Toward the optimal clinical use of the fraction excretion of solutes in oliguric azotemia

Renal Failure

Volumn 32, Issue 10, 2010, Pages 1245-1254

  Diskin, Charles J ^a   Stokes, Thomas J ^a   Dansby, Linda M ^a   Radcliff, Lautrec ^a   Carter, Thomas B ^a  

^a AUBURN UNIVERSITY   (United States)

Author keywords

Azotemia; Diagnosis; Renal failure; Renal physiology; Solute transport

Indexed keywords

ACETYLSALICYLIC ACID; ALCOHOL; AMINOGLYCOSIDE; AMINOGLYCOSIDE DERIVATIVE; BENZBROMARONE; CAFFEINE; CALCITONIN; CANDESARTAN; CISPLATIN; CYCLOSPORIN; DIURETIC AGENT; DOPAMINE; FENOFIBRATE; FUROSEMIDE; HYDROCHLOROTHIAZIDE; LITHIUM; LOSARTAN; METOLAZONE; NESIRITIDE; NISOLDIPINE; NONSTEROID ANTIINFLAMMATORY AGENT; PHENYLBUTAZONE; PROBENECID; PYRAZINAMIDE; SODIUM; SODIUM CHLORIDE; SULFINPYRAZONE; UNINDEXED DRUG; UREA; URIC ACID;

DIAGNOSTIC ACCURACY; DIAGNOSTIC VALUE; KIDNEY FAILURE; KIDNEY FUNCTION; KIDNEY TUBULE ABSORPTION; KIDNEY TUBULE EXCRETION; OLIGURIA; PRIORITY JOURNAL; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; REVIEW; SODIUM ABSORPTION; SODIUM EXCRETION; SOLUTE; UREMIA; URIC ACID URINE LEVEL; URINARY EXCRETION; WATER DEPRIVATION;

ABSORPTION; ACUTE KIDNEY INJURY; AZOTEMIA; BIOLOGICAL TRANSPORT, ACTIVE; DIAGNOSIS, DIFFERENTIAL; HUMANS; KIDNEY; KIDNEY MEDULLA; KIDNEY TUBULES; LITHIUM; NEPHRONS; OLIGURIA; SODIUM CHLORIDE; UREA; URIC ACID; WATER DEPRIVATION;

EID: 77958160703     PISSN: 0886022X     EISSN: 15256049     Source Type: Journal    
DOI: 10.3109/0886022X.2010.517353     Document Type: Review

References (125)

