Conditional inactivation of the murine serum response factor in the pancreas leads to severe pancreatitis

Laboratory Investigation

Volumn 86, Issue 10, 2006, Pages 1020-1036

  Miralles, Francisco ^a   Hebrard, Sophie ^a   Lamotte, Luciane ^a   Durel, Beatrice ^a   Gilgenkrantz, Helene ^a   Li, Zhenlin ^b   Daegelen, Dominique ^a   Tuil, David ^a   Joshi, Rajiv L ^a  

^a INSTITUT COCHIN   (France)

^b CNRS   (France)

Author keywords

Acinar cells; Pancreatitis; SRF; Transgenic animals

Indexed keywords

CYTOKINE; GLUCOSE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INSULIN; SERUM RESPONSE FACTOR;

ACINAR CELL; ADIPOSE TISSUE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL DAMAGE; CELL DEATH; CELL PROLIFERATION; CONTROLLED STUDY; DISEASE SEVERITY; GENE DISRUPTION; GENE EXPRESSION; GENE FUNCTION; GENE INACTIVATION; GENE TARGETING; HOMEOSTASIS; INFLAMMATION; INSULIN RELEASE; MORPHOLOGY; MOUSE; NONHUMAN; ONTOGENY; PANCREAS ISLET; PANCREATITIS; PRIORITY JOURNAL;

ANIMALS; DISEASE MODELS, ANIMAL; ISLETS OF LANGERHANS; MICE; MICE, TRANSGENIC; NF-KAPPA B; PANCREAS, EXOCRINE; PANCREATITIS; SERUM RESPONSE FACTOR;

EID: 33748857004     PISSN: 00236837     EISSN: 15300307     Source Type: Journal    
DOI: 10.1038/labinvest.3700457     Document Type: Article

References (53)

