Intrathecal gabapentin and clonidine synergistically inhibit allodynia in spinal nerve-ligated rats

Life Sciences

Volumn 87, Issue 17-18, 2010, Pages 565-571

  Yamama, Yoshihiro ^a   Nishikawa, Kiyonobu ^a   Funao, Tomoharu ^a   Mori, Takashi ^a   Asada, Akira ^a  

^a OSAKA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Clonidine; Dose response relationship; Drug interactions; Drug synergism; Gamma aminobutyric acid; Ligation; Pain measurement drug effects; Pain threshold drug effects; Rat; Spinal cord drug effects pathology; Spinal nerves physiology; Sprague Dawley

Indexed keywords

CLONIDINE; GABAPENTIN; SEVOFLURANE; 4 AMINOBUTYRIC ACID; AMINE; CYCLOHEXANECARBOXYLIC ACID DERIVATIVE;

ALLODYNIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CATHETER; CONTROLLED STUDY; DOSE RESPONSE; LUMBAR SPINE; MALE; MECHANICAL STIMULATION; MONOTHERAPY; NERVE LIGATION; NEUROPATHIC PAIN; NONHUMAN; RAT; SPINAL NERVE; ANIMAL; COMPARATIVE STUDY; DISEASE MODEL; DRUG COMBINATION; DRUG EFFECTS; DRUG POTENTIATION; INTRASPINAL DRUG ADMINISTRATION; LIGATION; NEURALGIA; PAIN MEASUREMENT; PATHOPHYSIOLOGY; SPRAGUE DAWLEY RAT;

AMINES; ANIMALS; CLONIDINE; CYCLOHEXANECARBOXYLIC ACIDS; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SYNERGISM; DRUG THERAPY, COMBINATION; GAMMA-AMINOBUTYRIC ACID; INJECTIONS, SPINAL; LIGATION; MALE; NEURALGIA; PAIN MEASUREMENT; RATS; RATS, SPRAGUE-DAWLEY; SPINAL NERVES;

RATTUS;

EID: 77957863479     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.lfs.2010.09.017     Document Type: Article

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