1. Espinel CH. The FENa test. Use in the differential diagnosis of acute renal failure. JAMA. 1976;236(6):579-581.
2. Naqvi HN, Zafar MN, Hussain A, Naqvi SA, Rizvi AH. Cyclosporine induced nephrotoxicity in renal transplant recipients: Clinical significance of fractional excretion of sodium, potassium and magnesium. J Pak Med Assoc. 2005;55(4):161-165.
3. Blanchard A, Poussou R, Houillier P. Exploration of renal tubular functions. Nephrol Ther. 2009;5(1):68-83.
4. Onem Y, Kucukardali Y, Sahan B, et al. Analyses of subjects with hypokalemic metabolic alkalosis, Gitelman's and Bartter's syndrome. Ren Fail. 2008;30(7):691-694.
5. Crow SJ, Rosenberg ME, Mitchell JE, Thuras P. Urine electrolytes as markers of bulimia nervosa. Int J Eat Disord. 2001;30(3):279-287.
6. Volpe A, Guerriero A, Marchetta A, Caramaschi P, Furlani L. Familial hypocalciuric hypercalcemia revealed by chondrocalcinosis. Joint Bone Spine. 2009;76(6):708-710.
7. Knox FG, Lechene C. Distal site of action of parathyroid hormone on phosphate reabsorption. Am J Physiol. 1975;229(6):1556-1560.
8. Steele TH, Engle JE, Tanaka Y, Lorenc RS, Dudgeon KL, De Luca HF. Phosphatemic action of 1, 25-dihydroxyvitamin D3. Am J Physiol. 1975;229(2):489-495.
9. Saxena R, Toto RD. Approach to the patient with kidney disease. In: Brenner BM, ed. The Kidney, 8th ed., Philadelphia, WB: Saunders; 2008:710.
10. Armstrong LE. Assessing hydration: The elusive gold standard. J Am Coll Nutr. 2007;26(5):575s-584s.
11. Bagshaw SM, Gibney RT. Acute kidney injury: Clinical value of urine microscopy in acute kidney injury. Nat Rev Nephrol. 2009;5(4):185-186.
12. La Villa G, Stefani L, Lazzeri C, et al. Acute effects of physiological increments of brain natriuretic peptide in humans. Hypertension. 1995;26(4):628-633.
13. Elliott C, Newman N, Madan A. Gentamicin effects on urinary electrolyte excretion in healthy subjects. Clin Pharmacol Ther. 2000;67(1):16-21.
14. Zanardo V, Vedovato S, Lago P, Piva D, Faggian D, Chiozza L. Effects of ibuprofen and indomethacin on urinary antidiuretic hormone excretion in preterm infants treated for patent ductus arteriosus. Fetal Diagn Ther. 2005;20(6):534-539. (Pubitemid 41552263)
15. Sheng MX, Li JZ, Wang HY. Therapeutic effect of Astragalus and Angelica on renal injury induced by ischemia/reperfusion in rats. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2001;21(1):43-46.
16. Fang LS, Sirota RA, Ebert TH, Lichtenstein NS. Low fractional excretion of sodium with contrast media-induced acute renal failure. Arch Intern Med. 1980;140(4):531-533.
17. Sasser JM, Baylis C. The natriuretic and diuretic response to dopamine is maintained during rat pregnancy. Am J Physiol Renal Physiol. 2008;294(6):F1342-F1344.
18. Lim SW, Li C, Sun BK, et al. Long-term treatment with cyclosporine decreases aquaporins and urea transporters in the rat kidney. Am J Physiol Renal Physiol. 2004;287(1):F139-F151.
19. Bachofen M, Bock H, Beglinger C, Fischer JA, Thiel G. Calcitonin, a proximal-tubular-acting diuretic: Lithium clearance measurements in humans. Schweiz Med Wochenschr. 1997;127(18):747752.
20. Nushiro N, Sakamaki T, Hoshino J, et al. Recombinant human erythropoietin stimulates tubular reabsorption of sodium in anesthetized rabbits. Hypertens Res. 1995;18(3):203-207.
21. Shirley DG, Walter SJ, Noormohamed FH. Natriuretic effect of caffeine: Assessment of segmental sodium reabsorption in humans. Clin Sci (Lond). 2002;103(5):461-466.
