trafficking results in oligodendrocyte apoptosis in an animal model of Pelizaeus-Merzbacher disease
    • Gow A, Southwood CM, Lazzarini RA (1998) Disrupted proteolipid protein trafficking results in oligodendrocyte apoptosis in an animal model of Pelizaeus-Merzbacher disease. J Cell Biol 140:925-934.
    • (1998) J Cell Biol , vol.140 , pp. 925-934
    • Gow, A.1    Southwood, C.M.2    Lazzarini, R.A.3
  • 26
    • 38349125335 scopus 로고    scopus 로고
    • Elevated activity and microglial expression of myeloperoxidase in demyelinated cerebral cortex in multiple sclerosis
    • Gray E, Thomas T, Betmouni S, Scolding N, Love S (2008). Elevated activity and microglial expression of myeloperoxidase in demyelinated cerebral cortex in multiple sclerosis. Brain Pathology 18:86-95
    • (2008) Brain Pathology , vol.18 , pp. 86-95
    • Gray, E.1    Thomas, T.2    Betmouni, S.3    Scolding, N.4    Love, S.5
  • 28
    • 0036759150 scopus 로고    scopus 로고
    • Myelin proteolipid protein forms a complex with integrins and may participate in integrin receptor signaling in oligodendrocytes
    • Gudz TI, Schneider TE, Haas TA, Macklin WB (2002) Myelin proteolipid protein forms a complex with integrins and may participate in integrin receptor signaling in oligodendrocytes. J Neurosci 22:7398-7407.
    • (2002) J Neurosci , vol.22 , pp. 7398-7407
    • Gudz, T.I.1    Schneider, T.E.2    Haas, T.A.3    MacKlin, W.B.4
  • 29
    • 71849101064 scopus 로고    scopus 로고
    • Differential regulation of microglial motility by ATP/ADP and adenosine
    • Gyoneva S, Orr AG, Traynelis SF (2009) Differential regulation of microglial motility by ATP/ADP and adenosine. Parkinsonism Relat Disord 15:S195-S199.
    • (2009) Parkinsonism Relat Disord , vol.15
    • Gyoneva, S.1    Orr, A.G.2    Traynelis, S.F.3
  • 30
    • 0027759985 scopus 로고
    • The genetics of Pelizaeus-Merzbacher disease
    • Hodes ME, Pratt VM, Dlouhy SR (1993) The genetics of Pelizaeus-Merzbacher disease. Dev Neurosci 15:383-394.
    • (1993) Dev Neurosci , vol.15 , pp. 383-394
    • Hodes, M.E.1    Pratt, V.M.2    Dlouhy, S.R.3
  • 32
    • 0030601207 scopus 로고    scopus 로고
    • A novel gene iba1 in the major histocompatibility complex class III region encoding an EF hand protein expressed in a monocytic lineage
    • Imai Y, Ibata I, Ito D, Ohsawa K, Kohsaka S (1996) A novel gene iba1 in the major histocompatibility complex class III region encoding an EF hand protein expressed in a monocytic lineage. Biochem Biophys Res Commun 224:855-862.
    • (1996) Biochem Biophys Res Commun , vol.224 , pp. 855-862
    • Imai, Y.1    Ibata, I.2    Ito, D.3    Ohsawa, K.4    Kohsaka, S.5
  • 33
    • 33748138567 scopus 로고    scopus 로고
    • Immune cells contribute to myelin degeneration and axonopathic changes in mice overexpressing proteolipid protein in oligodendrocytes
    • Ip CW, Kroner A, Bendszus M, Leder C, Kobsar I, Fischer S, Wiendl H, Nave KA, Martini R (2006) Immune cells contribute to myelin degeneration and axonopathic changes in mice overexpressing proteolipid protein in oligodendrocytes. Neurobiol Dis 26:8206-8216.
