Precise pattern of recombination in serotonergic and hypothalamic neurons in a Pdx1-cre transgenic mouse line

Journal of Biomedical Science

Volumn 17, Issue 1, 2010, Pages

  Honig, Gerard ^a,d   Liou, Angela ^a,b   Berger, Miles ^a,c   German, Michael S ^a   Tecott, Laurence H ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CRE RECOMBINASE; TRANSCRIPTION FACTOR PDX 1; HOMEODOMAIN PROTEIN; HYBRID PROTEIN; INSULIN PROMOTER FACTOR 1; INTEGRASE; SEROTONIN; TRANSACTIVATOR PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTERIOR HYPOTHALAMUS; ARCUATE NUCLEUS; ARTICLE; BRAIN REGION; BRAIN STEM; CONTROLLED STUDY; DIENCEPHALON; DNA RECOMBINATION; DORSAL RAPHE NUCLEUS; FOREBRAIN; GENE EXPRESSION; GENOTYPE; HISTOLOGY; HISTOPATHOLOGY; HYPOTHALAMUS; INNER EAR; MEDIAN RAPHE NUCLEUS; MOUSE; NERVE PROJECTION; NONHUMAN; OLIVARY NUCLEUS; PRIORITY JOURNAL; REPORTER GENE; RHOMBENCEPHALON; SEROTONINERGIC NERVE CELL; SPINAL CORD; STEM CELL; TRANSGENIC MOUSE; ANIMAL; ANIMAL EMBRYO; CYTOLOGY; GENETIC RECOMBINATION; GENETICS; METABOLISM; NERVE CELL; PHYSIOLOGY; PRENATAL DEVELOPMENT;

MUS; MUS MUSCULUS;

ANIMALS; EMBRYO, MAMMALIAN; GENES, REPORTER; GENOTYPE; HOMEODOMAIN PROTEINS; HYPOTHALAMUS; INTEGRASES; MICE; MICE, TRANSGENIC; NEURONS; RECOMBINANT FUSION PROTEINS; RECOMBINATION, GENETIC; SEROTONIN; TRANS-ACTIVATORS;

EID: 77957889131     PISSN: 10217770     EISSN: 14230127     Source Type: Journal    
DOI: 10.1186/1423-0127-17-82     Document Type: Article

References (61)

1. Talking about a revolution: The impact of site-specific recombinases on genetic analyses in mice. CS Branda SM Dymecki, Dev Cell 2004 6 1 7 28 10.1016/S1534-5807(03)00399-X 14723844
2. Structure and function of the brain serotonin system. BL Jacobs EC Azmitia, Physiol Rev 1992 72 1 165 229 1731370
3. Distinct transcriptomes define rostral and caudal serotonin neurons. CJ Wylie TJ Hendricks B Zhang L Wang P Lu P Leahy S Fox H Maeno ES Deneris, J Neurosci 2010 30 2 670 684 10.1523/JNEUROSCI.4656-09.2010 20071532
4. Redefining the serotonergic system by genetic lineage. P Jensen AF Farago RB Awatramani MM Scott ES Deneris SM Dymecki, Nat Neurosci 2008 11 4 417 419 10.1038/nn2050 18344997
5. A genetic approach to access serotonin neurons for in vivo and in vitro studies. MM Scott CJ Wylie JK Lerch R Murphy K Lobur S Herlitze W Jiang RA Conlon BW Strowbridge ES Deneris, Proc Natl Acad Sci USA 2005 102 45 16472 16477 10.1073/pnas.0504510102 16251278
6. Linking genetically defined neurons to behavior through a broadly applicable silencing allele. JC Kim MN Cook MR Carey C Shen WG Regehr SM Dymecki, Neuron 2009 63 3 305 315 10.1016/j.neuron.2009.07.010 19679071
7. Gene expression cascades in pancreatic development. ME Wilson D Scheel MS German, Mechanisms of Development 2003 120 1 65 80 10.1016/S0925-4773(02)00333- 7 12490297
8. Coordinated temporal and spatial control of motor neuron and serotonergic neuron generation from a common pool of CNS progenitors. A Pattyn A Vallstedt JM Dias OA Samad R Krumlauf FM Rijli JF Brunet J Ericson, Genes Dev 2003 17 6 729 737 10.1101/gad.255803 12651891
