Differential expression of apoptotic markers in jimpy and in Plp overexpressors: Evidence for different apoptotic pathways

Journal of Neurocytology

Volumn 30, Issue 9-10, 2002, Pages 841-855

  Cerghet, M ^a   Bessert, D A ^a   Nave, K A ^b   Skoff, R P ^a  

^a WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b MAX PLANCK INSTITUTE OF EXPERIMENTAL MEDICINE   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE; CASPASE 12; CASPASE 3; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEOLIPID PROTEIN; UNCLASSIFIED DRUG;

ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DNA DAMAGE; GENE MUTATION; GENE OVEREXPRESSION; IMMUNOHISTOCHEMISTRY; MOUSE; NERVE CELL NECROSIS; NICK END LABELING; NONHUMAN; OLIGODENDROGLIA; PRIORITY JOURNAL; TRANSGENIC MOUSE;

ANIMALS; APOPTOSIS; BCL-X PROTEIN; BIOLOGICAL MARKERS; CASPASE 12; CASPASE 3; CASPASES; CYTOCHROME C GROUP; ENDOPLASMIC RETICULUM; FEMALE; GENE EXPRESSION REGULATION; HEREDITARY CENTRAL NERVOUS SYSTEM DEMYELINATING DISEASES; IMMUNOHISTOCHEMISTRY; IN SITU NICK-END LABELING; MALE; MICE; MICE, JIMPY; MICE, TRANSGENIC; MITOCHONDRIA; MUTATION; MYELIN PROTEOLIPID PROTEIN; OLIGODENDROGLIA; POLY(ADP-RIBOSE) POLYMERASES; PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2; SPINAL CORD; SPINAL CORD DISEASES;

ANIMALIA; MAMMALIA; MUS MUSCULUS;

EID: 0035469764     PISSN: 03004864     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1019697506757     Document Type: Article

References (58)

