메뉴 건너뛰기




Volumn 151, Issue 2, 2010, Pages 296-306

A novel cell-cell signaling by microglial transmembrane TNFα with implications for neuropathic pain

Author keywords

CCL2; Microglia; Neuropathic pain; Substance P; Tumor necrosis factor

Indexed keywords

CD11B ANTIGEN; LIPOPOLYSACCHARIDE; MONOCYTE CHEMOTACTIC PROTEIN 1; PHOSPHATIDYLINOSITOL 3 KINASE; RECOMBINANT TUMOR NECROSIS FACTOR ALPHA; SUBSTANCE P; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR ALPHA CONVERTING ENZYME;

EID: 77957926716     PISSN: 03043959     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pain.2010.06.017     Document Type: Article
Times cited : (34)

References (53)
  • 1
    • 0029655582 scopus 로고    scopus 로고
    • Spinal cord substance P receptor immunoreactivity increases in both inflammatory and nerve injury models of persistent pain
    • C. Abbadie, J.L. Brown, P.W. Mantyh, and A.I. Basbaum Spinal cord substance P receptor immunoreactivity increases in both inflammatory and nerve injury models of persistent pain Neuroscience 70 1996 201 209
    • (1996) Neuroscience , vol.70 , pp. 201-209
    • Abbadie, C.1    Brown, J.L.2    Mantyh, P.W.3    Basbaum, A.I.4
  • 2
    • 0032570035 scopus 로고    scopus 로고
    • Increase of interleukin-6 mRNA in the spinal cord following peripheral nerve injury in the rat: Potential role of IL-6 in neuropathic pain
    • J.L. Arruda, R.W. Colburn, A.J. Rickman, M.D. Rutkowski, and J.A. DeLeo Increase of interleukin-6 mRNA in the spinal cord following peripheral nerve injury in the rat: potential role of IL-6 in neuropathic pain Brain Res Mol Brain Res 62 1998 228 235
    • (1998) Brain Res Mol Brain Res , vol.62 , pp. 228-235
    • Arruda, J.L.1    Colburn, R.W.2    Rickman, A.J.3    Rutkowski, M.D.4    Deleo, J.A.5
  • 3
    • 0034613224 scopus 로고    scopus 로고
    • Intrathecal anti-IL-6 antibody and IgG attenuates peripheral nerve injury-induced mechanical allodynia in the rat: Possible immune modulation in neuropathic pain
    • J.L. Arruda, S. Sweitzer, M.D. Rutkowski, and J.A. DeLeo Intrathecal anti-IL-6 antibody and IgG attenuates peripheral nerve injury-induced mechanical allodynia in the rat: possible immune modulation in neuropathic pain Brain Res 879 2000 216 225
    • (2000) Brain Res , vol.879 , pp. 216-225
    • Arruda, J.L.1    Sweitzer, S.2    Rutkowski, M.D.3    Deleo, J.A.4
  • 4
    • 0033529224 scopus 로고    scopus 로고
    • Distinct neurochemical features of acute and persistent pain
    • A.I. Basbaum Distinct neurochemical features of acute and persistent pain Proc Natl Acad Sci USA 96 1999 7739 7743
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 7739-7743
    • Basbaum, A.I.1
  • 5
    • 0034959741 scopus 로고    scopus 로고
    • Characterization of a novel brain-derived microglial cell line isolated from neonatal rat brain
    • P. Cheepsunthorn, L. Radov, S. Menzies, J. Reid, and J.R. Connor Characterization of a novel brain-derived microglial cell line isolated from neonatal rat brain Glia 35 2001 53 62
    • (2001) Glia , vol.35 , pp. 53-62
    • Cheepsunthorn, P.1    Radov, L.2    Menzies, S.3    Reid, J.4    Connor, J.R.5
  • 6
    • 67651048942 scopus 로고    scopus 로고
    • Neuropathic pain: A maladaptive response of the nervous system to damage
