Cyclosporine induced nephrotoxicity in renal transplant recipients: Clinical significance of fractional excretion of sodium, potassium and magnesium

Journal of the Pakistan Medical Association

Volumn 55, Issue 4, 2005, Pages 161-165

  Naqvi, Haider Nawaz ^a   Zafar, Mirza Naqi ^a   Hussain, Amna ^a   Naqvi, Syed Ali Anwar ^a   Rizvi, Adibul Hassan ^a  

^a DOW UNIVERSITY OF HEALTH SCIENCES   (Pakistan)

Author keywords

[No Author keywords available]

Indexed keywords

CREATININE; CYCLOSPORIN A; MAGNESIUM; POTASSIUM; SODIUM; BIOLOGICAL MARKER; CYCLOSPORIN; IMMUNOSUPPRESSIVE AGENT;

ACUTE KIDNEY TUBULE NECROSIS; ADOLESCENT; ADULT; AREA UNDER THE CURVE; ARTICLE; BLOOD CHEMISTRY; CLINICAL TRIAL; COLOR ULTRASOUND FLOWMETRY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG MEGADOSE; FEMALE; GRAFT DYSFUNCTION; GRAFT REJECTION; HUMAN; HUMAN TISSUE; KIDNEY ALLOGRAFT; KIDNEY BIOPSY; MAGNESIUM EXCRETION; MAJOR CLINICAL STUDY; MALE; NEPHROTOXICITY; POTASSIUM EXCRETION; PROSPECTIVE STUDY; SCHOOL CHILD; SODIUM EXCRETION; CHEMICALLY INDUCED DISORDER; CHILD; COMPARATIVE STUDY; CROSS-SECTIONAL STUDY; KIDNEY DISEASE; KIDNEY TRANSPLANTATION; METABOLISM; MIDDLE AGED; TIME;

ADOLESCENT; ADULT; BIOLOGICAL MARKERS; CHILD; CREATININE; CROSS-SECTIONAL STUDIES; CYCLOSPORINE; FEMALE; HUMANS; IMMUNOSUPPRESSIVE AGENTS; KIDNEY DISEASES; KIDNEY TRANSPLANTATION; MAGNESIUM; MALE; MIDDLE AGED; POTASSIUM; PROSPECTIVE STUDIES; SODIUM; TIME FACTORS;

EID: 23844454620     PISSN: 00309982     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (11)

1. Campistol JM, Sacks SH. Mechanisms of nephrotoxicity. Transplantation 2000;69 (12 Suppl):SS5-10.
2. Bennett WM, Burdmann EA, Andoh TF. Nephrotoxicity of immunosuppressive drugs. Nephrol Dial Transplant 1994;9:141-5.
3. Morales JM, Andres A, Prieto C, Ruilope LM, Alcazar JM, Oliet A, et al. Fractional excretion of sodium represents an index of cyclosporin nephrotoxicity in early post transplant period. Transplant Proc 1987;19:4005-7.
4. Miura K, Nakatani T, Asai T, Yamanaka S, Tamada S, Tashiro K, et al. Role of hypomagnesaemia in chronic cyclosporine nephropathy. Transplantation 2002;73:340-7.
5. Mazzachi BC, Peake MJ, Ehrhardt V. Reference range and method comparison studies for enzymatic and Jaffe creatinine assays in plasma and serum and early morning urine. Clin Lab 2000;46:53-5.
6. Mann CK, Yoe JH. Spectrophotometric determination of magnesium with sodium 1-azo-2-hydroxy-3-(2,4-dimethyl-carboxanili-do)-napthalene-1′-(2- hydroxy-berizene-5-sulfonate). Anal Chem 1956;28:202-5.
7. Futrekul P, Yenrudi S, Futrakul N, Sensirivatana R, Kingwatanakul P, Jungthirapanich J, et al. Tubular function and tubulo-interstitial disease. Am J Kid Dis 1999;33:886-91.
8. da Costa MC, deCastro I, Neto ALC, Ferreira AT, Burdmann IA, Yu L, et al. Cyclosporin A tubular effects contribute to nephrotoxicity: role of Ca2+ and Mg2+ ions. Nephrol Dial Transplant 2003;18:2262-8.
9. Hansen JM, Anderson NF, Leyssac PP, Strandgaard S. Glomerular and tubular function in renal transplant patients treated with and without cyclosporine A. Nephron 1998;80:450-7.
10. Shihab FS, Bennett WM, Tanner AM, Andoh TF. Angiotensin II blockade decreases TGF-Beta1 and matrix proteins in cyclosporine nephropathy. Kid Int 1997;52:660-73.
11. Shihab FS, Andoh TF, Tanner AM, Yi H, Bennett WM. Expression of apoptosis regulatory genes in a chronic cyclosporine nephrotoxicity favours apoptosis Kid Int 1999;56:2147-59.