Aminoglycoside ototoxicity in adult CBA, C57BL and BALB mice and the Sprague-Dawley rat

Hearing Research

Volumn 158, Issue 1-2, 2001, Pages 165-178

  Wu, Wei Jing ^a   Sha, Su Hua ^a   McLaren, John D ^a   Kawamoto, Kohei ^a   Raphael, Yehoash ^a   Schacht, Jochen ^a  

^a UNIVERSITY OF MICHIGAN HEALTH SYSTEM   (United States)

Author keywords

2, 3 Dihydroxybenzoate; Gentamicin; Kanamycin; Pigmentation; Protection; Reactive oxygen species

Indexed keywords

2,3 DIHYDROXYBENZOIC ACID; AMINOGLYCOSIDE; ANTIOXIDANT; KANAMYCIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUDITORY THRESHOLD; CELL LOSS; COCHLEA; CONCENTRATION RESPONSE; CONTROLLED STUDY; DISEASE PREDISPOSITION; DRUG EFFECT; EVOKED AUDITORY RESPONSE; EVOKED BRAIN STEM RESPONSE; GENETIC PREDISPOSITION; HAIR CELL; HEARING LOSS; MALE; MOUSE; NONHUMAN; OTOTOXICITY; PIGMENTATION; PRIORITY JOURNAL; RAT; TOXICOKINETICS; VESTIBULAR DISORDER; VESTIBULAR SYSTEM;

AMINOGLYCOSIDES; ANIMALS; ANTIOXIDANTS; AUDITORY THRESHOLD; CELL SURVIVAL; COCHLEA; EAR, INNER; EVOKED POTENTIALS, AUDITORY, BRAIN STEM; HAIR CELLS; HYDROXYBENZOIC ACIDS; KANAMYCIN; KIDNEY; MALE; MICE; MICE, INBRED STRAINS; RATS; RATS, SPRAGUE-DAWLEY; VESTIBULE;

EID: 0034897652     PISSN: 03785955     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-5955(01)00303-3     Document Type: Article

References (50)

1. Kanamycin induced ototoxicity in the laboratory rat
2. Studies of aminoglycoside ototoxicity in animal models
3. Supra-normal sensitivity to ototoxic antibiotic of the developing rat
4. Action de la streptomycine sur les cellules ciliées des organes vestibulaires de la souris
5. The sensitive period for ototoxicity of kanamycin in mice: Morphological evidence
6. Differential susceptibility to gentamicin ototoxicity between albino and pigmented guinea pig
7. Attenuation of aminoglycoside-induced cochlear damage with the metabolic antioxidant α-lipoic acid
8. Genetics of age-related hearing loss in mice: I. Inbred and F1 hybrid strains
9. Genetics of age-related hearing loss in mice. III. Susceptibility of inbred and F1 hybrid strains to noise-induced hearing loss
10. Aminoglycoside ototoxicity examined in vitro using organotypic cultures
11. Aminoglycoside antibiotics
12. Transgenic mice: Current applications to the study of the auditory and vestibular systems
13. Vulnerability to noise and ototoxic drugs in pigmented guinea pigs from two different commercial breeding colonies
14. Sensitive developmental periods for kanamycin ototoxic effects on distortion-product otoacoustic emissions
15. Pharmacokinetics of kanamycin in the developing rat
16. Increased ototoxicity in both young and old mice
17. Potentiation of ototoxicity by glutathione depletion
18. Age-related loss of distortion product otoacoustic emissions in four mouse strains
19. A major gene affecting age-related hearing loss in C57BL/6J mice
20. Cochlear degeneration in aged rats of four strains
21. Glutathione protection against gentamicin ototoxicity depends on nutritional status
22. Regional differences in sensitivity of the vestibular sensory epithelia to ototoxic antibiotics
23. The rise of the mouse, biomedicine's model mammal
24. Ototoxic effect of an aminoglycoside drug on an immature inner ear
25. Targeted deletion of the cytosolic Cu/Zn-superoxide dismutase gene (Sod1) increases susceptibility to noise-induced hearing loss
26. Vulnerability to noise-induced hearing loss in 'middle-aged' and young adult mice: A dose-response approach in CBA, C57BL, and BALB inbred strains
27. Age-dependent changes in susceptibility to ototoxic hearing loss
28. Formation of free radicals by gentamicin and iron and evidence for an iron/gentamicin complex
29. The role of mouse mutants in the identification of human hereditary hearing loss genes
30. The MRL-Ipr/Ipr mouse: A potential model of autoimmune inner ear disease
31. Antimicrobial agents; the aminoglycosides
32. Lipid peroxidation in pigmented and unpigmented liver tissues: Protective role of melanin
33. Formation of reactive oxygen species following bioactivation of gentamicin
34. Stimulation of free radical formation by aminoglycoside antibiotics
35. Salicylate attenuates gentamicin-induced ototoxicity
36. Antioxidants attenuate gentamicin-induced free-radical formation in vitro and ototoxicity in vivo: D-methionine is a potential protectant
37. Differential vulnerability of basal and apical hair cells is based on intrinsic susceptibility to free radicals
38. Overexpression of SOD protects from kanamycin-induced hearing loss
39. In vitro scavenger activity of some flavonoids and melanins against O2-(.)
40. Protection from ototoxicity of intraperitoneal gentamicin in guinea pig
41. Protection from gentamicin ototoxicity by iron chelators in guinea pig in vivo
42. Variable efficacy of radical scavengers and iron chelators to attenuate gentamicin ototoxicity in guinea pig in vivo
43. Iron chelators protect from aminoglycoside-induced cochleo- and vestibulotoxicity
44. Sensitive fluorimetric determination of gentamicin sulfate in biological matrices using solid-phase extraction, pre-column derivatization with 9-fluorenylmethyl chloroformate and reversed-phase high-performance liquid chromatography
45. Comparative ototoxicity of gentamicin in the guinea pig and two strains of rats
46. Experiments on ototoxic effects of antibiotics
47. Ototoxicity of gentamicin
48. Maturation of cochlear glutathione-S-transferases correlates with the end of the sensitive period for ototoxicity
49. The BALB/c mouse as an animal model for progressive sensorineural hearing loss