In vitro transformation of mesenchymal stem cells induces gradual genomic hypomethylation

Carcinogenesis

Volumn 31, Issue 10, 2010, Pages 1854-1862

  Wild, Laurence ^a   Funes, Juan M ^a   Boshoff, Chris ^a   Flanagan, James M ^a,b  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b HAMMERSMITH HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

RAS PROTEIN; SATELLITE DNA; ACYLTRANSFERASE; DIAMINE N-ACETYLTRANSFERASE;

ARTICLE; CELL TRANSFORMATION; CONTROLLED STUDY; DNA METHYLATION; EMBRYO; GENE CONSTRUCT; HUMAN; HUMAN CELL; INTERSPERSED REPEAT; MESENCHYMAL STEM CELL; MOLECULAR MECHANICS; MOUSE; NONHUMAN; ONCOGENE H RAS; PRIORITY JOURNAL; ANIMAL; CELL CULTURE; GENETICS; MESENCHYMAL STROMA CELL; METABOLISM; ONCOGENE RAS; PATHOLOGY;

ACETYLTRANSFERASES; ANIMALS; CELL TRANSFORMATION, NEOPLASTIC; CELLS, CULTURED; DNA METHYLATION; GENES, RAS; HUMANS; MESENCHYMAL STROMAL CELLS; MICE;

EID: 77957771140     PISSN: 01433334     EISSN: 14602180     Source Type: Journal    
DOI: 10.1093/carcin/bgq080     Document Type: Article

References (38)