    • M. Costigan, J. Scholz, and C.J. Woolf Neuropathic pain: a maladaptive response of the nervous system to damage Annu Rev Neurosci 32 2009 1 32
    • (2009) Annu Rev Neurosci , vol.32 , pp. 1-32
    • Costigan, M.1    Scholz, J.2    Woolf, C.J.3
  • 7
    • 0029783630 scopus 로고    scopus 로고
    • Interleukin-6-mediated hyperalgesia/allodynia and increased spinal IL-6 expression in a rat mononeuropathy model
    • J.A. DeLeo, R.W. Colburn, M. Nichols, and A. Malhotra Interleukin-6-mediated hyperalgesia/allodynia and increased spinal IL-6 expression in a rat mononeuropathy model J Interferon Cytokine Res 16 1996 695 700
    • (1996) J Interferon Cytokine Res , vol.16 , pp. 695-700
    • Deleo, J.A.1    Colburn, R.W.2    Nichols, M.3    Malhotra, A.4
  • 8
    • 0030751245 scopus 로고    scopus 로고
    • Cytokine and growth factor immunohistochemical spinal profiles in two animal models of mononeuropathy
    • J.A. DeLeo, R.W. Colburn, and A.J. Rickman Cytokine and growth factor immunohistochemical spinal profiles in two animal models of mononeuropathy Brain Res 759 1997 50 57
    • (1997) Brain Res , vol.759 , pp. 50-57
    • Deleo, J.A.1    Colburn, R.W.2    Rickman, A.J.3
  • 9
    • 0033996094 scopus 로고    scopus 로고
    • Transgenic expression of TNF by astrocytes increases mechanical allodynia in a mouse neuropathy model
    • J.A. DeLeo, M.D. Rutkowski, A.K. Stalder, and I.L. Campbell Transgenic expression of TNF by astrocytes increases mechanical allodynia in a mouse neuropathy model NeuroReport 11 2000 599 602
    • (2000) NeuroReport , vol.11 , pp. 599-602
    • Deleo, J.A.1    Rutkowski, M.D.2    Stalder, A.K.3    Campbell, I.L.4
  • 10
    • 1642579573 scopus 로고    scopus 로고
    • Neuroimmune activation and neuroinflammation in chronic pain and opioid tolerance/hyperalgesia
    • J.A. DeLeo, F.Y. Tanga, and V.L. Tawfik Neuroimmune activation and neuroinflammation in chronic pain and opioid tolerance/hyperalgesia Neuroscientist 10 2004 40 52
    • (2004) Neuroscientist , vol.10 , pp. 40-52
    • Deleo, J.A.1    Tanga, F.Y.2    Tawfik, V.L.3
  • 11
    • 47349092661 scopus 로고    scopus 로고
    • Remote activation of microglia and pro-inflammatory cytokines predict the onset and severity of below-level neuropathic pain after spinal cord injury in rats
    • M.R. Detloff, L.C. Fisher, V. McGaughy, E.E. Longbrake, P.G. Popovich, and D.M. Basso Remote activation of microglia and pro-inflammatory cytokines predict the onset and severity of below-level neuropathic pain after spinal cord injury in rats Exp Neurol 212 2008 337 347
    • (2008) Exp Neurol , vol.212 , pp. 337-347
    • Detloff, M.R.1    Fisher, L.C.2    McGaughy, V.3    Longbrake, E.E.4    Popovich, P.G.5    Basso, D.M.6
  • 12
    • 32644440589 scopus 로고    scopus 로고
    • Spontaneous pain, both neuropathic and inflammatory, is related to frequency of spontaneous firing in intact C-fiber nociceptors
    • L. Djouhri, S. Koutsikou, X. Fang, S. McMullan, and S.N. Lawson Spontaneous pain, both neuropathic and inflammatory, is related to frequency of spontaneous firing in intact C-fiber nociceptors J Neurosci 26 2006 1281 1292
    • (2006) J Neurosci , vol.26 , pp. 1281-1292
    • Djouhri, L.1    Koutsikou, S.2    Fang, X.3    McMullan, S.4    Lawson, S.N.5
  • 13
    • 4344694114 scopus 로고    scopus 로고
