Amiloride blocks lithium entry through the sodium channel thereby attenuating the resultant nephrogenic diabetes insipidus

Kidney International

Volumn 76, Issue 1, 2009, Pages 44-53

  Kortenoeven, Marleen L A ^a   Li, Yuedan ^a   Shaw, Stephen ^a   Gaeggeler, Hans Peter ^b   Rossier, Bernard C ^b   Wetzels, Jack F M ^a   Deen, Peter M T ^a  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^b UNIVERSITY OF LAUSANNE   (Switzerland)

Author keywords

Amiloride; Aquaporin 2; ENaC; Lithium; MCCD; Nephrogenic diabetes insipidus

Indexed keywords

AMILORIDE; AQUAPORIN 2; BENZAMIL; GLYCOGEN SYNTHASE KINASE 3BETA; LITHIUM; SODIUM CHANNEL; VASOPRESSIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APICAL MEMBRANE; ARTICLE; CONTROLLED STUDY; DISEASE MODEL; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; INTRACELLULAR TRANSPORT; KIDNEY COLLECTING TUBULE; MALE; MOUSE; NEPHROGENIC DIABETES INSIPIDUS; NONHUMAN; POLYURIA; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; VASOPRESSIN RELEASE;

AMILORIDE; ANIMALS; AQUAPORIN 2; CELL LINE; DIABETES INSIPIDUS, NEPHROGENIC; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; HUMANS; IMMUNOHISTOCHEMISTRY; INHIBITORY CONCENTRATION 50; KIDNEY TUBULES, COLLECTING; LITHIUM; MALE; MICE; RATS; RATS, WISTAR; SODIUM CHANNEL BLOCKERS; SODIUM CHANNELS;

EID: 67449158754     PISSN: 00852538     EISSN: 15231755     Source Type: Journal    
DOI: 10.1038/ki.2009.91     Document Type: Article

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