Nitric oxide, health and disease

Journal of Applied Biomedicine

Volumn 7, Issue 4, 2009, Pages 163-173

  Ferrari, Carlos Kusano Bucalen ^a   França, Eduardo Luzia ^a   Honorio França, Adenilda Cristina ^a  

^a FEDERAL UNIVERSITY OF MATO GROSSO   (Brazil)

Author keywords

Cancer; Cardiovascular diseases; Diabetes mellitus; Infection; Peroxynitrite; Phagocytosis

Indexed keywords

EID: 71949130867     PISSN: 1214021X     EISSN: 12140287     Source Type: Journal    
DOI: 10.32725/jab.2009.019     Document Type: Review

References (114)

1. Abdelrahman M, Mazzon E, Bauer M, Bauer I, Delbosc S, Cristol JP, Patel NS, Cuzzocrea S, Thiemermann C: Inhibitors of NADPH oxidase reduce the organ damage injury in hemorrhagic shock. Shock 23:107-114, 2005. (Pubitemid 40222945)
2. Akaike T, Noguchi Y, Ijiri S, Setoguchi K, Suga M, Zheng YM, Dietzschold B, Maeda H: Pathogenesis of influenza virus-induced pneumonia: involvement of both nitric oxide and oxygen radicals. Proc Natl Acad Sci USA 93:2448-2453, 1996. (Pubitemid 26104370)
3. Al-Mufti RA, Williamson RCN, Mathie RT: Increased nitric oxide activity in a rat model of acute pancreatitis. Gut 43:564-570, 1998. (Pubitemid 28462045)
4. Altavilla D, Saitta A, Squadrito G, Galeano M, Venuti SF, Guarini S, Bazzani C, Bertolini A, Caputi AP, Squadrito F: Evidence for a role of nuclear factor-κB in acute hypovolemic hemorrhagic shock. Surgery 131:50-58, 2002. (Pubitemid 34118596)
5. Angina AA, Abd-Allah SH: Plasma levels of nitric oxide in association with severe Plasmodium falciparum in Yemen. J Egypt Soc Parasitol 29:215-222, 1999.
6. Aoun S, Ramos E: Hypertension in the HIV-infected patient. Curr Hypertens Rep 2:478-481, 2000.
7. Aslan M, Thornley-Brown D, Freeman BA: Reactive species in sickle cell disease. Ann NY Acad Sci 899:375-391, 2000. (Pubitemid 30352801)
8. Bakan E, Taysi S, Polat MF, Dalga S, Umudum Z, Bakan N, Gumus M: Nitric oxide levels and lipid peroxidation in plasma of patients with gastric cancer. Jpn J Clin Oncol 32:162-166, 2002. (Pubitemid 41289003)
9. Balmer P, Phillips HM, Maestre AE, McMonagle FA, Phillips RS: The effect of nitric oxide on the growth of Plasmodium falciparum, P. chabaudi and P. berghei in vitro. Parasite Immunol 22:97-106, 2000. (Pubitemid 30098810)
10. Beevi SSS, Rasheed AMH, Geetha A: Evaluation of oxidative stress and nitric oxide levels in patients with oral cavity cancer. Jpn J Clin Oncol 34:379-385, 2004.
11. Berlett BS, Stadman ER: Protein oxidation in aging, disease, and oxidative stress. J Biol Chem 272:20313-20316, 1997. (Pubitemid 27355575)
12. Bonnet D, Aggoun Y, Szezepanski I, Bellal N, Blanche S: Arterial stiffness and endothelial dysfunction in HIV-infected children. AIDS 18:1037-1041, 2004. (Pubitemid 38591195)
13. Bourguignon SC, Alves CR, Giovanni-De-Simone S: Detrimental effect of nitric oxide on Trypanosoma cruzi and Leishmania major like cells. Acta Trop 66:109-118, 1997.
14. Boutlis CS, Tjitra E, Maniboey H, Misukonis MA, Saunders JR, Suprianto S, Weinberg JB, Anstey NM: Nitric oxide production and mononuclear cell nitric oxide synthase activity in Malaria-tolerant Papuan Adults. Infect Immun 71:3682-3689, 2003. (Pubitemid 36753687)
15. Brennan RE, Russell K, Zhang G, Samuel JE: Both inducible nitric oxide synthase and NADPH oxidase contribute to the control of virulent phase I Coxiella burnetii infections. Infect Immun 72:6666-6675, 2004.