1. Treisman R. Identification and purification of a polypeptide that binds to the c-fos serum response element. EMBO J 1987;6:2711-2717.
2. Chai J, Tarnawski AS. Serum response factor: discovery, biochemistry, biological roles and implications for tissue injury healing. J Physiol Pharmacol 2002;53: 147-157.
3. Shaw PE, Schroter H, Nordheim A. The ability of a ternary complex to form over the serum response element correlates with serum inducibility of the human c-fos promoter. Cell 1989;56:563-572.
4. Hill CS, Wynne J, Treisman R. The Rho family GTPases RhoA, Rac1, and CDC42Hs regulate transcriptional activation by SRF. Cell 1995;81:1159-1170.
5. Schratt G, Philippar U, Hockemeyer D, et al. SRF regulates Bcl-2 expression and promotes cell survival during murine embryonic development. EMBO J 2004; 23:1834-1844.
6. Arsenian S,Weinhold B, Oelgeschlager M, et al. Serum response factor is essential for mesoderm formation during mouse embryogenesis. EMBO J 1998;17: 6289-6299.
7. Zhang X, Chai J, Azhar G, et al. Early postnatal cardiac changes and premature death in transgenic mice overexpressing a mutant form of serum response factor. J Biol Chem 2001;276:40033-40040.
8. Niu Z, Yu W, Zhang SX, et al. Conditional mutagenesis of the murine serum response factor gene blocks cardiogenesis and the transcription of downstream gene targets. J Biol Chem 2005;280:32531-32538.
9. Parlakian A, Tuil D, Hamard G, et al. Targeted inactivation of serum response factor in the developing heart results in myocardial defects and embryonic lethality. Mol Cell Biol 2004;24:5281-5289.
10. Vickers ER, Kasza A, Kurnaz IA, et al. Ternary complex factor-serum response factor complex-regulated gene activity is required for cellular proliferation and inhibition of apoptotic cell death. Mol Cell Biol 2004; 24:10340-10351.
11. Bernal-Mizrachi E, Wice B, Inoue H, et al. Activation of serum response factor in the depolarization induction of Egr-1 transcription in pancreatic islet beta-cells. J Biol Chem 2000;275:25681-25689.
12. Drenckhahn D, Mannherz HG. Distribution of actin and the actin-associated proteins myosin, tropomyosin, alpha-actinin, vinculin, and villin in rat and bovine exocrine glands. Eur J Cell Biol 1983;30: 167-176.
13. Ketola I, Otonkoski T, Pulkkinen MA, et al. Transcription factor GATA-6 is expressed in the endocrine and GATA-4 in the exocrine pancreas. Mol Cell Endocrinol 2004;226:51-57.
14. Ankorina-Stark I, Amstrup J, Novak I. Regulation of the Na+/Ca2+ exchanger in rat pancreatic ducts. J Membr Biol 2002;186:43-53.
15. Ahmed N, Corey M, Forstner G, et al. Molecular consequences of cystic fibrosis transmembrane regulator (CFTR) gene mutations in the exocrine pancreas. Gut 2003;52:1159-1164.
16. Dormer RL, Capurro DE, Morris R, et al. Demonstration of two isoforms of the SERCA-2b type Ca2+,Mg(2+)-ATPase in pancreatic endoplasmic reticulum. Biochim Biophys Acta 1993;1152:225-230.
17. Gu G, Dubauskaite J, Melton DA. Direct evidence for the pancreatic lineage: NGN3+ cells are islet progenitors and are distinct from duct progenitors. Development 2002;129:2447-2457.
18. Jonsson J, Ahlgren U, Edlund T, et al. IPF1, a homeo-domain protein with a dual function in pancreas development. Int J Dev Biol 1995;39:789-798.
19. Pralong WF, Bartley C, Wollheim CB. Single islet beta-cell stimulation by nutrients: relationship between pyridine nucleotides, cytosolic Ca2+ and secretion. EMBO J 1990;9:53-60.
20. Algul H, Tando Y, Schneider G, et al. Acute experimental pancreatitis and NF-kappaB/Rel activation. Pancreatology 2002;2:503-509.
21. Altavilla D, Famulari C, Passaniti M, et al. Attenuated cerulein-induced pancreatitis in nuclear factor-kappaB-deficient mice. Lab Invest 2003;83:1723-1732.
22. Weber CK, Adler G. Acute pancreatitis. Curr Opin Gastroenterol 2003;19:447-450.
23. DiMagno MJ, DiMagno EP. Chronic pancreatitis. Curr Opin Gastroenterol 2003;19:451-457.
24. Steer ML, Saluja AK. Experimental acute pancreatitis: studies of the early events that lead to cell injury. In: Go V, DiMagno E, Gardner J, Lebenthal E, Reber H, Scheele G (eds). The Pancreas: Biology, Pathophysiology, and Disease, 2nd edn. Raven Press Ltd: New York, 1993, pp 489-500.
25. Scheele G, Adler G, Kern H. Exocytosis occurs at the lateral plasma membrane of the pancreatic acinar cell during supramaximal secretagogue stimulation. Gastroenterology 1987;92:345-353.
26. Gukovskaya AS, Gukovsky I, Zaninovic V, et al. Pancreatic acinar cells produce, release, and respond to tumor necrosis factor-alpha. Role in regulating cell death and pancreatitis. J Clin Invest 1997;100: 1853-1862.
27. Norman J. The role of cytokines in the pathogenesis of acute pancreatitis. Am J Surg 1998;175:76-83.
