Rapamycin suppresses the expansion and differentiation of porcine neonatal pancreas cell clusters

Transplantation

Volumn 90, Issue 7, 2010, Pages 717-724

  Sun, Cheng Lin ^a,b   Ham, Dong Sik ^a   Park, Heon Seok ^a   Kim, Ji Won ^a   Cho, Jae Hyoung ^a   Song, Ki Ho ^a   Son, Ho Young ^a   Yoon, Kun Ho ^a  

^a The Catholic University of Korea   (South Korea)

^b JILIN UNIVERSITY   (China)

Author keywords

Foxo1; PDX 1; Porcine NPCCs; Rapamycin

Indexed keywords

CASPASE 3; HOMEODOMAIN PROTEIN; INSULIN; RAPAMYCIN; SOMATOMEDIN B; TRANSCRIPTION FACTOR FKHR;

ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; CELL DIFFERENTIATION; CELL EXPANSION; CELL FUNCTION; CELL PROLIFERATION; CELL REGENERATION; CELL VIABILITY; CYTOPLASM; DOWN REGULATION; DRUG EFFECT; IN VITRO STUDY; INSULIN RELEASE; MOUSE; NONHUMAN; PANCREAS CELL; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

ANIMALS; ANIMALS, NEWBORN; CASPASE 3; CELL DIFFERENTIATION; CELL DIVISION; CELL SURVIVAL; DNA PRIMERS; DNA REPLICATION; GENE EXPRESSION REGULATION; INSULIN; INSULIN-SECRETING CELLS; MICE; MICE, INBRED BALB C; MICE, NUDE; PANCREAS; PANCREATECTOMY; POLYMERASE CHAIN REACTION; SIROLIMUS; SWINE;

EID: 77958022918     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/TP.0b013e3181eceaaf     Document Type: Article

References (39)