16. Brunner F, Maier R, Andrew P, Wölkart G, Zechner R, Mayer B: Attenuation of myocardial ischemia/reperfusion injury in mice with myocyte-specific overexpression of endothelial nitric oxide synthase. Cardiovasc Res 57:55-62, 2003. (Pubitemid 36009436)
17. Byun J, Mueller DM, Fabjan JS, Heinecke JW: Nitrogen dioxide radical generated by the myeloperoxidase-hydrogen peroxide-nitrite system promotes lipid peroxidation of low density lipoprotein. FEBS Lett 455:243-246, 1999. (Pubitemid 29333044)
18. Cole MP, Chaiswing L, Oberley TD, Edelman SE, Piascik MT, Lin S-M, Kiningham KK, St., Clair DK: The protective role of nitric oxide and superoxide dismutase in adriamycin-induced cardiotoxicity. Cardiovasc Res 69:186-197, 2006. (Pubitemid 41814822)
19. Cook T, Wang Z, Alber S, Liu K, Watkins SC, Vodovotz Y, Billiar TR, Blumblerg D: Nitric oxide and ionizing radiation synergistically promote poptosis and growth inhibition of cancer by activating p53. Cancer Res 64:8015-8021, 2004. (Pubitemid 39446937)
20. Dyet K, Moir J: Effect of combined oxidative and nitrosative stress on Neisseria meningitidis. Biochem Soc Trans 34:197-199, 2006.
21. Epstein SE: The multiple mechanisms by which infection may contribute to atherosclerosis development and course. Circ Res 90:2-4, 2002.
22. Estéves AG, Crow JP, Sampson JB, Reiter C, Zhuang Y, Richardson GJ et al.: Induction of nitric oxide-dependent apoptosis in motor neurons by zinc-deficient superoxide dismutase. Science 286:2498-2500, 1999. (Pubitemid 30026336)
23. Fernandez PD, Assreuy J: Role of nitric oxide and superoxide in Giardia lamblia killing. Braz J Med Biol Res 30:93-99, 1997.
24. Ferrari CKB: Free radicals, lipid peroxidation and antioxidants in apoptosis: implications in cancer, cardiovascular and neurological diseases. Biologia Cel Mol 55:581-590, 2000.
25. Ferrari CKB: Oxidative stress pathophysiology: Searching for an effective antioxidant protection. Intern Med J 8:175-184, 2001.
26. Ferrari CKB: Update: Clinical pathophysiology of metabolic syndrome. Arq Cat Med 36:90-95, 2007.
27. Ferrari CKB: Metabolic syndrome and obesity: epidemiology and prevention by physical activity and exercise. J Exerc Sci Fit 6:87-96, 2008.
28. Forlenza M, Scharsack JP, Kachamakova NM, Taverne-Thiele AJ, Rombout JH, Wiegertjes GF: Differential contribution of neutrophilic granulocytes and macrophages to nitrosative stress in a host-parasite animal model. Mol Immunol 45:3178-3189, 2008.
29. França EL, Feliciano ND, Silva KA, Ferrari CKB, Honorio-França AC: Modulatory role of melatonin on superoxide release by spleen macrophages isolated from alloxan-induced diabetic rats. Bratisl Med J 110:517-522, 2009.
30. Garcia-Monzon C, Majano PL, Zubia I, Sanz P, Apolinario A, Moreno-Otero R: Intrahepatic accumulation of nitrotyrosine in chronic viral hepatitis is associated with histological severity of liver disease. J Hepatol 32:331-338, 2001. (Pubitemid 30093914)
31. Giulivi C, Poderoso JJ, Boveris A: Production of nitric oxide by mitochondria. J Biol Chem 273:11038-11043, 1998.
32. Guidotti LG, McClary H, Loudis JM, Chisari FV: Nitric oxide inhibits hepatitis B virus replication in the livers of transgenic mice. J Exp Med 191:1247-1252, 2000. (Pubitemid 30207687)
33. Gyurko R, Boustany G, Huang PL, Kantarci A, Van Dyke TE, Genco CA, Gibson FC: Mice lacking inducible nitric oxide synthase demonstrate impaired killing of Porphyromonas gingivalis. Infect Immun 71:4917-4924, 2003.