22. Carney SL, Gillies AH, Ray CD. Acute effect of ethanol on renal electrolyte transport in the rat. Clin Exp Pharmacol Physiol. 1995;22(9):629-634.
23. Corwin HL, Schreiber MJ, Fang LS. Low fractional excretion of sodium. Occurrence with hemoglobinuric-and myoglobinuricinduced acute renal failure. Arch Intern Med. 1984;144(5):981-982.
24. Vaz AJ. Low fractional excretion of urine sodium in acute renal failure due to sepsis. Arch Intern Med. 1983;143(4):738-739.
25. Godon JP. Evidence of increased proximal sodium and water reabsorption in experimental glomerulonephritis. Role of a natriuretic factor of renal origin. Nephron. 1978;21(3):146-154.
26. Hoffman LM, Suki WN. Obstructive uropathy mimicking volume depletion. JAMA. 1976;236(18):2096-2097.
27. Cetin T, Oktenli C, Ozgurtas T, et al. Renal tubular dysfunction in beta-thalassemia minor. Am J Kidney Dis. 2003;42(6):1164-1168.
28. Carmine Z, Ettore B, Giuseppe C, Quirino M. The renal tubular defect of Bartter's syndrome. Nephron. 1982;32(2):140-148.
29. Kageyama K, Terui K, Shoji M, et al. Diagnosis of a case of Gitelman's syndrome based on renal clearance studies and gene analysis of a novel mutation of the thiazide-sensitive Na-Cl cotransporter. J Endocrinol Invest. 2005;28(9):822-826.
30. Li C, Wang W, Kwon TH, Knepper MA, Nielsen S, Frøkiaer J. Altered expression of major renal Na transporters in rats with unilateral ureteral obstruction. Am J Physiol Renal Physiol. 2003;284(1):F155-F166. (Pubitemid 35471295)
31. Nanji AJ. Increased fractional excretion of sodium in prerenal azotemia: Need for careful interpretation. Clin Chem. 1981;27(7):1314-1315.
32. Unwin R, Stidwell R, Taylor S, Capasso G. The effects of respiratory alkalosis and acidosis on net bicarbonate flux along the rat loop of Henle in vivo. Am J Physiol. 1997;273(5 Pt 2): F698-F705. (Pubitemid 27508364)
33. Menegon LF, Figueiredo JF, Gontijo JA. Effect of chronic metabolic acidosis on renal growth and renal sodium handling in uninephrectomized rats. Ren Fail. 1999;21(1):13-22.
34. Menegon LF, Figueiredo JF, Gontijo JA. Effect of metabolic acidosis on renal tubular sodium handling in rats as determined by lithium clearance. Braz J Med Biol Res. 1998;31(10):1269-1273.
35. Schück O. Fractional sodium excretion in patients with chronic renal failure with respect to the therapy. Nephron. 1982;30(1):95-96. (Pubitemid 12183943)
36. Kaplan AA, Kohn OF. Fractional excretion of urea as a guide to renal dysfunction. Am J Nephrol. 1992;12(1-2): 49-54.
37. Zarich S, Fang LS, Diamond JR. Fractional excretion of sodium. Exceptions to its diagnostic value. Arch Intern Med. 1985;145(1):108-112.
38. van Olden RW, Guchelaar HJ, Struijk DG, Krediet RT, Arisz L. Acute effects of high-dose furosemide on residual renal function in CAPD patients. Perit Dial Int. 2003;23(4):339-347.
39. Cheung CM, Ponnusamy A, Anderton JG. Management of acute renal failure in the elderly patient: A clinician's guide. Drugs Aging. 2008;25(6):455-476.
40. Inselmann G, Balaschke M, Heidemann HT. Enzymuria following amphotericin B application in the rat. Mycoses. 2003;46(5-6): 169-173.
41. Toribio RE, Kohn CW, Rourke KM, Levine AL, Rosol TJ. Effects of hypercalcemia on serum concentrations of magnesium, potassium, and phosphate and urinary excretion of electrolytes in horses. Am J Vet Res. 2007;68(5):543-554.
42. Ishizaki Y, Isozaki-Fukuda Y, Kojima T, Sasai M, Matsuzaki S, Kobayashi Y. Evaluation of diagnostic criteria of acute renal failure in premature infants. Acta Paediatr Jpn. 1993;35(4):311-315.
