Inflammasome inhibition as a pathogenic stealth mechanism

Cell Host and Microbe

Volumn 8, Issue 1, 2010, Pages 7-11

  Taxman, Debra J ^a   Huang, Max T H ^a   Ting, Jenny P Y ^a  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTOR PROTEIN; INFLAMMASOME; INTERLEUKIN 18; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; NUCLEOTIDE BINDING DOMAIN AND LEUCINE RICH REPEAT PROTEIN; PROTEIN; PROTEIN PYCARD; UNCLASSIFIED DRUG; VIRUS PROTEIN;

BACTERIAL VIRULENCE; ENZYME ACTIVATION; HOST RESISTANCE; HUMAN; NONHUMAN; PRIORITY JOURNAL; PROTEIN SYNTHESIS INHIBITION; REVIEW; SIGNAL TRANSDUCTION; VIRUS VIRULENCE; ANIMAL; BACTERIAL INFECTION; BACTERIUM; DOWN REGULATION; HOST PATHOGEN INTERACTION; IMMUNOLOGY; MICROBIOLOGY; PATHOGENICITY; VIROLOGY; VIRUS; VIRUS INFECTION;

BACTERIA (MICROORGANISMS);

ANIMALS; BACTERIA; BACTERIAL INFECTIONS; DOWN-REGULATION; HOST-PATHOGEN INTERACTIONS; HUMANS; VIRUS DISEASES; VIRUSES;

EID: 77958170202     PISSN: 19313128     EISSN: 19346069     Source Type: Journal    
DOI: 10.1016/j.chom.2010.06.005     Document Type: Review

References (29)