    • Ligands working as receptors: Reverse signaling by members of the TNF superfamily enhance the plasticity of the immune system
    • G. Eissner, W. Kolch, and P. Scheurich Ligands working as receptors: reverse signaling by members of the TNF superfamily enhance the plasticity of the immune system Cytokine Growth Factor Rev 15 2004 353 366
    • (2004) Cytokine Growth Factor Rev , vol.15 , pp. 353-366
    • Eissner, G.1    Kolch, W.2    Scheurich, P.3
  • 14
    • 28444496349 scopus 로고    scopus 로고
    • In vivo tumor targeting of tumor necrosis factor-alpha-loaded stealth nanoparticles: Effect of MePEG molecular weight and particle size
    • C. Fang, B. Shi, Y.Y. Pei, M.H. Hong, J. Wu, and H.Z. Chen In vivo tumor targeting of tumor necrosis factor-alpha-loaded stealth nanoparticles: effect of MePEG molecular weight and particle size Eur J Pharm Sci 27 2005 27 36
    • (2005) Eur J Pharm Sci , vol.27 , pp. 27-36
    • Fang, C.1    Shi, B.2    Pei, Y.Y.3    Hong, M.H.4    Wu, J.5    Chen, H.Z.6
  • 15
  • 17
    • 0036849018 scopus 로고    scopus 로고
    • Microglia as a source and target of cytokines
    • U.K. Hanisch Microglia as a source and target of cytokines Glia 40 2002 140 155
    • (2002) Glia , vol.40 , pp. 140-155
    • Hanisch, U.K.1
  • 18
    • 34250766660 scopus 로고    scopus 로고
    • Gene transfer to interfere with TNFalpha signaling in neuropathic pain
    • S. Hao, M. Mata, J.C. Glorioso, and D.J. Fink Gene transfer to interfere with TNFalpha signaling in neuropathic pain Gene Ther 14 2007 1010 1016
    • (2007) Gene Ther , vol.14 , pp. 1010-1016
    • Hao, S.1    Mata, M.2    Glorioso, J.C.3    Fink, D.J.4
  • 19
    • 0034657820 scopus 로고    scopus 로고
    • Spinal glial activation and cytokine expression after lumbar root injury in the rat
    • H. Hashizume, J.A. DeLeo, R.W. Colburn, and J.N. Weinstein Spinal glial activation and cytokine expression after lumbar root injury in the rat Spine 25 2000 1206 1217
    • (2000) Spine , vol.25 , pp. 1206-1217
    • Hashizume, H.1    Deleo, J.A.2    Colburn, R.W.3    Weinstein, J.N.4
  • 20
    • 17944371991 scopus 로고    scopus 로고
    • The intriguing biology of the tumour necrosis factor/tumour necrosis factor receptor superfamily: Players, rules and the games
    • T. Hehlgans, and K. Pfeffer The intriguing biology of the tumour necrosis factor/tumour necrosis factor receptor superfamily: players, rules and the games Immunology 115 2005 1 20
    • (2005) Immunology , vol.115 , pp. 1-20
    • Hehlgans, T.1    Pfeffer, K.2
  • 21
    • 0035256911 scopus 로고    scopus 로고
    • The molecular dynamics of pain control
    • S.P. Hunt, and P.W. Mantyh The molecular dynamics of pain control Nat Rev Neurosci 2 2001 83 91
    • (2001) Nat Rev Neurosci , vol.2 , pp. 83-91
    • Hunt, S.P.1    Mantyh, P.W.2
  • 22
    • 30644463076 scopus 로고    scopus 로고
    • Acute p38-mediated modulation of tetrodotoxin-resistant sodium channels in mouse sensory neurons by tumor necrosis factor-alpha
    • X. Jin, and R.W.t. Gereau Acute p38-mediated modulation of tetrodotoxin-resistant sodium channels in mouse sensory neurons by tumor necrosis factor-alpha J Neurosci 26 2006 246 255
    • (2006) J Neurosci , vol.26 , pp. 246-255
    • Jin, X.1
  • 23
    • 53049109161 scopus 로고    scopus 로고