43. Musso CG, Reynaldi J, Vilas M, De Miguel R, Imperiali N, Algranati L. Fractional excretion of K, Na and Cl following furosemide infusion in healthy, young and very old people. Int Urol Nephrol. 2010;42(1):273-277.
44. Musso CG, Michelangelo H, Vilas M, Reynaldi J, Martinez B, Algranati L, Marcia-Nunez JF. Creatinine reabsorption in the aged kidney. Int Urol Nephrol. 2009;41(3):727-731.
45. Decaux G, Dumont I, Naeije N, Mols P, Melot C, Mockel J. High uric acid and urea clearance in cirrhosis secondary to increased "effective vascular volume". Am J Med. 1982;73(3):328-334.
46. Fushimi K, Shichiri M, Marumo F. Decreased fractional excretion of urate as an indicator of prerenal azotemia. Am J Nephrol. 1990;10(6):489-494.
47. Shichiri M, Hirata Y. Serum uric acid level and fractional excretion of urate in fluid and electrolyte disturbances. Rinsho Byori. 1999;47(5):417-423.
48. Steinhäuslin F, Burnier M, Magnin JL, et al. Fractional excretion of trace lithium and uric acid in acute renal failure. J Am Soc Nephrol. 1994;4(7):1429-1437.
49. Carvounis CP, Nisar S, Guro-Razuman S. Significance of the fractional excretion of urea in the differential diagnosis of acute renal failure. Kidney Int. 2002;62(6):2223-2229.
50. Diskin CJ, Stokes TJ, Dansby LM, Radcliff L, Carter TB. The comparative benefits of the fractional excretion of urea and sodium in various azotemic oliguric states. Nephron Clin Pract. 2009;114(2):c145-c150.
51. Diskin CJ, Stokes TJ, Dansby LM, Radcliff L, Carter TB. The evolution of the fractional excretion of urea as a diagnostic tool in oliguric states. Am J Kidney Dis. 2008;51(5):869-870.
52. Pepin MN, Bouchard J, Legault L, Ethier J. Diagnostic performance of fractional excretion of urea and fractional excretion of sodium in the evaluations of patients with acute kidney injury with or without diuretic treatment. Am J Kidney Dis. 2007;50(4):566-573.
53. Jang WC, Nam YH, Park SM, et al. T6092C polymorphism of SLC22A12 gene is associated with serum uric acid concentrations in Korean male subjects. Clin Chim Acta. 2008;398(1-2): 140-144.
54. Bitew S, Imbriano L, Miyawaki N, Fishbane S, Maesaka JK. More on renal salt wasting without cerebral disease: Response to saline infusion. Clin J Am Soc Nephrol. 2009;4(2):309-315.
55. el-Awady ES, Walker LA. Effects of morphine on the renal handling of sodium and lithium in conscious rats. J Pharmacol Exp Ther. 1990;254(3):957-961.
56. Heimeier RA, Donald JA. Renal C-type natriuretic peptide and natriuretic peptide receptor B mRNA expression are affected by water deprivation in the Spinifex Hopping mouse. Comp Biochem Physiol A Mol Integr Physiol. 2003;136(3):565-575.
57. Salman IM, Ameer OZ, Sattar MA, et al. Role of the renal sympathetic nervous system in mediating renal ischemic injury-induced reductions in renal hemodynamic and excretory functions. Pathology. 2010;42(3):259-266.
58. Melin B, Koulmann N, Jimenez C, et al. Comparison of passive heat or exercise-induced dehydration on renal water and electrolyte excretion: The hormonal involvement. Eur J Appl Physiol. 2001;85(3-4): 250-258.
59. Halperin ML, Kamel KS, Oh MS. Mechanisms to concentrate the urine: An opinion. Curr Opin Nephrol Hypertens. 2008;17(4):416-422.
60. Chasis H, Smith HW. The excretion of urea in normal man and in subjects with glomerulonephritis. J Clin Invest. 1938;17(3):347-358.
61. Dole VP. Back diffusion of urea in the mammalian kidney. Am J Physiol. 1943;139:504-513.
