Transgenic Lewis rats overexpressing the proteolipid protein gene: Myelin degeneration and its effect on T cell-mediated experimental autoimmune encephalomyelitis

Acta Neuropathologica

Volumn 97, Issue 6, 1999, Pages 595-606

  Bradl, Monika ^a   Bauer, Jan ^b   Inomata, Takayuki ^a   Zielasek, Jürgen ^c   Nave, Klaus Armin ^d   Toyka, Klaus ^c   Lassmann, Hans ^b   Wekerle, Hartmut ^a  

^a MAX PLANCK INSTITUTE OF NEUROBIOLOGY   (Germany)

^b Experimentelle Neuropathologie   (Austria)

^c UNIVERSITY HOSPITAL WÜRZBURG   (Germany)

^d UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

Experimental autoimmune encephalomyelitis; Expression; Proteolipid protein; Transgenic rats

Indexed keywords

GENE PRODUCT; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; MESSENGER RNA; MYELIN; PROTEOLIPID PROTEIN;

ALLERGIC ENCEPHALOMYELITIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; ASTROCYTOSIS; CELL ACTIVATION; CELL INFILTRATION; CELL PROLIFERATION; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; DEMYELINATION; GENE OVEREXPRESSION; GENE SEQUENCE; HEMIZYGOTE; HISTOCOMPATIBILITY GENE; HISTOLOGY; HOMOZYGOSITY; IN SITU HYBRIDIZATION; LIFE EXPECTANCY; MICROGLIA; MYELIN SHEATH; NERVE CONDUCTION; NONHUMAN; NUCLEOTIDE SEQUENCE; OLIGODENDROGLIA; PERIPHERAL NERVOUS SYSTEM; PHENOTYPE; PRIORITY JOURNAL; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SCIATIC NERVE; SEQUENCE HOMOLOGY; TRANSGENE; TRANSGENIC ANIMAL; TREMOR; ZYGOTE;

ANIMALS; AUTOIMMUNE DISEASES; ENCEPHALOMYELITIS; MICROSCOPY, ELECTRON; MYELIN PROTEOLIPID PROTEIN; MYELIN SHEATH; NERVE DEGENERATION; NEURAL CONDUCTION; POLYMERASE CHAIN REACTION; RATS; RATS, INBRED LEW; RNA, MESSENGER; T-LYMPHOCYTES;

EID: 0032900037     PISSN: 00016322     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004010051035     Document Type: Article

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