    • Up-regulation of tumor necrosis factor-alpha in spinal cord contributes to vincristine-induced mechanical allodynia in mice
    • N. Kiguchi, T. Maeda, Y. Kobayashi, and S. Kishioka Up-regulation of tumor necrosis factor-alpha in spinal cord contributes to vincristine-induced mechanical allodynia in mice Neurosci Lett 445 2008 140 143
    • (2008) Neurosci Lett , vol.445 , pp. 140-143
    • Kiguchi, N.1    Maeda, T.2    Kobayashi, Y.3    Kishioka, S.4
  • 24
    • 17044417657 scopus 로고    scopus 로고
    • Minocycline attenuates mechanical allodynia and proinflammatory cytokine expression in rat models of pain facilitation
    • A. Ledeboer, E.M. Sloane, E.D. Milligan, M.G. Frank, J.H. Mahony, S.F. Maier, and L.R. Watkins Minocycline attenuates mechanical allodynia and proinflammatory cytokine expression in rat models of pain facilitation Pain 115 2005 71 83
    • (2005) Pain , vol.115 , pp. 71-83
    • Ledeboer, A.1    Sloane, E.M.2    Milligan, E.D.3    Frank, M.G.4    Mahony, J.H.5    Maier, S.F.6    Watkins, L.R.7
  • 25
    • 11244254104 scopus 로고    scopus 로고
    • Temporal expression of cytokines and their receptors mRNAs in a neuropathic pain model
    • H.L. Lee, K.M. Lee, S.J. Son, S.H. Hwang, and H.J. Cho Temporal expression of cytokines and their receptors mRNAs in a neuropathic pain model NeuroReport 15 2004 2807 2811
    • (2004) NeuroReport , vol.15 , pp. 2807-2811
    • Lee, H.L.1    Lee, K.M.2    Son, S.J.3    Hwang, S.H.4    Cho, H.J.5
  • 26
    • 0036712503 scopus 로고    scopus 로고
    • Increased sensitivity of sensory neurons to tumor necrosis factor alpha in rats with chronic compression of the lumbar ganglia
    • B. Liu, H. Li, S.J. Brull, and J.M. Zhang Increased sensitivity of sensory neurons to tumor necrosis factor alpha in rats with chronic compression of the lumbar ganglia J Neurophysiol 88 2002 1393 1399
    • (2002) J Neurophysiol , vol.88 , pp. 1393-1399
    • Liu, B.1    Li, H.2    Brull, S.J.3    Zhang, J.M.4
  • 29
    • 0034020230 scopus 로고    scopus 로고
    • The importance of shedding of membrane proteins for cytokine biology
    • J. Mullberg, K. Althoff, T. Jostock, and S. Rose-John The importance of shedding of membrane proteins for cytokine biology Eur Cytokine Netw 11 2000 27 38
    • (2000) Eur Cytokine Netw , vol.11 , pp. 27-38
    • Mullberg, J.1    Althoff, K.2    Jostock, T.3    Rose-John, S.4
  • 30
    • 2442489671 scopus 로고    scopus 로고
    • TNF-alpha and TNF-alpha receptor type 1 upregulation in glia and neurons after peripheral nerve injury: Studies in murine DRG and spinal cord
    • S. Ohtori, K. Takahashi, H. Moriya, and R.R. Myers TNF-alpha and TNF-alpha receptor type 1 upregulation in glia and neurons after peripheral nerve injury: studies in murine DRG and spinal cord Spine 29 2004 1082 1088
    • (2004) Spine , vol.29 , pp. 1082-1088
    • Ohtori, S.1    Takahashi, K.2    Moriya, H.3    Myers, R.R.4
  • 31
    • 0031259777 scopus 로고    scopus 로고
    • Functional characterization of substance P receptors on cultured human spinal cord astrocytes: Synergism of substance P with cytokines in inducing interleukin-6 and prostaglandin E2 production
    • C. Palma, L. Minghetti, M. Astolfi, E. Ambrosini, F.C. Silberstein, S. Manzini, G. Levi, and F. Aloisi Functional characterization of substance P receptors on cultured human spinal cord astrocytes: synergism of substance P with cytokines in inducing interleukin-6 and prostaglandin E2 production Glia 21 1997 183 193