34. Hoeldtke RD, Bryner KD, McNeill DR, Hobbs GR, Riggs JE, Warehime SS, Christie I, Ganser G, van Dyke K: Nitrosative stress, uric acid, and peripheral nerve function in early type 1 diabetes. Diabetes 51:2817-2825, 2002. (Pubitemid 34970936)
35. Hogg N, Darley-Usmar VM, Graham A, Moncada S: Peroxynitrite and atherosclerosis. Biochem Soc Trans 21:358-362, 1993.
36. Hogikyan RV, Galecki AT, Pitt B, Halter JB, Greene DA, Supiano MA: Specific impairment of endothelium-dependent vasodilation in subjects with type 2 diabetes independent of obesity. J Clin Endocrinol Metab 83:1946-1952, 1998.
37. Hölscher C, Köhler G, Müller U, Mossmann H, Schaub GA, Brombacher F: Defective nitric oxide effector functions lead to extreme susceptibility of Trypanosoma cruzi-infected mice deficient in gamma interferon receptor or inducible nitric oxide synthase. Infect Immun 66:1208-1215, 1998.
38. Holzmuller P, Sereno D, Cavaleyra M, Mangot I, Daulouede S, Vincendeau P, Lemesre JL: Nitric oxide-mediated proteasome-dependent oligonucleosomal DNA fragmentation in Leishmania amazonensis amastigotes. Infect Immun 70:3727-3735, 2002.
39. Husain K, Somani SM, Boley TM, Hazelrigg SR: Interaction of physical training and chronic nitroglycerin treatment on blood pressure and plasma oxidant/antioxidant systems in rats. Mol Cel Biochem 247:37-44, 2003. (Pubitemid 36798507)
40. Imam SZ, El-Yasal J, Newport GD, Itzhak Y, Cadet JL , Slikker W, Jr., Ali SF : Methamphetamine-induced dopaminergic neurotoxicity: role of peroxynitrite and neuroprotective role of antioxidants and peroxynitrite decomposition catalysts. Ann NY Acad Sci 939:366-380, 2001. (Pubitemid 32620088)
41. Iovine NM, Pursnani S, Voldman A, Wasserman G, Blaser MJ, Weinrauch Y: Reactive nitrogen species contribute to innate host defense against Campylobacter jejuni. Infect Immun 76:986-993, 2008.
42. Kato GJ, McGowan V, Machado RF, Little JA, Taylor J, Morris CR, Nichols JS, Wang X, Poljakovic M, Morris SM, Jr., Gladwin MT: Lactate dehydrogenase as a biomarker of hemolysis-associated nitric oxide resistance, priapism, leg ulceration, pulmonary hypertension, and death in patients with sickle cell disease. Blood 107:2279-2285, 2006. (Pubitemid 43345545)
43. Keil U, Bonert A, Marques CA, Scherping I, Weyermann J, Strosznajder JB, Müller-Spahn F, Haass C, Czech C, Pradier L, Müller WE, Eckert A: Amyloid-induced changes in nitric oxide production and mitochondrial activity lead to apoptosis. J Biol Chem 279:50310-50320, 2004. (Pubitemid 39577847)
44. Kim JY, Wand MP, Hauser R, Mukherjee S, Herrick RF, Christiani DC: Association of expired nitric oxide with occupational particulate exposure. Environ Health Perspect 111:676-680, 2003. (Pubitemid 36621595)
45. Kim YS, Täuber MG: Neurotoxicity of glia activated by gram-positive bacterial products depends on nitric oxide production. Infect Immun 64:3148-3153, 1996.
