Treatment of Alzheimer's disease with anti-homocysteic acid antibody in 3xTg-AD male mice

PLoS ONE

Volumn 5, Issue 1, 2010, Pages

  Hasegawa, Tohru ^a   Mikoda, Nobuyuki ^b   Kitazawa, Masashi ^c   LaFerla, Frank M ^c  

^a Saga Women's Junior College   (Japan)

^b Kyudo Ltd   (Japan)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; HOMOCYSTEIC ACID; HOMOCYSTEIC ACID ANTIBODY; SODIUM CHLORIDE; TAU PROTEIN; UNCLASSIFIED DRUG; ANTIBODY; DRUG DERIVATIVE; HOMOCYSTEINE;

ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN; CANNULA; COGNITIVE DEFECT; COMPARATIVE STUDY; CONTROLLED STUDY; DIET; DRUG EFFECT; EXPERIMENTAL MODEL; FOOD INTAKE; HIPPOCAMPUS; MALE; MEMORY DISORDER; MOUSE; NEUROPROTECTION; NONHUMAN; PATHOPHYSIOLOGY; PYRIDOXINE DEFICIENCY; TRANSGENIC MOUSE; ANIMAL; IMMUNOHISTOCHEMISTRY; IMMUNOLOGY; IMMUNOTHERAPY; MAZE TEST;

MUS;

ALZHEIMER DISEASE; ANIMALS; ANTIBODIES; HOMOCYSTEINE; IMMUNOHISTOCHEMISTRY; IMMUNOTHERAPY; MALE; MAZE LEARNING; MICE; MICE, TRANSGENIC;

EID: 77649314768     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0008593     Document Type: Article

References (19)

1. Hasegawa T (2007) Prolonged stress will induce Alzheimer's disease in elderly people by increased release of homocysteic acid. Medical Hypotheses 69: 1135-1139.
2. Do KQ, Herrling PL, Streit P, Cuenod M (1988) Release of neuroactive substances: homocysteic acid as an endogenous agonist of the NMDA receptor. J Neural Transm 2(3): 185-190.
3. Do KQ, Benz B, Sorg O, Pellerin L, Magistretti PJ (1997) Beta-Adrenergic stimulation promotes homocysteic acid release from astrocyte cultures: evidence for a role of astrocytes in the modulation of synaptic transmission. J Neurochem 68(6): 2386-2394.
4. Lockhart B, Jones C, Cuisinier C, Villain N, Peyroulan D, et al. (2000) Inhibition of L-homocysteic acid and buthionine sulphoximine-mediated neurotoxicity in rat embryonic neuronal cultures with a-lipoic acid enantiomers. Brain Research 855(2): 292-297.
5. Folbergrová J, Ješina P, Drahota Z, Haugvicová VL, Vojtíšková A, et al. (2007) Mitochondrial complex I inhibition in cerebral cortex of immature rats following homocysteic acid-induced seizures. Experimental Neurology 204(2): 597-609.
6. Sommer S, Hunzinger C, Schillo S, Klemm M, Biefang-Arndt K, et al. (2004) Molecular analysis of homocysteic acid-induced neuronal stress. J Proteome Res 3(3): 572-581.
7. Chwatko G, Boers HJ, Strauss K, Shih D, Jakubowski H (2007) Mutations in methylenetetrahydrofolate reductase or cystathionine β-syntase gene, or a high-methionine diet, increase homocysteine thiolactone levels in humans and mice. The FASEB Journal 21: 1707-1713.
8. Oddo S, Caccamo A, Shepherd JD, Murphy MP, Golde TE, et al. (2003) Triple-Transgenic Model of Alzheimer's Disease with Plaques and Tangles: Intracellular Aβ and Synaptic Dysfunction. Neuron 39: 409-421.
9. Billings LM, Oddo S, Green KN, McGaugh JL, LaFerla FM (2005) Intraneuronal Aβ Causes the Onset of Early Alzheimer's Disease-Related Cognitive Deficits in Transgenic Mice. Neuron 45: 675-688.
10. Ohmori S (1975) Biosynthesis of homocysteine sulfinic acid in the vitamin B6-deficient rat. Hoppe Seylers Z Physiol Chem 356(9): 1369-1373.
11. Emily Alspector, The Relationship Between Neurogenesis and Pain Behavior http://hdl.handle.net/10066/1325.
12. McMahon J, Green T, Murray C, Knight R, Mann J, Williams S (2006) A Controlled Trial of Homocysteine Lowering and Cognitive Performance. N England J Med 354: 2764-2772.
13. Lieberman M, Kunishi AT (1965) Ethylene production from methionine. Biochem J 97(2): 449-459.
14. Langmeier M, Folbergrová J, Haugvicová R, Pokorný J, Mares P (2003) Neuronal cell death in hippocampus induced by homocysteic acid in immature rats. Epilepsia 44(3): 299-304.
15. Qu K, Lee SW, Bian JS, Low CM, Wong PTH (2008) Hydrogen sulfide: Neurochemistry and neurobiology. Neurochemistry International 52: 155-165.
16. Kluska MM, Witte OW, Bolz J, Redecker C (2005) Neurogenesis in the adult dentate gyrus after cortical infarcts: effects of infarct location, N-methyl-D-aspartate receptor blockade and anti-inflammatory treatment. Neuroscience 135(3): 723-735.
17. Shankar GM, Bloodgood BL, Townsend M, Walsh DM, Selkoe DJ, et al. (2007) Natural Oligomers of the Alzheimer Amyloid-s Protein Induce Reversible Synapse Loss by Modulating an NMDA-Type Glutamate Receptor-Dependent Signaling Pathway. J Neurosci 27(11): 2866-2875.
18. Akbari Y, Hitt BD, Murphy MP, Dagher NN, Tseng BP, et al. (2004) Presenilin regulates capacitative calcium entry dependently and independently of gamma-secretase activity. Biochem Biophys Res Commun 322(4): 1145-1152.
19. Hasegawa T, Ukai W, Jo DG, Xu X, Mattson MP, Nakagawa M, et al. (2005) Homocysteic Acid Induces Intraneuronal Accumulation of Neurotoxic Aβ42: Implication for the Pathogenesis of Alzheimer's disease. J Neurosci Res 80: 869-876.