    • (1997) Glia , vol.21 , pp. 183-193
    • Palma, C.1    Minghetti, L.2    Astolfi, M.3    Ambrosini, E.4    Silberstein, F.C.5    Manzini, S.6    Levi, G.7    Aloisi, F.8
  • 32
    • 0031569583 scopus 로고    scopus 로고
    • Contact with T cells modulates monocyte IL-10 production: Role of T cell membrane TNF-alpha
    • S.L. Parry, M. Sebbag, M. Feldmann, and F.M. Brennan Contact with T cells modulates monocyte IL-10 production: role of T cell membrane TNF-alpha J Immunol 158 1997 3673 3681
    • (1997) J Immunol , vol.158 , pp. 3673-3681
    • Parry, S.L.1    Sebbag, M.2    Feldmann, M.3    Brennan, F.M.4
  • 33
    • 33646379090 scopus 로고    scopus 로고
    • Tumor necrosis factor alpha contributes to below-level neuropathic pain after spinal cord injury
    • X. Peng, Z. Zhou, J.C. Glorioso, D.J. Fink, and M. Mata Tumor necrosis factor alpha contributes to below-level neuropathic pain after spinal cord injury Ann Neurol 59 2006 843 851
    • (2006) Ann Neurol , vol.59 , pp. 843-851
    • Peng, X.1    Zhou, Z.2    Glorioso, J.C.3    Fink, D.J.4    Mata, M.5
  • 34
    • 0037622717 scopus 로고    scopus 로고
    • Inhibition of microglial activation attenuates the development but not existing hypersensitivity in a rat model of neuropathy
    • V. Raghavendra, F. Tanga, and J.A. DeLeo Inhibition of microglial activation attenuates the development but not existing hypersensitivity in a rat model of neuropathy J Pharmacol Exp Ther 306 2003 624 630
    • (2003) J Pharmacol Exp Ther , vol.306 , pp. 624-630
    • Raghavendra, V.1    Tanga, F.2    Deleo, J.A.3
  • 35
    • 35748952835 scopus 로고    scopus 로고
    • Interaction between transmembrane TNF and TNFR1/2 mediates the activation of monocytes by contact with T cells
    • M. Rossol, U. Meusch, M. Pierer, S. Kaltenhauser, H. Hantzschel, S. Hauschildt, and U. Wagner Interaction between transmembrane TNF and TNFR1/2 mediates the activation of monocytes by contact with T cells J Immunol 179 2007 4239 4248
    • (2007) J Immunol , vol.179 , pp. 4239-4248
    • Rossol, M.1    Meusch, U.2    Pierer, M.3    Kaltenhauser, S.4    Hantzschel, H.5    Hauschildt, S.6    Wagner, U.7
  • 36
    • 0036668305 scopus 로고    scopus 로고
    • Lumbar nerve root injury induces central nervous system neuroimmune activation and neuroinflammation in the rat: Relationship to painful radiculopathy
    • M.D. Rutkowski, B.A. Winkelstein, W.F. Hickey, J.L. Pahl, and J.A. DeLeo Lumbar nerve root injury induces central nervous system neuroimmune activation and neuroinflammation in the rat: relationship to painful radiculopathy Spine 27 2002 1604 1613
    • (2002) Spine , vol.27 , pp. 1604-1613
    • Rutkowski, M.D.1    Winkelstein, B.A.2    Hickey, W.F.3    Pahl, J.L.4    Deleo, J.A.5
  • 37
    • 45849118673 scopus 로고    scopus 로고
    • Alarm or curse? the pain of neuroinflammation
    • C.Y. Saab, S.G. Waxman, and B.C. Hains Alarm or curse? The pain of neuroinflammation Brain Res Rev 58 2008 226 235
    • (2008) Brain Res Rev , vol.58 , pp. 226-235
    • Saab, C.Y.1    Waxman, S.G.2    Hains, B.C.3
  • 38
    • 17144451153 scopus 로고    scopus 로고