1. Bedoya, F., Sandler, L.L., and Harton, J.A. (2007). Pyrin-only protein 2 modulates NF-kappaB and disrupts ASC:CLR interactions. J. Immunol. 178, 3837-3845. (Pubitemid 46417653)
2. Brodsky, I.E., Palm, N.W., Sadanand, S., Ryndak, M.B., Sutterwala, F.S., Flavell, R.A., Bliska, J.B., and Medzhitov, R. (2010). A Yersinia effector protein promotes virulence by preventing inflammasome recognition of the type III secretion system. Cell Host Microbe 7, 376-387.
3. Bruey, J.M., Bruey-Sedano, N., Luciano, F., Zhai, D., Balpai, R., Xu, C., Kress, C.L., Bailly-Maitre, B., Li, X., Osterman, A., et al. (2007). Bcl-2 and Bcl-XL regulate proinflammatory caspase-1 activation by interaction with NALP1. Cell 129, 45-56. (Pubitemid 46507581)
4. Bump, N.J., Hackett, M., Hugunin, M., Seshagiri, S., Brady, K., Chen, P., Ferenz, C., Franklin, S., Ghayur, T., Li, P., et al. (1995). Inhibition of ICE family proteases by baculovirus antiapoptotic protein p35. Science 269, 1885-1888.
5. Cordoba-Rodriguez, R., Fang, H., Lankford, C.S., and Frucht, D.M. (2004). Anthrax lethal toxin rapidly activates caspase-1/ICE and induces extracellular release of interleukin (IL)-1beta and IL-18. J. Biol. Chem. 279, 20563-20566. (Pubitemid 38656448)
6. Craven, R.R., Gao, X., Allen, I.C., Gris, D., Bubeck Wardenburg, J., McElvania- Tekippe, E., Ting, J.P., and Duncan, J.A. (2009). Staphylococcus aureus alpha-hemolysin activates the NLRP3-inflammasome in human and mouse monocytic cells. PLoS ONE 4, e7446.
7. Dinarello, C.A. (2009). Immunological and inflammatory functions of the interleukin- 1 family. Annu. Rev. Immunol. 27, 519-550.
8. Dorfleutner, A., Bryan, N.B., Talbott, S.J., Funya, K.N., Rellick, S.L., Reed, J.C., Shi, X., Rojanasakul, Y., Flynn, D.C., and Stehlik, C. (2007). Cellular pyrin domain-only protein 2 is a candidate regulator of inflammasome activation. Infect. Immun. 75, 1484-1492. (Pubitemid 46385842)
9. Galle, M., Schotte, P., Haegman, M., Wullaert, A., Yang, H.J., Jin, S., and Beyaert, R. (2008). The Pseudomonas aeruginosa Type III secretion system plays a dual role in the regulation of caspase-1 mediated IL-1beta maturation. J. Cell. Mol. Med. 12(5A, 5A), 1767-1776.
10. Guarda, G., Dostert, C., Staehli, F., Cabalzar, K., Castillo, R., Tardivel, A., Schneider, P., and Tschopp, J. (2009). T cells dampen innate immune responses through inhibition of NLRP1 and NLRP3 inflammasomes. Nature 460, 269-273.
11. Hornung, V., and Latz, E. (2010). Intracellular DNA recognition. Nat. Rev. Immunol. 10, 123-130.
12. Johnston, J.B., Barrett, J.W., Nazarian, S.H., Goodwin, M., Ricciuto, D., Ricuttio, D., Wang, G., and McFadden, G. (2005). A poxvirus-encoded pyrin domain protein interacts with ASC-1 to inhibit host inflammatory and apoptotic responses to infection. Immunity 23, 587-598. (Pubitemid 41779481)
13. Kettle, S., Alcamí, A., Khanna, A., Ehret, R., Jassoy, C., and Smith, G.L. (1997). Vaccinia virus serpin B13R (SPI-2) inhibits interleukin-1beta-converting enzyme and protects virus-infected cells from TNF- and Fas-mediated apoptosis, but does not prevent IL-1beta-induced fever. J. Gen. Virol. 78, 677-685. (Pubitemid 27116792)
14. Littmann, M., Albiger, B., Frentzen, A., Normark, S., Henriques-Normark, B., and Plant, L. (2009). Streptococcus pneumoniae evades human dendritic cell surveillance by pneumolysin expression. EMBO Mol Med 1, 211-222.
15. Master, S.S., Rampini, S.K., Davis, A.S., Keller, C., Ehlers, S., Springer, B., Timmins, G.S., Sander, P., and Deretic, V. (2008). Mycobacterium tuberculosis prevents inflammasome activation. Cell Host Microbe 3, 224-232. (Pubitemid 351494718)
16. Mayer-Barber, K.D., Barber, D.L., Shenderov, K., White, S.D., Wilson, M.S., Cheever, A., Kugler, D., Hieny, S., Caspar, P., Núñez, G., et al. (2010). Caspase- 1 independent IL-1beta production is critical for host resistance to mycobacterium tuberculosis and does not require TLR signaling in vivo. J. Immunol. 184, 3326-3330.
17. Pedra, J.H., Cassel, S.L., and Sutterwala, F.S. (2009). Sensing pathogens and danger signals by the inflammasome. Curr. Opin. Immunol. 21, 10-16.
18. Petit, F., Bertagnoli, S., Gelfi, J., Fassy, F., Boucraut-Baralon, C., and Milon, A. (1996). Characterization of a myxoma virus-encoded serpin-like protein with activity against interleukin-1 beta-converting enzyme. J. Virol. 70, 5860-5866. (Pubitemid 26266797)
19. Poeck, H., Bscheider, M., Gross, O., Finger, K., Roth, S., Rebsamen, M., Hannesschll̀ger, N., Schlee, M., Rothenfusser, S., Barchet, W., et al. (2010). Recognition of RNA virus by RIG-I results in activation of CARD9 and inflammasome signaling for interleukin 1 beta production. Nat. Immunol. 11, 63-69.
20. Rahman, M.M., Mohamed, M.R., Kim, M., Smallwood, S., and McFadden, G. (2009). Co-regulation of NF-kappaB and inflammasome-mediated inflammatory responses by myxoma virus pyrin domain-containing protein M013. PLoS Pathog. 5, e1000635.
21. Ray, C.A., Black, R.A., Kronheim, S.R., Greenstreet, T.A., Sleath, P.R., Salvesen, G.S., and Pickup, D.J. (1992). Viral inhibition of inflammation: cowpox virus encodes an inhibitor of the interleukin-1 beta converting enzyme. Cell 69, 597-604.
22. Saleh, M., Vaillancourt, J.P., Graham, R.K., Huyck, M., Srinivasula, S.M., Alnemri, E.S., Steinberg, M.H., Nolan, V., Baldwin, C.T., Hotchkiss, R.S., et al. (2004). Differential modulation of endotoxin responsiveness by human caspase-12 polymorphisms. Nature 429, 75-79. (Pubitemid 38620553)
23. Saleh, M., Mathison, J.C., Wolinski, M.K., Bensinger, S.J., Fitzgerald, P., Droin, N., Ulevitch, R.J., Green, D.R., and Nicholson, D.W. (2006). Enhanced bacterial clearance and sepsis resistance in caspase-12-deficient mice. Nature 440, 1064-1068.
24. Schotte, P., Denecker, G., Van Den Broeke, A., Vandenabeele, P., Cornelis, G.R., and Beyaert, R. (2004). Targeting Rac1 by the Yersinia effector protein YopE inhibits caspase-1-mediated maturation and release of interleukin- 1beta. J. Biol. Chem. 279, 25134-25142. (Pubitemid 38756762)
25. Stasakova, J., Ferko, B., Kittel, C., Sereinig, S., Romanova, J., Katinger, H., and Egorov, A. (2005). Influenza A mutant viruses with altered NS1 protein function provoke caspase-1 activation in primary human macrophages, resulting in fast apoptosis and release of high levels of interleukins 1beta and 18. J. Gen. Virol. 86, 185-195. (Pubitemid 40081165)
26. Stehlik, C., Krajewska, M., Welsh, K., Krajewski, S., Godzik, A., and Reed, J.C. (2003). The PAAD/PYRIN-only protein POP1/ASC2 is a modulator of ASCmediated nuclear-factor-kappa B and pro-caspase-1 regulation. Biochem. J. 373, 101-113. (Pubitemid 36819506)
27. Sutterwala, F.S., Mijares, L.A., Li, L., Ogura, Y., Kazmierczak, B.I., and Flavell, R.A. (2007). Immune recognition of Pseudomonas aeruginosa mediated by the IPAF/NLRC4 inflammasome. J. Exp. Med. 204, 3235-3245.
28. Turner, S.J., Silke, J., Kenshole, B., and Ruby, J. (2000). Characterization of the ectromelia virus serpin, SPI-2. J. Gen. Virol. 81, 2425-2430.
29. Young, J.L., Sukhova, G.K., Foster, D., Kisiel, W., Libby, P., and Schönbeck, U. (2000). The serpin proteinase inhibitor 9 is an endogenous inhibitor of interleukin 1beta-converting enzyme (caspase-1) activity in human vascular smooth muscle cells. J. Exp. Med. 191, 1535-1544. (Pubitemid 30257350)