46. Kingwell BA: Nitric oxide-mediated metabolic regulation during exercise: effects of training in health and cardiovascular disease. FASEB J 14:1685-1696, 2000. (Pubitemid 30688618)
47. Koarai A, Ichinose M, Sugiura H, Tomaki M, Watanabe M, Yamagata S, Komaki Y, Shirato K, Hattori T: iNOS depletion completely diminishes reactive nitrogen-species formation after an allergic response. Eur Respir J 20:609-616, 2002. (Pubitemid 35050153)
48. Kobayashi H, Hataishi R, Mitsufuji H, Tanaka M, Jacobson M, Tomita T, Zapol WM, Jones RC: Antiinflammatory properties of inducible nitric oxide synthase in acute hyperoxic lung injury. Am J Respir Cel Mol Biol 24:390-397, 2001. (Pubitemid 32324726)
49. Kondo H, Takahashi M, Niki E: Peroxynitrite-induced hemolysis of human erythrocytes and its inhibition by antioxidants. FEBS Lett 413:236-238, 1997. (Pubitemid 27353275)
50. Kondo S, Toyokuni S, Tsuruyama T, Ozeki M, Tachibana T, Echizenya M, Hiai H, Onodera H, Imamura M: Peroxynitrite-mediated stress is associated with proliferation of human metastatic colorectal carcinoma in the liver. Cancer Lett 179:87-93, 2002. (Pubitemid 34195657)
51. Kröncke KD, Suschek CV: Adulterated effects of nitric oxide-generating donors. J Invest Dermatol 128:258-260, 2008.
52. Lakey JRT, Suarez-Pinzon WL, Strynadka K, Korbutt GS, Rajotte RV, Mabley JG, Szabó C, Rabinovitch A: Peroxynitrite is a mediator of cytokine-induced destruction of human pancreatic islet β cells. Lab Invest 81:1683-1692, 2001. (Pubitemid 33144430)
53. Lamas S, Pérez-Sala D, Moncada S: Nitric oxide: from discovery to the clinic. Trends Pharmacol Sci 19:436-438, 1998.
54. Lemesre JL, Sereno D, Daulouede S, Veyret B, Brajon N, Vincendeau P: Leishmania spp: nitric oxide-mediated inhibition of promastigote and axenically grown amastigote forms. Exp Parasitol 86:58-68, 1997.
55. Linden SK, Sutton P, Karlsson NG, Korolik V, McGuckin MA: Mucins in the mucosal barrier to infection. Mucosal Immunol 1:183-197, 2008.
56. Liu D, Ling X, Wen J, Liu J: The role of reactive nitrogen species in secondary spinal cord injury: formation of nitric oxide, peroxynitrite, and nitrated protein. J Neurochem 75:2144-2154, 2000. (Pubitemid 30783520)
57. Lizard G, Gambert P: Implication et modes d'action des agents infectieux dans la formation de la plaque d'atherome. Infection et athérosclé rose. Pathol Biol 49:824-829, 2001. (Pubitemid 33130955)
58. Lopansri BK, Anstey NM, Weinberg JB, Stoddard GJ, Hobbs MR, Levesque MC, Mwaikambo ED, Granger DL: Low plasma arginine concentrations in children with cerebral malaria and decreased nitric oxide production. Lancet 361:676-678, 2003.
59. Loscalzo J: Functional polymorphisms in a candidate gene for atherothrombosis: unraveling the complex fabric of a polygenic phenotype. J Am Coll Cardiol 41:946-948, 2003.
60. Machado RFP: Hipertensão arterial pulmonar associada à anemia falciforme. J Bras Pneumol 33:583-591, 2007.
61. MacMicking J, Xie Q-W, Nathan C: Nitric oxide and macrophage function. Annu Rev Immunol 15:323-350, 1997.
62. Mastrocola R, Restivo F, Vercellinatto I, Danni O, Brignardello E, Aragno M, Boccuzzi G: Oxidative and nitrosative stress in brain mitochondria of diabetic rats. J Endocrinol 187:37-44, 2005. (Pubitemid 41556399)
63. Mather KJ, Lteif A, Steinberg HO, Baron AD: Interactions between endothelin and nitric oxide in the regulation of vascular tone in obesity and diabetes. Diabetes 53:2060-2066, 2004. (Pubitemid 38970755)
64. Mazie D, Idrissa-Boubou M: Immunogénétique et paludisme cerebral. Bull Soc Pathol Exot 92:249-255, 1999.
65. Mayer M, Hermanova Z: Effect of nitric oxide metabolism upon peripheral blood chemiluminiscence and leukocyte and erythrocyte adherence in multiple sclerosis. Bratisl Lek Listy 100:531-536, 1999.
66. 2 levels in refractory hemorrhagic-shocked rats. J Surg Res 123:206-214, 2005.
