Chemoenzymatic Synthesis, Inhibition Studies, and X-ray Crystallographic Analysis of the Phosphono Analog of UDP-Galp as an Inhibitor and Mechanistic Probe for UDP-Galactopyranose Mutase

Journal of Molecular Biology

Volumn 403, Issue 4, 2010, Pages 578-590

  Partha, Sarathy Karunan ^a   Sadeghi Khomami, Ali ^b,c   Slowski, Kathryn ^a   Kotake, Toshihisa ^d   Thomas, Neil R ^c   Jakeman, David L ^b   Sanders, David A R ^a  

^a UNIVERSITY OF SASKATCHEWAN   (Canada)

^b DALHOUSIE UNIVERSITY   (Canada)

^c UNIVERSITY OF NOTTINGHAM   (United Kingdom)

^d SAITAMA UNIVERSITY   (Japan)

Author keywords

Enzyme inhibition and binding; Phosphonate analog; UDP galactopyranose mutase

Indexed keywords

ARGININE; FURAN DERIVATIVE; GALACTOFURANOSE; GALACTOPYRANOSE MUTASE; GLYCOCONJUGATE; HEXOSE; MUTASE; PHOSPHONIC ACID DERIVATIVE; UNCLASSIFIED DRUG; URIDINE DIPHOSPHATE; URIDINE DIPHOSPHATE ALPHA DEXTRO GALACTOFURANOSE; URIDINE DIPHOSPHATE GALACTOSE; URIDINE DIPHOSPHATE PHOSPHONOGALACTOPYRANOSE; ARABIDOPSIS PROTEIN; GALACTOSE; MOLECULAR PROBE; NUCLEOTIDYLTRANSFERASE; RECOMBINANT PROTEIN; UDP-GALACTOPYRANOSE MUTASE; UDP-SUGAR PYROPHOSPHORYLASE, ARABIDOPSIS; URIDINE DIPHOSPHATE GALACTOFURANOSE;

ARTICLE; BIOSYNTHESIS; CATALYSIS; CELL WALL; COMPLEX FORMATION; CRYSTAL STRUCTURE; DEINOCOCCUS RADIODURANS; DRUG TARGETING; ENZYME ACTIVE SITE; ENZYME BINDING; ENZYME INHIBITION; ENZYME SYNTHESIS; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PRIORITY JOURNAL; X RAY CRYSTALLOGRAPHY; ANALOGS AND DERIVATIVES; ANTAGONISTS AND INHIBITORS; CHEMICAL STRUCTURE; CHEMISTRY; DEINOCOCCUS; ENZYMOLOGY; GENETICS; KLEBSIELLA PNEUMONIAE; MOLECULAR PROBE; PHARMACOLOGY; PROTEIN CONFORMATION; SYNTHESIS;

BACTERIA (MICROORGANISMS); DEINOCOCCUS RADIODURANS; MYCOBACTERIUM TUBERCULOSIS;

ARABIDOPSIS PROTEINS; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; DEINOCOCCUS; GALACTOSE; INTRAMOLECULAR TRANSFERASES; KLEBSIELLA PNEUMONIAE; MODELS, MOLECULAR; MOLECULAR PROBES; MYCOBACTERIUM TUBERCULOSIS; NUCLEOTIDYLTRANSFERASES; PROTEIN CONFORMATION; RECOMBINANT PROTEINS; URIDINE DIPHOSPHATE;

EID: 77957900135     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jmb.2010.08.053     Document Type: Article

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