62. Jamison RL, Kriz W. Urinary Concentrating Mechanism. New York: Oxford University Press; 1982:340 pp.
63. Zotta E, Ochoa F, Tironi Farinati C, et al. UT-A expression in pars recta from a rat model of chronic renal failure. J Nephrol. 2008;21(6):947-958.
64. Fenton RA, Knepper MA. Urea and renal function in the 21st century: Insights from knockout mice. J Am Soc Nephrol. 2007;18(3):679-688.
65. Schmidt C, Hocherl K, Bucher M. Cytokine-mediated regulation of urea transporters during experimental endotoxemia. Am J Physiol Renal Physiol. 2007;292(5):F1479-F1489.
66. Lewis WH, Alving AS. Changes with age in renal function in adult men: I. Clearance of urea. II. Amount of urea nitrogen in the blood. III. Concentrating ability of the kidneys. Am J Physiol. 1938;123:500-515.
67. Musch W, Verfaillie L, Decaux G. Age-related increase in plasma urea level and decrease in fractional urea excretion: Clinical application in the syndrome of inappropriate secretion of antidiuretic hormone. Clin J Am Soc Nephrol. 2006;1(5):909-914.
68. Murdaugh HV Jr, Schmidt-Nielsen B, Doyle EM, O'Dell R. Renal tubular regulation of urea excretion in man. J Appl Physiol. 1958;13(2):263-268.
69. Decaux G, Prospert F, Namias B, Schlesser M, Soupart A. Raised urea clearance in cirrhotic patients with high uric acid clearance is related to low salt excretion. Gut. 1992;33(8):1105-1108.
70. Fröhlich O, Aggarwal D, Klein JD, et al. Stimulation of UT-A1-mediated transepithelial urea flux in MDCK cells by lithium. Am J Physiol Renal Physiol. 2008;294(3):F518-F524.
71. Gertner RA, Klein JD, Bailey JL, et al. Aldosterone decreases UT-A1 urea transporter expression via the mineralocorticoid receptor. J Am Soc Nephrol. 2004;15:558-565.
72. Cappuccio FP, Strazzullo P, Farinaro E, Trevisan M. Uric acid metabolism and tubular sodium handling. Results from a population-based study. JAMA. 1993;270(3):354-359.
73. Anzai N, Ichida K, Jutabha P, et al. Plasma urate level is directly regulated by a voltage-driven urate efflux transporter URATv1 (SLC2A9) in humans. J Biol Chem. 2008;283(40):26834-26838.
74. Endou H, Anzai N. Urate transport across the apical membrane of renal proximal tubules. Nucleosides Nucleotides Nucleic Acids. 2008;27(6):578-584.
75. Taniguchi A, Kamatani N. Control of renal uric acid excretion and gout. Curr Opin Rheumatol. 2008;20(2):192-197.
76. Eraly SA, Vallon V, Rieg T, et al. Multiple organic anion transporters contribute to net renal excretion of uric acid. Physiol Genomics. 2008;33(2):180-192.
77. Li Y, Sato M, Yanagisawa Y, et al. Effects of angiotensin II receptor blockers on renal handling of uric acid in rats. Drug Metab Pharmacokinet. 2008;23(4):263-270.
78. Mount DB, Kwon CY, Zandi-Nejad K. Renal urate transport. Rheum Dis Clin North Am. 2006;32(2):313-331, vi.
79. Uetake D, Ohno I, Ichida K, et al. Effect of fenofibrate on uric acid metabolism and urate transporter 1. Intern Med. 2010;49(2):89-94.
80. Perez-Ruiz F, Calabozo M, Erauskin GG, Ruibal A, Herrero-Beites AM. Renal underexcretion of uric acid is present in patients with apparent high urinary uric acid output. Arthritis Rheum. 2002;47(6):610-613.
81. Radin MJ, Swayne DE, Gigliotti A, Hoepf T. Renal function and organic anion and cation transport during dehydration and/or food restriction in chickens. J Comp Physiol B. 1996;166(2):138-143.
82. Marangella M. Uric acid elimination in the urine. Pathophysiological implications. Contrib Nephrol. 2005;147:132-148.