    • Increased sensitivity of injured and adjacent uninjured rat primary sensory neurons to exogenous tumor necrosis factor-α after spinal nerve ligation
    • M. Schafers, D.H. Lee, D. Brors, T.L. Yaksh, and L.S. Sorkin Increased sensitivity of injured and adjacent uninjured rat primary sensory neurons to exogenous tumor necrosis factor-alpha after spinal nerve ligation J Neurosci 23 2003 3028 3038 (Pubitemid 36418639)
    • (2003) Journal of Neuroscience , vol.23 , Issue.7 , pp. 3028-3038
    • Schafers, M.1    Lee, D.H.2    Brors, D.3    Yaksh, T.L.4    Sorkin, L.S.5
  • 39
    • 55949083030 scopus 로고    scopus 로고
    • Selective stimulation of either tumor necrosis factor receptor differentially induces pain behavior in vivo and ectopic activity in sensory neurons in vitro
    • M. Schafers, C. Sommer, C. Geis, T. Hagenacker, P. Vandenabeele, and L.S. Sorkin Selective stimulation of either tumor necrosis factor receptor differentially induces pain behavior in vivo and ectopic activity in sensory neurons in vitro Neuroscience 157 2008 414 423
    • (2008) Neuroscience , vol.157 , pp. 414-423
    • Schafers, M.1    Sommer, C.2    Geis, C.3    Hagenacker, T.4    Vandenabeele, P.5    Sorkin, L.S.6
  • 40
    • 0345701254 scopus 로고    scopus 로고
    • Tumor necrosis factor-alpha induces mechanical allodynia after spinal nerve ligation by activation of p38 MAPK in primary sensory neurons
    • M. Schafers, C.I. Svensson, C. Sommer, and L.S. Sorkin Tumor necrosis factor-alpha induces mechanical allodynia after spinal nerve ligation by activation of p38 MAPK in primary sensory neurons J Neurosci 23 2003 2517 2521
    • (2003) J Neurosci , vol.23 , pp. 2517-2521
    • Schafers, M.1    Svensson, C.I.2    Sommer, C.3    Sorkin, L.S.4
  • 41
    • 0036829011 scopus 로고    scopus 로고
    • Can we conquer pain?
    • J. Scholz, and C.J. Woolf Can we conquer pain? Nat Neurosci 5 2002 1062 1067
    • (2002) Nat Neurosci , vol.5 , pp. 1062-1067
    • Scholz, J.1    Woolf, C.J.2
  • 42
    • 0032080243 scopus 로고    scopus 로고
    • Hyperalgesia in experimental neuropathy is dependent on the TNF receptor 1
    • C. Sommer, C. Schmidt, and A. George Hyperalgesia in experimental neuropathy is dependent on the TNF receptor 1 Exp Neurol 151 1998 138 142
    • (1998) Exp Neurol , vol.151 , pp. 138-142
    • Sommer, C.1    Schmidt, C.2    George, A.3
  • 43
    • 0033917250 scopus 로고    scopus 로고
    • Epineurial application of TNF elicits an acute mechanical hyperalgesia in the awake rat
    • L.S. Sorkin, and C.M. Doom Epineurial application of TNF elicits an acute mechanical hyperalgesia in the awake rat J Peripher Nerv Syst 5 2000 96 100
    • (2000) J Peripher Nerv Syst , vol.5 , pp. 96-100
    • Sorkin, L.S.1    Doom, C.M.2
  • 44
    • 17444408199 scopus 로고    scopus 로고
    • Spinal blockade of TNF blocks spinal nerve ligation-induced increases in spinal P-p38
    • C.I. Svensson, M. Schafers, T.L. Jones, H. Powell, and L.S. Sorkin Spinal blockade of TNF blocks spinal nerve ligation-induced increases in spinal P-p38 Neurosci Lett 379 2005 209 213
    • (2005) Neurosci Lett , vol.379 , pp. 209-213
    • Svensson, C.I.1    Schafers, M.2    Jones, T.L.3    Powell, H.4    Sorkin, L.S.5
  • 45
    • 0035857748 scopus 로고    scopus 로고
