Mechanisms to concentrate the urine: An opinion

Current Opinion in Nephrology and Hypertension

Volumn 17, Issue 4, 2008, Pages 416-422

  Halperin, Mitchell L ^a   Kamel, Kamel S ^a   Oh, Man S ^b  

^a ST MICHAEL'S HOSPITAL   (Canada)

^b STATE UNIVERSITY OF NEW YORK   (United States)

Author keywords

aquaporin 1; Kidney stones; Urea

Indexed keywords

AQUAPORIN 1; CALCIUM OXALATE; ELECTROLYTE; SODIUM POTASSIUM CHLORIDE COTRANSPORTER; UREA;

CONCENTRATION (PARAMETERS); ELECTROLYTE URINE LEVEL; HENLE LOOP; HUMAN; KIDNEY COLLECTING TUBULE; KIDNEY CONCENTRATING CAPACITY; KIDNEY DISTAL TUBULE; KIDNEY MEDULLA; KIDNEY TUBULE ABSORPTION; NEPHRON; OLIGURIA; PRIORITY JOURNAL; REVIEW; URINARY EXCRETION; URINE FLOW RATE; WATER PERMEABILITY; ANIMAL; KIDNEY; METABOLISM; PHYSIOLOGY; URINE;

ANIMALS; HUMANS; KIDNEY; KIDNEY CONCENTRATING ABILITY; KIDNEY MEDULLA; LOOP OF HENLE; URINE;

EID: 55249105708     PISSN: 10624821     EISSN: None     Source Type: Journal    
DOI: 10.1097/MNH.0b013e328304b3f5     Document Type: Review

References (32)

1. Lassiter WE, Gottschalk CW, Mylle M. Micropuncture study of net transtubular movement of water and urea in nondiuretic mammalian kidney. Am J Physiol 1961; 200:1139-1146.
2. Ullrich KJ, Schmidt-Nielsen B, O'Dell R, et al. Micropuncture study of composition of proximal and distal tubular fluid in rat kidney. Am J Physiol 1963; 204:527-531.
3. Gilbert RM, Weber H,Turchin L, et al. A study of intrarenal recycling of urea in the rat with chronic experimental pyelonephritis. J Clin Invest 1976; 58:1348-1357.
4. Gottschalk CW, Mylle M. Evidence that the mammalian nephron functions as a countercurrent multiplier system. Science 1958; 188:504.
5. Stevenson JL Central core model of the renal counterflow system. Kidney Int 1972; 2:85-94.
6. Kokko JP, Rector FCJ. Countercurrent multiplication system without active transport in the inner medulla. Kidney Int 1972; 2:214-223.
7. Jamison RL, Roy DR, Layton HE. Countercurrent mechanisms and its regulation. In: Seldin DW, Giebisch GH, editors. Clinical disturbances of water metabolism. New York: Raven Press; 1993. pp. 119-156.
8. Knepper MA, Hoffert JD, Packer RK, Fenton RA. Urine concentration and dilution. In: Brenner BM, editor. The kidney. Philadelphia: Saunders, Elsevier; 2008. pp. 308-329.
9. Sands JM, Layton HE. Urine concentrating mechanism and its regulation. In: Seldin DW, Giebisch G, editors. The kidney: physiology & pathophysiology. Philadelphia: Lippincott Williams & Wilkins; 2000. pp. 1175-1216.
10. st ed. London: Portland Press; 1993.
11. Reeves WB, Andreoli TA. Sodium and chloride transport in the loop of Henle, distal convoluted tubule and the collecting duct. In: Alpern R, Hebert SC, editors. The Kidney, 4th ed. New York: Raven press; 2007. pp. 849-887.
12. Watanabe S, Fukomoto S, Chang H, et al. Association between activating mutations of calcium-sensing receptor and Bartter's syndrome. Lancet 2002; 360:692-694.
13. Hebert SC. Extracellular calcium-sensing receptor: Implications for calcium and magnesium handling in the kidney. Kidney Int 1996; 50:2129-2139.
14. 2+ and other ions as extracellular (first) messengers. Physiol Rev 1991; 71:371-411.
15. Zeffren JL, Heinemann HO. Reversible defect in renal concentrating mechanism in patients with hypercalcemia. Am J Med 1962; 33:54-63.
16. Zhai X, Fenton R, Andreasen A, et al. Aquaporin-1 is not expressed in descending thin limbs of short-loop nephrons. J Am Soc Nephrol 2007; 18:2937-2944.
17. Bruun NE, Skott P, Nielsen MD, et al. Normal renal tubular response to changes of sodium intake in hypertensive man. J Hypertens 1990; 8:219-227.
18. Berliner RW, Levinsky NG, Davidson DG, Eden M. Dilution and concentration of the urine and the action of antidiuretic hormone. Am J Med 1958; 27:730-744.
19. Gamble JL, McKhann CF, Butler AM, Tuthill E. An economy of water in renal function referable to urea. Am J Physiol 1934; 109:139-154.
20. Gowrishankar M, Lenga I, Cheung RY, et al. Minimum urine flow rate during water deprivation: Importance of the permeability of urea in the inner medulla. Kidney Int 1998; 53:159-166.
21. You G, Smith CP, Kanai Y, et al. Expression cloning and characterization of the vasopressin-regulated urea transporter. Nature 1993; 365:844-847.
22. Sands JM. The medullary collecting duct urea transporters. CurrOpin Nephrol Hypertens 1999; 8:499-504.
23. Nielsen S, Terris J, Smith CP, et al. Cellular and subcellular localization of the vasopressin-regulated urea transporter in the kidney. Proc Natl Acad Sci U S A 1996; 93:5495-5500.
24. Knepper MA, Star RA. The vasopressin-regulated urea transporter in renal inner medullary collecting duct. Am J Physiol Renal Physiol 1990; 259:F393-F401.
25. Oh MS, Halperin ML. The mechanisms of urine concentration in the inner medulla. Nephron 1997; 75:384-393.
26. Jung J-Y, Madsen KM, Han K-H, et al. Expression of urea transporters in potassium-depleted mouse kidney. Am J Physiol Renal Physiol 2003; 285: F1210-F1224.
27. Chou C-L, Knepper MA. In vitro perfusion of chinchilla thin limb segments: urea and NaCl permeabilities. Am J Physiol Renal Physiol 1993; 264:F337-F343.
28. Layton HE, Knepper MA, Chou C-L. Permeability criteria for effective function of passive countercurrent multiplier. Am J Physiol Renal Physiol 1996; 270: F9-F20.
29. Layton AT, Pannabecker TL, Dantzler WH, Layton HE. Two modes of concentrating the urine in rat inner medulla. Am J Physiol Renal Physiol 2004; 287:F816-F839.
30. Soroka SD, Chayaraks S, Cheema-Dhadli S, et al. Minimum urine flow rate during water deprivation: importance of the urea and nonurea osmole concentration and excretion rate. J Am Soc Nephrol 1997; 8:880-886.
31. Kamel KS, Cheema-Dhadli S, Shafiee MA, Halperin ML. Dogmas and conundrums for the excretion of nitrogenous wastes in human subjects. J Exp Biology 2004; 207:1985-1991.
32. Zhang C, Sands JM, Klein JD. Vasopressin rapidly increases phosphorylation of UT-A1 urea transporter in rat IMCDs through PKA. Am J Physiol Renal Physiol 2002; 282:F85-F90.