A new role for cortactin in invadopodia: Regulation of protease secretion

European Journal of Cell Biology

Volumn 87, Issue 8-9, 2008, Pages 581-590

  Clark, Emily S ^a   Weaver, Alissa M ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Cortactin; Invadopodia; Matrix metalloproteinase; Membrane trafficking; Protease; Vesicle

Indexed keywords

ACTIN; BETA ACTIN; CORTACTIN; GELATINASE A; GELATINASE B; GREEN FLUORESCENT PROTEIN; MATRIX METALLOPROTEINASE; MELATONIN 1 RECEPTOR;

ARTICLE; CANCER CELL CULTURE; CELL FUNCTION; CELL INTERACTION; CELL MIGRATION; CELL ORGANELLE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; ENZYME RELEASE; EXTRACELLULAR MATRIX; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; INVADOPODIA; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION;

ACTINS; BIOLOGICAL TRANSPORT; CELL ADHESION; CELL LINE, TUMOR; CELL MEMBRANE; CELL MOVEMENT; CORTACTIN; EXTRACELLULAR MATRIX; HUMANS; MATRIX METALLOPROTEINASE 2; MATRIX METALLOPROTEINASE 9; MATRIX METALLOPROTEINASES; MICROSCOPY, CONFOCAL; MODELS, BIOLOGICAL;

EID: 44149106941     PISSN: 01719335     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejcb.2008.01.008     Document Type: Article

References (42)