    • Intrathecal interleukin-1 receptor antagonist in combination with soluble tumor necrosis factor receptor exhibits an anti-allodynic action in a rat model of neuropathic pain
    • S. Sweitzer, D. Martin, and J.A. DeLeo Intrathecal interleukin-1 receptor antagonist in combination with soluble tumor necrosis factor receptor exhibits an anti-allodynic action in a rat model of neuropathic pain Neuroscience 103 2001 529 539
    • (2001) Neuroscience , vol.103 , pp. 529-539
    • Sweitzer, S.1    Martin, D.2    Deleo, J.A.3
  • 46
    • 0035018058 scopus 로고    scopus 로고
    • Propentofylline, a glial modulating agent, exhibits antiallodynic properties in a rat model of neuropathic pain
    • S.M. Sweitzer, P. Schubert, and J.A. DeLeo Propentofylline, a glial modulating agent, exhibits antiallodynic properties in a rat model of neuropathic pain J Pharmacol Exp Ther 297 2001 1210 1217
    • (2001) J Pharmacol Exp Ther , vol.297 , pp. 1210-1217
    • Sweitzer, S.M.1    Schubert, P.2    Deleo, J.A.3
  • 48
    • 0036788082 scopus 로고    scopus 로고
    • Beyond neurons: Evidence that immune and glial cells contribute to pathological pain states
    • L.R. Watkins, and S.F. Maier Beyond neurons: evidence that immune and glial cells contribute to pathological pain states Physiol Rev 82 2002 981 1011
    • (2002) Physiol Rev , vol.82 , pp. 981-1011
    • Watkins, L.R.1    Maier, S.F.2
  • 50
    • 1642276200 scopus 로고    scopus 로고
    • Dissecting out mechanisms responsible for peripheral neuropathic pain: Implications for diagnosis and therapy
    • C.J. Woolf Dissecting out mechanisms responsible for peripheral neuropathic pain: implications for diagnosis and therapy Life Sci 74 2004 2605 2610
    • (2004) Life Sci , vol.74 , pp. 2605-2610
    • Woolf, C.J.1
  • 51
    • 33745700149 scopus 로고    scopus 로고
    • The role of tumor necrosis factor-alpha in the neuropathic pain induced by Lumbar 5 ventral root transection in rat
    • J.T. Xu, W.J. Xin, Y. Zang, C.Y. Wu, and X.G. Liu The role of tumor necrosis factor-alpha in the neuropathic pain induced by Lumbar 5 ventral root transection in rat Pain 123 2006 306 321
    • (2006) Pain , vol.123 , pp. 306-321
    • Xu, J.T.1    Xin, W.J.2    Zang, Y.3    Wu, C.Y.4    Liu, X.G.5
  • 52
    • 0036715218 scopus 로고    scopus 로고
    • Acute topical application of tumor necrosis factor alpha evokes protein kinase A-dependent responses in rat sensory neurons
    • J.M. Zhang, H. Li, B. Liu, and S.J. Brull Acute topical application of tumor necrosis factor alpha evokes protein kinase A-dependent responses in rat sensory neurons J Neurophysiol 88 2002 1387 1392
    • (2002) J Neurophysiol , vol.88 , pp. 1387-1392
    • Zhang, J.M.1    Li, H.2    Liu, B.3    Brull, S.J.4
  • 53
    • 38549160006 scopus 로고    scopus 로고
    • HSV-mediated transfer of interleukin-10 reduces inflammatory pain through modulation of membrane tumor necrosis factor alpha in spinal cord microglia
    • Z. Zhou, X. Peng, S. Hao, D.J. Fink, and M. Mata HSV-mediated transfer of interleukin-10 reduces inflammatory pain through modulation of membrane tumor necrosis factor alpha in spinal cord microglia Gene Ther 15 2008 183 190
    • (2008) Gene Ther , vol.15 , pp. 183-190
    • Zhou, Z.1    Peng, X.2    Hao, S.3    Fink, D.J.4    Mata, M.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.