Antihyperalgesic and side effects of intrathecal clonidine and tizanidine in a rat model of neuropathic pain

Anesthesiology

Volumn 98, Issue 6, 2003, Pages 1480-1483

  Kawamata, Tomoyuki ^a   Omote, Keiichi ^b   Yamamoto, Hiroki ^b   Toriyabe, Masaki ^b   Wada, Kohsuke ^b   Namiki, Akiyoshi ^b  

^a SAPPORO MEDICAL UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; CLONIDINE; TIZANIDINE;

ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINOCICEPTION; ARTICLE; BRADYCARDIA; DRUG EFFECT; HYPERALGESIA; HYPOTENSION; MALE; MICTURITION; NEUROPATHIC PAIN; NONHUMAN; PRIORITY JOURNAL; RAT; SEDATION;

ADRENERGIC ALPHA-AGONISTS; ANALGESICS; ANIMALS; BEHAVIOR, ANIMAL; BLOOD PRESSURE; BRADYCARDIA; CLONIDINE; HEART RATE; HEAT; HYPERALGESIA; HYPOTENSION; INJECTIONS, SPINAL; MALE; PAIN MEASUREMENT; PERIPHERAL NERVOUS SYSTEM DISEASES; PHYSICAL STIMULATION; RATS; RATS, SPRAGUE-DAWLEY;

EID: 0037767115     PISSN: 00033022     EISSN: None     Source Type: Journal    
DOI: 10.1097/00000542-200306000-00027     Document Type: Article

References (18)

1. 2-adrenergic agonists, tizanidine and clonidine, with lidocaine in rats. ANESTHESIOLOGY 1997; 87:436-48
2. Leiphart JW, Dills CV, Zikel OM, Kim DL, Levy RM: A comparison of intrathecally administered narcotic and nonnarcotic analgesics for experimental chronic neuropathic pain. J Neurosurg 1995; 82:595-9
3. Ono N, Kroin JS, Penn RD, Paice JA: Effects of intrathecal nonnarcotic analgesics on chronic tactile allodynia in rats: Alpha 2-agonists versus somatostatin analog. Neurol Med Chir 1997; 37:6-10
4. Vrinten DH, Adan RAH, Groen GJ, Gispen WH: Chronic blockade of melanocortin receptors alleviates allodynia in rats with neuropathic pain. Anesth Analg 2001; 93:1572-7
5. Bennett GJ, Xie YK: A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man. Pain 1988; 33:87-107
6. Stone LS, Vulchanova L, Riedl MS, Wang J, Williams FG, Wilcox GL, Elde R: Effects of peripheral nerve injury on alpha-2A and alpha-2C adrenergic receptor immunoreactivity in the rat spinal cord. Neuroscience 1999; 93:1399-407
7. Dowlatshahi P, Yaksh TL: Differential effects of two intraventricularly injected alpha 2 agonists, ST-91 and dexmedetomidine, on electroencephalogram, feeding, and electromyogram. Anesth Analg 1997; 84:133-8
8. Kroin JS, McCarthy RJ, Penn RD, Lubenow TR, Ivankovich AD: Intrathecal clonidine and tizanidine in conscious dogs: Comparison of analgesic and hemodynamic effects. Anesth Analg 1996; 82:627-35
9. McCarthy RJ, Kroin JS, Lubenow TR, Penn RD, Ivankovich AD: Effect of intrathecal tizanidine on antinociception and blood pressure in the rat. Pain 1990; 40:333-8
10. Solomon SE, Brody MJ, Gebhart GF: Pharmacological characterization of alpha adrenoceptors involved in the antinociceptive and cardiovascular effects of intrathecally administered clonidine. J Pharmacol Exp Ther 1989; 251:27-38
11. Jarrott B, Conway EL, Maccarrone C, Lewis SJ: Clonidine: Understanding its disposition, sites and mechanism of action. Clin Exp Pharmacol Physiol 1987; 14:471-9
12. Scriabine A, Stavorski J, Wenger HC, Torchiana ML, Stone CA: Cardiac slowing effects of clonidine (St 155) in dogs. J Pharmacol Exp Ther 1970; 171:256-64
13. Maze M, Tranquilli W: Alpha-2 adrenoceptor agonists: Defining the role in clinical anesthesia. ANESTHESIOLOGY 1991; 74:581-60
14. Correa-Sales C, Rabin BC, Maze M: A hypnotic response to dexmedetomidine, an alpha 2 agonist, is mediated in the locus coeruleus in rats. ANESTHESIOLOGY 1992; 76:948-52
15. Smyth DD, Umemura S, Yang E, Pettinger W: Inhibition of rennin release by α adrenoceptor stimulation in the isolated perfused rat kidney. Eur J Pharmacol 1987; 140:33-8
16. Chen M, Lee J, Huang BS, Grekin RJ, Malvin RL: Clonidine and morphine increase atrial natriuretic peptide secretion in anesthetized rats. Proc Soc Exp Biol Med 1989; 191:299-303
17. 2 adrenoceptor. Gen Pharmacol 1985; 16:501-3
18. Ochs G, Tonn LJ, Toyka K: Distribution, tolerability and tissue compatibility of intrathecal tizanidine in the sheep. Acta Anaesthesiol Scand 1998; 42:786-93