1. BANSAL, R., STEFANSSON, K. & PFEIFFER, S. E. (1992) Proligodendroblast antigen (POA), a developmental antigen expressed by A007/04-positive oligodendrocyte progenitors prior to the appearance of sulfatide and galactocerebroside. Journal of Neurochemistry 58, 2221-2229.
2. BAUER, J., BRADL, M., KLEIN, M., LEISSER, M., DECKWERTH, T. L., WEKERLE, H. & LASSMANN, H. (2002) Endoplasmic reticulum stress in PLP- overexpressing transgenic rats: Gray matter oligodendrocytes are more vulnerable than white matter oligodendrocytes. Journal of Neuropathology and Experimental Neurology 61, 12-22.
3. BEESLEY, J. S., LAVY, L., ERAYDIN, N. B., SIMAN, R. & GRINSPAN, J. B. (2001) Caspase-3 activation in oligodendrocytes from the myelin-deficient rat. Journal of Neuroscience Research 64, 371-379.
4. BONGARZONE, E. R., JACOBS, E., SCHONMANN, V., KAMPF, K., CAMPAGNONI, C. W. & CAMPAGNONI, A. T. (2001) Differential sensitivity in the survival of oligodendrocyte cell lines to overexpression of myelin proteolipid protein gene products. Journal of Neuroscience Research 65, 485-492.
5. BOUCHER, S. E. M., CYPHER, M. A., CARLOCK, L. R. & SKOFF, R. P. (2002) Proteolipid protein gene modulates viability and phenotype of neurons. Journal of Neuroscience 22, 1772-1783.
6. BRADL, M., BAUER, J., INOMATA, T., ZIELASEK, J., NAVE, K.-A., TOYKA, K., LASSMANN, H. & WEKERLE, H. (1999) Transgenic Lewis rats overexpressing the proteolipid protein gene: Myelin degeneration and its effect on T cell-mediated experimental autoimmune encephalomyelitis. Acta Neuropathologica 97, 595-606.
7. BREDESEN, D. E. (2000) Apoptosis: Overview and signal transduction pathways. Journal of Neurotrauma 17, 801-810.
8. CARDONE, M. H., ROY, N., STENNICKE, H. R., SALVESSEN, H. R., FRANKE, T. F., STANBRIDGE, E., FRISCH, S. & REED, J. C. (1998) Regulation of cell death protease caspase-9 by phosphorylation. Science 282, 1318-1321.
9. COOKSON, M. R., INCE, P. G., USHER, P. A. & SHAW, P. J. (1999) Poly (ADP-ribose) polymerase is found in both the nucleus and cytoplasm of human CNS neurons. Brain Research 834, 182-185.
10. DENECKER, G., VERCAMMEN, D., DECLERCQ, W. & VANDENABEELE, P. (2001) Apoptotic and necrotic cell death induced by death domain receptors. Cellular and Molecular Life Sciences 58, 356-370.
11. FEUTZ, A. C., PHAM-DINH, D., ALLINQUANT, B., MIEHE, M. & GHANDOUR, M. S. (2001) An immortalized jimpy oligodendrocyte cell line: Defects in cell cycle and cAMP pathway. Glia 34, 241-252.
12. FLORES, A. I., MALLON, B. S., MATSUI, T., OGAWA, W., ROSENZWEIG, A., OKAMOTO, T. & MACKLIN, W. B. (2000) Akt-mediated survival of oligodendrocytes induced by neuregulins. Journal of Neuroscience 20, 7622-7630.
13. FUKUZONO, S., TAKESHITA, T., SAKAMOTO, T., HISADA, A., SHIMIZU, N. & MIKOSHIBA, K. (1998) Overproduction and immuno-affinity purification of myelin proteolipid protein (PLP), an inositol hexakisphosphate-binding protein, in a baculovirus expression system. Biochemical and Biophysical Research Communications 249, 66-72.
14. GARDINER, L. & HICKSON, I. D. (2002) Mechanisms of DNA damage and repair. Celltransmissions (Sigma-RBI) 18, 3-10.
15. GHANDOUR, M. S. & SKOFF, R. P. (1988) Expression of galactocerebroside in developing normal and jimpy oligodendrocytes in situ. Journal of Neurocytology 17, 485-498.
16. GOW, A., FRIEDRICH, V. L. & LAZZARINI, R. A. (1994) Many naturally occurring mutations of myelin proteolipid protein impair its intracellular transport. Journal of Neuroscience Research 37, 574-583.
17. GOW, A., SOUTHWOOD, C. M. & LAZZARINI, R. A. (1998) Disrupted proteolipid protein trafficking results in oligodendrocyte apoptosis in an animal model of Pelizaeus-Merzbacher disease. Journal of Cell Biology 140, 925-934.
18. GRINSPAN, J. B., COULALAGLOU, M., BEESLEY, J. S., CARPIO, D. F. & SCHERER, S. S. (1998) Maturation-dependent apoptotic cell death of oligodendrocytes in myelin-deficient rats. Journal of Neuroscience Research 54, 623-634.