83. Maesaka JK, Batuman V, Yudd M, Salem M, Sved AF, Venkatesan J. Hyponatremia and hypouricemia: Differentiation from SIADH. Clin Nephrol. 1990;33(4):174-178.
84. Fenske W, Störk S, Koschker AC, et al. Value of fractional uric acid excretion in differential diagnosis of hyponatremic patients on diuretics. J Clin Endocrinol Metab. 2008;93(8):2991-2997.
85. Walter SJ, Sampson B, Shirley DG. A micropuncture study of renal tubular lithium reabsorption in sodium-depleted rats. J Physiol. 1995;483(Pt 2):473-479.
86. Thomsen K, Shirley DG. A hypothesis linking sodium and lithium reabsorption in the distal nephron. Nephrol Dial Transplant. 2006;21(4):869-880.
87. Leyssac PP, Holstein-Rathlou NH, Skøtt P, Alfrey AC. A micropuncture study of proximal tubular transport of lithium during osmotic diuresis. Am J Physiol. 1990;258(4 Pt 2): F1090-F1095.
88. Shirley DG, Walter SJ, Sampson B. A micropuncture study of renal lithium reabsorption: Effects of amiloride and furosemide. Am J Physiol. 1992;263(6 Pt 2): F1128-F1133.
89. Kortenoeven ML, Li Y, Shaw S, et al. Amiloride blocks lithium entry through the sodium channel thereby attenuating the resultant nephrogenic diabetes insipidus. Kidney Int. 2009;76(1):44-53.
90. Boer WH, Fransen R, Boer P, de Roos R, Koomans HA. Prostaglandin synthesis inhibition stimulates lithium reabsorption in Henle's loop in rats. Kidney Int. 1993;43(2):301-306.
91. Nielsen JB, Vestergaard P. Lithium intoxication: Assessment, treatment and prevention. Ugeskr Laeger. 2007;169(6):522.
92. Eyer F, Pfab R, Felgenhauer N, et al. Lithium poisoning: Pharmacokinetics and clearance during different therapeutic measures. J Clin Psychopharmacol. 2006;26(3):325-330.
93. Wilting I, Movig KL, Moolenaar M, et al. Drug-drug interactions as a determinant of elevated lithium serum levels in daily clinical practice. Bipolar Disord. 2005;7(3):274-280.
94. Laville M. Loop diuretics and angiotensin-converting enzyme inhibitors increased risk for hospitalization for lithium toxicity. ACP J Club. 2005;142(1):25.
95. Nielsen FT, Starklint H, Dieperink H. Impaired glomerular and tubular function as a short-term effect of sirolimus treatment in the rat. Am J Nephrol. 2005;25(4):411-416.
96. Sansoè G, Silvano S, Mengozzi G, et al. Loss of tubuloglomerular feedback in decompensated liver cirrhosis: Physiopathological implications. Dig Dis Sci. 2005;50(5):955-963.
97. Boer PA, Morelli JM, Figueiredo JF, Gontijo JA. Early altered renal sodium handling determined by lithium clearance in spontaneously hypertensive rats (SHR): Role of renal nerves. Life Sci. 2005;76(16):1805-1815.
98. Kaloyanides GJ, Azer M. Evidence for a humoral mechanism in volume expansion natriuresis. J Clin Invest. 1971;50(8):1603-1612.
99. Wesson LG Jr, Anslow WP Jr. Excretion of sodium and water during osmotic diuresis in the dog. Am J Physiol. 1948;153(3):465-474.
100. Shannon JA. Glomerular filtration and urea excretion in relation to urine flow in the dog. Am J Physiol. 1936;117:206-225.
101. Shannon JA. Urea excretion in the normal dog during forced diuresis. Am J Physiol. 1938;122:782-787.
102. Steele TH, Dudgeon KL, Larmore CK. Pharmacological characterization of lithium reabsorption in the rat. J Pharmacol Exp Ther. 1976;196(1):188-193.
103. Berglund H, Frisk AR. Uric acid elimination in man. Acta Med Scand. 1935;86:233.
104. Higgins JT Jr, Meinders AE. Quantitative relationship of renal glucose and sodium reabsorption during ECF expansion. Am J Physiol. 1975;229(1):66-71.
