Dementia revealed: Novel chromosome 6 locus for Late-onset alzheimer disease provides genetic evidence for Folate-pathway abnormalities

PLoS Genetics

Volumn 6, Issue 9, 2010, Pages

  Naj, Adam C ^a   Beecham, Gary W ^a   Martin, Eden R ^a   Gallins, Paul J ^a   Powell, Eric H ^a   Konidari, Ioanna ^a   Whitehead, Patrice L ^a   Cai, Guiqing ^b   Haroutunian, Vahram ^b   Scott, William K ^a   Vance, Jeffery M ^a   Slifer, Michael A ^a   Gwirtsman, Harry E ^c   Gilbert, John R ^a   Haines, Jonathan L ^d   Buxbaum, Joseph D ^b   Pericak Vance, Margaret A ^a  

^a UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

^b MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

^d VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APOLIPOPROTEIN E; FOLIC ACID; HOMOCYSTEINE; METHYLENETETRAHYDROFOLATE DEHYDROGENASE; METHYLENETETRAHYDROFOLATE DEHYDROGENASE 1 LIKE PROTEIN; UNCLASSIFIED DRUG;

AGED; ALZHEIMER DISEASE; ARTICLE; CHROMOSOME 6Q; CHROMOSOME SIZE; CONTROLLED STUDY; ENZYME SYNTHESIS; FEMALE; GENE FREQUENCY; GENE FUNCTION; GENE LINKAGE DISEQUILIBRIUM; GENE LOCUS; GENE REPLICATION; GENETIC ASSOCIATION; GENETIC IDENTIFICATION; GENETIC RISK; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; ONSET AGE; SINGLE NUCLEOTIDE POLYMORPHISM;

AGED; ALZHEIMER DISEASE; AMINOHYDROLASES; BASE PAIRING; CHROMOSOMES, HUMAN, PAIR 6; DATABASES, GENETIC; DEMENTIA; DEMOGRAPHY; FEMALE; FOLIC ACID; FORMATE-TETRAHYDROFOLATE LIGASE; GENETIC LOCI; GENOME-WIDE ASSOCIATION STUDY; HUMANS; MALE; METABOLIC NETWORKS AND PATHWAYS; METHYLENETETRAHYDROFOLATE DEHYDROGENASE (NADP); MULTIENZYME COMPLEXES; POLYMORPHISM, SINGLE NUCLEOTIDE; REPRODUCIBILITY OF RESULTS;

EID: 77957910119     PISSN: 15537390     EISSN: 15537404     Source Type: Journal    
DOI: 10.1371/journal.pgen.1001130     Document Type: Article

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