67. Mercie P, Thiebaut R, Lavignolle V, Pellegrin JL, Yvorra-Vives MC, Morlat P, Ragnaud JM, Dupon M, Malvy D, Bellet H, Lawson-Ayayi S, Roudaut R, Dabis F: Evaluation of cardiovascular risk factors in HIV-1 infected patients using carotid intima-media thickness measurement. Ann Med 34:55-63, 2002. (Pubitemid 34454422)
68. Mhanna MJ, Ferkol T, Martin RJ, Dreshaj IA, van Heeckeren AM, Kelley TJ, Haxhiu MA: Nitric oxide deficiency contributes to impairment of airway relaxation in cystic fibrosis mice. Am J Respir Cel Mol Biol 24:621-626, 2001. (Pubitemid 32442771)
69. Missal TA, Pusateri ME, Donlin MJ, Chambers KT, Corbett JA, Lodge JK: Posttranslational, translational, and transcriptional responses to nitric oxide stress in Cryptococcus neoformans: implications for virulence. Eukaryot Cell 5:518-529, 2006.
70. Napoli C, Ignaro LJ: Nitric oxide and atherosclerosis. Nitric Oxide 5:88-97, 2001.
71. Nappi AJ, Vass E: Interactions of iron with reactive intermediates of oxygen and nitrogen. Dev Neurosci 24:134-142, 2002. (Pubitemid 36151443)
72. Noiri E, Nakao A, Uchida K, Tsukahara H, Ohno M, Fujita T, Brodsky S, Goligorsky MS: Oxidative and nitrosative stress in acute renal ischemia. Am J Physiol Renal Physiol 281:F948-F957, 2001. (Pubitemid 33123840)
73. Nordstrom CK, Dwyer KM, Merz NB, Shircore A, Dwyer JH: Leisure time physical activity and early atherosclerosis: The Los Angeles Atherosclerosis Study. Am J Med 115:19-25, 2003. (Pubitemid 36831117)
74. Obrosova IG, Mabley JG, Zsengellér Z, Charniauskaya T, Abatan OI, Groves JT, Szabó C: Role for nitrosative stress in diabetic neuropathy: evidence from studies with a peroxynitrite decomposition catalyst. FASEB J 19:401-403, 2005.
75. Obrosova IG, Drel VR, Oltman CL, Mashtalir N, Tibrewala J, Groves JT, Yorek MA: Role of nitrosative stress in early neuropathy and vascular dysfunction in streptozotocin-diabetic rats. Am J Physiol Endocrinol Metab 293:E1645-E1655, 2007. (Pubitemid 350255115)
76. Ogawa R, Pacelli R, Espey MG, Miranda KM, Friedman N, Kim SM, Cox G, Mitchell JB, Wink DA, Russo A: Comparison of control of Listeria by nitric oxide redox chemistry from murine macrophages and NO donors: insights into listerocidal activity of oxidative and nitrosative stress. Free Radic Biol Med 30:268-276, 2001.
77. Oliveira GV, Shimoda K, Enkhbaatar P, Jodoin J, Burke AS, Chinkes DL, Hawkins HK, Herndon DN, Traber L, Traber D, Murakami K: Skin nitric oxide and its metabolites are increased in nonburned skin after thermal injuries. Shock 22:278-282, 2004. (Pubitemid 39468994)
78. Pacher P, Szabó C: Role of the peroxynitrite-poly(ADP-ribose) polymerase pathway in human disease. Am J Pathol 173:2-13, 2008. (Pubitemid 351947950)
79. Pasaoglu H, Bukan N, Bulduk G, Çelen S: Lipid peroxidation, nitrate and nitrite levels in eclamptic and intrauterine growth retarded pregnancies. Turk J Med Sci 33:89-93, 2003. (Pubitemid 36604407)
80. Pennathur S, Bergt C, Shao B, Byun J, Kassim SY, Singh P, Green PS, McDonald TO, Brunzell J, Chait A, Oram JF, O'Brien K et al.: Human atherosclerotic intima and blood of patients with established coronary artery disease contain high density lipoprotein damaged by reactive nitrogen species. J Biol Chem 279:42977-44283, 2004. (Pubitemid 39372190)