28. DiMagno E, Layer P, JE C. Chronic pancreatitis. In: Go VL DE, Gardner JD, Lebenthal E, Reber HA, Scheele GA (eds). The Pancreas: Biology, Pathophysiology, and Disease. Raven Press Ltd: New York, 1993, pp 665-706.
29. Nagashio Y, Ueno H, Imamura M, et al. Inhibition of transforming growth factor beta decreases pancreatic fibrosis and protects the pancreas against chronic injury in mice. Lab Invest 2004;84:1610-1618.
30. Luttenberger T, Schmid-Kotsas A, Menke A, et al. Platelet-derived growth factors stimulate proliferation and extracellular matrix synthesis of pancreatic stellate cells: implications in pathogenesis of pancreas fibrosis. Lab Invest 2000;80:47-55.
31. Apte MV, Haber PS, Darby SJ, et al. Pancreatic stellate cells are activated by proinflammatory cytokines: implications for pancreatic fibrogenesis. Gut 1999;44: 534-541.
32. Gukovskaya AS, Perkins P, Zaninovic V, et al. Mechanisms of cell death after pancreatic duct obstruction in the opossum and the rat. Gastroenterology 1996;110:875-884.
33. Kaiser AM, Saluja AK, Sengupta A, et al. Relationship between severity, necrosis, and apoptosis in five models of experimental acute pancreatitis. Am J Physiol 1995;269(5 Part 1):C1295-C1304.
34. Dimagno MJ, Lee SH, Hao Y, et al. A proinflammatory, antiapoptotic phenotype underlies the susceptibility to acute pancreatitis in cystic fibrosis transmembrane regulator (-/-) mice. Gastroenterology 2005;129: 665-681.
35. Sarner M. Pancreatitis: definitions and classifications. In: Go VL DE, Gardner JD, Lebenthal E, Reber HA, Scheele GA (eds). The Pancreas: Biology, Pathophysiology, and Disease, 2nd edn. Raven Press Ltd: New York, 1993, pp 575-580.
36. Whitcomb DC, Gorry MC, Preston RA, et al. Hereditary pancreatitis is caused by a mutation in the cationic trypsinogen gene. Nat Genet 1996;14:141-145.
37. Witt H, Luck W, Hennies HC, et al. Mutations in the gene encoding the serine protease inhibitor, Kazal type 1 are associated with chronic pancreatitis. Nat Genet 2000;25:213-216.
38. Sharer N, Schwarz M, Malone G, et al. Mutations of the cystic fibrosis gene in patients with chronic pancreatitis. N Engl J Med 1998;339:645-652.
39. Kruger B, Albrecht E, Lerch MM. The role of intracellular calcium signaling in premature protease activation and the onset of pancreatitis. Am J Pathol 2000;157:43-50.
40. Mooren F, Hlouschek V, Finkes T, et al. Early changes in pancreatic acinar cell calcium signaling after pancreatic duct obstruction. J Biol Chem 2003;278: 9361-9369.
41. Ward JB, Petersen OH, Jenkins SA, et al. Is an elevated concentration of acinar cytosolic free ionised calcium the trigger for acute pancreatitis? Lancet 1995;346: 1016-1019.
42. Baker DL, Dave V, Reed T, et al. A novel E box/AT-rich element is required for muscle-specific expression of the sarcoplasmic reticulum Ca2+-ATPase (SERCA2) gene. Nucleic Acids Res 1998;26:1092-1098.
43. Cheng G, Hagen TP, Dawson ML, et al. The role of GATA, CArG, E-box, and a novel element in the regulation of cardiac expression of the Na+-Ca2+ exchanger gene. J Biol Chem 1999;274:12819-12826.
44. Pozzan T, Rizzuto R, Volpe P, et al. Molecular and cellular physiology of intracellular calcium stores. Physiol Rev 1994;74:595-636.
45. Voronina S, Longbottom R, Sutton R, et al. Bile acids induce calcium signals in mouse pancreatic acinar cells: implications for bile-induced pancreatic pathology. J Physiol 2002;540(Part 1):49-55.
46. Kim JY, Kim KH, Lee JA, et al. Transporter-mediated bile acid uptake causes Ca2+-dependent cell death in rat pancreatic acinar cells. Gastroenterology 2002;122: 1941-1953.
47. Blaustein MP, Lederer WJ. Sodium/calcium exchange: its physiological implications. Physiol Rev 1999;79: 763-854.
48. Mithofer K, Fernandez-del Castillo C, Frick TW, et al. Acute hypercalcemia causes acute pancreatitis and ectopic trypsinogen activation in the rat. Gastroenterology 1995;109:239-246.
49. Lee MG, Choi JY, Luo X, et al. Cystic fibrosis transmembrane conductance regulator regulates luminal Cl-/HCO3- exchange in mouse submandibular and pancreatic ducts. J Biol Chem 1999;274:14670-14677.
50. Rene C, Taulan M, Iral F, et al. Binding of serum response factor to cystic fibrosis transmembrane conductance regulator CArG-like elements, as a new potential CFTR transcriptional regulation pathway. Nucleic Acids Res 2005;33:5271-5290.
51. Snouwaert JN, Brigman KK, Latour AM, et al. An animal model for cystic fibrosis made by gene targeting. Science 1992;257:1083-1088.
52. Frossard JL, Rubbia-Brandt L, Wallig MA, et al. Severe acute pancreatitis and reduced acinar cell apoptosis in the exocrine pancreas of mice deficient for the Cx32 gene. Gastroenterology 2003;124:481-493.
53. Dessimoz J, Bonnard C, Huelsken J, et al. Pancreas-specific deletion of beta-catenin reveals Wnt-dependent and Wnt-independent functions during development. Curr Biol 2005;15:1677-1683.