1. Artym V.V., Zhang Y., Seillier-Moiseiwitsch F., Yamada K.M., and Mueller S.C. Dynamic interactions of cortactin and membrane type 1 matrix metalloproteinase at invadopodia: defining the stages of invadopodia formation and function. Cancer Res. 66 (2006) 3034-3043
2. Baldassarre M., Pompeo A., Beznoussenko G., Castaldi C., Cortellino S., McNiven M.A., Luini A., and Buccione R. Dynamin participates in focal extracellular matrix degradation by invasive cells. Mol. Biol. Cell 14 (2003) 1074-1084
3. Bowden E.T., Barth M., Thomas D., Glazer R.I., and Mueller S.C. An invasion-related complex of cortactin, paxillin and PKCmu associates with invadopodia at sites of extracellular matrix degradation. Oncogene 18 (1999) 4440-4449
4. Brabek J., Constancio S.S., Shin N.Y., Pozzi A., Weaver A.M., and Hanks S.K. CAS promotes invasiveness of Src-transformed cells. Oncogene 23 (2004) 7406-7415
5. Bryce N.S., Clark E.S., Leysath J.L., Currie J.D., Webb D.J., and Weaver A.M. Cortactin promotes cell motility by enhancing lamellipodial persistence. Curr. Biol. 15 (2005) 1276-1285
6. Cao H., Orth J.D., Chen J., Weller S.G., Heuser J.E., and McNiven M.A. Cortactin is a component of clathrin-coated pits and participates in receptor-mediated endocytosis. Mol. Cell. Biol. 23 (2003) 2162-2170
7. Cao H., Weller S., Orth J.D., Chen J., Huang B., Chen J.L., Stamnes M., and McNiven M.A. Actin and Arf1-dependent recruitment of a cortactin-dynamin complex to the Golgi regulates post-Golgi transport. Nat. Cell Biol. 7 (2005) 483-492
8. Chen W.T., Chen J.M., Parsons S.J., and Parsons J.T. Local degradation of fibronectin at sites of expression of the transforming gene product pp60src. Nature 316 (1985) 156-158
9. Chen W.T., Yeh Y., and Nakahara H. An in vitro cell invasion assay: determination of cell surface proteolytic activity that degrades extracellular matrix. J. Tissue Culture Methods 16 (1994) 177-181
10. Clark E.S., Whigham A.S., Yarbrough W.G., and Weaver A.M. Cortactin is an essential regulator of matrix metalloproteinase secretion and extracellular matrix degradation in invadopodia. Cancer Res. 67 (2007) 4227-4235
11. Cosen-Binker L.I., and Kapus A. Cortactin: the gray eminence of the cytoskeleton. Physiology (Bethesda) 21 (2006) 352-361
12. Gasman S., Chasserot-Golaz S., Malacombe M., Way M., and Bader M.F. Regulated exocytosis in neuroendocrine cells: a role for subplasmalemmal Cdc42/N-WASP-induced actin filaments. Mol. Biol. Cell 15 (2004) 520-531
13. Hill A., McFarlane S., Mulligan K., Gillespie H., Draffin J.E., Trimble A., Ouhtit A., Johnston P.G., Harkin D.P., McCormick D., and Waugh D.J. Cortactin underpins CD44-promoted invasion and adhesion of breast cancer cells to bone marrow endothelial cells. Oncogene 25 (2006) 6079-6091
14. Hoon D.S., Kitago M., Kim J., Mori T., Piris A., Szyfelbein K., Mihm Jr. M.C., Nathanson S.D., Padera T.P., Chambers A.F., Vantyghem S.A., MacDonald I.C., Shivers S.C., Alsarraj M., Reintgen D.S., Passlick B., Sienel W., and Pantel K. Molecular mechanisms of metastasis. Cancer Metastasis Rev. 25 (2006) 203-220
15. Huang C., Liu J., Haudenschild C.C., and Zhan X. The role of tyrosine phosphorylation of cortactin in the locomotion of endothelial cells. J. Biol. Chem. 273 (1998) 25770-25776
16. Lanzetti L. Actin in membrane trafficking. Curr. Opin. Cell Biol. 19 (2007) 453-458
17. Linder S. The matrix corroded: podosomes and invadopodia in extracellular matrix degradation. Trends Cell Biol 17 (2007) 107-117
18. Merrifield C.J., Perrais D., and Zenisek D. Coupling between clathrin-coated-pit invagination, cortactin recruitment, and membrane scission observed in live cells. Cell 121 (2005) 593-606
19. Mizutani K., Miki H., He H., Maruta H., and Takenawa T. Essential role of neural Wiskott-Aldrich syndrome protein in podosome formation and degradation of extracellular matrix in src-transformed fibroblasts. Cancer Res. 62 (2002) 669-674
20. Myllykangas S., Bohling T., and Knuutila S. Specificity, selection and significance of gene amplifications in cancer. Semin. Cancer Biol. 17 (2007) 42-55
21. Ormandy C.J., Musgrove E.A., Hui R., Daly R.J., and Sutherland R.L. Cyclin D1, EMS1 and 11q13 amplification in breast cancer. Breast Cancer Res. Treat. 78 (2003) 323-335