    • (2006) Neurobiol Dis , vol.26 , pp. 8206-8216
    • Ip, C.W.1    Kroner, A.2    Bendszus, M.3    Leder, C.4    Kobsar, I.5    Fischer, S.6    Wiendl, H.7    Nave, K.A.8    Martini, R.9
  • 36
    • 65549162204 scopus 로고    scopus 로고
    • Abnormal production of macrophage inflammatory protein-1alpha by microglial cell lines derived from neonatal brains of Sandhoff disease model mice
    • Kawashita E, Tsuji D, Kawashima N, Nakayama K, Matsuno H, Itoh K (2009) Abnormal production of macrophage inflammatory protein-1alpha by microglial cell lines derived from neonatal brains of Sandhoff disease model mice. J Neurochem 109:1215-1224.
    • (2009) J Neurochem , vol.109 , pp. 1215-1224
    • Kawashita, E.1    Tsuji, D.2    Kawashima, N.3    Nakayama, K.4    Matsuno, H.5    Itoh, K.6
  • 37
    • 0029777329 scopus 로고    scopus 로고
    • Proteolipid protein: Is it more than just a structural component of myelin?
    • Knapp PE (1996) Proteolipid protein: is it more than just a structural component of myelin? Dev Neurosci 18:297-308.
    • (1996) Dev Neurosci , vol.18 , pp. 297-308
    • Knapp, P.E.1
  • 38
    • 0027229366 scopus 로고
    • The pH of jimpy glia is increased: Intracellular measurements using fluorescent laser cytometry
    • Knapp PE, Booth CS, Skoff RP (1993) The pH of jimpy glia is increased: intracellular measurements using fluorescent laser cytometry. Int J Dev Neurosci 11:215-226.
    • (1993) Int J Dev Neurosci , vol.11 , pp. 215-226
    • Knapp, P.E.1    Booth, C.S.2    Skoff, R.P.3
  • 39
    • 77952558054 scopus 로고    scopus 로고
    • Chemokine expression in the white matter spinal cord precursor niche after force-defined spinal cord contusion injuries in adult rats
    • Knerlich-Lukoschus F, von der Ropp-Brenner B, Lucius R, Mehdorn HM, Held- Feindt J (2010) Chemokine expression in the white matter spinal cord precursor niche after force-defined spinal cord contusion injuries in adult rats. Glia 58:916-931.
    • (2010) Glia , vol.58 , pp. 916-931
    • Knerlich-Lukoschus, F.1    von der Ropp-Brenner, B.2    Lucius, R.3    Mehdorn, H.M.4    Held-Feindt, J.5
  • 40
    • 0030222037 scopus 로고    scopus 로고
    • Microglia: A sensor for pathological events in the CNS
    • Kreutzberg GW (1996) Microglia: a sensor for pathological events in the CNS. Trends Neurosci 19:312-318.
    • (1996) Trends Neurosci , vol.19 , pp. 312-318
    • Kreutzberg, G.W.1
  • 42
    • 77957241864 scopus 로고    scopus 로고
    • Distinct migratory and cytokine responses of human microglia and macrophages to ATP
    • doi:10.1016/j.bbi.2010.02.010
    • Lambert C, Ase AR, Séguéla P, Antel JP (2010) Distinct migratory and cytokine responses of human microglia and macrophages to ATP. Brain Behav Immun, doi:10.1016/j.bbi.2010.02.010.
    • (2010) Brain Behav Immun
    • Lambert, C.1    Ase, A.R.2    Séguéla, P.3    Antel, J.P.4
  • 44
    • 0026023845 scopus 로고
    • Mutations in the myelin proteolipid protein gene alter oligodendrocyte gene expression in jimpy and jimpy msd mice
    • Macklin WB, Gardinier MV, Obeso ZO, King KD, Wight PA (1991) Mutations in the myelin proteolipid protein gene alter oligodendrocyte gene expression in jimpy and jimpy msd mice. J Neurochem 56:163-171.