9. Conditional expression demonstrates the role of the homeodomain transcription factor Pdx1 in maintenance and regeneration of beta-cells in the adult pancreas. AM Holland LJ Gonez G Naselli RJ Macdonald LC Harrison, Diabetes 2005 54 9 2586 2595 10.2337/diabetes.54.9.2586 16123346
10. Direct evidence for the pancreatic lineage: NGN3+ cells are islet progenitors and are distinct from duct progenitors. G Gu J Dubauskaite DA Melton, Development 2002 129 10 2447 2457 11973276
11. Mouse Genome Database. http://www.informatics.jax.org/
12. The Mouse Genome Database (MGD): mouse biology and model systems. CJ Bult JT Eppig JA Kadin JE Richardson JA Blake, Nucleic Acids Res 2008 36 Database 724 728 18158299
13. Activated Kras and Ink4a/Arf deficiency cooperate to produce metastatic pancreatic ductal adenocarcinoma. AJ Aguirre N Bardeesy M Sinha L Lopez DA Tuveson J Horner MS Redston RA DePinho, Genes Dev 2003 17 24 3112 3126 10.1101/gad.1158703 14681207
14. Both p16(Ink4a) and the p19(Arf)-p53 pathway constrain progression of pancreatic adenocarcinoma in the mouse. N Bardeesy AJ Aguirre GC Chu KH Cheng LV Lopez AF Hezel B Feng C Brennan R Weissleder U Mahmood D Hanahan MS Redston L Chin RA Depinho, Proc Natl Acad Sci USA 2006 103 15 5947 5952 10.1073/pnas.0601273103 16585505
15. Smad4 is dispensable for normal pancreas development yet critical in progression and tumor biology of pancreas cancer. N Bardeesy KH Cheng JH Berger GC Chu J Pahler P Olson AF Hezel J Horner GY Lauwers D Hanahan RA DePinho, Genes Dev 2006 20 22 3130 3146 10.1101/gad.1478706 17114584
16. Primary cilia deletion in pancreatic epithelial cells results in cyst formation and pancreatitis. DA Cano S Sekine M Hebrok, Gastroenterology 2006 131 6 1856 1869 10.1053/j.gastro.2006.10.050 17123526
17. Embryonic endocrine pancreas and mature beta cells acquire alpha and PP cell phenotypes upon Arx misexpression. P Collombat J Hecksher-Sorensen J Krull J Berger D Riedel PL Herrera P Serup A Mansouri, J Clin Invest 2007 117 4 961 970 10.1172/JCI29115 17404619
18. Notch/Rbp-j signaling prevents premature endocrine and ductal cell differentiation in the pancreas. J Fujikura K Hosoda H Iwakura T Tomita M Noguchi H Masuzaki K Tanigaki D Yabe T Honjo K Nakao, Cell Metab 2006 3 1 59 65 10.1016/j.cmet.2005.12.005 16399505
19. Rbp-j regulates expansion of pancreatic epithelial cells and their differentiation into exocrine cells during mouse development. J Fujikura K Hosoda Y Kawaguchi M Noguchi H Iwakura S Odori E Mori T Tomita M Hirata K Ebihara H Masuzaki A Fukuda K Furuyama K Tanigaki D Yabe K Nakao, Dev Dyn 2007 236 10 2779 2791 10.1002/dvdy.21310 17849436
20. In Vivo and in Vitro Studies of a Functional Peroxisome Proliferator-activated Receptor {gamma} Response Element in the Mouse pdx-1 Promoter. D Gupta TL Jetton RM Mortensen SZ Duan M Peshavaria JL Leahy, J Biol Chem 2008 283 47 32462 32470 10.1074/jbc.M801813200 18718916
