Effects of the quantity of water and milk ingested concomitantly with AS-924, a novel ester-type cephem antibiotic, on its pharmacokinetics

International Journal of Antimicrobial Agents

Volumn 18, Issue 5, 2001, Pages 471-476

  Matsumoto, Fumio ^a   Sakurai, Iwao ^a   Morita, Masayuki ^a   Takahashi, Takayuki ^a   Mori, Nobuhiro ^b   Sugihara, Taisuke ^b   Sakai, Atsushi ^b   Yamaji, Shinya ^b   Akaike, Yasuhiro ^b   Yano, Kazuo ^b  

^a Kanagawa Prefecture Midwives and Nurses Training School Hospital   (Japan)

^b ASAHI KASEI PHARMA CORPORATION   (Japan)

Author keywords

Absorbtion; Antibiotic; AS 924; Ceftizoxime; Milk; Prodrug; Water

Indexed keywords

ANTIBIOTIC AGENT; CEFTERAM; CEFTERAM PIVOXIL; CEFTIZOXIME; CEFTIZOXIME ALAPIVOXIL; CEFTIZOXIME ARAPIVOXIL; CEPHAM DERIVATIVE; ESTER; PRODRUG; UNCLASSIFIED DRUG; WATER;

ADULT; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DRUG BLOOD LEVEL; DRUG STRUCTURE; HUMAN; HUMAN EXPERIMENT; INTESTINE ABSORPTION; MALE; MILK; PRIORITY JOURNAL; STRUCTURE ANALYSIS; URINARY EXCRETION; VOLUNTEER;

ADMINISTRATION, ORAL; ADULT; ANIMALS; ANTI-BACTERIAL AGENTS; CEFMENOXIME; CEFTIZOXIME; CROSS-OVER STUDIES; FOOD-DRUG INTERACTIONS; HUMANS; INTESTINAL ABSORPTION; MALE; MILK; PRODRUGS; TIME FACTORS; URINE; WATER;

EID: 0035165738     PISSN: 09248579     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0924-8579(01)00447-2     Document Type: Article

References (11)

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3. Effect of food intake on absorption of T-2588
4. Investigations of pharmacokinetics of CS-807 in vivo
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7. AS-924, a novel orally active bifunctional prodrug of ceftizoxime; synthesis and relationship between physicochemical properties and oral absorption
8. AS-924: A novel, orally active, bifunctional prodrug of ceftizoxime: Physicochemical properties, oral absorption in animals, and antibacterial activity
9. Carnitine deficiency induced by pivampicillin and pivmecillinam therapy
10. Determination of pivaloylcarnitine in human plasma and urine by high-performance liquid chromatography with fluorescence detection
11. Effects of antacid pretreatment on the pharmacokinetics of AS-924, a novel ester-type cephem antibiotic - Comparison with cefteram pivoxil