    • (1991) J Neurochem , vol.56 , pp. 163-171
    • MacKlin, W.B.1    Gardinier, M.V.2    Obeso, Z.O.3    King, K.D.4    Wight, P.A.5
  • 46
    • 0026514073 scopus 로고
    • Microglial and astroglial reactions to inflammatory lesions of experimental autoimmune encephalomyelitis in the rat central nervous system
    • Matsumoto Y, Ohmori K, Fujiwara M (1992) Microglial and astroglial reactions to inflammatory lesions of experimental autoimmune encephalomyelitis in the rat central nervous system. J Neuroimmunol 37:23-33.
    • (1992) J Neuroimmunol , vol.37 , pp. 23-33
    • Matsumoto, Y.1    Ohmori, K.2    Fujiwara, M.3
  • 48
    • 64849087753 scopus 로고    scopus 로고
    • The P2X7 receptor drives microglial activation and proliferation: A trophic role for P2X7R pore
    • Monif M, Reid CA, Powell KL, Smart ML, Williams DA (2009) The P2X7 receptor drives microglial activation and proliferation: a trophic role for P2X7R pore. J Neurosci 29:3781-3791.
    • (2009) J Neurosci , vol.29 , pp. 3781-3791
    • Monif, M.1    Reid, C.A.2    Powell, K.L.3    Smart, M.L.4    Williams, D.A.5
  • 49
    • 0032434023 scopus 로고    scopus 로고
    • Myelin proteolipid protein: Function in myelin structure is distinct from its role in oligodendrocyte development
    • Nadon NL, West M (1998) Myelin proteolipid protein: function in myelin structure is distinct from its role in oligodendrocyte development. Dev Neurosci 20:533-539.
    • (1998) Dev Neurosci , vol.20 , pp. 533-539
    • Nadon, N.L.1    West, M.2
  • 50
    • 70449668939 scopus 로고    scopus 로고
    • Microglial precursors derived from mouse embryonic stem cells
    • Napoli I, Kierdorf K, Neumann H (2009) Microglial precursors derived from mouse embryonic stem cells. Glia 57:1660-1671.
    • (2009) Glia , vol.57 , pp. 1660-1671
    • Napoli, I.1    Kierdorf, K.2    Neumann, H.3
  • 51
    • 0029762023 scopus 로고    scopus 로고
    • Review: Cytokines and the pathogenesis of multiple sclerosis
    • Navikas V, Link H (1996) Review: cytokines and the pathogenesis of multiple sclerosis. J Neurosci Res 45:322-333.
    • (1996) J Neurosci Res , vol.45 , pp. 322-333
    • Navikas, V.1    Link, H.2
  • 52
    • 0034842126 scopus 로고    scopus 로고
    • Transected neurites, apoptotic neurons, and reduced inflammation in cortical multiple sclerosis lesions
    • Peterson JW, Bo L, Mork S, Chang A, Trapp BD (2001) Transected neurites, apoptotic neurons, and reduced inflammation in cortical multiple sclerosis lesions. Ann Neurol 50:389-400.
    • (2001) Ann Neurol , vol.50 , pp. 389-400
    • Peterson, J.W.1    Bo, L.2    Mork, S.3    Chang, A.4    Trapp, B.D.5
  • 53
    • 62849125290 scopus 로고    scopus 로고
    • Extracellular ATP induces retinal photoreceptor apoptosis through activation of purinoceptors in rodents
    • Puthussery T, Fletcher E (2009) Extracellular ATP induces retinal photoreceptor apoptosis through activation of purinoceptors in rodents. J Comp Neurol 513:430-440.
    • (2009) J Comp Neurol , vol.513 , pp. 430-440
    • Puthussery, T.1    Fletcher, E.2
  • 54
    • 0028325902 scopus 로고
    • Premature arrest of myelinformation in transgenic mice with increased proteolipid protein gene dosage
    • Readhead C, Schneider A, Griffiths I, Nave KA (1994) Premature arrest of myelinformation in transgenic mice with increased proteolipid protein gene dosage. Neuron 12:583-595.