21. Stabilization of beta-catenin induces pancreas tumor formation. PW Heiser DA Cano L Landsman GE Kim JG Kench DS Klimstra MM Taketo AV Biankin M Hebrok, Gastroenterology 2008 135 4 1288 1300 10.1053/j.gastro.2008.06.089 18725219
22. Pancreatic LKB1 deletion leads to acinar polarity defects and cystic neoplasms. AF Hezel S Gurumurthy Z Granot A Swisa GC Chu G Bailey Y Dor N Bardeesy RA Depinho, Mol Cell Biol 2008 28 7 2414 2425 10.1128/MCB.01621-07 18227155
23. PPAR-gamma knockout in pancreatic epithelial cells abolishes the inhibitory effect of rosiglitazone on caerulein-induced acute pancreatitis. CY Ivashchenko SZ Duan MG Usher RM Mortensen, Am J Physiol Gastrointest Liver Physiol 2007 293 1 319 326 10.1152/ajpgi.00056.2007 17463185
24. Inactivation of Smad4 accelerates Kras(G12D)-mediated pancreatic neoplasia. K Kojima SM Vickers NV Adsay NC Jhala HG Kim TR Schoeb WE Grizzle CA Klug, Cancer Res 2007 67 17 8121 8130 10.1158/0008-5472.CAN-06-4167 17804724
25. Role of VEGF-A in vascularization of pancreatic islets. E Lammert G Gu M McLaughlin D Brown R Brekken LC Murtaugh HP Gerber N Ferrara DA Melton, Curr Biol 2003 13 12 1070 1074 10.1016/S0960-9822(03)00378-6 12814555
26. The transcription factor Stat3 is dispensable for pancreatic beta-cell development and function. JY Lee L Hennighausen, Biochem Biophys Res Commun 2005 334 3 764 768 10.1016/j.bbrc.2005.06.162 16026757
27. Generation of a reporter mouse line expressing Akt and EGFP upon Cre-mediated recombination. Lynda Elghazi AJ W AP G B H DH G E B-M, genesis 2008 46 5 256 264 10.1002/dvg.20388 18442046
28. MicroRNA Expression Is Required for Pancreatic Islet Cell Genesis in the Mouse. FC Lynn P Skewes-Cox Y Kosaka MT McManus BD Harfe MS German, Diabetes 2007 56 12 2938 2945 10.2337/db07-0175 17804764
29. Conditional inactivation of the murine serum response factor in the pancreas leads to severe pancreatitis. F Miralles S Hebrard L Lamotte B Durel H Gilgenkrantz Z Li D Daegelen D Tuil RL Joshi, Lab Invest 2006 86 10 1020 1036 10.1038/labinvest.3700457 16894357
30. {beta}-Catenin is essential for pancreatic acinar but not islet development. LC Murtaugh AC Law Y Dor DA Melton, Development 2005 132 21 4663 4674 10.1242/dev.02063 16192304
31. Notch signaling controls multiple steps of pancreatic differentiation. LC Murtaugh BZ Stanger KM Kwan DA Melton, Proc Natl Acad Sci USA 2003 100 25 14920 14925 10.1073/pnas.2436557100 14657333
32. Signals from the neural crest regulate beta-cell mass in the pancreas. N Nekrep J Wang T Miyatsuka MS German, Development 2008 135 12 2151 2160 10.1242/dev.015859 18506029
33. Hedgehog/Ras interactions regulate early stages of pancreatic cancer. M Pasca di Magliano S Sekine A Ermilov J Ferris AA Dlugosz M Hebrok, Genes Dev 2006 20 22 3161 3173 10.1101/gad.1470806 17114586
34. SOX9 is required for maintenance of the pancreatic progenitor cell pool. PA Seymour KK Freude MN Tran EE Mayes J Jensen R Kist G Scherer M Sander, Proc Natl Acad Sci USA 2007 104 6 1865 1870 10.1073/pnas.0609217104 17267606