105. Saha H, Mustonen J, Helin H, Pasternack A. Limited value of the fractional excretion of sodium test in the diagnosis of acute renal failure. Nephrol Dial Transplant. 1987;2(2):79-82.
106. D'Elia JA, Kaldany A, Weinrauch LA, Buchbinder EM. Inadequacy of fractional excretion of sodium test. Arch Intern Med. 1981;141(6):818.
107. Brosius FC, Lau K. Low fractional excretion of sodium in acute renal failure: Role of timing of the test and ischemia. Am J Nephrol. 1986;6(6):450-457.
108. Miller PD, Krebs RA, Neal BJ, McIntyre DO. Polyuric prerenal failure. Arch Intern Med. 1980;140(7):907-909.
109. Wan L, Bellomo R, May CN. The effect of normal saline resuscitation on vital organ blood flow in septic sheep. Intensive Care Med. 2006;32(8):1238- 1242. (Pubitemid 44232420)
110. Langenberg C, Wan L, Bagshaw SM, Egi M, May CN, Bellomo R. Urinary biochemistry in experimental septic acute renal failure. Nephrol Dial Transplant. 2006;21(12):3389-3397. (Pubitemid 44817086)
111. Bagshaw SM, Bellomo R. Fluid resuscitation and the septic kidney. Curr Opin Crit Care. 2006;12(6):527-530.
112. Musch W, Hedeshi A, Decaux G. Low sodium excretion in SIADH patients with low diuresis. Nephron Physiol. 2004;96(1):P11-P18.
113. Bochud M, Staessen JA, Maillard M, et al. Ethnic differences in proximal and distal tubular sodium reabsorption are heritable in black and white populations. J Hypertens. 2009;27(3):606-612.
114. Owada A, Tomita K, Ujiie K, Akiba T, Marumo F. Decreased lithium clearance in patients with hyperthyroidism. Nephron. 1993;64(1):37-41.
115. Musch W, Thimpont J, Vandervelde D, Verhaeverbeke I, Berghmans T, Decaux G. Combined fractional excretion of sodium and urea better predicts response to saline in hyponatremia than do usual clinical and biochemical parameters. Am J Med. 1995;99(4):348-355.
116. Inoue H, Jackson SD, Vikulina T, Klein JD, Tomita K, Bagnasco SM. Identification and characterization of a Kidd antigen/UT-B urea transporter expressed in human colon. Am J Physiol Cell Physiol. 2004;287: C30-C35.
117. Smith CP, Potter EA, Fenton RA, Stewart GS. Characterization of a human colonic cDNA encoding a structurally novel urea transporter, hUT-A6. Am J Physiol Cell Physiol. 2004;287(4):C1087-C1093.
118. Inoue H, Kozlowski SD, Klein JD, Bailey JL, Sands JM, Bagnasco SM. Regulated expression of renal and intestinal UT-B urea transporter in response to varying urea load. Am J Physiol Renal Physiol. 2005;289(2):F451-F458.
119. Kosmadakis G, Viskaduraki M, Michail S. The validity of fractional excretion of uric acid in the diagnosis of acute kidney injury due to decreased kidney perfusion. Am J Kidney Dis. 2009;54(6):1186-1187.
120. McBride MB, Simmonds HA, Moro F. Familial renal disease or familial juvenile hyperuricaemic nephropathy?. J Inherit Metab Dis. 1997;20(3):351-353.
121. Schönermarck U, Kehl K, Samtleben W. Diagnostic performance of fractional excretion of urea and sodium in acute kidney injury. Am J Kidney Dis. 2008;51(5):870-871.
122. Bagshaw SM, Langenberg C, Bellomo R. Urinary biochemistry and microscopy in septic acute renal failure: A systematic review. Am J Kidney Dis. 2006;48(5):695-705.
123. Schmidt C, Höcherl K, Schweda F, Bucher M. Proinflammatory cytokines cause down-regulation of renal chloride entry pathways during sepsis. Crit Care Med. 2007;35(9):2110-2119.
124. Liaño F, Gámez C, Pascual J, et al. Use of urinary parameters in the diagnosis of total acute renal artery occlusion. Nephron. 1994;66(2):170-175.
125. Diskin CJ, Stokes TJ, Dansby LM, Radcliff L, Carter TB. (unpublished data)