    • (1994) Neuron , vol.12 , pp. 583-595
    • Readhead, C.1    Schneider, A.2    Griffiths, I.3    Nave, K.A.4
  • 55
    • 20044380378 scopus 로고    scopus 로고
    • Diagnosis of Pelizaeus-Merzbacher disease: Detection of proteolipid protein gene copy number by real-time PCR
    • Regis S, Grossi S, Lualdi S, Biancheri R, Filocamo M (2005) Diagnosis of Pelizaeus-Merzbacher disease: detection of proteolipid protein gene copy number by real-time PCR. Neurogenetics 6:73-78.
    • (2005) Neurogenetics , vol.6 , pp. 73-78
    • Regis, S.1    Grossi, S.2    Lualdi, S.3    Biancheri, R.4    Filocamo, M.5
  • 57
    • 0016739669 scopus 로고
    • The fine structure of pulse labeled (3-H-thymidine cells) in degenerating rat optic nerve
    • Skoff RP (1975) The fine structure of pulse labeled (3-H-thymidine cells) in degenerating rat optic nerve. J Comp Neurol 161:595-611.
    • (1975) J Comp Neurol , vol.161 , pp. 595-611
    • Skoff, R.P.1
  • 58
    • 0017189173 scopus 로고
    • Myelin deficit in the Jimpy mouse may be due to cellular abnormalities in astroglia
    • Skoff RP (1976) Myelin deficit in the Jimpy mouse may be due to cellular abnormalities in astroglia. Nature 264:560-562.
    • (1976) Nature , vol.264 , pp. 560-562
    • Skoff, R.P.1
  • 59
    • 0025668011 scopus 로고
    • Expression of the jimpy phenotype in relation to proteolipid protein appearance
    • Skoff RP, Knapp PE (1990) Expression of the jimpy phenotype in relation to proteolipid protein appearance. Ann NY Acad Sci 605:122-134.
    • (1990) Ann NY Acad Sci , vol.605 , pp. 122-134
    • Skoff, R.P.1    Knapp, P.E.2
  • 61
    • 10844233945 scopus 로고    scopus 로고
    • Analyses of proteolipid protein mutants show levels of proteolipid protein regulate oligodendrocyte number and cell death in vitro and in vivo
    • Skoff RP, Saluja I, Bessert D, Yang X (2004b) Analyses of proteolipid protein mutants show levels of proteolipid protein regulate oligodendrocyte number and cell death in vitro and in vivo. Neurochem Res 29:2095-2103.
    • (2004) Neurochem Res , vol.29 , pp. 2095-2103
    • Skoff, R.P.1    Saluja, I.2    Bessert, D.3    Yang, X.4
  • 62
    • 0021844206 scopus 로고
    • Amino-acid sequence of human and bovine brain myelin proteolipid protein (lipophilin) is completely conserved
    • Stoffel W, Giersiefen H, Hillen H, Schroeder W, Tunggal B (1985) Amino-acid sequence of human and bovine brain myelin proteolipid protein (lipophilin) is completely conserved. Biol Chem Hoppe-Seyler 366:627-635.
    • (1985) Biol Chem Hoppe-Seyler , vol.366 , pp. 627-635
    • Stoffel, W.1    Giersiefen, H.2    Hillen, H.3    Schroeder, W.4    Tunggal, B.5
  • 63
    • 0036604274 scopus 로고    scopus 로고
    • Experimental allergic encephalomyelitis is inhibited in transgenic mice expressing human Creactive protein
    • Szalai AJ, Nataf S, Hu XZ, Barnum SR (2002) Experimental allergic encephalomyelitis is inhibited in transgenic mice expressing human Creactive protein. J Immunol 168:5792-5797.
    • (2002) J Immunol , vol.168 , pp. 5792-5797
    • Szalai, A.J.1    Nataf, S.2    Hu, X.Z.3    Barnum, S.R.4
  • 64
    • 0026708978 scopus 로고
    • Brain macrophages: Evaluation of microglia and their functions
    • Thomas WE (1992) Brain macrophages: evaluation of microglia and their functions. Brain Res Rev 17:61-74.