81. Potenza MA, Marasciulo FL, Chieppa DM, Brigiani GS, Formoso G, Quon MJ, Montagnani M: Insulin resistance in spontaneously hypertensive rats is associated with endothelial dysfunction characterized by imbalance between NO and ET-1 production. Am J Physiol Heart Circ Physiol 289:HH813-H822, 2005. (Pubitemid 41129399)
82. Prasanna SJ, Saha B, Nandi D: Involvement of oxidative and nitrosative stress in modulation of gene expression and functional responses by IFNγ. Int Immunol 19:867-879, 2007. (Pubitemid 47241895)
83. Rai RM, Lee FYJ, Rosen A, Yang SQ, Lin HZ, Koteish A, Liew FY, Zaragoza C, Lowenstein C, Diehl AM: Impaired liver regeneration in inducible nitric oxide synthase deficient mice. Proc Natl Acad Sci USA 95:13829-13834, 1998. (Pubitemid 28523058)
84. Rashid PA, Whitehurst A, Lawson N, Bath PMW: Plasma nitric oxide (nitrate/nitrite) levels in acute stroke and their relationships with severity and outcome. J Stroke Cerebrovasc Dis 12:82-87, 2003. (Pubitemid 36506247)
85. Ridnour LA, Thomas DD, Mancardi D, Espey MG, Miranda KM, Paolocci N, Feelisch M, Fukutu J, Wink DA: The chemistry of nitrosative stress induced by nitric oxide and reactive nitrogen species. Putting perspective on stressful biological situations. Biol Chem 385:1-10, 2004.
86. Roberts CK, Vaziri ND, Barnard J: Effect of diet and exercise intervention on blood pressure, insulin, oxidative stress, and nitric oxide availability. Circulation 106:2530-2532, 2002.
87. Rockett KA, Awburn MM, Cowden WB, Clark IA: Killing of Plasmodium falciparum in vitro by nitric oxide derivatives. Infect Immun 59:3280-3283, 1991.
88. Roediger WEW: Nitric oxide damage to colonocytes in colitis-by- association: remote transfer of nitric oxide to the colon. Digestion 65:191-195, 2002.
89. Shankar SS, Considine RV, Gorski JC, Steinberg HO: Insulin sensitivity is preserved despite disrupted endothelial function. Am J Physiol Endocrinol Metab 291:E691-E696, 2006.
90. Shekhter AB, Serezhenkov VA, Rudenko TG, Pekshev AV, Vanin AF: Beneficial effect of gaseous nitric oxide on the healing of skin wounds. Nitric Oxide 12:210-219, 2005.
91. Smith MA, Harris PLR, Sayre LM, Beckman JS, Perry G: Widespread peroxynitrite-mediated damage in Alzheimer's disease. J Neurosci 17:2653-2657, 1997.
92. Sogut S, Zoroglu SS, Özyurt H, Yilmaz HR, Özugurlu F, Sivasli E, Yetkin Ö, Yanik M, Tutkun H, Savas HA, Tarakçioglu M, Akyol Ö: Changes in nitric oxide levels and antioxidant enzyme activities may have a role in the pathophysiological mechanisms involved in autism. Clin Chim Acta 331:111-117, 2003. (Pubitemid 36412032)
93. Sözmen B, Kazaz C, Taskiran D, Aslan L, Akyol A, Sözmen EY: Plasma antioxidant status and nitrate levels in patients with hypertension and coronary heart disease. Turk J Med Sci 28:525-531, 1998.
94. Sözmen B, Uysal F, Gazitepe D, Aslan L, Sözmen EY: A novel clinical and laboratory based approach to coronary heart disease: relationship between angiography findings, antioxidant enzymes and NO. Turk J Med Sci 29:117-123, 1999.
95. Spoto B, Benedetto FA, Testa A, Tripepi G, Mallamaci F, Maas R, Boeger RH, Zoccali C: An addictive effect of endothelial nitric oxide synthase polymorphisms contributes to the severity of atherosclerosis in patients on dialysis. Am J Hypert 20:758-763, 2007. (Pubitemid 46936172)
96. Szabó C, Thiemermann C: Role of nitric oxide in hemorrhagic, traumatic, and anaphylactic shock and thermal injury. Shock 2:145-155, 1994.