1. Feinberg,A.P. et al. (2004) The history of cancer epigenetics. Nat. Rev. Cancer, 4, 143-153.
2. Feinberg,A.P. et al. (1983) Hypomethylation distinguishes genes of some human cancers from their normal counterparts. Nature, 301, 89-92.
3. Narayan,A. et al. (1998) Hypomethylation of pericentromeric DNA in breast adenocarcinomas. Int. J. Cancer, 77, 833-838.
4. Feinberg,A.P. et al. (1988) Reduced genomic 5-methylcytosine content in human colonic neoplasia. Cancer Res., 48, 1159-1161.
5. Weisenberger,D.J. et al. (2005) Analysis of repetitive element DNA methylation by MethyLight. Nucleic Acids Res., 33, 6823-6836.
6. Ehrlich,M. et al. (2002) Hypomethylation and hypermethylation of DNA in Wilms tumors. Oncogene, 21, 6694-6702.
7. Pradhan,S. et al. (1999) Recombinant human DNA (cytosine-5) methyltransferase. I. Expression, purification, and comparison of de novo and maintenance methylation. J. Biol. Chem., 274, 33002-33010.
8. Gama-Sosa,M.A. et al. (1983) The 5-methylcytosine content of DNA from human tumors. Nucleic Acids Res., 11, 6883-6894.
9. Yegnasubramanian,S. et al. (2008) DNA hypomethylation arises later in prostate cancer progression than CpG island hypermethylation and contributes to metastatic tumor heterogeneity. Cancer Res., 68, 8954-8967.
10. Li,E. et al. (1992) Targeted mutation of the DNA methyltransferase gene results in embryonic lethality. Cell, 69, 915-926.
11. Jackson-Grusby,L. et al. (2001) Loss of genomic methylation causes p53-dependent apoptosis and epigenetic deregulation. Nat. Genet., 27, 31-39.
12. Chen,T. et al. (2007) Complete inactivation of DNMT1 leads to mitotic catastrophe in human cancer cells. Nat. Genet., 39, 391-396.
13. Dodge,J.E. et al. (2005) Inactivation of Dnmt3b in mouse embryonic fibroblasts results in DNA hypomethylation, chromosomal instability, and spontaneous immortalization. J. Biol. Chem., 280, 17986-17991.
14. Hansen,R.S. et al. (1999) The DNMT3B DNA methyltransferase gene is mutated in the ICF immunodeficiency syndrome. Proc. Natl Acad. Sci. USA, 96, 14412-14417.
15. Xu,G.L. et al. (1999) Chromosome instability and immunodeficiency syndrome caused by mutations in a DNA methyltransferase gene. Nature, 402, 187-191.
16. Mayer,W. et al. (2000) Demethylation of the zygotic paternal genome. Nature, 403, 501-502.
17. Barreto,G. et al. (2007) Gadd45a promotes epigenetic gene activation by repair-mediated DNA demethylation. Nature, 445, 671-675.
18. Jin,S.-G. et al. (2008) GADD45A does not promote DNA demethylation. PLoS Genet., 4, e1000013.
19. Rai,K. et al. (2008) DNA demethylation in zebrafish involves the coupling of a deaminase, a glycosylase, and gadd45. Cell, 135, 1201-1212.
20. Funes,J.M. et al. (2007) Transformation of human mesenchymal stem cells increases their dependency on oxidative phosphorylation for energy production. Proc. Natl Acad. Sci. USA, 104, 6223-6228.
21. Flanagan,J.M. et al. (2009) Genomics screen in transformed stem cells reveals RNASEH2A, PPAP2C, and ADARB1 as putative anticancer drug targets. Mol. Cancer Ther., 8, 249-260.
22. Sambrook,J. et al. (2001) Molecular cloning. Cold Spring Harbor Laboratory Press, Plainview, NY.
23. Danielian,P.S. et al. (1993) Identification of residues in the estrogen receptor that confer differential sensitivity to estrogen and hydroxytamoxifen. Mol. Endocrinol., 7, 232-240.
24. Mattioni,T. et al. (1994) Regulation of protein activities by fusion to steroid binding domains. Methods Cell Biol., 43 Pt A, 335-352.
25. Fearon,E.R. et al. (1990) A genetic model for colorectal tumorigenesis. Cell, 61, 759-767.
26. Feinberg,A.P. et al. (2006) The epigenetic progenitor origin of human cancer. Nat. Rev. Genet., 7, 21-33.
27. Gaudet,F. et al. (2003) Induction of tumors in mice by genomic hypomethylation. Science, 300, 489-492.
28. MacLeod,A.R. et al. (1995) Regulation of DNA methylation by the Ras signaling pathway. J. Biol. Chem., 270, 11327-11337.
29. Rouleau,J. et al. (1995) Regulation of the DNA methyltransferase by the Ras-AP-1 signaling pathway. J. Biol. Chem., 270, 1595-1601.
30. Lund,P. et al. (2006) Oncogenic HRAS suppresses clusterin expression through promoter hypermethylation. Oncogene, 25, 4890-4903.
31. Szyf,M. et al. (1995) Ras induces a general DNA demethylation activity in mouse embryonal P19 cells. J. Biol. Chem., 270, 12690-12696.
32. Eden,A. et al. (2003) Chromosomal instability and tumors promoted by DNA hypomethylation. Science, 300, 455.
33. Yamada,Y. et al. (2005) Opposing effects of DNA hypomethylation on intestinal and liver carcinogenesis. Proc. Natl Acad. Sci. USA, 102, 13580-5.
34. Goelz,S.E. et al. (1985) Hypomethylation of DNA from benign and malignant human colon neoplasms. Science, 228, 187-190.
35. Suter,C.M. et al. (2004) Hypomethylation of L1 retrotransposons in colorectal cancer and adjacent normal tissue. Int. J. Colorectal Dis., 19, 95-101.
36. Ehrlich,M. et al. (2006) Quantitative analysis of associations between DNA hypermethylation, hypomethylation, and DNMT RNA levels in ovarian tumors. Oncogene, 25, 2636-2645.
37. Florl,A.R. et al. (2004) Coordinate hypermethylation at specific genes in prostate carcinoma precedes LINE-1 hypomethylation. Br. J. Cancer, 91, 985-994.
38. Yegnasubramanian,S. et al. (2004) Hypermethylation of CpG islands in primary and metastatic human prostate cancer. Cancer Res., 64, 1975-1986.