35. Concomitant pancreatic activation of Kras(G12D) and Tgfa results in cystic papillary neoplasms reminiscent of human IPMN. JT Siveke H Einwachter B Sipos C Lubeseder-Martellato G Kloppel RM Schmid, Cancer Cell 2007 12 3 266 279 10.1016/j.ccr.2007.08.002 17785207
36. Direct regulation of intestinal fate by Notch. BZ Stanger R Datar LC Murtaugh DA Melton, Proc Natl Acad Sci USA 2005 102 35 12443 12448 10.1073/pnas.0505690102 16107537
37. Pten constrains centroacinar cell expansion and malignant transformation in the pancreas. BZ Stanger B Stiles GY Lauwers N Bardeesy M Mendoza Y Wang A Greenwood K-h Cheng M McLaughlin D Brown RA DePinho H Wu DA Melton Y Dor, Cancer Cell 2005 8 3 185 195 10.1016/j.ccr.2005.07.015 16169464
38. Total insulin and IGF-I resistance in pancreatic beta cells causes overt diabetes. K Ueki T Okada J Hu CW Liew A Assmann GM Dahlgren JL Peters JG Shackman M Zhang I Artner LS Satin R Stein M Holzenberger RT Kennedy CR Kahn RN Kulkarni, Nat Genet 2006 38 5 583 588 10.1038/ng1787 16642022
39. Loss of Myt1 function partially compromises endocrine islet cell differentiation and pancreatic physiological function in the mouse. S Wang J Zhang A Zhao S Hipkens MA Magnuson G Gu, Mech Dev 2007 124 11-12 898 910 10.1016/j.mod.2007.08.004 17928203
40. The FoxM1 transcription factor is required to maintain pancreatic beta-cell mass. H Zhang AM Ackermann GA Gusarova D Lowe X Feng UG Kopsombut RH Costa M Gannon, Mol Endocrinol 2006 20 8 1853 1866 10.1210/me.2006-0056 16556734
41. PERK EIF2AK3 control of pancreatic beta cell differentiation and proliferation is required for postnatal glucose homeostasis. W Zhang D Feng Y Li K Iida B McGrath DR Cavener, Cell Metab 2006 4 6 491 497 10.1016/j.cmet.2006. 11.002 17141632
42. Z/EG, a double reporter mouse line that expresses enhanced green fluorescent protein upon Cre-mediated excision. A Novak C Guo W Yang A Nagy CG Lobe, Genesis 2000 28 3-4 147 155 10.1002/1526-968X(200011/12)28:3/4<147:: AID-GENE90>3.0.CO;2-G 11105057
43. Generalized lacZ expression with the ROSA26 Cre reporter strain. P Soriano, Nat Genet 1999 21 1 70 71 10.1038/5007 9916792
44. Melting curve analysis of SNPs (McSNP): a gel-free and inexpensive approach for SNP genotyping. JM Akey D Sosnoski E Parra S Dios K Hiester B Su C Bonilla L Jin MD Shriver, Biotechniques 2001 30 2 358 362 11233605
45. High-throughput SNP genotyping by single-tube PCR with Tm-shift primers. J Wang K Chuang M Ahluwalia S Patel N Umblas D Mirel R Higuchi S Germer, Biotechniques 2005 39 6 885 893 10.2144/000112028 16382908
46. Rapid Genotyping of Mouse Tissue Using Sigma's Extract-N-Amp Tissue PCR Kit. L Doan ES Monuki, J Vis Exp 2008 11 19066558
47. Single-Tube Genotyping without Oligonucleotide Probes. S Germer R Higuchi, Genome Res 1999 9 1 72 78 9927486
48. Genotype identification of Math1/LacZ knockout mice based on real-time PCR with SYBR Green I dye. V Krizhanovsky E Golenser N Ben-Arie, Journal of Neuroscience Methods 2004 136 2 187 192 10.1016/j.jneumeth.2004.01.007 15183270