1. Shapiro AM, Lakey JR, Ryan EA, et al. Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free im-munosuppressive regimen. N Engl J Med 2000; 343: 230.
2. Shapiro AM, Ricordi C, Hering BJ, et al. International trial of the Edmonton protocol for islet transplantation. N Engl J Med 2006; 355: 1318.
3. Hauben E, Gregori S, Draghici E, et al. Activation of the aryl hydrocarbon receptor promotes allograft-specific tolerance through direct and dendritic cell-mediated effects on regulatory T cells. Blood 2008; 112: 1214.
4. Barilli A, Visigalli R, Sala R, et al. In human endothelial cells rapamycin causes mTORC2 inhibition and impairs cell viability and function. Cardiovasc Res 2008; 78: 563.
5. Valdés-González RA, Dorantes LM, Garibay GN, et al. Xenotransplan-tationofporcine neonatal isletsofLangerhans and sertoli cells:A4-year study. Eur J Endocrinol 2005; 153: 419.
6. Elliott RB, Escobar L, Tan PL, et al. Live encapsulated porcine islets from a type 1 diabetic patient 9.5 yr after xenotransplantation. Xenotransplantation 2007; 14: 157.
7. Tatarkiewicz K, López-Avalos MD, Yoon KH, et al. Development and retroviral transduction of porcine neonatal pancreatic islet cells in monolayer culture. Dev Growth Differ 2003; 45: 39.
8. Hao E, Tyrberg B, Itkin-Ansari P, et al. Beta-cell differentiation from nonendocrine epithelial cells of the adult human pancreas. Nat Med 2006; 12: 310.
9. Lock LT, Tzanakakis ES. Stem/progenitor cell sources of insulin-producing cells for the treatment of diabetes. Tissue Eng 2007; 13: 1399.
10. Zhang YQ, Kritzik M, Sarvetnick N. Identification and expansion of pancreatic stem/progenitor cells. J Cell Mol Med 2005; 9: 331.
11. Suarez-Pinzon WL, Lakey JR, Brand SJ, et al. Combination therapy with epidermal growth factor and gastrin induces neogenesis of human islet {beta}-cells from pancreatic duct cells and an increase in functional {beta}-cell mass. J Clin Endocrinol Metab 2005; 90: 3401.
12. Todorov I, Omori K, Pascual M, et al. Generation of human islets through expansion and differentiation of non-islet pancreatic cells discarded (pancreatic discard) after islet isolation. Pancreas 2006; 32: 130.
13. Trivedi N, Hollister-Lock J, Lopez-Avalos MD, et al. Increase in beta-cell mass in transplanted porcine neonatal pancreatic cell clusters is due to proliferation of beta-cells and differentiation of duct cells. Endocrinology 2001; 142: 2115.
14. Kim MS, Kim JW, Sun C, et al. Induction of efficient differentiation and survival of porcine neonatal pancreatic cell clusters using an EBV-based plasmid expressing HGF. J Biochem 2008; 143: 497.
15. Weir GC, Quickel RR, Yoon KH, et al. Porcine neonatal pancreatic cell clusters (NPCCs): A potential source of tissue for islet transplantation. Ann Transplant 1997; 2: 63.
16. Yoon KH, Quickel RR, Tatarkiewicz K, et al. Differentiation and expansion of beta cell mass in porcine neonatal pancreatic cell clusters transplanted into nude mice. Cell Transplant 1999; 8: 673.
17. Ko SH, Kwon HS, Suh SH, et al. Dexamethasone suppresses the expansion and transdifferentiation of transplanted porcine neonatal pancreas cell clusters (NPCCs) into beta-cells in normal nude mice. Diabetes Res Clin Pract 2004; 66: S97.
18. Bussiere CT, Lakey JR, Shapiro AM, et al. The impact of the mTOR inhibitor sirolimus on the proliferation and function of pancreatic islets and ductal cells. Diabetologia 2006; 49: 2341.
19. Zhang N, Su D, Qu S, et al. Sirolimus is associated with reduced islet engraftment and impaired beta-cell function. Diabetes 2006; 55: 2429.
20. Fraenkel M, Ketzinel-Gilad M, Ariav Y, et al. mTOR inhibition by rapamycin prevents beta-cell adaptation to hyperglycemia and exacerbates the metabolic state in type 2 diabetes. Diabetes 2008; 57: 945.
21. Reffet S, Thivolet C. Immunology of pancreatic islet transplantation. Diabetes Metab 2006; 32: 523.
22. Bell E, Cao X, Moibi JA, et al. Rapamycin has a deleterious effect on MIN-6 cells and rat and human islets. Diabetes 2003; 51: 2731.
23. Zahr E, Molano RD, Pileggi A, et al. Rapamycin impairs in vivo proliferation of islet beta-cells. Transplantation 2007; 84: 1576.
24. Erbay E, Park IH, Nuzzi PD, et al. IGF-II transcription in skeletal myo-genesis is controlled by mTOR and nutrients. J Cell Biol 2003; 163: 931.
25. Estil les E, Téllez N, Soler J, et al. High sensitivity of {beta}-cell replication to the inhibitory effects of interleukin-1{beta}. Modulation by adenoviral overexpression of insulin-like growth factor-II in rat islets. J Endocrinol. 2009; 203: 55.
26. Wu AL, Kim JH, Zhang C, et al. Forkhead box protein O1 negatively regulates skeletal myocyte differentiation through degradation of mammalian target of rapamycin pathway components. Endocrinology 2008; 149: 1407.
27. Kawamori D, Kaneto H, Nakatani Y, et al. The forkhead transcription factor Foxo1 bridges the JNK pathway and the transcription factor PDX-1 through its intracellular translocation. J Biol Chem 2006; 281: 1091.
28. Calderari S, Gangnerau MN, Thibault M, et al. Defective IGF2 and IGF1R protein production in embryonic pancreas precedes beta cell mass anomaly in the Goto-Kakizaki rat model of type 2 diabetes. Diabetologia 2007; 50: 1463.
29. Martín MA, Serradas P, Ramos S, et al. Protein-caloric food restriction affects insulin-like growth factor system in fetal Wister rat. Endocrinology 2005; 146: 1364.
30. Hamid M, McCluskey JT, McClenaghan NH, et al. Comparison of the secretory properties of four insulin-secreting cell lines. Endocr Res 2002; 28: 35.
31. Erbay E, Chen J. The mammalian target of rapamycin regulates C2C12 myogenesis via a kinase-independent mechanism. J Biol Chem 2001; 276: 36079.
32. Han J, Wang B, Xiao Z, et al. Mammalian target of rapamycin (mTOR) is involved in the neuronal differentiation of neural progenitors induced by insulin. Mol Cell Neurosci 2008; 39: 118.
33. Zeng M, Zhou JN. Roles of autophagy and mTOR signaling in neuronal differentiation of mouse neuroblastoma cells. Cell Signal 2008; 20: 659.
34. Kaneto H, Nakatani Y, Miyatsuka T, et al. PDX-1/VP16 fusion protein, together with NeuroD or Ngn3, markedly induces insulin gene transcription and ameliorates glucose tolerance. Diabetes 2005; 54: 1009.
35. Sander M, German MS. The beta cell transcription factors and development of the pancreas. J Mol Med 1997; 75: 327.
36. Jiang J, Au M, Lu K, et al. Generation of insulin-producing islet-like clusters from human embryonic stem cells. Stem Cells 2007; 25: 1940.
37. Kodama S,Toyonaga T, Kondo T, et al. Enhanced expression ofPDX-1 and Ngn3 by exendin-4 during beta cell regeneration in STZ-treated mice. Biochem Biophys Res Commun 2005; 327: 1170.
38. Palmes D, Zibert A, Budny T, et al. Impact of rapamycin on liver regeneration. Virchows Arch 2008; 452: 545.
39. Boldt A, Barten MJ, Weiss C, et al. Novel apoptosis assay to analyze immunosuppression. Cytometry A 2006; 69: 158.