22. Pantel K., and Brakenhoff R.H. Dissecting the metastatic cascade. Nat. Rev. Cancer 4 (2004) 448-456
23. Patel A.S., Schechter G.L., Wasilenko W.J., and Somers K.D. Overexpression of EMS1/cortactin in NIH3T3 fibroblasts causes increased cell motility and invasion in vitro. Oncogene 16 (1998) 3227-3232
24. Rodrigo J.P., Garcia L.A., Ramos S., Lazo P.S., and Suarez C. EMS1 gene amplification correlates with poor prognosis in squamous cell carcinomas of the head and neck. Clin. Cancer Res. 6 (2000) 3177-3182
25. Rothschild B.L., Shim A.H., Ammer A.G., Kelley L.C., Irby K.B., Head J.A., Chen L., Varella-Garcia M., Sacks P.G., Frederick B., Raben D., and Weed S.A. Cortactin overexpression regulates actin-related protein 2/3 complex activity, motility, and invasion in carcinomas with chromosome 11q13 amplification. Cancer Res. 66 (2006) 8017-8025
26. Schuuring E., Verhoeven E., Mooi W.J., and Michalides R.J. Identification and cloning of two overexpressed genes, U21B31/PRAD1 and EMS1, within the amplified chromosome 11q13 region in human carcinomas. Oncogene 7 (1992) 355-361
27. Schuuring E., Verhoeven E., Litvinov S., and Michalides R.J. The product of the EMS1 gene, amplified and overexpressed in human carcinomas, is homologous to a v-src substrate and is located in cell-substratum contact sites. Mol. Cell. Biol. 13 (1993) 2891-2898
28. Seals D.F., Azucena Jr. E.F., Pass I., Tesfay L., Gordon R., Woodrow M., Resau J.H., and Courtneidge S.A. The adaptor protein Tks5/Fish is required for podosome formation and function, and for the protease-driven invasion of cancer cells. Cancer Cell 7 (2005) 155-165
29. Tehrani S., Faccio R., Chandrasekar I., Ross F.P., and Cooper J.A. Cortactin has an essential and specific role in osteoclast actin assembly. Mol. Biol. Cell 17 (2006) 2882-2895
30. Tehrani S., Tomasevic N., Weed S., Sakowicz R., and Cooper J.A. Src phosphorylation of cortactin enhances actin assembly. Proc. Natl. Acad. Sci. USA 104 (2007) 11933-11938
31. Uruno T., Liu J., Zhang P., Fan Y., Egile C., Li R., Mueller S.C., and Zhan X. Activation of Arp2/3 complex-mediated actin polymerization by cortactin. Nat. Cell Biol. 3 (2001) 259-266
32. van Rossum A.G., Moolenaar W.H., and Schuuring E. Cortactin affects cell migration by regulating intercellular adhesion and cell spreading. Exp. Cell Res. 312 (2006) 1658-1670
33. Weaver A.M. Invadopodia: specialized cell structures for cancer invasion. Clin. Exp. Metastasis 23 (2006) 97-105
34. Weaver A.M., Karginov A.V., Kinley A.W., Weed S.A., Li Y., Parsons J.T., and Cooper J.A. Cortactin promotes and stabilizes Arp2/3-induced actin filament network formation. Curr. Biol. 11 (2001) 370-374
35. Webb B.A., Eves R., and Mak A.S. Cortactin regulates podosome formation: roles of the protein interaction domains. Exp. Cell Res. 312 (2006) 760-769
36. Webb B.A., Jia L., Eves R., and Mak A.S. Dissecting the functional domain requirements of cortactin in invadopodia formation. Eur. J. Cell Biol. 86 (2007) 189-206
37. Weed S.A., and Parsons J.T. Cortactin: coupling membrane dynamics to cortical actin assembly. Oncogene 20 (2001) 6418-6434
38. Weichselbaum R.R., Dahlberg W., Beckett M., Karrison T., Miller D., Clark J., and Ervin T.J. Radiation-resistant and repair-proficient human tumor cells may be associated with radiotherapy failure in head- and neck-cancer patients. Proc. Natl. Acad. Sci. USA 83 (1986) 2684-2688
39. Yamaguchi H., and Condeelis J. Regulation of the actin cytoskeleton in cancer cell migration and invasion. Biochim. Biophys. Acta 1773 (2007) 642-652
40. Yamaguchi H., Lorenz M., Kempiak S., Sarmiento C., Coniglio S., Symons M., Segall J., Eddy R., Miki H., Takenawa T., and Condeelis J. Molecular mechanisms of invadopodium formation: the role of the N-WASP-Arp2/3 complex pathway and cofilin. J. Cell Biol. 168 (2005) 441-452
41. Yarar D., To W., Abo A., and Welch M.D. The Wiskott-Aldrich syndrome protein directs actin-based motility by stimulating actin nucleation with the Arp2/3 complex. Curr. Biol. 9 (1999) 555-558
42. Zhu J., Zhou K., Hao J.J., Liu J., Smith N., and Zhan X. Regulation of cortactin/dynamin interaction by actin polymerization during the fission of clathrin-coated pits. J. Cell Sci. 118 (2005) 807-817