19. GU, C., CASACCIA-BONNEFIL, P., SRINIVASAN, A. & CHAO, M. V. (1999) Oligodendrocyte apoptosis mediated by caspase activation. Journal of Neuroscience 19, 3043-3049.
20. HACKI, J., EGGER, L., MONNEY, L., CONUS, S., ROSSE, T., FELLAY, I. & BORNER, C. (2000) Apoptotic crosstalk between the endoplasmic reticulum and mitochondria controlled by Bcl-2. Oncogene 19, 2286-2295.
21. HISAHARA, S., YUAN, J., MOMOI, T., OKANO, H. & MIURA, M. (2001) Caspase-11 mediates oligodendrocyte cell death and pathogenesis of autoimmune- mediated demyelination. Journal of Experimental Medicine 193, 111-122.
22. HUDSON, L. D. & NADON, N. L. (1992) Amino acid substitution in proteolipid protein that cause dysmyelination. In Myelin: Biology and Chemistry (edited by Martenson, R. E.) pp. 677-702. Boca Raton: CRC Press.
23. IMAIZUMI, K., MIYOSHI, K., KATAYAMA, T., YONEDA, T., TANIGUCHI, M., KUDO, T. & TOHYAMA, M. (2001) The unfolded protein response and Alzheimer's disease. Biochimica et Biophysica Acta 1536, 85-96.
24. KAGAWA, T., IKENAKA, K., INOUE, Y., KURIYAMA, S., TSUJII, T., NAKAO, J., NAKAJIMA, K., ARUGA, J., OKANO, H. & MIKOSHIBA, K. (1994) Glial cell degeneration and hypomyelination caused by overexpression of myelin proteolipid protein gene. Neuron 13, 427-442.
25. KAUFMANN, S. H., DESNOYERS, S., OTTAVIANO, Y., DAVIDSON, N. E. & POIRIER, G. G. (1993) Specific proteolytic cleavage of poly (ADP-ribose) polymerase: An early marker of chemotherapy-induced apoptosis. Cancer Research 53, 3976-3985.
26. KITAGAWA, K., SINOWAY, M. P., YANG, C., GOULD, R. M. & COLMAN, D. R. (1993) A proteolipid protein gene family: Expression in sharks and rays and possible evolution from an ancestral gene encoding a poreforming polypeptide. Neuron 11, 433-448.
27. KLUGMANN, M., SCHWAB, M., PÜHLHOFER, A., SCHNEIDER, A., ZIMMERMANN, F., GRIFFITHS, I. R. & NAVE, K.-A. (1997) Assembly of CNS myelin in the absence of proteolipid protein. Neuron 18, 69-70.
28. KNAPP, P. E. (1996) Proteolipid protein: Is it more than just a structural component of myelin? Developmental Neuroscience 18, 297-308.
29. KNAPP, P. E., BARTLETT, W. P., WILLIAMS, L. A., YAMADA, M., IKENAKA, K. & SKOFF, R. P. (1999a) Programmed cell death without DNA fragmentation in the jimpy mouse: Secreted factors can enhance survival. Cell Death and Differentiation 6, 136-145.
30. KNAPP, P. E., DUTTA, S. & SKOFF, R. P. (1990) Differences in levels of neuroglia cell death in jimpy male mice and carrier females. Developmental Neuroscience 12, 145-152.
31. 2+ regulation in oligodendrocytes from the dysmyelinating jimpy mouse. Brain Research 847, 332-337.
32. KNAPP, P. E., SKOFF, R. P. & REDSTONE, D. W. (1986) Oligodendroglial cell death in jimpy mice: An explanation for the myelin deficit. Journal of Neuroscience 6, 2813-2822.
33. LAMARRE, D., TALBOT, B., DE MURCIA, G., LAPLANTE, C., LEDUC, Y., MAZEN, A. & POIRIER, G. G. (1988) Structural and functional analysis of poly (ADP ribose) polymerase: An immunological study. Biochimica et Biophysica Acta 950, 147-160.
34. LAZEBNIK, Y. A., KAUFMANN, S. H., DESNOYERS, S., POIRIER, G. G. & EARNSHAW, W. C. (1994) Cleavage of poly (ADP-ribose) polymerase by a proteinase with properties like ICE. Nature 371, 346-347.
35. LI, P.-A., HE, Q.-P., OUYANG, Y.-B., LIU, C.-L., HU, B.-R. & SIESJÖ, B. K. (2001) Early release of cytochrome c and activation of caspas-3 in hyperglycemic rats subjected to transient forebrain ischemia. Brain Research 896, 69-76.
36. LIPSITZ, D., GOETZ, B. D. & DUNCAN, I. D. (1998) Apoptotic glial cell death and kinetics in the spinal cord of the myelin-deficient rat. Journal of Neuroscience Research 51, 497-507.
37. MOLDRICH, R. X., BEART, P. M., PASCOE, C. J. & CHEUNG, N. S. (2000) Low-affinity kainate receptor agonists induce insult-dependent apoptosis and necrosis in cultured murine cortical neurons. Journal of Neuroscience Research 59, 788-796.
38. NAKAGAWA, T. & YUAN, J. (2000) Cross-talk between two cysteine protease families: Activation of caspase-12 by calpain in apoptosis. Journal of Cell Biology 150, 887-894.