49. Single nucleotide polymorphism genotyping using allele-specific PCR and fluorescence melting curves. AC Papp JK Pinsonneault G Cooke W Sadee, Biotechniques 2003 34 5 1068 1072 12765033
50. Rapid zygosity determination in mice by SYBR Green real-time genomic PCR of a crude DNA solution. T Sakurai A Kamiyoshi S Watanabe M Sato T Shindo, Transgenic Research 2008 17 1 149 155 10.1007/s11248-007-9134-7 17851772
51. Origin of climbing fiber neurons and their developmental dependence on Ptf1a. M Yamada M Terao T Terashima T Fujiyama Y Kawaguchi Y Nabeshima M Hoshino, J Neurosci 2007 27 41 10924 10934 10.1523/JNEUROSCI.1423-07.2007 17928434
52. Ptf1a, a bHLH transcriptional gene, defines GABAergic neuronal fates in cerebellum. M Hoshino S Nakamura K Mori T Kawauchi M Terao YV Nishimura A Fukuda T Fuse N Matsuo M Sone M Watanabe H Bito T Terashima CV Wright Y Kawaguchi K Nakao Y Nabeshima, Neuron 2005 47 2 201 213 10.1016/j.neuron.2005.06.007 16039563
53. Staying awake for dinner: hypothalamic integration of sleep, feeding, and circadian rhythms. CB Saper, Prog Brain Res 2006 153 243 252 full-text 16876579
54. Neuronal glucosensing: what do we know after 50 years? BE Levin VH Routh L Kang NM Sanders AA Dunn-Meynell, Diabetes 2004 53 10 2521 2528 10.2337/diabetes.53.10.2521 15448079
55. PI3K integrates the action of insulin and leptin on hypothalamic neurons. AW Xu CB Kaelin K Takeda S Akira MW Schwartz GS Barsh, J Clin Invest 2005 115 4 951 958 15761497
56. Pancreatic homeodomain transcription factor IDX1/IPF1 expressed in developing brain regulates somatostatin gene transcription in embryonic neural cells. PT Schwartz B Perez-Villamil A Rivera R Moratalla M Vallejo, J Biol Chem 2000 275 25 19106 19114 10.1074/jbc.M000655200 10751390
57. The pancreatic homeodomain transcription factor IDX1/IPF1 is expressed in neural cells during brain development. B Perez-Villamil PT Schwartz M Vallejo, Endocrinology 1999 140 8 3857 3860 10.1210/en.140.8.3857 10433248
58. Conditional gene targeting in mouse pancreatic {beta}-cells: Analysis of ectopic Cre transgene expression in the brain. B Wicksteed M Brissova W Yan DM Opland JL Plank RB Reinert LM Dickson NA Tamarina LH Philipson A Shostak E Bernal-Mizrachi L Elghazi MW Roe PA Labosky MM Myers Jr M Gannon AC Powers PJ Dempsey, Diabetes 2010 20802254
59. Brain expression of Cre recombinase driven by pancreas-specific promoters. J Song Y Xu X Hu B Choi Q Tong, Genesis 2010 20824628
60. Targeting Cre Recombinase to Specific Neuron Populations with Bacterial Artificial Chromosome Constructs. S Gong M Doughty CR Harbaugh A Cummins ME Hatten N Heintz CR Gerfen, J Neurosci 2007 27 37 9817 9823 10.1523/JNEUROSCI. 2707-07.2007 17855595
61. 5-HT2CRs expressed by pro-opiomelanocortin neurons regulate energy homeostasis. Y Xu JE Jones D Kohno KW Williams CE Lee MJ Choi JG Anderson LK Heisler JM Zigman BB Lowell JK Elmquist, Neuron 2008 60 4 582 589 10.1016/j.neuron.2008.09.033 19038216