    • (1992) Brain Res Rev , vol.17 , pp. 61-74
    • Thomas, W.E.1
  • 65
    • 0038407855 scopus 로고    scopus 로고
    • Differential proliferative response in the postischemic hippocampus, temporal cortex, and olfactory bulb of young adult macaque monkeys
    • Tonchev AB, Yamashima T, Zhao L, Okano H (2003) Differential proliferative response in the postischemic hippocampus, temporal cortex, and olfactory bulb of young adult macaque monkeys. Glia 42:209-224.
    • (2003) Glia , vol.42 , pp. 209-224
    • Tonchev, A.B.1    Yamashima, T.2    Zhao, L.3    Okano, H.4
  • 66
    • 0029103080 scopus 로고
    • Microglial cell reaction in the gray and white matter in spinal cords from jimpy mice. An enzyme histochemical study at the light electron microscope level
    • Vela J, Dalmau I, Acrín L, González B, Castellano B (1995) Microglial cell reaction in the gray and white matter in spinal cords from jimpy mice. An enzyme histochemical study at the light electron microscope level. Brain Res 694:287-298.
    • (1995) Brain Res , vol.694 , pp. 287-298
    • Vela, J.1    Dalmau, I.2    Acrín, L.3    González, B.4    Castellano, B.5
  • 67
    • 0029875548 scopus 로고    scopus 로고
    • Understanding glial abnormalities associated with myelin deficiency in the jimpy mutant mouse
    • Vela J, Dalmau I, González, B, Castellano B (1996) Understanding glial abnormalities associated with myelin deficiency in the jimpy mutant mouse. Brain Res 712:134-142.
    • (1996) Brain Res , vol.712 , pp. 134-142
    • Vela, J.1    Dalmau, I.2    González, B.3    Castellano, B.4
  • 68
    • 0036435526 scopus 로고    scopus 로고
    • Cerebrospinal fluid and serum protein levels of tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6) and soluble interleukin-6 receptor (sIL-6-R gp80) in multiple sclerosis patients
    • Vladic A, Horvat G, Vukadin S, Sucic Z, Simaga S (2002) Cerebrospinal fluid and serum protein levels of tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6) and soluble interleukin-6 receptor (sIL-6-R gp80) in multiple sclerosis patients. Cytokine 20:86-89.
    • (2002) Cytokine , vol.20 , pp. 86-89
    • Vladic, A.1    Horvat, G.2    Vukadin, S.3    Sucic, Z.4    Simaga, S.5
  • 71
    • 33750844272 scopus 로고    scopus 로고
    • X-ray structures of the microglia/macrophage-specific protein Iba1 from human and mouse demonstrate novel molecular conformation change induced by calcium binding
    • Yamada M, Ohsawa K, Imai Y, Kohsaka S, Kamitori S (2006) X-ray structures of the microglia/macrophage-specific protein Iba1 from human and mouse demonstrate novel molecular conformation change induced by calcium binding. J Mol Biol 364:449-457.
    • (2006) J Mol Biol , vol.364 , pp. 449-457
    • Yamada, M.1    Ohsawa, K.2    Imai, Y.3    Kohsaka, S.4    Kamitori, S.5
  • 72
    • 0031016980 scopus 로고    scopus 로고
    • Proteolipid protein regulates the survival and differentiation of oligodendrocytes
    • Yang X, Skoff RP (1997) Proteolipid protein regulates the survival and differentiation of oligodendrocytes. J Neurosci 17:2056-2070.
    • (1997) J Neurosci , vol.17 , pp. 2056-2070
    • Yang, X.1    Skoff, R.P.2
  • 73
    • 43449108588 scopus 로고    scopus 로고
    • Selective activation of microglia in spinal cord but not higher cortical regions following nerve injury in adult mouse
    • Zhang F, Vadakkan K, Kim S, Wu L, Shang Y, Zhuo M (2008) Selective activation of microglia in spinal cord but not higher cortical regions following nerve injury in adult mouse. Mol Pain 4:15.
    • (2008) Mol Pain , vol.4 , pp. 15
    • Zhang, F.1    Vadakkan, K.2    Kim, S.3    Wu, L.4    Shang, Y.5    Zhuo, M.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.