39. NAVE, K.-A., BLOOM, F. E. & MILNER, R. J. (1987) A single nucleotide difference in the gene for myelin proteolipid protein defines the jimpy mutation in mouse. Journal of Neurochemistry 49, 1873-1877.
40. PIEPER, A. A., VERMA, A., ZHANG, J. & SNYDER, S. H. (1999) Poly (ADP-ribose) polymerase, nitric oxide and cell death. Trends in Pharmacological Science 20, 171-181.
41. RAO, R. V., HERMEL, E., CASTRO-OBREGON, S., DEL RIO, G., ELLERBY, L. M., ELLERBY, H. M. & BREDESEN, D. E. (2001) Coupling endoplasmic reticulum stress to the cell death program. Journal of Biological Chemistry 276, 33869-33874.
42. READHEAD, C., SCHNEIDER, A., GRIFFITHS, I. R. & NAVE, K.-A. (1994) Premature arrest of myelin formation in transgenic mice with increased proteolipid protein gene dosage. Neuron 12, 583-595.
43. ROUSSEL, G., NESKOVIC, N. M., TRIFILIEFF, E., ARTAULT, J.-C. & NUSSBAUM, J.-L. (1987) Arrest of proteolipid transport through the Golgi apparatus in jimpy brain. Journal of Neurocytology 16, 195-204.
44. SAKAHIRA, H., ENARI, M., OHSAWA, Y., UCHIYAMA, Y. & NAGATA, S. (1999) Apoptotic nuclear morphological change without DNA fragmentation. Current Biology 9, 543-546.
45. SCURLOCK, B. & DAWSON, G. (1999) Differential responses of oligodendrocytes to tumor necrosis factor and other pro-apoptotic agents: Role of ceramide in apoptosis. Journal of Neuroscience Research 55, 514-522.
46. SHIBATA, M., HISAHARA, S., HARA, H., YAMAWAKI, T., FUKUUCHI, Y., YUAN, J., OKANO, H. & MIURA, M. (2000) Caspases determine the vulnerability of oligodendrocytes in the ischemic brain. Journal of Clinical Investigation 106, 643-653.
47. SIMONS, M., KRÄMER, E.-A., MACCHI, P., RATHKE-HARTLIEB, S., TROTTER, J., NAVE, K.-A. & SCHULZ, J. (2002) Overexpression of the myelin proteolipid protein leads to accumulation of cholesterol and proteolipid protein in endosomes/lysosomes: Implications for Pelizaeus-Merzbacher disease. Journal of Cell Biology 157, 327-336.
48. SKOFF, R. P. (1995) Programmed cell death in the dysmyelinating mutants. Brain Pathology 5, 283-288.
49. SKOFF, R. P. (2002) TUNEL (TdT-mediated dUTP nick end labeling). In Wiley Encyclopedia of Molecular Medicine (edited by CREIGHTON, T. E.) pp. 3273-3277. New York: John Wiley & Sons.
50. SKOFF, R. P., GHANDOUR, M. S. & KNAPP, P. E. (1994) Postmitotic oligodendrocytes generated during postnatal cerebral development are derived from proliferation of immature oligodendrocytes. Glia 12, 12-23.
51. SOUTHWOOD, C. & GOW, A. (2001) Molecular pathways of oligodendrocyte apoptosis revealed by mutations in the proteolipid protein gene. Microscopy Research and Technique 52, 700-708.
52. SPRINGER, J. E., AZBILL, R. D. & KNAPP, P. E. (1999) Activation of the caspase-3 apoptotic cascade in traumatic spinal cord injury. Nature Medicine 5, 943-946.
53. THOMSON, C. E., MONTAGUE, P., JUNG, M., NAVE, K.-A. & GRIFFITHS, I. R. (1997) Phenotypic severity of murine Plp mutants reflects in vivo and in vitro variations in transport of PLP isoproteins. Glia 20, 322-332.
54. THORNBERRY, N. A. & LAZEBNIK, Y. (1998) Caspases: Enemies within. Science 281, 1312-1316.
55. WILLIAMS, W. C. & GARD, A. L. (1997) in vitro death of jimpy oligodendrocytes: Correlation with onset of DM-20/PLP expression and resistance to oligodendrogliotrophic factors. Journal of Neuroscience Research 50, 177-189.
56. YAMAGUCHI, Y., IKENAKA, K., NIINOBE, M., YAMADA, H. & MIKOSHIBA, K. (1996) Myelin proteolipid protein (PLP), but not DM-20, is an inositol hexakisphosphate-binding protein. Journal of Biological Chemistry 271, 27838-27846.
57. YANG, X. & SKOFF, R. P. (1997) Proteolipid protein regulates the survival and differentiation of oligodendrocytes. Journal of Neuroscience 17, 2056-2070.
58. ZHU, C., WANG, X., HAGBERG, H. & BLOMGREN, K. (2000) Correlation between caspase-3 activation and three different markers of DNA damage in neonatal cerebral hypoxia-ischemia. Journal of Neurochemistry 75, 819-829.