Synthesis, NMR characterization and divergent biological actions of 2′-hydroxy-ceramide/dihydroceramide stereoisomers in MCF7 cells

Bioorganic and Medicinal Chemistry

Volumn 18, Issue 21, 2010, Pages 7565-7579

  Szulc, Zdzislaw M ^a   Bai, Aiping ^a   Bielawski, Jacek ^a   Mayroo, Nalini ^a   Miller, Doreen E ^a,b   Gracz, Hanna ^c   Hannun, Yusuf A ^a   Bielawska, Alicja ^a  

^a MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^b Roche Carolina   (United States)

^c NORTH CAROLINA STATE UNIVERSITY   (United States)

Author keywords

(2 R) 2 Hydroxy ceramide; (2 S) 2 Hydroxy ceramide; Cellular sphingolipids; Ceramide; Cytotoxicity; LC MS MS; NMR; Stereospecificity; Synthesis

Indexed keywords

CERAMIDE DERIVATIVE;

ARTICLE; CELL STRAIN MCF 7; CONTROLLED STUDY; DRUG ACTIVITY; DRUG CYTOTOXICITY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; MASS SPECTROMETRY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; OPTICAL ROTATION; PROTEIN LIPID INTERACTION; STEREOISOMERISM; STEREOSPECIFICITY;

CELL LINE, TUMOR; CERAMIDES; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; SPHINGOLIPIDS; STEREOISOMERISM; TIME FACTORS;

EID: 77958004987     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2010.08.050     Document Type: Article

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