97. Takemura S, Minamiyama Y, Inoue M, Kubo S, Hirohashi K, Kinoshita H: Nitric oxide synthase inhibitor increases hepatic injury with formation of oxidative DNA damage and microcirculatory disturbance in endotoxemic rats. Hepatogastroenterology 47:1364-1370, 2000. (Pubitemid 30836719)
98. Talvani A, Machado FS, Santana GC, Klein A, Barcelos L, Silva JS, Teixeira MM: Leukotriene B4 induces nitric oxide synthesis in Trypanosamoa cruzi-infected murine macrophages and mediates resistance to infection. Infect Immun 70:4247-4253, 2002.
99. Tavazzi B, Vagnozzi R, Signoretti S, Amorini AM, Belli A, Cimatti M, Delfini R, Di Pietro V, Finocchiaro A, Lazzarino G: Temporal window of metabolic brain vulnerability to concussions: oxidative and nitrosative stresses - part II. Neurosurgery 61:390-395, 2007. (Pubitemid 47357346)
100. Thomas PS, Gibson PG, Wang H, Shah S, Henry RL: The relationship of exhaled nitric oxide to airway inflammation and responsiveness in children. J Asthma 42:291-295, 2005. (Pubitemid 40967721)
101. Tsoumakidou M, Tzanakis N, Chrysofakis G, Siafakas NM: Nitrosative stress, heme oxygenase-1 expression and airway inflammation during severe exacerbations of COPD. Chest 127:1911-1918, 2005.
102. Turco J, Liu H, Gottlieb SF, Winkler HH: Nitric oxide-mediated inhibition of the ability of Rickettsia prowasekii to infect mouse fibroblasts and mouse macrophagelike cells. Infect Immun 66:558-566, 1998.
103. Vazquez-Torres A, Jones-Carson J, Balish E: Peroxynitrite contributes to the candidacidal activity of nitric oxide-producing macrophages. Infect Immun 64:3127-3133, 1996. (Pubitemid 26256155)
104. 1-42- and lypopolyssacharide-activated microglia. J Neurosci 22:3484-3492, 2002.
105. Wang C-H, Kuo H-P: Nitric oxide modulates interleukin-1β and tumour necrosis factor-α synthesis, and disease regression by alveolar macrophages in pulmonary tuberculosis. Respirology 6:79-84, 2001.
106. Wang X, Zalcestein A, Oren M: Nitric oxide promotes p53 nuclear retention and sensitizes neuroblastoma cells to apoptosis by ionizing radiation. Cell Death Differ 10:468-476, 2003. (Pubitemid 36626359)
107. Weinberger B, Laskin DL, Heck DE, Laskin JD: The toxicology of inhaled nitric oxide. Toxicol Sci 59:5-16, 2001.
108. Weiner DL, Hibberd PL, Betit P, Copper AB, Botelho CA, Brugnara C: Preliminary assessment of inhaled nitric oxide for acute vaso-occlusive crisis in pediatric patients with sickle cell disease. J Am Med Assoc 289:1136-1142, 2003. (Pubitemid 37430328)
109. Wilcox CS: Oxidative stress and nitric oxide deficiency in the kidney: a critical link to hypertension? Am J Physiol Regul Integr Comp Physiol 289:R913-935, 2005.
110. Wink DA, Cook JA, Pacelli R, Liebmann J, Krishna MC, Mitchell JB: Nitric oxide (NO) protects against cellular damage by reactive oxygen species. Toxicol Lett 82/83:221-226, 1995. (Pubitemid 26054708)
111. Woodman RJ, Playford DA, Watts GF: Basal production of nitric oxide (NO) and non-NO vasodilators in the forearm microcirculation in type 2 diabetes: associations with blood pressure and HDL cholesterol. Diabetes Res Clin Pract 71:59-67, 2006.
112. Yamaguchi Y, Kagota S, Haginaka J, Kunitomo M: Peroxynitrite-generating species: good candidate oxidants in aqueous extracts of cigarette smoke. Jpn J Pharmacol 82:78-81, 2000. (Pubitemid 30098656)
113. Yu S-W, Andrabi SA, Wang H, Kim NS, Poirier GG, Dawson TM, Dawson VL: Apoptosis-inducing factor mediates poly(ADP-ribose)(PAR) polymer-induced cell death. Proc Natl Acad Sci USA 103:18314-18319, 2006. (Pubitemid 44871655)
114. 2+-dependent apoptosis of pancreatic β cells, which can be prevented by inhibition of nitric oxide synthase. Lab Invest 82:1229-1239, 2002.